메뉴 건너뛰기




Volumn 4, Issue 2, 2012, Pages 201-212

Novel routes for allergen immunotherapy: Safety, efficacy and mode of action

Author keywords

allergen; APC; immunotherapy; mucosal immunity; regulatory T lymphocyte

Indexed keywords

PLACEBO; POLLEN ANTIGEN;

EID: 84857523576     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.11.171     Document Type: Review
Times cited : (26)

References (148)
  • 1
    • 50249230114 scopus 로고
    • Prophylactic inoculation against hay fever
    • Noon L. Prophylactic inoculation against hay fever. Lancet 2, 1572-1573 (1911).
    • (1911) Lancet , vol.2 , pp. 1572-1573
    • Noon, L.1
  • 2
    • 75849127328 scopus 로고    scopus 로고
    • Sub-lingual immunotherapy: World Allergy Organization position paper 2009
    • Canonica G, Bousquet J, Casale T et al. Sub-lingual immunotherapy: World Allergy Organization position paper 2009. Allergy 64, 1-59 (2009).
    • (2009) Allergy , vol.64 , pp. 1-59
    • Canonica, G.1    Bousquet, J.2    Casale, T.3
  • 3
    • 33746691245 scopus 로고    scopus 로고
    • Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis
    • Dahl R, Kapp A, Colombo G et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J. Allergy Clin. Immunol. 118, 434-440 (2006).
    • (2006) J. Allergy Clin. Immunol. , vol.118 , pp. 434-440
    • Dahl, R.1    Kapp, A.2    Colombo, G.3
  • 4
    • 36248986032 scopus 로고    scopus 로고
    • Optimal dose, efficacy and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis
    • Didier A, Malling HJ, Worm M et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J. Allergy Clin. Immunol. 120, 1338-1345 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 1338-1345
    • Didier, A.1    Malling, H.J.2    Worm, M.3
  • 5
    • 34547642693 scopus 로고    scopus 로고
    • Safety of specific sublingual immunotherapy with SQ standardized grass allergen tablets in children
    • Ibanez MD, Kaiser F, Knecht R et al. Safety of specific sublingual immunotherapy with SQ standardized grass allergen tablets in children. Pediatr. Allergy Immunol. 18, 516-522 (2007).
    • (2007) Pediatr. Allergy Immunol. , vol.18 , pp. 516-522
    • Ibanez, M.D.1    Kaiser, F.2    Knecht, R.3
  • 6
    • 39149127957 scopus 로고    scopus 로고
    • Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years
    • Dahl R, Kapp A, Colombo G et al. Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. J. Allergy Clin. Immunol. 121, 512-518 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 512-518
    • Dahl, R.1    Kapp, A.2    Colombo, G.3
  • 7
    • 58149109018 scopus 로고    scopus 로고
    • Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis
    • Wahn U, Tabar A, Kuna P et al. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis. J. Allergy Clin. Immunol. 123, 160-166 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.123 , pp. 160-166
    • Wahn, U.1    Tabar, A.2    Kuna, P.3
  • 8
    • 58149121462 scopus 로고    scopus 로고
    • Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy
    • Didier A, Melac M, Montagut A et al. Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy. Allergy 64, 166-171 (2009).
    • (2009) Allergy , vol.64 , pp. 166-171
    • Didier, A.1    Melac, M.2    Montagut, A.3
  • 9
    • 58849093549 scopus 로고    scopus 로고
    • Implementation of pre-seasonal sublingual immunotherapy with a five-grass pollen tablet during optimal dosage assessment
    • Horak F, Jaeger S, Worm M, Melac M, Didier A. Implementation of pre-seasonal sublingual immunotherapy with a five-grass pollen tablet during optimal dosage assessment. Clin. Exp. Allergy 39, 394-400 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 394-400
    • Horak, F.1    Jaeger, S.2    Worm, M.3    Melac, M.4    Didier, A.5
  • 10
    • 58849100338 scopus 로고    scopus 로고
    • Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis
    • Malling HJ, Montagut A, Melac M et al. Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis. Clin. Exp. Allergy 39, 387-393 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 387-393
    • Malling, H.J.1    Montagut, A.2    Melac, M.3
  • 11
    • 0031736285 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases a WHO position paper
    • Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: Therapeutic vaccines for allergic diseases. A WHO position paper. J. Allergy Clin. Immunol. 102, 558-562 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 558-562
    • Bousquet, J.1    Lockey, R.2    Malling, H.J.3
  • 12
    • 0034442058 scopus 로고    scopus 로고
    • Specific immunotherapy
    • Larche M. Specific immunotherapy. Br. Med. Bull. 56, 1019-1036 (2000).
    • (2000) Br. Med. Bull. , vol.56 , pp. 1019-1036
    • Larche, M.1
  • 13
    • 0032901823 scopus 로고    scopus 로고
    • Monitoring allergen immunotherapy of pollen-allergic patients: The ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome
    • Gehlhar K, Schlaak M, Becker W, Bufe A. Monitoring allergen immunotherapy of pollen-allergic patients: The ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome. Clin. Exp. Allergy 29, 497-506 (1999).
    • (1999) Clin. Exp. Allergy , vol.29 , pp. 497-506
    • Gehlhar, K.1    Schlaak, M.2    Becker, W.3    Bufe, A.4
  • 14
    • 0031843857 scopus 로고    scopus 로고
    • Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to subclass expression
    • Michils A, Mairesse M, Ledent C et al. Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to subclass expression. J. Allergy Clin. Immunol. 102, 118-126 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 118-126
    • Michils, A.1    Mairesse, M.2    Ledent, C.3
  • 15
    • 0035103661 scopus 로고    scopus 로고
    • Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: Significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity
    • Pichler CE, Helbling A, Pichler WJ. Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: Significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity. Allergy 56, 301-306 (2001).
    • (2001) Allergy , vol.56 , pp. 301-306
    • Pichler, C.E.1    Helbling, A.2    Pichler, W.J.3
  • 16
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis the PAT-study
    • Moller C, Dreborg S, Ferdousi HA et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J. Allergy Clin. Immunol. 109, 251-256 (2002).
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 251-256
    • Moller, C.1    Dreborg, S.2    Ferdousi, H.A.3
  • 17
    • 35148818759 scopus 로고    scopus 로고
    • Effect of grass pollen immunotherapy with Alutard SQ on quality of life in seasonal allergic rhinoconjunctivitis
    • Powell RJ, Frew AJ, Corrigan CJ, Durham SR. Effect of grass pollen immunotherapy with Alutard SQ on quality of life in seasonal allergic rhinoconjunctivitis. Allergy 62, 1335-1338 (2007).
    • (2007) Allergy , vol.62 , pp. 1335-1338
    • Powell, R.J.1    Frew, A.J.2    Corrigan, C.J.3    Durham, S.R.4
  • 18
    • 0035853103 scopus 로고    scopus 로고
    • Intralymphatic immunization enhances DNA vaccination
    • USA
    • Maloy KJ, Erdmann I, Basch V et al. Intralymphatic immunization enhances DNA vaccination. Proc. Natl Acad. Sci. USA 98, 3299-3303 (2001).
