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Journal of Assisted Reproduction and Genetics
Volumn 29, Issue 1, 2012, Pages 15-23
Aqueous extract of Azadirachta indica (neem) leaf induces generation of reactive oxygen species and mitochondria-mediated apoptosis in rat oocytes
Author keywords

Aqueous neem leaf extract; Caspase 3; Caspase 9; Cytochrome c; DNA fragmentation; Morphological apoptotic features; Oocyte; Reactive oxygen species
Indexed keywords

AZADIRACHTA INDICA EXTRACT; CASPASE 3; CASPASE 9; CYTOCHROME C; HYDROGEN PEROXIDE; NITRIC OXIDE; QUERCETIN; REACTIVE OXYGEN METABOLITE;
EID: 84857638294     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-011-9671-0     Document Type: Article
Times cited : (24)
References (35)
  • 1
    • 14844301650 scopus 로고    scopus 로고
    • Medicinal properties of neem leaves: A review
    • DOI 10.2174/1568011053174828
    • R Subapriya S Nagini 2005 Medicinal properties of neem leaves: a review Curr Med Chem Anti-Canc Agents 5 149 56 10.2174/1568011053174828 1:CAS:528:DC%2BD2MXhvVCjurY%3D (Pubitemid 40347988)
    • (2005) Current Medicinal Chemistry - Anti-Cancer Agents , vol.5 , Issue.2 , pp. 149-156
    • Subapriya, R.1    Nagini, S.2
  • 2
    • 33645734477 scopus 로고    scopus 로고
    • Extract of Azadirachta indica (Neem) leaf induces apoptosis in rat oocytes cultured in vitro
    • 10.1016/j.fertnstert.2005.11.034
    • SK Chaube PV Prasad B Khillare TG Shrivastav 2006 Extract of Azadirachta indica (Neem) leaf induces apoptosis in rat oocytes cultured in vitro Fertl Steril 85 1223 31 10.1016/j.fertnstert.2005.11.034
    • (2006) Fertl Steril , vol.85 , pp. 1223-31
    • Chaube, S.K.1    Prasad, P.V.2    Khillare, B.3    Shrivastav, T.G.4
  • 3
    • 61449211207 scopus 로고    scopus 로고
    • Variability of antioxidative quercetin content in Siamese neem tree leaves in Thailand by TLC-densitometry
    • 1:CAS:528:DC%2BD1cXos1aksbs%3D
    • P Sithisarn W Gritsanapan 2008 Variability of antioxidative quercetin content in Siamese neem tree leaves in Thailand by TLC-densitometry Acta Hort (ISHS) 786 161 9 1:CAS:528:DC%2BD1cXos1aksbs%3D
    • (2008) Acta Hort (ISHS) , vol.786 , pp. 161-9
    • Sithisarn, P.1    Gritsanapan, W.2
  • 4
    • 77951887248 scopus 로고    scopus 로고
    • Induction of apoptosis by quercetin is mediated through AMPKα1/ask1/p38 pathway
    • 20083342 10.1016/j.canlet.2009.12.005 1:CAS:528:DC%2BC3cXkvFemtrc%3D
    • YK Lee JT Hwang DY Kwon YJ Surh OJ Park 2010 Induction of apoptosis by quercetin is mediated through AMPKα1/ask1/p38 pathway Cancer Lett 292 228 36 20083342 10.1016/j.canlet.2009.12.005 1:CAS:528:DC%2BC3cXkvFemtrc%3D
    • (2010) Cancer Lett , vol.292 , pp. 228-36
    • Lee, Y.K.1    Hwang, J.T.2    Kwon, D.Y.3    Surh, Y.J.4    Park, O.J.5
  • 5
    • 58649083936 scopus 로고    scopus 로고
    • Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
    • 19009557 10.1002/jcb.21977 1:CAS:528:DC%2BD1MXns1Ghug%3D%3D
    • JH Jeong JY An YT Kwon JG Rhee YJ Lee 2009 Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression J Cell Biochem 106 73 82 19009557 10.1002/jcb.21977 1:CAS:528:DC%2BD1MXns1Ghug%3D%3D
    • (2009) J Cell Biochem , vol.106 , pp. 73-82
    • Jeong, J.H.1    An, J.Y.2    Kwon, Y.T.3    Rhee, J.G.4    Lee, Y.J.5
  • 6
    • 34547641948 scopus 로고    scopus 로고
    • Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells
    • DOI 10.1158/0008-5472.CAN-07-1089
    • PL Kuo CY Chen YL Hsu 2007 Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells Cancer Res 67 7406 20 17671211 10.1158/0008-5472.CAN-07-1089 1:CAS:528:DC%2BD2sXosVemtLo%3D (Pubitemid 47206571)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7406-7420
