Tolerogenic T cells, Th1/Th17 cytokines and TLR2/TLR4 expressing dendritic cells predominate the microenvironment within distinct oral mucosal sites

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 4, 2011, Pages 532-539

  Allam, J P ^a   Duan, Y ^a   Winter, J ^a   Stojanovski, G ^a   Fronhoffs, F ^a   Wenghoefer, M ^a   Bieber, T ^a   Peng, W M ^a   Novak, N ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Oral mucosa; Subcutaneous allergen specific immunotherapy; Sublingual allergen specific immunotherapy; Th1; Th17; Tolerance

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 26; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; DENDRITIC CELL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROENVIRONMENT; MOUTH MUCOSA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN; TH1 CELL; TH17 CELL; TH2 CELL;

AGED; CELL SEPARATION; CYTOKINES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOUTH MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH17 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 79952033344     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02510.x     Document Type: Article

References (26)

1. Novak N, Allam JP, Betten H, Haberstok J, Bieber T. The role of antigen presenting cells at distinct anatomic sites: they accelerate and they slow down allergies. Allergy 2004; 59:5-14. (Pubitemid 38167945)
2. Novak N, Haberstok J, Bieber T, Allam JP. The immune privilege of the oral mucosa. Trends Mol Med 2008;14:191-198.
3. Hugoson A, Sjodin B, Norderyd O. Trends over 30 years, 1973-2003, in the prevalence and severity of periodontal disease. J Clin Periodontol 2008;35:405-414.
4. Allam JP, Stojanovski G, Friedrichs N, Peng W, Bieber T, Wenzel J et al. Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 2008;63:720-727.
5. Kraft S, Wessendorf JH, Hanau D, Bieber T. Regulation of the high affinity receptor for IgE on human epidermal Langerhans cells. J Immunol 1998;161:1000-1006. (Pubitemid 28323568)
6. Moingeon P, Batard T, Fadel R, Frati F, Sieber J, Van Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 2006;61:151-165. (Pubitemid 43381824)
7. James LK, Durham SR. Update on mechanisms of allergen injection immunotherapy. Clin Exp Allergy 2008;38:1074-1088.
8. Gutcher I, Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation. J Clin Invest 2007;117:1119-1127. (Pubitemid 46718396)
9. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009;27:485-517.
10. Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006;311: 17-58. (Pubitemid 47413194)
11. Terhorst D, Kalali BN, Ollert M, Ring J, Mempel M. The role of toll-like receptors in host defenses and their relevance to dermatologic diseases. Am J Clin Dermatol 2009;11:1-10.
12. Allam JP, Bieber T, Novak N. Dendritic cells as potential targets for mucosal immunotherapy. Curr Opin Allergy Clin Immunol 2009;9:554-557.
13. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005;60:4-12.
14. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003;3:331-341. (Pubitemid 37328685)
15. Allam JP, Klein E, Bieber T, Novak N. Transforming growth factor-beta1 regulates the expression of the high-affinity receptor for IgE on CD34 stem cell-derived CD1a dendritic cells in vitro. J Invest Dermatol 2004;123:676-682. (Pubitemid 39281608)
16. Belladonna ML, Volpi C, Bianchi R, Vacca C, Orabona C, Pallotta MT et al. Cutting edge: autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells. J Immunol 2008;181:5194-5198.
17. Curtis MM, Way SS. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009;126: 177-185.
18. Pathirana RD, O'Brien-Simpson NM, Reynolds EC. Host immune responses to Porphyromonas gingivalis antigens. Periodontology 2000;52:218-237.
19. Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 2007;109:3794-3802. (Pubitemid 46641730)
20. Mascarell L, Lombardi V, Zimmer A, Louise A, Tourdot S, Van Overtvelt L et al. Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cells. Clin Exp Allergy 2009;39:1910-1919.
21. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 2007; 8:369-377. (Pubitemid 46745412)
22. Drachenberg KJ, Heinzkill M, Urban E, Woroniecki SR. Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents. Allergol Immunopathol (Madr) 2003;31:270-277. (Pubitemid 37429027)
23. Mothes N, Heinzkill M, Drachenberg KJ, Sperr WR, Krauth MT, Majlesi Y et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 2003;33:1198-1208. (Pubitemid 37108522)
24. Allam JP, Peng WM, Appel T, Wenghoefer M, Niederhagen B, Bieber T et al. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol 2008;121:368-374.e1.
25. Scadding GW, Shamji MH, Jacobson MR, Lee DI, Wilson D, Lima MT et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010;40:598-606.
26. Allam JP, Wurtzen PA, Reinartz M, Winter J, Vrtala S, Chen KW et al. Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta 1 and IL-10-producing properties. J Allergy Clin Immunol 2010;126:638-645.e1.