    • (2001) Proc. Natl Acad. Sci. , vol.98 , pp. 3299-3303
    • Maloy, K.J.1    Erdmann, I.2    Basch, V.3
  • 19
    • 20044366365 scopus 로고    scopus 로고
    • Direct intralymphatic injection of peptide vaccines enhances immunogenicity
    • Johansen P, Haffner AC, Koch F et al. Direct intralymphatic injection of peptide vaccines enhances immunogenicity. Eur. J. Immunol. 35, 568-574 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 568-574
    • Johansen, P.1    Haffner, A.C.2    Koch, F.3
  • 20
    • 20844455173 scopus 로고    scopus 로고
    • Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration
    • von Beust BR, Johansen P, Smith KA et al. Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration. Eur. J. Immunol. 35, 1869-1876 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1869-1876
    • Von Beust, B.R.1    Johansen, P.2    Smith, K.A.3
  • 22
    • 56649120612 scopus 로고    scopus 로고
    • Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial
    • USA
    • Senti G, Prinz Vavricka BM, Erdmann I et al. Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial. Proc. Natl Acad. Sci. USA 105, 17908-17912 (2008).
    • (2008) Proc. Natl Acad. Sci. , vol.105 , pp. 17908-17912
    • Senti, G.1    Prinz Vavricka, B.M.2    Erdmann, I.3
  • 23
    • 70449294786 scopus 로고
    • Treatment of pollinosis with pollen extracts by the method of cutaneous quadrille ruling
    • Blamoutier P, Blamoutier J, Guibert L. Treatment of pollinosis with pollen extracts by the method of cutaneous quadrille ruling. La Presse Medicale 67, 2299-2301 (1959).
    • (1959) La Presse Medicale , vol.67 , pp. 2299-2301
    • Blamoutier, P.1    Blamoutier, J.2    Guibert, L.3
  • 24
    • 71949128954 scopus 로고    scopus 로고
    • Epicutaneous allergen administration: A novel approach for allergen-specific immunotherapy
    • Werfel T. Epicutaneous allergen administration: A novel approach for allergen-specific immunotherapy? J. Allergy Clin. Immunol. 124, 1003-1004 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 1003-1004
    • Werfel, T.1
  • 25
    • 79955466306 scopus 로고    scopus 로고
    • Epicutaneous allergen administration: Is this the future of allergen-specific immunotherapy
    • Senti G, von Moos S, Kundig TM. Epicutaneous allergen administration: Is this the future of allergen-specific immunotherapy? Allergy 66, 798-809 (2011).
    • (2011) Allergy , vol.66 , pp. 798-809
    • Senti, G.1    Von Moos, S.2    Kundig, T.M.3
  • 26
    • 71749106471 scopus 로고    scopus 로고
    • Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy
    • Senti G, Graf N, Haug S et al. Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy. J. Allergy Clin. Immunol. 124, 997-1002 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 997-1002
    • Senti, G.1    Graf, N.2    Haug, S.3
  • 27
    • 77951681486 scopus 로고    scopus 로고
    • Cows milk epicutaneous immunotherapy in children: A pilot trial of safety acceptability and impact on allergic reactivity
    • Dupont C, Kalach N, Soulaines P et al. Cow's milk epicutaneous immunotherapy in children: A pilot trial of safety, acceptability, and impact on allergic reactivity. J. Allergy Clin. Immunol. 125, 1165-1167 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.125 , pp. 1165-1167
    • Dupont, C.1    Kalach, N.2    Soulaines, P.3
  • 28
    • 0017648262 scopus 로고
    • Hyposensitization of patients with allergic rhinitis by intranasal administration of chemically modified grass pollen allergen a pilot study
    • Deuschl H, Johansson GO. Hyposensitization of patients with allergic rhinitis by intranasal administration of chemically modified grass pollen allergen. A pilot study. Acta Allergol. 32, 248-262 (1977).
    • (1977) Acta Allergol. , vol.32 , pp. 248-262
    • Deuschl, H.1    Johansson, G.O.2
  • 29
    • 0019404302 scopus 로고
    • Local intranasal immunotherapy for ragweed allergic rhinitis I clinical response
    • Nickelsen JA, Goldstein S, Mueller U et al. Local intranasal immunotherapy for ragweed allergic rhinitis. I. Clinical response. J. Allergy Clin. Immunol. 68, 33-40 (1981).
    • (1981) J. Allergy Clin. Immunol. , Issue.68 , pp. 33-40
    • Nickelsen, J.A.1    Goldstein, S.2    Mueller, U.3
  • 31
    • 85004844198 scopus 로고
    • Local nasal immunotherapy for ragweed-allergic rhinitis. III. A second year of treatment
    • Nickelsen JA, Georgitis JW, Mueller UR et al. Local nasal immunotherapy for ragweed-allergic rhinitis. III. A second year of treatment. Clin. Exp. Allergy 13, 509-519 (1983).
    • (1983) Clin. Exp. Allergy , vol.13 , pp. 509-519
    • Nickelsen, J.A.1    Georgitis, J.W.2    Mueller, U.R.3
  • 32
    • 0026646471 scopus 로고
    • Local nasal immunotherapy in allergic rhinitis to Parietaria a double-blind controlled study
    • Andri L, Senna GE, Betteli C et al. Local nasal immunotherapy in allergic rhinitis to Parietaria. A double-blind controlled study. Allergy 47, 318-323 (1992).
    • (1992) Allergy , vol.47 , pp. 318-323
    • Andri, L.1    Senna, G.E.2    Betteli, C.3
  • 33
    • 0027225226 scopus 로고
    • Local nasal immunotherapy for Dermatophagoides-induced rhinitis: Efficacy of a powder extract
    • Andri L, Senna G, Betteli C et al. Local nasal immunotherapy for Dermatophagoides-induced rhinitis: Efficacy of a powder extract. J. Allergy Clin. Immunol. 91, 987-996 (1993).
    • (1993) J. Allergy Clin. Immunol. , vol.91 , pp. 987-996
    • Andri, L.1    Senna, G.2    Betteli, C.3
  • 34
    • 0028962098 scopus 로고
    • A double-blind placebo-controlled trial of local nasal immunotherapy in allergic rhinitis to Parietaria pollen
    • D'Amato G, Lobefalo G, Liccardi G, Cazzola M. A double-blind, placebo-controlled trial of local nasal immunotherapy in allergic rhinitis to Parietaria pollen. Clin. Exp. Allergy 25, 141-148 (1995).
    • (1995) Clin. Exp. Allergy , vol.25 , pp. 141-148
    • D'Amato, G.1    Lobefalo, G.2    Liccardi, G.3    Cazzola, M.4
  • 35
    • 0029242329 scopus 로고
    • Local nasal immunotherapy
    • Andri L, Senna G. Local nasal immunotherapy. Allergy 50, 190 (1995).