    • Kuo, P.-L.1    Chen, C.-Y.2    Hsu, Y.-L.3
  • 7
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • DOI 10.1016/j.drup.2004.01.004
    • H Pelicano D Carney P Huang 2004 ROS stress in cancer cells and therapeutic implications Drug Resist Update 7 97 110 10.1016/j.drup.2004.01.004 1:CAS:528:DC%2BD2cXkt1Wquro%3D (Pubitemid 38736063)
    • (2004) Drug Resistance Updates , vol.7 , Issue.2 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 8
    • 78650334862 scopus 로고    scopus 로고
    • Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of bax
    • 21138867 10.1158/1078-0432.CCR-10-1565 1:CAS:528:DC%2BC3cXhsFamtLrM
    • S Cheng N Gao Z Zhang G Chen A Budhraja Z Ke YO Son X Wang J Luo X Shi 2010 Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of bax Clin Cancer Res 16 5679 91 21138867 10.1158/1078-0432. CCR-10-1565 1:CAS:528:DC%2BC3cXhsFamtLrM
    • (2010) Clin Cancer Res , vol.16 , pp. 5679-91
    • Cheng, S.1    Gao, N.2    Zhang, Z.3    Chen, G.4    Budhraja, A.5    Ke, Z.6    Son, Y.O.7    Wang, X.8    Luo, J.9    Shi, X.10
  • 9
    • 77957319672 scopus 로고    scopus 로고
    • Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells
    • 20803121 10.1007/s12272-010-0808-y 1:CAS:528:DC%2BC3cXhtVyltLvO
    • CC Chou JS Yang HF Lu SW Ip C Lo CC Wu JP Lin NY Tang JG Chung MJ Chou YH Teng DR Chen 2010 Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells Arch Pharm Res 33 1181 91 20803121 10.1007/s12272-010-0808-y 1:CAS:528:DC%2BC3cXhtVyltLvO
    • (2010) Arch Pharm Res , vol.33 , pp. 1181-91
    • Chou, C.C.1    Yang, J.S.2    Lu, H.F.3    Ip, S.W.4    Lo, C.5    Wu, C.C.6    Lin, J.P.7    Tang, N.Y.8    Chung, J.G.9    Chou, M.J.10    Teng, Y.H.11    Chen, D.R.12
  • 10
    • 70349680622 scopus 로고    scopus 로고
    • Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells
    • 10.1177/0960327109107002
    • SY Chien YC Wu JG Chung JS Yang HF Lu MF Tsou WG Wood SJ Kuo DR Chen 2010 Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells Hum Exp Toxicol 28 493 503 10.1177/0960327109107002
    • (2010) Hum Exp Toxicol , vol.28 , pp. 493-503
    • Chien, S.Y.1    Wu, Y.C.2    Chung, J.G.3    Yang, J.S.4    Lu, H.F.5    Tsou, M.F.6    Wood, W.G.7    Kuo, S.J.8    Chen, D.R.9
  • 11
    • 65949121609 scopus 로고    scopus 로고
    • AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
    • 19293639 10.3858/emm.2009.41.3.023 1:CAS:528:DC%2BD1MXksVKkt74%3D
    • YK Lee SY Park YM Kim WS Lee OJ Park 2009 AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin Exp Mol Med 41 201 7 19293639 10.3858/emm.2009.41.3.023 1:CAS:528:DC%2BD1MXksVKkt74%3D
    • (2009) Exp Mol Med , vol.41 , pp. 201-7
    • Lee, Y.K.1    Park, S.Y.2    Kim, Y.M.3    Lee, W.S.4    Park, O.J.5
  • 12
    • 0037226618 scopus 로고    scopus 로고
    • s in Xenopus oocytes induces BH3-dependent and caspase-dependent cytochrome c release and apoptosis
    • T Braun S Dar D Vorobiov L Lindenboim N Dascal R Stein 2003 Expression of Bcl-x(S) in Xenopus oocytes induces BH3-dependent and caspase-dependent cytochrome c release and apoptosis Mol Cancer Res 1 186 94 12556558 1:CAS:528:DC%2BD3sXnt1yltg%3D%3D (Pubitemid 36330200)
    • (2003) Molecular Cancer Research , vol.1 , Issue.3 , pp. 186-194
    • Braun, T.1    Dar, S.2    Vorobiov, D.3    Lindenboim, L.4    Dascal, N.5    Stein, R.6
  • 13
    • 77449092311 scopus 로고    scopus 로고
    • Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring
    • 19730443 10.1038/cdd.2009.120 1:CAS:528:DC%2BD1MXhsFGnurjJ
    • CE Johnson CD Freel S Kornbluth 2010 Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring Cell Death Differ 17 170 9 19730443 10.1038/cdd.2009.120 1:CAS:528:DC%2BD1MXhsFGnurjJ
