Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-β1 and IL-10-producing properties

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 3, 2010, Pages

  Allam, Jean Pierre ^a   Würtzen, Peter A ^b   Reinartz, Markus ^a   Winter, Jochen ^a   Vrtala, Susanne ^c   Chen, Kuan Wei ^c   Valenta, Rudolf ^c   Wenghoefer, Matthias ^a   Appel, Thorsten ^a   Gros, Eva ^a   Niederhagen, Bernd ^a   Bieber, Thomas ^a   Lund, Kaare ^b   Novak, Natalija ^a  

^a UNIVERSITY OF BONN   (Germany)

^b ALK ABELLÓ   (Denmark)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Langerhans cells; oral mucosa; Phl p 5; Sublingual immunotherapy; tolerance

Indexed keywords

ALLERGEN; CYTOKINE; GRASS POLLEN ALLERGEN PHL P 5; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; PHL P V PROTEIN, PHLEUM PRATENSE; PROTEIN BINDING; VEGETABLE PROTEIN;

ADULT; ARTICLE; ATTENUATION; BINDING AFFINITY; CELL MATURATION; CELL MIGRATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOTHERAPY; INCUBATION TIME; LANGERHANS CELL; MAJOR CLINICAL STUDY; MALE; MOUTH MUCOSA; ORAL BIOPSY; PHENOTYPE; PRIORITY JOURNAL; SUBLINGUAL IMMUNOTHERAPY; T LYMPHOCYTE; ASTHMA; BIOLOGICAL MODEL; CELL CULTURE; CELL MOTION; DOSE RESPONSE; IMMUNOLOGY; METABOLISM; RHINITIS; SUBLINGUAL DRUG ADMINISTRATION; TIME; UPREGULATION;

ADMINISTRATION, SUBLINGUAL; ADULT; ALLERGENS; ASTHMA; CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-10; LANGERHANS CELLS; MALE; MODELS, BIOLOGICAL; MOUTH MUCOSA; PLANT PROTEINS; PROTEIN BINDING; RHINITIS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 77956383005     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.04.039     Document Type: Article

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