    • (1995) Allergy , vol.50 , pp. 190
    • Andri, L.1    Senna, G.2
  • 36
    • 0030065924 scopus 로고    scopus 로고
    • Local nasal immunotherapy with extract in powder form is effective and safe in grass pollen rhinitis: A double-blind study
    • Andri L, Senna G, Betteli C et al. Local nasal immunotherapy with extract in powder form is effective and safe in grass pollen rhinitis: A double-blind study. J. Allergy Clin. Immunol. 97, 34-41 (1996).
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 34-41
    • Andri, L.1    Senna, G.2    Betteli, C.3
  • 38
    • 63149115396 scopus 로고    scopus 로고
    • The effect of local nasal immunotherapy in allergic rhinitis: Using strips of the allergen dermatophagoides pteronyssinus
    • Tsai JJ, Liao EC, Tsai FH, Hsieh CC, Lee MF. The effect of local nasal immunotherapy in allergic rhinitis: using strips of the allergen dermatophagoides pteronyssinus. J. Asthma 46, 165-170 (2009).
    • (2009) J. Asthma , vol.46 , pp. 165-170
    • Tsai, J.J.1    Liao, E.C.2    Tsai, F.H.3    Hsieh, C.C.4    Lee, M.F.5
  • 40
    • 0742288507 scopus 로고    scopus 로고
    • Symptomatic relief after grass nasal immunotherapy: Lasting efficacy after 4-5 years
    • Andri L, Falagiani P. Symptomatic relief after grass nasal immunotherapy: lasting efficacy after 4-5 years. J. Investig. Allergol. Clin. Immunol. 13, 228-231 (2003).
    • (2003) J. Investig. Allergol. Clin. Immunol. , vol.13 , pp. 228-231
    • Andri, L.1    Falagiani, P.2
  • 41
    • 78649828969 scopus 로고    scopus 로고
    • Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses
    • Egger C, Horak F, Vrtala S, Valenta R, Niederberger V. Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses. J. Allergy Clin. Immunol. 126, 1312-1315 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.126 , pp. 1312-1315
    • Egger, C.1    Horak, F.2    Vrtala, S.3    Valenta, R.4    Niederberger, V.5
  • 42
    • 0019958195 scopus 로고
    • Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts a prospective study
    • Rebien W, Puttonen E, Maasch HJ, Stix E, Wahn U. Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts. A prospective study. Eur. J. Pediatr. 138, 341-344 (1982).
    • (1982) Eur. J. Pediatr. , vol.138 , pp. 341-344
    • Rebien, W.1    Puttonen, E.2    Maasch, H.J.3    Stix, E.4    Wahn, U.5
  • 43
    • 0021023538 scopus 로고
    • Orally administered grass pollen
    • Taudorf E, Weeke B. Orally administered grass pollen. Allergy 38, 561-564 (1983).
    • (1983) Allergy , vol.38 , pp. 561-564
    • Taudorf, E.1    Weeke, B.2
  • 44
    • 0023193306 scopus 로고
    • High dose grass pollen tablets used for hyposensitization in hay fever patients a one-year double blind placebo-controlled study
    • Mosbech H, Dreborg S, Madsen F et al. High dose grass pollen tablets used for hyposensitization in hay fever patients. A one-year double blind placebo-controlled study. Allergy 42, 451-455 (1987).
    • (1987) Allergy , vol.42 , pp. 451-455
    • Mosbech, H.1    Dreborg, S.2    Madsen, F.3
  • 45
    • 0025368353 scopus 로고
    • Oral immunotherapy with grass pollen in enterosoluble capsules a prospective study of the clinical and immunological response
    • Urbanek R, Burgelin KH, Kahle S, Kuhn W, Wahn U. Oral immunotherapy with grass pollen in enterosoluble capsules. A prospective study of the clinical and immunological response. Eur. J. Pediatr. 149, 545-550 (1990).
    • (1990) Eur. J. Pediatr. , vol.149 , pp. 545-550
    • Urbanek, R.1    Burgelin, K.H.2    Kahle, S.3    Kuhn, W.4    Wahn, U.5
  • 47
    • 0022529176 scopus 로고
    • Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy a double blind study
    • Moller C, Dreborg S, Lanner A, Bjorksten B. Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. A double blind study. Allergy 41, 271-279 (1986).
    • (1986) Allergy , vol.41 , pp. 271-279
    • Moller, C.1    Dreborg, S.2    Lanner, A.3    Bjorksten, B.4
  • 48
    • 0024593964 scopus 로고
    • Specific IgE IgG and IgA antibody response to oral immunotherapy in birch pollinosis
    • Taudorf E, Laursen L, Lanner A et al. Specific IgE, IgG, and IgA antibody response to oral immunotherapy in birch pollinosis. J. Allergy Clin. Immunol. 83, 589-594 (1989).
    • (1989) J. Allergy Clin. Immunol. , vol.83 , pp. 589-594
    • Taudorf, E.1    Laursen, L.2    Lanner, A.3
  • 49
    • 0025117368 scopus 로고
    • A double-blind trial of oral immunotherapy for Artemisia pollen asthma with evaluation of bronchial response to the pollen allergen and serum-specific IgE antibody
    • Leng X, Fu YX, Ye ST, Duan SQ. A double-blind trial of oral immunotherapy for Artemisia pollen asthma with evaluation of bronchial response to the pollen allergen and serum-specific IgE antibody. Ann. Allergy 64, 27-31 (1990).
    • (1990) Ann. Allergy , vol.64 , pp. 27-31
    • Leng, X.1    Fu, Y.X.2    Ye, S.T.3    Duan, S.Q.4
  • 50
    • 0030839694 scopus 로고    scopus 로고
    • Oral immunotherapy with short ragweed extract in a novel encapsulated preparation: A double-blind study
    • Litwin A, Flanagan M, Entis G et al. Oral immunotherapy with short ragweed extract in a novel encapsulated preparation: A double-blind study. J. Allergy Clin. Immunol. 100, 30-38 (1997).
    • (1997) J. Allergy Clin. Immunol. , vol.100 , pp. 30-38
    • Litwin, A.1    Flanagan, M.2    Entis, G.3
  • 51
    • 0028302017 scopus 로고
    • A three-year double-blind placebo-controlled study with specific oral immunotherapy to Dermatophagoides: Evidence of safety and efficacy in paediatric patients
    • Giovane AL, Bardare M, Passalacqua G et al. A three-year double-blind placebo-controlled study with specific oral immunotherapy to Dermatophagoides: Evidence of safety and efficacy in paediatric patients. Clin. Exp. Allergy 24, 53-59 (1994).
    • (1994) Clin. Exp. Allergy , vol.24 , pp. 53-59
    • Giovane, A.L.1    Bardare, M.2    Passalacqua, G.3
  • 52
    • 44649156220 scopus 로고    scopus 로고
    • Oral tolerance food allergy and immunotherapy: Implications for future treatment
    • Burks AW, Laubach S, Jones SM. Oral tolerance, food allergy, and immunotherapy: Implications for future treatment. J. Allergy Clin. Immunol. 121, 1344-1350 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1344-1350
    • Burks, A.W.1    Laubach, S.2    Jones, S.M.3
  • 53
    • 33845927892 scopus 로고    scopus 로고
    • Egg oral immunotherapy in nonanaphylactic children with egg allergy
    • Buchanan AD, Green TD, Jones SM et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J. Allergy Clin. Immunol. 119, 199-205 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 199-205
    • Buchanan, A.D.1    Green, T.D.2    Jones, S.M.3
  • 54
    • 4344690534 scopus 로고    scopus 로고
    • A protocol for oral desensitization in children with IgE-mediated cows milk allergy
    • Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 59, 980-987 (2004).