    • (2010) Cell Death Differ , vol.17 , pp. 170-9
    • Johnson, C.E.1    Freel, C.D.2    Kornbluth, S.3
  • 14
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl- 2 regulation of apoptosis
    • DOI 10.1126/science.275.5303.1132
    • RM Kluck E Bossy-Wetzel DR Green DD Newmeyer 1997 The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1132 6 9027315 10.1126/science.275.5303.1132 1:CAS:528: DyaK2sXhtlKjtro%3D (Pubitemid 27097313)
    • (1997) Science , vol.275 , Issue.5303 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 15
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • DOI 10.1016/S0092-8674(00)80085-9
    • X Liu CN Kim J Yang R Jemmerson X Wang 1996 Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 86 147 57 8689682 10.1016/S0092-8674(00)80085-9 1:CAS:528:DyaK28XktlGnsbY%3D (Pubitemid 26256586)
    • (1996) Cell , vol.86 , Issue.1 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 16
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • DOI 10.1126/science.275.5303.1129
    • J Yang X Liu K Bhalla CN Kim AM Ibrado J Cai TI Peng DP Jones X Wang 1997 Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked Science 275 1129 32 9027314 10.1126/science.275.5303.1129 1:CAS:528:DyaK2sXhtlKjs70%3D (Pubitemid 27097312)
    • (1997) Science , vol.275 , Issue.5303 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6    Peng, T.-I.7    Jones, D.P.8    Wang, X.9
  • 17
    • 33749129398 scopus 로고    scopus 로고
    • Redox-Induced Apoptosis of Human Oocytes in Resting Follicles In Vitro
    • DOI 10.1016/j.jsgi.2006.05.005, PII S1071557606014250
    • X Zhang XH Li X Ma ZH Wang S Lu YL Guo 2006 Redox-induced apoptosis of human oocytes in resting follicles in vitro J Soc Gynecol Investig 13 451 8 16879991 10.1016/j.jsgi.2006.05.005 1:CAS:528:DC%2BD28XptFCnsbY%3D (Pubitemid 46059278)
    • (2006) Journal of the Society for Gynecologic Investigation , vol.13 , Issue.6 , pp. 451-458
    • Zhang, X.1    Li, X.-H.2    Ma, X.3    Wang, Z.-H.4    Lu, S.5    Guo, Y.-L.6
  • 18
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • DOI 10.1016/S1097-2765(02)00442-2
    • D Acehan X Jiang DG Morgan JE Heuser X Wang CW Akey 2002 Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation Mol Cell 9 423 32 11864614 10.1016/S1097-2765(02)00442-2 1:CAS:528:DC%2BD38XhvFKgsrg%3D (Pubitemid 34195566)
    • (2002) Molecular Cell , vol.9 , Issue.2 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 19
    • 0033596980 scopus 로고    scopus 로고
    • An APAf-1 · cytochrome C multimeric complex is a functional apoptosome that activates procaspase-9
    • DOI 10.1074/jbc.274.17.11549
    • H Zou Y Li X Liu X Wang 1999 An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 J Biol Chem 274 11549 56 10206961 10.1074/jbc.274.17.11549 1:CAS:528:DyaK1MXislGmur8%3D (Pubitemid 29197809)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.17 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4
  • 20
    • 10644282148 scopus 로고    scopus 로고
    • The protein structures that shape caspase activity, specificity, activation and inhibition
    • DOI 10.1042/BJ20041142
    • P Fuentes-Prior GS Salvesen 2004 The protein structures that shape caspase activity, specificity, activation and inhibition Biochem J 384 201 32 15450003 10.1042/BJ20041142 1:CAS:528:DC%2BD2cXhtVSqs7rP (Pubitemid 39656233)
    • (2004) Biochemical Journal , vol.384 , Issue.2 , pp. 201-232
    • Fuentes-Prior, P.1    Salvesen, G.S.2
  • 21
    • 17644387220 scopus 로고    scopus 로고
    • Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c
    • DOI 10.1074/jbc.M414325200
