Genome wide adaptations of Plasmodium falciparum in response to Lumefantrine selective drug pressure

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Mwai, Leah ^a,b   Diriye, Abdi ^a   Masseno, Victor ^a   Muriithi, Steven ^a   Feltwell, Theresa ^c   Musyoki, Jennifer ^a   Lemieux, Jacob ^e   Feller, Avi ^d   Mair, Gunnar R ^f   Marsh, Kevin ^a,b   Newbold, Chris ^e   Nzila, Alexis ^a,b   Carret, Céline K ^f  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COA BINDING PROTEIN ISOFORM 1; ACYL COA BINDING PROTEIN ISOFORM 2; ADENOSINE TRIPHOSPHATASE; ADENYLATE TRANSLOCASE; ARTEMETHER PLUS BENFLUMETOL; BENFLUMETOL; BETA HYDROXYACYL ACP DEHYDRATASE PRECURSOR; CARRIER PROTEIN; CYTIDINE DIPHOSPHATE DIACYLGLYCEROL INOSITOL 3 PHOSPHATIDYLTRANSFERASE; FOLATE BIOPTERIN TRANSPORTER; MITOCHONDRIAL INNER MEMBRANE TRANSLOCASE; MULTIDRUG RESISTANCE PROTEIN; OXOGLUTARATE MALATE TRANSLOCATOR PROTEIN; P TYPE ATPASE; SUGAR TRANSPORTER; SYNAPTOJANIN; UNCLASSIFIED DRUG; V TYPE PROTON PUMP PYROPHOSPHATASE 2; ANTIMALARIAL AGENT; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; MESSENGER RNA;

ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CHROMOSOME 10; CHROMOSOME 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; FATTY ACID METABOLISM; GENE; GENE EXPRESSION PROFILING; GENE LOCUS; IC 50; IN VITRO STUDY; MICROBIOLOGICAL EXAMINATION; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE GENE 1; NONHUMAN; PARASITE CULTURE; PLASMODIUM FALCIPARUM; ANIMAL; DNA MICROARRAY; DRUG DESIGN; DRUG EFFECT; ERYTHROCYTE; GENETICS; HUMAN; MALARIA; METABOLISM; METHODOLOGY; MUTATION; PARASITE; PARASITOLOGY; PHENOTYPE; POLYMERASE CHAIN REACTION; STATISTICAL MODEL;

PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DRUG DESIGN; ERYTHROCYTES; ETHANOLAMINES; FLUORENES; GENE EXPRESSION PROFILING; HUMANS; INHIBITORY CONCENTRATION 50; LIKELIHOOD FUNCTIONS; LINEAR MODELS; MALARIA; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARASITES; PHENOTYPE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84857584901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031623     Document Type: Article

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