    • (2004) Allergy , vol.59 , pp. 980-987
    • Meglio, P.1    Bartone, E.2    Plantamura, M.3    Arabito, E.4    Giampietro, P.G.5
  • 55
    • 47249163738 scopus 로고    scopus 로고
    • Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy - Follow-up at 4 yr and 8 months
    • Meglio P, Giampietro PG, Gianni S, Galli E. Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy - follow-up at 4 yr and 8 months. Pediatr. Allergy Immunol. 19, 412-419 (2008).
    • (2008) Pediatr. Allergy Immunol. , vol.19 , pp. 412-419
    • Meglio, P.1    Giampietro, P.G.2    Gianni, S.3    Galli, E.4
  • 56
    • 35148896805 scopus 로고    scopus 로고
    • Specific oral tolerance induction in food allergy in children: Efficacy and clinical patterns of reaction
    • Staden U, Rolinck-Werninghaus C, Brewe F et al. Specific oral tolerance induction in food allergy in children: Efficacy and clinical patterns of reaction. Allergy 62, 1261-1269 (2007).
    • (2007) Allergy , vol.62 , pp. 1261-1269
    • Staden, U.1    Rolinck-Werninghaus, C.2    Brewe, F.3
  • 57
    • 39149138406 scopus 로고    scopus 로고
    • Specific oral tolerance induction in children with very severe cow's milk-induced reactions
    • Longo G, Barbi E, Berti I et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J. Allergy Clin. Immunol. 121, 343-347 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 343-347
    • Longo, G.1    Barbi, E.2    Berti, I.3
  • 58
    • 57149124345 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled study of milk oral immunotherapy for cow's milk allergy
    • Skripak JM, Nash SD, Rowley H et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J. Allergy Clin. Immunol. 122, 1154-1160 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.122 , pp. 1154-1160
    • Skripak, J.M.1    Nash, S.D.2    Rowley, H.3
  • 59
    • 79952302102 scopus 로고    scopus 로고
    • A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response
    • Varshney P, Jones SM, Scurlock AM et al. A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response. J. Allergy Clin. Immunol. 127, 654-660 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 654-660
    • Varshney, P.1    Jones, S.M.2    Scurlock, A.M.3
  • 60
    • 0014863619 scopus 로고
    • Treatment of respiratory disease with ultra-small doses of antigens
    • Morris DL. Treatment of respiratory disease with ultra-small doses of antigens. Ann. Allergy 28, 494-500 (1970).
    • (1970) Ann. Allergy , vol.28 , pp. 494-500
    • Morris, D.L.1
  • 61
    • 0033006767 scopus 로고    scopus 로고
    • Sublingual-swallow immunotherapy SLIT in patients with asthma due to house-dust mites: A double-blind placebo-controlled study
    • Bousquet J, Scheinmann P, Guinnepain MT et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: A double-blind, placebo-controlled study. Allergy 54, 249-260 (1999).
    • (1999) Allergy , vol.54 , pp. 249-260
    • Bousquet, J.1    Scheinmann, P.2    Guinnepain, M.T.3
  • 62
    • 0032866139 scopus 로고    scopus 로고
    • Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis
    • La Rosa M, Ranno C, Andre C et al. Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J. Allergy Clin. Immunol. 104, 425-432 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 425-432
    • La Rosa, M.1    Ranno, C.2    Andre, C.3
  • 64
    • 0031864005 scopus 로고    scopus 로고
    • Clinical efficacy of sublingual-swallow immunotherapy: A double-blind placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis
    • Clavel R, Bousquet J, Andre C. Clinical efficacy of sublingual-swallow immunotherapy: A double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 53, 493-498 (1998).
    • (1998) Allergy , vol.53 , pp. 493-498
    • Clavel, R.1    Bousquet, J.2    Andre, C.3
  • 65
    • 0031825102 scopus 로고    scopus 로고
    • Double-blind placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization
    • Vourdas D, Syrigou E, Potamianou P et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy 53, 662-672 (1998).
    • (1998) Allergy , vol.53 , pp. 662-672
    • Vourdas, D.1    Syrigou, E.2    Potamianou, P.3
  • 67
    • 0033898123 scopus 로고    scopus 로고
    • Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: A double-blind, placebo-controlled study
    • Pajno GB, Morabito L, Barberio G, Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: A double-blind, placebo-controlled study. Allergy 55, 842-849 (2000).
    • (2000) Allergy , vol.55 , pp. 842-849
    • Pajno, G.B.1    Morabito, L.2    Barberio, G.3    Parmiani, S.4
  • 68
    • 20444449626 scopus 로고    scopus 로고
    • Clinical functional and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study
    • Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3?year randomized controlled study. J. Allergy Clin. Immunol. 115, 1184-1188 (2005).
    • (2005) J. Allergy Clin. Immunol. , vol.115 , pp. 1184-1188
    • Marogna, M.1    Spadolini, I.2    Massolo, A.3    Canonica, G.W.4    Passalacqua, G.5
  • 69
    • 12444291506 scopus 로고    scopus 로고
    • Sublingual immunotherapy for allergic rhinitis: Systematic review and meta-analysis
    • Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: Systematic review and meta-analysis. Allergy 60, 4-12 (2005).
    • (2005) Allergy , vol.60 , pp. 4-12
    • Wilson, D.R.1    Lima, M.T.2    Durham, S.R.3
  • 70
    • 17444420775 scopus 로고    scopus 로고
    • Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis
    • Olaguibel JM, Alvarez Puebla MJ. Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis. J. Investig. Allergol. Clin. Immunol. 15, 9-16 (2005).
    • (2005) J. Investig. Allergol. Clin. Immunol. , vol.15 , pp. 9-16
    • Olaguibel, J.M.1    Alvarez Puebla, M.J.2
  • 71
    • 33748289993 scopus 로고    scopus 로고
    • Efficacy of sublingual immunotherapy in asthma: Systematic review of randomized-clinical trials using the cochrane collaboration method
    • Calamita Z, Saconato H, Pela AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: Systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy 61, 1162-1172 (2006).
    • (2006) Allergy , vol.61 , pp. 1162-1172
    • Calamita, Z.1    Saconato, H.2    Pela, A.B.3    Atallah, A.N.4
  • 72
    • 33747688429 scopus 로고    scopus 로고
    • Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: A meta-analysis of randomized placebo-controlled double-blind trials
    • Penagos M, Compalati E, Tarantini F et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: A meta-analysis of randomized, placebo-controlled, double-blind trials. Ann. Allergy Asthma Immunol. 97, 141-148 (2006).