    • MC Martin LA Allan M Lickrish C Sampson N Morrice PR Clarke 2005 Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c J Biol Chem 280 15449 55 15703181 10.1074/jbc.M414325200 1:CAS:528: DC%2BD2MXjtFSltbk%3D (Pubitemid 40562903)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.15 , pp. 15449-15455
    • Martin, M.C.1    Allan, L.A.2    Lickrish, M.3    Sampson, C.4    Morrice, N.5    Clarke, P.R.6
  • 22
    • 46349098382 scopus 로고    scopus 로고
    • Regulation of apoptosis by the redox state of cytochrome c
    • 18439415 10.1016/j.bbabio.2008.03.024 1:CAS:528:DC%2BD1cXnsFCmtbY%3D
    • GC Brown V Borutaite 2008 Regulation of apoptosis by the redox state of cytochrome c Biochem Biophys Acta 1777 877 1781 18439415 10.1016/j.bbabio.2008. 03.024 1:CAS:528:DC%2BD1cXnsFCmtbY%3D
    • (2008) Biochem Biophys Acta , vol.1777 , pp. 877-1781
    • Brown, G.C.1    Borutaite, V.2
  • 23
    • 78049294193 scopus 로고    scopus 로고
    • The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition
    • 10.1016/j.ejphar.2010.09.020
    • RV Priyadarsini RS Murugan S Maitreyi K Ramalingam D Karunagaran S Nagini 2010 The flavonoid quercetin induces cell cycle arrest and mitochondria- mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition Eur J Pharmacol 649 84 91 10.1016/j.ejphar.2010.09. 020
    • (2010) Eur J Pharmacol , vol.649 , pp. 84-91
    • Priyadarsini, R.V.1    Murugan, R.S.2    Maitreyi, S.3    Ramalingam, K.4    Karunagaran, D.5    Nagini, S.6
  • 25
    • 23944474150 scopus 로고    scopus 로고
    • Hydrogen peroxide modulates meiotic cell cycle and induces morphological features characteristic of apoptosis in rat oocytes cultured in vitro
    • DOI 10.1007/s10495-005-0367-8
    • SK Chaube PV Prasad SC Thakur TG Shrivastav 2005 Hydrogen peroxide modulates meiotic cell cycle and induces morphological features characteristic of apoptosis in rat oocytes in vitro Apoptosis 10 863 74 16133876 10.1007/s10495-005-0367-8 1:CAS:528:DC%2BD2MXotFenurw%3D (Pubitemid 41187084)
    • (2005) Apoptosis , vol.10 , Issue.4 , pp. 863-874
    • Chaube, S.K.1    Prasad, P.V.2    Thakur, S.C.3    Shrivastav, T.G.4
  • 26
    • 41049089871 scopus 로고    scopus 로고
    • Calcium ionophore-induced egg activation and apoptosis are associated with the generation of intracellular hydrogen peroxide
    • DOI 10.1080/10715760701868352, PII 790769544
    • SK Chaube PK Dubey SK Mishra PV Prasad TG Shrivastav 2008 Calcium ionophore-induced egg activation or apoptosis is associated with the generation of intracellular hydrogen peroxide Free Radic Res 42 212 20 18344115 10.1080/10715760701868352 1:CAS:528:DC%2BD1cXjtlWiurk%3D (Pubitemid 351419907)
    • (2008) Free Radical Research , vol.42 , Issue.3 , pp. 212-220
    • Chaube, S.K.1    Khatun, S.2    Misra, S.K.3    Shrivastav, T.G.4
  • 27
    • 61349102381 scopus 로고    scopus 로고
    • Extracellular calcium protects against verapamil-induced metaphase-II arrest and initiation of apoptosis in aged rat eggs
    • 10.1016/j.cellbi.2009.01.001 1:CAS:528:DC%2BD1MXivVWlsr8%3D
    • SK Chaube A Tripathi S Khatun SK Mishra PV Prasad TG Shrivastav 2009 Extracellular calcium protects against verapamil-induced metaphase-II arrest and initiation of apoptosis in aged rat eggs Cell Biol Intl 33 337 43 10.1016/j.cellbi.2009.01.001 1:CAS:528:DC%2BD1MXivVWlsr8%3D
    • (2009) Cell Biol Intl , vol.33 , pp. 337-43
    • Chaube, S.K.1    Tripathi, A.2    Khatun, S.3    Mishra, S.K.4    Prasad, P.V.5    Shrivastav, T.G.6
  • 28
    • 61849173956 scopus 로고    scopus 로고
    • Intracellular levels of hydrogen peroxide and nitric oxide in oocytes at various stages of meiotic cell cycle and apoptosis
    • 19184696 10.1080/10715760802695985 1:CAS:528:DC%2BD1MXjtVyht74%3D
