Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion

PLoS Pathogens

Volumn 3, Issue 8, 2007, Pages 1023-1035

  Cortés, Alfred ^a,b   Carret, Celine ^c   Kaneko, Osamu ^d,e   Yim Lim, Brian Y S ^a   Ivens, Alasdair ^c   Holder, Anthony A ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACBP GENE; ARTICLE; CELL INVASION; CLAG GENE; CONTROLLED STUDY; EBA 140 GENE; EPIGENETICS; ERYTHROCYTE; GENE; GENE EXPRESSION; GENE INSERTION; GENE SILENCING; HOST CELL; NONHUMAN; PFRH GENE; PHENOTYPE; PLASMODIUM FALCIPARUM; RHOPH 1 GENE; AMINO ACID SEQUENCE; ANIMAL; CELL CLONE; DNA MICROARRAY; GENETIC EPIGENESIS; GENETICS; HOST PARASITE INTERACTION; HUMAN; MOLECULAR GENETICS; PARASITOLOGY; PATHOGENICITY;

PLASMODIUM FALCIPARUM;

CARRIER PROTEIN; EBA140 PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CLONE CELLS; EPIGENESIS, GENETIC; ERYTHROCYTES; GENE SILENCING; HOST-PARASITE INTERACTIONS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 34548428327     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.0030107     Document Type: Article

References (30)

1. Aikawa M, Miller LH, Johnson J, Rabbege J (1978) Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J Cell Biol 77: 72-82.
2. Cowman AF, Crabb BS (2006) Invasion of red blood cells by malaria parasites. Cell 124: 755-766.
3. Sim BK, Chitnis CE, Wasniowska K, Hadley TJ, Miller LH (1994) Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum. Science 264: 1941-1944.
4. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, et al. (2005) Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science 309: 1384-1387.
5. Baum J, Pinder M, Conway DJ (2003) Erythrocyte invasion phenotypes of Plasmodium falciparum in The Gambia. Infect Immun 71: 1856-1863.
6. Okoyeh JN, Pillai CR, Chitnis CE (1999) Plasmodium falciparum field isolates commonly use erythrocyte invasion pathways that are independent of sialic acid residues of glycophorin A. Infect Immun 67: 5784-5791.
7. Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, et al. (2004) The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion. Mol Microbiol 52: 107-118.
8. Kaneko O, Yim Lim BYS, Iriko H, Ling IT, Otsuki H, et al. (2005) Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol 143: 20-28.
9. Cortés A, Benet A, Cooke BM, Barnwell JW, Reeder JC (2004) Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines. Blood 104: 2961-2966.
10. Mayer DC, Kaneko O, Hudson-Taylor DE, Reid ME, Miller LH (2001) Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175. Proc Natl Acad Sci USA 98: 5222-5227.
11. Lobo CA, Fujioka H, Aikawa M, Kumar N (1999) Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum. Mol Cell 3: 793-798.
12. Cortés A (2005) A chimeric Plasmodium falciparum Pfnbp2b/Pfnbp2a gene originated during asexual growth. Int J Parasitol 35: 125-130.
13. Walliker D, Quakyi IA, Wellems TE, McCutchan TF, Szarfman A, et al. (1987) Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236: 1661-1666.
14. Taylor HM, Grainger M, Holder AA (2002) Variation in the expression of a Plasmodium falciparum protein family implicated in erythrocyte invasion. Infect Immun 70: 5779-5789.
15. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, et al. (2003) Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J 22: 1047-1057.
16. Nery S, Deans AM, Mosobo M, Marsh K, Rowe JA, et al. (2006) Expression of Plasmodium falciparum genes involved in erythrocyte invasion varies among isolates cultured directly from patients. Mol Biochem Parasitol 149: 208-215.
17. Bethke LL, Zilversmit M, Nielsen K, Daily J, Volkman SK, et al. (2006) Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol Biochem Parasitol 150: 10-24.
18. Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, et al. (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301: 1503-1508.
19. Bozdech Z, Llinas M, Pulliam BL, Wong ED, Zhu J, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1: e5. doi:10.1371/journal.pbio.0000005.
20. Gaur D, Furuya T, Mu J, Jiang LB, Su XZ, et al. (2006) Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway. Mol Biochem Parasitol 145: 205-215.
21. Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, et al. (1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J 17: 5418-5426.
22. Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, et al. (2005) Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell 121: 13-24.
23. Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, et al. (2005) Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell 121: 25-36.
24. Frank M, Dzikowski R, Costantini D, Amulic B, Berdougo E, et al. (2006) Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. J Biol Chem 281: 9942-9952.
25. Triglia T, Duraisingh MT, Good RT, Cowman AF (2005) Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol 55: 162-174.
26. Reed MB, Caruana SR, Batchelor AH, Thompson JK, Crabb BS, et al. (2000) Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion. Proc Natl Acad Sci USA 97: 7509-7514.
27. Rayner JC, Tran TM, Corredor V, Huber CS, Barnwell JW, et al. (2005) Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes. Am J Trop Med Hyg 72: 666-674.
28. Verra F, Chokejindachai W, Weedall GD, Polley SD, Mwangi TW, et al. (2006) Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene family. Mol Biochem Parasitol 149: 182-190.
29. Felger I, Tavul L, Beck HP (1993) Plasmodium falciparum: A rapid technique for genotyping the merozoite surface protein 2. Exp Parasitol 77: 372-375.
30. Persson KE, Lee CT, Marsh K, Beeson JG (2006) Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies. J Clin Microbiol 44: 1665-1673.