    • (2006) Ann. Allergy Asthma Immunol. , vol.97 , pp. 141-148
    • Penagos, M.1    Compalati, E.2    Tarantini, F.3
  • 73
    • 65549118741 scopus 로고    scopus 로고
    • Sublingual immunotherapy in children: Complete and updated review supporting evidence of effect
    • Larenas-Linnemann D. Sublingual immunotherapy in children: Complete and updated review supporting evidence of effect. Curr. Opin Allergy Clin. Immunol. 9, 168-176 (2009).
    • (2009) Curr. Opin Allergy Clin. Immunol. , vol.9 , pp. 168-176
    • Larenas-Linnemann, D.1
  • 75
    • 0344011568 scopus 로고    scopus 로고
    • Safety of sublingual immunotherapy in children with asthma
    • Pajno GB, Peroni DG, Vita D et al. Safety of sublingual immunotherapy in children with asthma. Paediatr. Drugs 5, 777-781 (2003).
    • (2003) Paediatr. Drugs , vol.5 , pp. 777-781
    • Pajno, G.B.1    Peroni, D.G.2    Vita, D.3
  • 76
  • 78
    • 20044392476 scopus 로고    scopus 로고
    • Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years
    • Fiocchi A, Pajno G, La Grutta S et al. Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years. Ann. Allergy Asthma Immunol. 95, 254-258 (2005).
    • (2005) Ann. Allergy Asthma Immunol. , vol.95 , pp. 254-258
    • Fiocchi, A.1    Pajno, G.2    La Grutta, S.3
  • 79
    • 33744742506 scopus 로고    scopus 로고
    • Efficacy and safety of sublingual immunotherapy grass pollen tablets in grass pollen rhinoconjonctivitis
    • Didier A, Melac M, Combebias A, Andre C. Efficacy and safety of sublingual immunotherapy grass pollen tablets in grass pollen rhinoconjonctivitis. J. Allergy Clin. Immunol. 117, 721 (2006).
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 721
    • Didier, A.1    Melac, M.2    Combebias, A.3    Andre, C.4
  • 80
    • 33845211828 scopus 로고    scopus 로고
    • Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis
    • Bussmann C, Bockenhoff A, Henke H, Werfel T, Novak N. Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis? J. Allergy Clin. Immunol. 118, 1292-1298 (2006).
    • (2006) J. Allergy Clin. Immunol. , vol.118 , pp. 1292-1298
    • Bussmann, C.1    Bockenhoff, A.2    Henke, H.3    Werfel, T.4    Novak, N.5
  • 81
    • 34548501796 scopus 로고    scopus 로고
    • Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: A pilot study
    • Bussmann C, Maintz L, Hart J et al. Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: A pilot study. Clin. Exp. Allergy 37, 1277-1285 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1277-1285
    • Bussmann, C.1    Maintz, L.2    Hart, J.3
  • 82
    • 34250836330 scopus 로고    scopus 로고
    • Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized double-blind placebo-controlled study
    • Pajno GB, Caminiti L, Vita D et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study. J. Allergy Clin. Immunol. 120, 164-170 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 164-170
    • Pajno, G.B.1    Caminiti, L.2    Vita, D.3
  • 83
    • 78650896208 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy for respiratory allergies: From meta-analysis to registration and beyond
    • Calderon MA, Casale TB, Togias A et al. Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond. J. Allergy Clin. Immunol. 127, 30-38 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 30-38
    • Calderon, M.A.1    Casale, T.B.2    Togias, A.3
  • 84
    • 77956378655 scopus 로고    scopus 로고
    • Allergic rhinitis and its impact on asthma ARIA guidelines: 2010 revision
    • Brozek JL, Bousquet J, Baena-Cagnani CE et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J. Allergy Clin. Immunol. 126, 466-476 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.126 , pp. 466-476
    • Brozek, J.L.1    Bousquet, J.2    Baena-Cagnani, C.E.3
  • 85
    • 77958013242 scopus 로고    scopus 로고
    • Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts
    • Mondoulet L, Dioszeghy V, Vanoirbeek JA et al. Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int. Arch. Allergy Immunol. 154, 299-309 (2011).
    • (2011) Int. Arch. Allergy Immunol. , vol.154 , pp. 299-309
    • Mondoulet, L.1    Dioszeghy, V.2    Vanoirbeek, J.A.3
  • 86
    • 77949360619 scopus 로고    scopus 로고
    • Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy
    • Mondoulet L, Dioszeghy V, Ligouis M et al. Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy. Clin. Exp. Allergy 40, 659-667 (2010).
    • (2010) Clin. Exp. Allergy , vol.40 , pp. 659-667
    • Mondoulet, L.1    Dioszeghy, V.2    Ligouis, M.3
  • 87
    • 33644910900 scopus 로고    scopus 로고
    • 3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice
    • 3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice. Allergy 61, 173-180 (2006).
    • (2006) Allergy , vol.61 , pp. 173-180
    • Winkler, B.1    Hufnagl, K.2    Spittler, A.3
  • 88
    • 80054903500 scopus 로고    scopus 로고
    • Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice
    • Mascarell L, Saint-Lu N, Moussu H et al. Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice. Mucosal Immunol. 4, 638-647 (2011).
    • (2011) Mucosal Immunol. , vol.4 , pp. 638-647
    • Mascarell, L.1    Saint-Lu, N.2    Moussu, H.3
  • 89
    • 77949655424 scopus 로고    scopus 로고
    • Lactic acid bacteria as adjuvants for sublingual allergy vaccines
    • Van Overtvelt L, Moussu H, Horiot S et al. Lactic acid bacteria as adjuvants for sublingual allergy vaccines. Vaccine. 28, 2986-2992 (2010).
    • (2010) Vaccine , vol.28 , pp. 2986-2992
    • Van Overtvelt, L.1    Moussu, H.2    Horiot, S.3
  • 90
    • 66749106297 scopus 로고    scopus 로고
    • Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction
    • Saint-Lu N, Tourdot S, Razafindratsita A et al. Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction. Allergy 64, 1003-1013 (2009).
    • (2009) Allergy , vol.64 , pp. 1003-1013
    • Saint-Lu, N.1    Tourdot, S.2    Razafindratsita, A.3
  • 91
    • 40149092860 scopus 로고    scopus 로고
    • Inhibition of airway allergic disease by co-administration of flagellin with allergen
    • Lee SE, Koh YI, Kim MK et al. Inhibition of airway allergic disease by co-administration of flagellin with allergen. J. Clin. Immunol. 28, 157-165 (2008).
    • (2008) J. Clin. Immunol. , vol.28 , pp. 157-165
    • Lee, S.E.1    Koh, Y.I.2    Kim, M.K.3
  • 92
    • 50649120499 scopus 로고    scopus 로고
    • Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route
    • Lombardi V, Van Overtvelt L, Horiot S et al. Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route. Clin. Exp. Allergy 38, 1819-1829 (2008).
    • (2008) Clin. Exp. Allergy , vol.38 , pp. 1819-1829
    • Lombardi, V.1    Van Overtvelt, L.2    Horiot, S.3
  • 93
    • 36749096949 scopus 로고    scopus 로고
    • IL-10-inducing adjuvants enhance sublingual immunotherapy efficacy in a murine asthma model
    • Van Overtvelt L, Lombardi V, Razafindratsita A et al. IL-10-inducing adjuvants enhance sublingual immunotherapy efficacy in a murine asthma model. Int. Arch. Allergy Immunol. 145, 152-162 (2008).
