Platinated DNA affects zinc finger conformation. Interaction of a platinated single-stranded oligonucleotide and the C-terminal zinc finger of nucleocapsid protein HIVNCp7

Biochemistry

Volumn 51, Issue 8, 2012, Pages 1752-1761

  Quintal, Susana ^a,b   Viegas, Aldino ^b   Erhardt, Stefan ^b   Cabrita, Eurico J ^b   Farrell, Nicholas P ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b DEPARTAMENTO DE QUÍMICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RINGS; COORDINATION COMPOUNDS; DISTANCE CONSTRAINTS; DNA REPAIR; H NMR SPECTROSCOPY; MACROCYCLES; N-TERMINALS; NUCLEAR OVERHAUSER EFFECTS; NUCLEOCAPSID PROTEINS; PLATINATION; SITE-SPECIFIC; SMALL MOLECULES; SOLUTION STRUCTURES; STERIC EFFECT; TARGETTING; ZINC FINGER; ZINC FINGER PEPTIDES;

COBALT COMPOUNDS; DNA; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGONUCLEOTIDES; PLATINUM; ZINC;

PLATINUM COMPOUNDS;

COBALT; CYSTEINE; DNA; GLUTAMIC ACID; GLUTAMINE; GUANINE; HISTIDINE; LYSINE; MACROCYCLIC COMPOUND; METHIONINE; NUCLEIC ACID BASE; NUCLEOCAPSID PROTEIN; NUCLEOCAPSID PROTEIN HIVNCP7; OLIGONUCLEOTIDE; PLATINUM; TRYPTOPHAN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DNA REPAIR; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS; MASS SPECTROMETRY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

BINDING SITES; COORDINATION COMPLEXES; DNA; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; OLIGONUCLEOTIDES; PLATINUM; PROTEIN CONFORMATION; ZINC FINGERS;

EID: 84857623813     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201834g     Document Type: Article

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