Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cells

Clinical and Experimental Allergy

Volumn 39, Issue 12, 2009, Pages 1910-1919

  Mascarell, L ^a   Lombardi, V ^a   Zimmer, A ^a   Louise, A ^b   Tourdot, S ^a   Van Overtvelt, L ^a   Moingeon, P ^a  

^a Stallergenes SA   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Antigen presenting cells; CD103; Mucosal CD4+ T cell; Mucosal immunity; Sublingual immunotherapy

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; LANGERIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOHISTOLOGY; LAMINA PROPRIA; MACROPHAGE; MAST CELL; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CYTOKINES; DENDRITIC CELLS; EOSINOPHILS; FEMALE; GRANULOCYTES; IMMUNE TOLERANCE; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MACROPHAGES; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOUTH FLOOR; MOUTH MUCOSA; MUSCLES; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND; TOLL-LIKE RECEPTORS; TONGUE; VACCINATION;

EID: 72449152861     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03337.x     Document Type: Article

References (45)

1. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005 60 : 4 12.
2. Passalacqua G, Guerra L, Pasquali M, Lombardi C, Canonica GW. Efficacy and safety of sublingual immunotherapy. Ann Allergy Asthma Immunol 2004 93 : 3 12 quiz 12-3, 103.
3. Pajno GB, Peroni DG, Vita D et al. Safety of sublingual immunotherapy in children with asthma. Paediatr Drugs 2003 5 : 777 781.
4. Penagos M, Compalati E, Tarantini F et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 2006 97 : 141 148.
5. Mascarell L, Van Overtvelt L, Moingeon P. Novel ways for immune intervention in immunotherapy: mucosal allergy vaccines. Immunol Allergy Clin North Am 2006 26 : 283 306, vii-viii.
6. Dahl R, Kapp A, Colombo G et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006 118 : 434 440.
7. Didier A, Malling HJ, Worm M et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007 120 : 1338 1345.
8. Moingeon P, Batard T, Fadel R et al. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 2006 61 : 151 165. (Pubitemid 43381824)
9. Allam JP, Novak N, Fuchs C et al. Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression. J Allergy Clin Immunol 2003 112 : 141 148.
10. Allam JP, Peng WM, Appel T et al. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol 2008 121 : 368 374.
11. Mascarell L, Lombardi V, Louise A et al. Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. J Allergy Clin Immunol 2008 122 : 603 609.
12. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo. Science 1990 250 : 1720 1723.
13. Mascarell L, Van Overtvelt L, Lombardi V et al. A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route. Vaccine 2007 26 : 108 118.
14. Durham SR, Till SJ. Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol 1998 102 : 157 164.
15. El Biaze M, Boniface S, Koscher V et al. T cell activation, from atopy to asthma: more a paradox than a paradigm. Allergy 2003 58 : 844 853.
16. Ippoliti F, De Santis W, Volterrani A et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol 2003 14 : 216 221.
17. Mavroleon G. Restoration of cytokine imbalance by immunotherapy. Clin Exp Allergy 1998 28 : 917 920.
18. Hamid QA, Schotman E, Jacobson MR, Walker SM, Durham SR. Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. J Allergy Clin Immunol 1997 99 : 254 260.
19. Benjaponpitak S, Oro A, Maguire P et al. The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy. J Allergy Clin Immunol 1999 103 : 468 475.
20. Ebner C, Siemann U, Bohle B et al. Immunological changes during specific immunotherapy of grass pollen allergy reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 1997 27 : 1007 1015.
21. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993 178 : 2123 2130.
22. Laaksonen K, Junikka M, Lahesmaa R, Terho EO, Savolainen J. In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy. J Allergy Clin Immunol 2003 112 : 1171 1177.
23. Meissner N, Kochs S, Coutelle J et al. Modified T-cell activation pattern during specific immunotherapy (SIT) in cat-allergic patients. Clin Exp Allergy 1999 29 : 618 625.
24. Majori M, Caminati A, Corradi M et al. T-cell cytokine pattern at three time points during specific immunotherapy for mite-sensitive asthma. Clin Exp Allergy 2000 30 : 341 347.
25. Gabrielsson S, Soderlund A, Paulie S et al. Specific immunotherapy prevents increased levels of allergen-specific IL-4- and IL-13-producing cells during pollen season. Allergy 2001 56 : 293 300.
26. Norman PS. Immunotherapy 1999-2004. J Allergy Clin Immunol 2004 113 : 1013 1023.
27. Jutel M, Akdis M, Budak F et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003 33 : 1205 1214.
28. Gardner LM, Thien FC, Douglass JA, Rolland JM, O'Hehir RE. Induction of T 'regulatory' cells by standardized house dust mite immunotherapy an increase in CD4+ CD25+ interleukin-10+ T cells expressing peripheral tissue trafficking markers. Clin Exp Allergy 2004 34 : 1209 1219.
29. Taylor A, Verhagen J, Akdis CA, Akdis M. T regulatory cells in allergy and health: a question of allergen specificity and balance. Int Arch Allergy Immunol 2004 135 : 73 82.
30. Ciprandi G, Fenoglio D, Cirillo I et al. Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report. Ann Allergy Asthma Immunol 2005 95 : 38 44.
31. Novak N, Bieber T, Katoh N. Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells. J Immunol 2001 167 : 797 804. (Pubitemid 32660834)
32. Marcucci F, Sensi L, Incorvaia C et al. Oral reactions to sublingual immunotherapy: a bioptic study. Allergy 2007 62 : 1475 1477.
33. Allam JP, Stojanovski G, Friedrichs N et al. Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 2008 63 : 720 727.
34. Steinman RM, Hawiger D, Liu K et al. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann NY Acad Sci 2003 987 : 15 25.
35. Hawiger D, Inaba K, Dorsett Y et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001 194 : 769 779.
36. Suffia I, Reckling SK, Salay G, Belkaid Y. A role for CD103 in the retention of CD4+ CD25+ Treg and control of Leishmania major infection. J Immunol 2005 174 : 5444 5455.
37. Allakhverdi Z, Fitzpatrick D, Boisvert A et al. Expression of CD103 identifies human regulatory T-cell subsets. J Allergy Clin Immunol 2006 118 : 1342 1349.
38. Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 2007 8 : 1086 1094.
39. Iwasaki A, Kelsall BL. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med 1999 190 : 229 239.
40. Sun JB, Flach CF, Czerkinsky C, Holmgren J. B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit. J Immunol 2008 181 : 8278 8287.
41. Cuburu N, Kweon MN, Song JH et al. Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 2007 25 : 8598 8610.
42. Song JH, Nguyen HH, Cuburu N et al. Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proc Natl Acad Sci USA 2008 105 : 1644 1649.
43. Conti HR, Shen F, Nayyar N et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 2009 206 : 299 311.
44. Lombardi V, Van Overtvelt L, Horiot S et al. Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route. Clin Exp Allergy 2008 38 : 1819 1829.
45. Van Overtvelt L, Lombardi V, Razafindratsita A et al. IL-10-inducing adjuvants enhance sublingual immunotherapy efficacy in a murine asthma model. Int Arch Allergy Immunol 2008 145 : 152 162.