    • (2008) Int. Arch. Allergy Immunol. , vol.145 , pp. 152-162
    • Van Overtvelt, L.1    Lombardi, V.2    Razafindratsita, A.3
  • 94
    • 34548693921 scopus 로고    scopus 로고
    • Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation
    • Razafindratsita A, Saint-Lu N, Mascarell L et al. Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation. J. Allergy Clin. Immunol. 120, 278-285 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 278-285
    • Razafindratsita, A.1    Saint-Lu, N.2    Mascarell, L.3
  • 95
    • 34548490530 scopus 로고    scopus 로고
    • In vivo and in vitro immunomodulation of Der p 1 allergen-specific response by Lactobacillus plantarum bacteria
    • Hisbergues M, Magi M, Rigaux P et al. In vivo and in vitro immunomodulation of Der p 1 allergen-specific response by Lactobacillus plantarum bacteria. Clin. Exp. Allergy. 37, 1286-1295 (2007).
    • (2007) Clin. Exp. Allergy. , vol.37 , pp. 1286-1295
    • Hisbergues, M.1    Magi, M.2    Rigaux, P.3
  • 96
    • 36749060150 scopus 로고    scopus 로고
    • A synthetic triacylated pseudo-dipeptide molecule promotes Th1/Treg immune responses and enhances tolerance induction via the sublingual route
    • Mascarell L, Van Overtvelt L, Lombardi V et al. A synthetic triacylated pseudo-dipeptide molecule promotes Th1/Treg immune responses and enhances tolerance induction via the sublingual route. Vaccine 26, 108-118 (2007).
    • (2007) Vaccine , vol.26 , pp. 108-118
    • Mascarell, L.1    Van Overtvelt, L.2    Lombardi, V.3
  • 97
    • 27544499298 scopus 로고    scopus 로고
    • Production of salivary immunoglobulin A and suppression of dermatophagoides pteronyssinus-induced airway inflammation by local nasal immunotherapy
    • Liu YH, Tsai JJ. Production of salivary immunoglobulin A and suppression of Dermatophagoides pteronyssinus-induced airway inflammation by local nasal immunotherapy. Int. Arch. Allergy Immunol. 138, 161-168 (2005).
    • (2005) Int. Arch. Allergy Immunol. , vol.138 , pp. 161-168
    • Liu, Y.H.1    Tsai, J.J.2
  • 98
    • 54449093890 scopus 로고    scopus 로고
    • Airway inflammation induced after allergic poly-sensitization can be prevented by mucosal but not by systemic administration of poly-peptides
    • Hufnagl K, Focke M, Gruber F et al. Airway inflammation induced after allergic poly-sensitization can be prevented by mucosal but not by systemic administration of poly-peptides. Clin. Exp. Allergy 38, 1192-1202 (2008).
    • (2008) Clin. Exp. Allergy , vol.38 , pp. 1192-1202
    • Hufnagl, K.1    Focke, M.2    Gruber, F.3
  • 99
    • 79952033344 scopus 로고    scopus 로고
    • Tolerogenic T cells Th1/Th17 cytokines and TLR2/TLR4 expressing dendritic cells predominate the microenvironment within distinct oral mucosal sites
    • Allam JP, Duan Y, Winter J et al. Tolerogenic T cells, Th1/Th17 cytokines and TLR2/TLR4 expressing dendritic cells predominate the microenvironment within distinct oral mucosal sites. Allergy 66, 532-539 (2011).
    • (2011) Allergy , vol.66 , pp. 532-539
    • Allam, J.P.1    Duan, Y.2    Winter, J.3
  • 100
    • 33747055056 scopus 로고    scopus 로고
    • 4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions
    • 4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions. Scand. J. Immunol. 64, 251-259 (2006).
    • (2006) Scand. J. Immunol. , vol.64 , pp. 251-259
    • Sun, J.B.1    Cuburu, N.2    Blomquist, M.3
  • 101
    • 34447308554 scopus 로고    scopus 로고
    • Sublingual oral tolerance induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells
    • Sun JB, Czerkinsky C, Holmgren J. Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells. Scand. J. Immunol. 66, 278-286 (2007).
    • (2007) Scand. J. Immunol. , vol.66 , pp. 278-286
    • Sun, J.B.1    Czerkinsky, C.2    Holmgren, J.3
  • 102
    • 33745139808 scopus 로고    scopus 로고
    • Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1
    • Daniel C, Repa A, Wild C et al. Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy 61, 812-819 (2006).
    • (2006) Allergy , vol.61 , pp. 812-819
    • Daniel, C.1    Repa, A.2    Wild, C.3
  • 103
    • 53349153154 scopus 로고    scopus 로고
    • CpG immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma IL-10 and IgE responses in intranasal and subcutaneous administrations
    • Mousavi T, Tajik N, Moradi M, Radjabzadeh MF. CpG immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations. Clin. Mol. Allergy 6, 10 (2008).
    • (2008) Clin. Mol. Allergy , vol.6 , pp. 10
    • Mousavi, T.1    Tajik, N.2    Moradi, M.3    Radjabzadeh, M.F.4
  • 104
    • 66149103652 scopus 로고    scopus 로고
    • Local nasal immunotherapy: Efficacy of Dermatophagoides farinae - chitosan vaccine in murine asthma
    • Liu Z, Guo H, Wu Y et al. Local nasal immunotherapy: Efficacy of Dermatophagoides farinae - chitosan vaccine in murine asthma. Int. Arch. Allergy Immunol. 150, 221-228 (2009).
    • (2009) Int. Arch. Allergy Immunol. , vol.150 , pp. 221-228
    • Liu, Z.1    Guo, H.2    Wu, Y.3
  • 105
    • 79956201500 scopus 로고    scopus 로고
    • Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice
    • Dioszeghy V, Mondoulet L, Dhelft V et al. Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice. J. Immunol. 186, 5629-5637 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 5629-5637
    • Dioszeghy, V.1    Mondoulet, L.2    Dhelft, V.3
  • 107
    • 33845662118 scopus 로고    scopus 로고
    • Oral tolerance: Therapeutic implications for autoimmune diseases
    • Faria AM, Weiner HL. Oral tolerance: Therapeutic implications for autoimmune diseases. Clin. Dev. Immunol. 13, 143-157 (2006).
