Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis

Clinical and Experimental Allergy

Volumn 39, Issue 3, 2009, Pages 387-393

  Malling, H J ^a   Montagut, A ^b   Melac, M ^c   Patriarca, G ^d   Panzner, P ^e   Seberova, E ^f   Didier, A ^g  

^a Rigshospitalet   (Denmark)

^b Delta Consultants   (France)

^c Stallergenes SA   (France)

^d FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^e CHARLES UNIVERSITY   (Czech Republic)

^f Alergologicka Ambulance   (Czech Republic)

^g SERVICE DE PNEUMOLOGIE   (France)

Author keywords

Allergic asthma; Monosensitized; Polysensitized; Rhinitis; Rhinoconjunctivitis; Safety; Severity; Sublingual grass pollen tablets

Indexed keywords

GRASS POLLEN EXTRACT; PLACEBO;

ACTIVE IMMUNIZATION; ADULT; ALLERGIC ASTHMA; ALLERGIC CONJUNCTIVITIS; ALLERGIC RHINITIS; ARTICLE; CLINICAL FEATURE; CLINICAL PRACTICE; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; FEMALE; GASTROINTESTINAL PAIN; HEADACHE; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL PRURITUS; POLLEN ALLERGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOCONJUNCTIVITIS; RHINOCONJUNCTIVITIS TOTAL SYMPTOM SCORE; RHINOPHARYNGITIS; RISK BENEFIT ANALYSIS; SCORING SYSTEM; SENSITIZATION; SORE THROAT; THROAT IRRITATION; TONGUE EDEMA;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ADULT; ANTIGENS, PLANT; ASTHMA; COMORBIDITY; CONJUNCTIVITIS, ALLERGIC; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; EUROPE; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; POACEAE; POLLEN; QUALITY OF LIFE; RHINITIS, ALLERGIC, SEASONAL; RISK ASSESSMENT; TABLETS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 58849100338     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03152.x     Document Type: Article

References (18)

1. Plaut M, Valentine MD. Clinical practice. Allergic rhinitis. N Engl J Med 2005 353 : 1934 44.
2. **). Allergy 2008 63 (Suppl 86) : 8 160.
3. Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis. Eur Resp J 2004 24 : 758 64.
4. Bauchau V, Durham SR. Epidemiological characterization of the intermittent and persistent types of allergic rhinitis. Allergy 2005 60 : 350 3.
5. Bousquet J, Neukirch F, Bousquet PJ et al. Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol 2006 117 : 158 62.
6. Leynaert B, Neukirch C, Kony S et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004 113 : 86 93.
7. Bousquet PJ, Chinn S, Janson C et al. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. Allergy 2007 62 : 301 9.
8. Huynen MMTE, Menne B. Phenology and human health: allergic disorders (Report of a meeting, 16-17 January, Rome, Italy). Copenhagen : WHO Regional Office for Europe, 2003.
9. Sunyer J, Jarvis D, Pekkanen J et al. European Community Respiratory Health Survey Study Group. Geographic variations in the effect of atopy on asthma in the European Community Respiratory Health Study. J Allergy Clin Immunol 2004 114 : 1033 9.
10. Zureik M, Neukirch C, Leynaert B et al. European community respiratory health survey. Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ 2002 325 : 411 4.
11. Jarvis D, Luczynska C, Chinn S et al. Change in prevalence of IgE sensitization and mean total IgE with age and cohort. J Allergy Clin Immunol 2005 116 : 675 82.
12. Didier A, Malling HJ, Worm M et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007 120 : 1338 45.
13. Malling HJ. Immunotherapy as an effective tool in allergy treatment. Allergy 1998 53 : 461 72.
14. Dahl R, Kapp A, Colombo G et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006 118 : 434 40.
15. Durham SR, Yang WH, Pedersen MR, Johansen N, Rak S. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006 117 : 802 9.
16. Marogna M, Spadolini I, Massolo A et al. Effects of sublingual immunotherapy for multiple or single allergens in polysensitized patients. Ann Allergy Asthma Immunol 2007 98 : 274 80.
17. Passalacqua G, Durham SR Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol 2007 119 : 881 91.
18. Van Cauwenberge P, Watelet JB, Van Zele T et al. Does rhinitis lead to asthma. Rhinology 2007 45 : 112 21.