CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations

Clinical and Molecular Allergy

Volumn 6, Issue , 2008, Pages

  Mousavi, Tahereh ^a   Tajik, Nader ^a   Moradi, Maziar ^a   Radjabzadeh, Masoomeh Fallah ^a  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; PHOSPHATE BUFFERED SALINE; POLLEN EXTRACT;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CHENOPODIUM ALBUM; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOTHERAPY; LUNG LAVAGE; MONOTHERAPY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; SENSITIZATION; SPLEEN CELL; STATISTICAL SIGNIFICANCE; STUDENT T TEST; SUPERNATANT;

EID: 53349153154     PISSN: None     EISSN: 14767961     Source Type: Journal    
DOI: 10.1186/1476-7961-6-10     Document Type: Article

References (25)

1. Doina M Racilam JN Kline M Perspectives in asthma: Molecular use of microbial products in asthma prevention and treatment J Allergy Clin Immunol 2005, 116(6):1202-1206. 10.1016/j.jaci.2005.08.050 16337446
2. Jain VV Kline JN CpG DNA: Immunomodulation and remodeling of the asthmatic airway Expert Opin Biol Ther 2004, 4(9):1533-40. 10.1517/ 14712598.4.9.1533 15335319
3. Ikeda RK Nayar J Cho JY Miller M Rodriguez M Rosa DS Resolution of airway inflammation following ovalbumin inhalation. Comparison of ISS DNA and corticosteroids Am J Respir Cell Mol Biol 2003, 28:139-142. 10.1165/rcmb.4853
4. Krieg AM CpG motifs in bacterial DNA and their immune effects Annu Rev Immunol 2002, 20:709-760. 10.1146/annurev.immunol.20.100301.064842 11861616
5. Liu N Ohnishi N Ni L Akira S Bacon KB CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells Nat Immunol 2003, 4:687-693. 10.1038/ni941 12766768
6. Linghua Z Xingshan T Fengzhen Z In vivo oral administration effects of various Oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to psodorabied attenuated virus vaccine in newborn piglets Vaccine 2008, 26(2):224-233. 10.1016/ j.vaccine.2007.10.058 18063448
7. Klinman DM Therapeutic applications of CpG-containing Oligodeoxynucleotides Antisense Nucleic Acid Drug Dev 1998, 8(2):181-184. 9593061
8. Hussain I Jain VV Kitagaki K Businga TR O'Shaughnessy P Kline JN Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides J Laryngoscope 2002, 112(10):1819-26. 10.1097/ 00005537-200210000-00021
9. Broide DH Stachnick G Castaneda D Nayar J Miller M Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma J Clin Immunol 2001, 21:175-182. 10.1023/A:1011078930363 11403224
10. Jain VV Businga TR Kitagaki K George CL O'Shaughnessy PT Kline JN Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure Am J Physiol Lung Cell Mol Physiol 2003, 285(5):L1137-46. 12857672
11. Mousavi T Asadi N Tebiyanian M Study of Chenopodium album allergenic extract to induce allergic asthma in a murine model Iranian Journal of Immunology 2005, 2(3):56-59.
12. Mousavi T Salek Moghadam A Falak R Tebyanian M Co-administration of CpG Oligonucleotides and Chenopodium album extract reverse IgG2a/IgG1 ratios and increase IFN-gamma and IL-10 production in a murine model of asthma Iran J Allergy, Asthma Immunol 2008, 7(1):1-6. 18322305
13. Macaubas C DeKruyff RH Umetsu DT Respiratory tolerance in the protection against asthma Curr Drug Targets Inflamm Allergy 2003, 2(2):175-86. 10.2174/1568010033484304 14561171
14. Mousavi T Asadi N Movahedi M The comparison of conventional and WHO methods for protein determination of allergic extract Journal of Allergy, Asthma and Immunology 2003, 2(2):107-9. 17301365
15. Kunihiko K Vipul VJ Thomas RB Iflikhar H Joel NK Immunomodulatory effects of CpG oligos on established Th2 responses Clinical and Laboratory Immunoll 2002, 9(6):1260-1269. 10.1128/CDLI.9.6.1260-1269.2002
16. Wild JS Sigounas A Sur N Siddiqui M Alam R Kurimoto M Sur S IFN-γ - inducing factor increases allergic sensitization, serum IgE, Th2 cytokines and airway eosinophilia in a mouse model of allergic asthma The Journal of Immunology 2000, 164:2701-2710. 10679111
17. Mo JH Park SW Rhee CS Takabayashi K Lee SS Quan SH Kim IS Suppression of allergic response by CpG motif-house-dust mite conjugate in animal model of allergic rhinitis Am J Rhinol 2006, 20(2):212-218. 16686392
18. Santeliz JV Nest GV Traquina P Larsen E Wills-Karp M Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma J Allergy Clin Immunol 2002, 109:455-462. 10.1067/mai.2002.122156 11897991
19. Fransson M Benson M Adner M Bjornesson S Erjefalt J Uddman R cardell LO Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis Respir Rec 8 17 2007, feb 38 10.1186/1465-9921-8-17
20. Hartmann E Graefe H Hopert A Pries R Rothenfusser S Poeek H Mack B Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium Clin Vaccine Immunol 2006, 13(11):1278-86. 1656540 16928885 10.1128/ CVI.00172-06
21. Van Scott MR Justice JP Bradfield JF Enright E Sigounas A Sur S IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice Am J Physiol Lung Cell Mol Physiol 2000, 278:L667-L674. 10749743
22. Sano K Shirota H Terui T Hattori T Tamura G Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of the differentiation in a sequence-independent manner J Immunol 2003, 170(5):2367-2373. 12594259
23. Suzuki M Matsumoto T Ohta N Min WP Murakami S Intranasal CpG DNA therapy during allergen exposure in allergic rhinitis Otolaryngol Head Neck Surg 2007, 136(2):246-251. 10.1016/j.otohns.2006.09.009 17275548
24. Inoue J Yotsumoto S Sakamoto T Tsuchiya S Aramaki Y Changes in immune responses to mite antigen sentisized through barrier-disrupted skin with CPG-Oligo in mice Biol Pharm Bull 2006, 29(2):385-387. 10.1248/ bpb.29.385 16462052
25. Suzuki M Ohta N Min WP Matsumoto T Min R Zhang X Toida K Murakami S Immunotherapy with CpG DNA conjugated with T-cell epitope of an allergenic Cry J 2 protein is useful for control of allergic conditions in mice Int Immunopharmacol 2007, 7(1):46-54. 10.1016/ j.intimp.2006.08.010 17161816