    • (2006) Clin. Dev. Immunol. , vol.13 , pp. 143-157
    • Faria, A.M.1    Weiner, H.L.2
  • 108
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4 + CD25 + regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194, 629-644 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 109
    • 0037371301 scopus 로고    scopus 로고
    • 4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism
    • 4+CD45RBhigh- induced colitis by a TGF-beta-dependent mechanism. J. Immunol. 170, 2516-2522 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2516-2522
    • Oida, T.1    Zhang, X.2    Goto, M.3
  • 110
    • 47249119632 scopus 로고    scopus 로고
    • 4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
    • 4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J. Immunol. 180, 7327-7337 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 7327-7337
    • Chen, M.L.1    Yan, B.S.2    Bando, Y.3    Kuchroo, V.K.4    Weiner, H.L.5
  • 111
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of FoxP3 T reg cells via retinoic acid
    • Sun CM, Hall JA, Blank RB et al. Small intestine lamina propria dendritic cells promote de novo generation of FoxP3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3
  • 112
    • 58849161852 scopus 로고    scopus 로고
    • B lymphocytes promote expansion of regulatory T cells in oral tolerance: Powerful induction by antigen coupled to cholera toxin B subunit
    • Sun JB, Flach CF, Czerkinsky C, Holmgren J. B lymphocytes promote expansion of regulatory T cells in oral tolerance: Powerful induction by antigen coupled to cholera toxin B subunit. J. Immunol. 181, 8278-8287 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8278-8287
    • Sun, J.B.1    Flach, C.F.2    Czerkinsky, C.3    Holmgren, J.4
  • 113
    • 79951772860 scopus 로고    scopus 로고
    • 3+ regulatory T cells in the lamina propria
    • 3+ regulatory T cells in the lamina propria. Immunity 34, 237-246 (2011).
    • (2011) Immunity , vol.34 , pp. 237-246
    • Hadis, U.1    Wahl, B.2    Schulz, O.3
  • 114
    • 42749095525 scopus 로고    scopus 로고
    • Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
    • Francis JN, James LK, Paraskevopoulos G et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J. Allergy Clin. Immunol. 121, 1120-1125 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1120-1125
    • Francis, J.N.1    James, L.K.2    Paraskevopoulos, G.3
  • 115
    • 0019447297 scopus 로고
    • Local intranasal immunotherapy for ragweed allergic rhinitis II Immunologic response
    • Nickelsen JA, Goldstein S, Mueller U et al. Local intranasal immunotherapy for ragweed allergic rhinitis. II. Immunologic response. J. Allergy Clin. Immunol. 68, 41-45 (1981).
    • (1981) J. Allergy Clin. Immunol. , vol.68 , pp. 41-45
    • Nickelsen, J.A.1    Goldstein, S.2    Mueller, U.3
  • 116
    • 0037330234 scopus 로고    scopus 로고
    • Oral desensitizing treatment in food allergy: Clinical and immunological results
    • Patriarca G, Nucera E, Roncallo C et al. Oral desensitizing treatment in food allergy: Clinical and immunological results. Aliment. Pharmacol. Ther. 17, 459-465 (2003).
    • (2003) Aliment. Pharmacol. Ther. , vol.17 , pp. 459-465
    • Patriarca, G.1    Nucera, E.2    Roncallo, C.3
  • 117
    • 0041735323 scopus 로고    scopus 로고
    • Induction of blocking IgG antibodies during immunotherapy
    • Wachholz PA, Durham SR. Induction of 'blocking' IgG antibodies during immunotherapy. Clin. Exp. Allergy 33, 1171-1174 (2003).
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1171-1174
    • Wachholz, P.A.1    Durham, S.R.2
  • 118
    • 0034058399 scopus 로고    scopus 로고
    • Altered allergen binding capacities of Amb a 1-specific IgE and IgG4 from ragweed-sensitive patients receiving immunotherapy
    • Pierson-Mullany LK, Jackola D, Blumenthal M, Rosenberg A. Altered allergen binding capacities of Amb a 1-specific IgE and IgG4 from ragweed-sensitive patients receiving immunotherapy. Ann. Allergy Asthma. Immunol. 84, 241-243 (2000).
    • (2000) Ann. Allergy Asthma. Immunol. , vol.84 , pp. 241-243
    • Pierson-Mullany, L.K.1    Jackola, D.2    Blumenthal, M.3    Rosenberg, A.4
  • 119
    • 0025732717 scopus 로고
    • Effects of immunotherapy on the early late and rechallenge nasal reaction to provocation with allergen: Changes in inflammatory mediators and cells
    • Iliopoulos O, Proud D, Adkinson NF Jr et al. Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: Changes in inflammatory mediators and cells. J. Allergy Clin. Immunol. 87, 855-866 (1991).
    • (1991) J. Allergy Clin. Immunol. , vol.87 , pp. 855-866
    • Iliopoulos, O.1    Proud, D.2    Adkinson Jr., N.F.3
  • 120
    • 78650922803 scopus 로고    scopus 로고
    • The consolidated standards of reporting trials consort statement applied to allergen-specific immunotherapy with inhalant allergens: A global allergy and asthma european network ga 2 len article
    • Bousquet PJ, Calderon MA, Demoly P et al. The Consolidated Standards of Reporting Trials (CONSORT) statement applied to allergen-specific immunotherapy with inhalant allergens: A Global Allergy and Asthma European Network (GA(2)LEN) article. J. Allergy Clin. Immunol. 127, 49-56 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 49-56
    • Bousquet, P.J.1    Calderon, M.A.2    Demoly, P.3
  • 121
    • 0033197966 scopus 로고    scopus 로고
    • 4+ T cells by inhibiting serum-IgE-facilitated allergen presentation
    • 4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J. Immunol. 163, 2944-2952 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 2944-2952
    • Van Neerven, R.J.1    Wikborg, T.2    Lund, G.3
  • 122
    • 1642265044 scopus 로고    scopus 로고
    • A double-blind placebo-controlled birch allergy vaccination study: Inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation
    • van Neerven RJ, Arvidsson M, Ipsen H et al. A double-blind, placebo-controlled birch allergy vaccination study: Inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation. Clin. Exp. Allergy 34, 420-428 (2004).
    • (2004) Clin. Exp. Allergy , vol.34 , pp. 420-428
    • Van Neerven, R.J.1    Arvidsson, M.2    Ipsen, H.3
  • 123
    • 77949393210 scopus 로고    scopus 로고
    • Sublingual grass pollen immunotherapy is associated with increases in sublingual FoxP3-expressing cells and elevated allergen-specific immunoglobulin G4 immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells
    • Scadding GW, Shamji MH, Jacobson MR et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual FoxP3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin. Exp. Allergy 40, 598-606 (2010).
    • (2010) Clin. Exp. Allergy , vol.40 , pp. 598-606
    • Scadding, G.W.1    Shamji, M.H.2    Jacobson, M.R.3
  • 124
    • 16444365595 scopus 로고    scopus 로고
    • Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites
    • Bahceciler NN, Arikan C, Taylor A et al. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int. Arch. Allergy Immunol. 136, 287-294 (2005).
    • (2005) Int. Arch. Allergy Immunol. , vol.136 , pp. 287-294
    • Bahceciler, N.N.1    Arikan, C.2    Taylor, A.3
  • 125
    • 0031784380 scopus 로고    scopus 로고
    • Immunologic changes associated with allergen immunotherapy
    • Durham SR, Till SJ. Immunologic changes associated with allergen immunotherapy. J. Allergy Clin. Immunol. 102, 157-164 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 157-164
    • Durham, S.R.1    Till, S.J.2
  • 126
    • 0042827302 scopus 로고    scopus 로고
    • T cell activation from atopy to asthma: More a paradox than a paradigm
    • El Biaze M, Boniface S, Koscher V et al. T cell activation, from atopy to asthma: more a paradox than a paradigm. Allergy 58, 844-853 (2003).