    • A Tripathi S Khatun AN Pandey SK Mishra R Chaube TG Shrivastav SK Chaube 2009 Intracellular levels of hydrogen peroxide and nitric oxide in oocytes at various stages of meiotic cell cycle and apoptosis Free Radic Res 43 287 94 19184696 10.1080/10715760802695985 1:CAS:528:DC%2BD1MXjtVyht74%3D
    • (2009) Free Radic Res , vol.43 , pp. 287-94
    • Tripathi, A.1    Khatun, S.2    Pandey, A.N.3    Mishra, S.K.4    Chaube, R.5    Shrivastav, T.G.6    Chaube, S.K.7
  • 29
    • 64649097438 scopus 로고    scopus 로고
    • Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells
    • 18719855 10.1007/s10637-008-9170-z 1:CAS:528:DC%2BD1MXkt1yhs7k%3D
    • G Harish Kumar KV Chandra Mohan A Jagannadha Rao S Nagini 2009 Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells Invest New Drugs 27 246 52 18719855 10.1007/s10637-008-9170-z 1:CAS:528:DC%2BD1MXkt1yhs7k%3D
    • (2009) Invest New Drugs , vol.27 , pp. 246-52
    • Harish Kumar, G.1    Chandra Mohan, K.V.2    Jagannadha Rao, A.3    Nagini, S.4
  • 30
    • 77956630283 scopus 로고    scopus 로고
    • The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis
    • 19458912 10.1007/s10637-009-9263-3 1:CAS:528:DC%2BC3cXmtlyhu7o%3D
    • G Harish Kumar RV Priyadarsini G Vinothini P Vidjaya Letchoumy S Nagini 2010 The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis Invest New Drugs 28 392 401 19458912 10.1007/s10637-009-9263-3 1:CAS:528:DC%2BC3cXmtlyhu7o%3D
    • (2010) Invest New Drugs , vol.28 , pp. 392-401
    • Harish Kumar, G.1    Priyadarsini, R.V.2    Vinothini, G.3    Vidjaya Letchoumy, P.4    Nagini, S.5
  • 31
    • 4544304070 scopus 로고    scopus 로고
    • Deadly decisions: The role of genes regulating programmed cell death in human preimplantation embryo development
    • DOI 10.1530/rep.1.00241
    • A Jurisicova BM Acton 2004 Deadly decisions: the role of genes regulating programmed cell death in human preimplantation embryo development Reproduction 128 281 91 15333779 10.1530/rep.1.00241 1:CAS:528:DC%2BD2cXot1KitLo%3D (Pubitemid 39242704)
    • (2004) Reproduction , vol.128 , Issue.3 , pp. 281-291
    • Jurisicova, A.1    Acton, B.M.2
  • 32
    • 0027191429 scopus 로고
    • In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
    • B Ansari PJ Coates BD Greenstein PA Hall 1993 In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states J Pathol 170 1 8 8326456 10.1002/path.1711700102 1:CAS:528: DyaK3sXltlCksrc%3D (Pubitemid 23130577)
    • (1993) Journal of Pathology , vol.170 , Issue.1 , pp. 1-8
    • Ansari, B.1    Coates, P.J.2    Greenstein, B.D.3    Hall, P.A.4
  • 33
    • 2642567653 scopus 로고    scopus 로고
    • Apoptosis in parthenogenetic preimplantation porcine embryos
    • DOI 10.1095/biolreprod.103.026005
    • Y Hao L Lai J Mao GS Im A Bonk RS Prather 2004 Apoptosis in parthenogenetic preimplantation porcine embryos Biol Reprod 70 1644 9 14766725 10.1095/biolreprod.103.026005 1:CAS:528:DC%2BD2cXktlOmtrw%3D (Pubitemid 38715619)
    • (2004) Biology of Reproduction , vol.70 , Issue.6 , pp. 1644-1649
    • Hao, Y.1    Lai, L.2    Mao, J.3    Im, G.-S.4    Bonk, A.5    Prather, R.S.6
  • 35
    • 9744250178 scopus 로고    scopus 로고
    • Involvement of apoptosis in disruption of developmental competence of bovine oocytes by heat shock during maturation
    • DOI 10.1095/biolreprod.104.031690
    • Z Roth PJ Hansen 2004 Involvement of apoptosis in disruption of developmental competency of bovine oocytes by heat shock during maturation Biol Reprod 71 1898 906 15306551 10.1095/biolreprod.104.031690 1:CAS:528: DC%2BD2cXhtVWgsrzL (Pubitemid 39586934)
    • (2004) Biology of Reproduction , vol.71 , Issue.6 , pp. 1898-1906
    • Roth, Z.1    Hansen, P.J.2

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