    • (2003) Allergy , vol.58 , pp. 844-853
    • El Biaze, M.1    Boniface, S.2    Koscher, V.3
  • 127
    • 0031709705 scopus 로고    scopus 로고
    • Restoration of cytokine imbalance by immunotherapy
    • Mavroleon G. Restoration of cytokine imbalance by immunotherapy. Clin. Exp. Allergy 28, 917-920 (1998).
    • (1998) Clin. Exp. Allergy , vol.28 , pp. 917-920
    • Mavroleon, G.1
  • 128
    • 0031041686 scopus 로고    scopus 로고
    • Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy
    • Hamid QA, Schotman E, Jacobson MR, Walker SM, Durham SR. Increases in IL?12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. J. Allergy Clin. Immunol. 99, 254-260 (1997).
    • (1997) J. Allergy Clin. Immunol. , vol.99 , pp. 254-260
    • Hamid, Q.A.1    Schotman, E.2    Jacobson, M.R.3    Walker, S.M.4    Durham, S.R.5
  • 129
    • 0033016327 scopus 로고    scopus 로고
    • The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy
    • Benjaponpitak S, Oro A, Maguire P et al. The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy. J. Allergy Clin. Immunol. 103, 468-475 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 468-475
    • Benjaponpitak, S.1    Oro, A.2    Maguire, P.3
  • 130
    • 9844266243 scopus 로고    scopus 로고
    • Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from Th2 to Th1 in T-cell clones specific for Phl p 1 a major grass pollen allergen
    • Ebner C, Siemann U, Bohle B et al. Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from Th2 to Th1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin. Exp. Allergy 27, 1007-1015 (1997).
    • (1997) Clin. Exp. Allergy , vol.27 , pp. 1007-1015
    • Ebner, C.1    Siemann, U.2    Bohle, B.3
  • 132
    • 77956510028 scopus 로고    scopus 로고
    • Subcutaneous and sublingual immunotherapy and T regulatory cells: There is clinical relevance
    • Ciprandi G, Morandi F, Olcese R, Silvestri M, Tosca MA. Subcutaneous and sublingual immunotherapy and T regulatory cells: There is clinical relevance. Clin. Exp. Allergy 40, 1578-1579 (2010).
    • (2010) Clin. Exp. Allergy , vol.40 , pp. 1578-1579
    • Ciprandi, G.1    Morandi, F.2    Olcese, R.3    Silvestri, M.4    Tosca, M.A.5
  • 133
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler F, Zumkehr J, Klunker S et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med. 205, 2887-2898 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3
  • 135
    • 78650630382 scopus 로고    scopus 로고
    • Immunological effects of sublingual immunotherapy: Clinical efficacy is associated with modulation of programmed cell death ligand 1 IL-10 and IgG4
    • Piconi S, Trabattoni D, Rainone V et al. Immunological effects of sublingual immunotherapy: Clinical efficacy is associated with modulation of programmed cell death ligand 1, IL-10, and IgG4. J. Immunol. 185, 7723-7730 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 7723-7730
    • Piconi, S.1    Trabattoni, D.2    Rainone, V.3
  • 136
  • 137
    • 0037661991 scopus 로고    scopus 로고
    • Characterization of dendritic cells from human oral mucosa: A new Langerhans cell type with high constitutive FcepsilonRI expression
    • Allam JP, Novak N, Fuchs C et al. Characterization of dendritic cells from human oral mucosa: A new Langerhans' cell type with high constitutive FcepsilonRI expression. J. Allergy Clin. Immunol. 112, 141-148 (2003).
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 141-148
    • Allam, J.P.1    Novak, N.2    Fuchs, C.3
  • 138
    • 77956383005 scopus 로고    scopus 로고
    • Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells attenuates their maturation and enhances their migratory and TGF-beta1 and IL-10-producing properties
    • Allam JP, Wurtzen PA, Reinartz M et al. Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties. J. Allergy Clin. Immunol. 126, 638-645 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.126 , pp. 638-645
    • Allam, J.P.1    Wurtzen, P.A.2    Reinartz, M.3
  • 139
    • 38949121675 scopus 로고    scopus 로고
    • Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells
    • Allam JP, Peng WM, Appel T et al. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J. Allergy Clin. Immunol. 121, 368-374 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 368-374
    • Allam, J.P.1    Peng, W.M.2    Appel, T.3
  • 140
    • 35748933466 scopus 로고    scopus 로고
    • Oral reactions to sublingual immunotherapy: A bioptic study
    • Marcucci F, Sensi L, Incorvaia C et al. Oral reactions to sublingual immunotherapy: A bioptic study. Allergy 62, 1475-1477 (2007).
    • (2007) Allergy , vol.62 , pp. 1475-1477
    • Marcucci, F.1    Sensi, L.2    Incorvaia, C.3
  • 141
    • 42549119146 scopus 로고    scopus 로고
    • Distribution of Langerhans cells and mast cells within the human oral mucosa: New application sites of allergens in sublingual immunotherapy
    • Allam JP, Stojanovski G, Friedrichs N et al. Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 63, 720-727 (2008).
    • (2008) Allergy , vol.63 , pp. 720-727
    • Allam, J.P.1    Stojanovski, G.2    Friedrichs, N.3
  • 143
    • 0036598404 scopus 로고    scopus 로고
    • The future of antigen-specific immunotherapy of allergy
    • Valenta R. The future of antigen-specific immunotherapy of allergy. Nat. Rev. Immunol. 2, 446-453 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 446-453
    • Valenta, R.1
  • 144
    • 20144387936 scopus 로고    scopus 로고
    • Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy
    • Batard T, Didierlaurent A, Chabre H et al. Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy. Int. Arch. Allergy Immunol. 136, 239-249 (2005).
    • (2005) Int. Arch. Allergy Immunol. , vol.136 , pp. 239-249
    • Batard, T.1    Didierlaurent, A.2    Chabre, H.3
  • 146
    • 62449179406 scopus 로고    scopus 로고
    • Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: A Phase I/IIa clinical trial
    • Senti G, Johansen P, Haug S et al. Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: A Phase I/IIa clinical trial. Clin. Exp. Allergy Immunol. 39, 562-570 (2009).
    • (2009) Clin. Exp. Allergy Immunol. , vol.39 , pp. 562-570
    • Senti, G.1    Johansen, P.2    Haug, S.3
  • 147
    • 77958150039 scopus 로고    scopus 로고
    • Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: A Phase I/IIa study
    • Pfaar O, Barth C, Jaschke C, Hormann K, Klimek L. Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: A Phase I/IIa study. Int. Arch. Allergy Immunol. 154, 336-344 (2011).
    • (2011) Int. Arch. Allergy Immunol. , vol.154 , pp. 336-344
    • Pfaar, O.1    Barth, C.2    Jaschke, C.3    Hormann, K.4    Klimek, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.