Prospects for translational regenerative medicine

Biotechnology Advances

Volumn 30, Issue 3, 2012, Pages 658-672

  Chen, Fa Ming ^a   Zhao, Yi Min ^a   Jin, Yan ^a   Shi, Songtao ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Clinical translation; Regenerative dentistry; Regenerative medicine; Stem cell therapy; Tissue engineering; Translational medicine

Indexed keywords

BASIC RESEARCH; CLINICAL CARE; CLINICAL DISEASE; CLINICAL OUTCOME; CLINICAL THERAPY; CLINICAL TRANSLATION; FUNCTIONAL TISSUE; FUNDAMENTAL PRINCIPLES; MEDICAL RESEARCH; MULTI-DISCIPLINARY; REGENERATIVE MEDICINE; STEM CELL THERAPY; TRANSLATIONAL MEDICINE;

DIAGNOSIS; STEM CELLS; TISSUE; TISSUE ENGINEERING;

RESEARCH;

BIOTECHNOLOGY; DISEASE CONTROL; DISEASE TREATMENT; MEDICINE; PHARMACEUTICAL INDUSTRY; REGENERATION; RESEARCH AND DEVELOPMENT;

DENTISTRY; HUMAN; MEDICAL RESEARCH; METHODOLOGY; PERSONALIZED MEDICINE; REGENERATIVE MEDICINE; REVIEW; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TRANSLATIONAL RESEARCH;

BIOMEDICAL RESEARCH; DENTISTRY; HUMANS; INDIVIDUALIZED MEDICINE; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84857505883     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.11.005     Document Type: Review

References (201)

1. Ahrlund-Richter L., De Luca M., Marshak D.R., Munsie M., Veiga A., Rao M. Isolation and production of cells suitable for human therapy: challenges ahead. Cell Stem Cell 2009, 4:20-26.
2. Albani S., Prakken B. The advancement of translational medicine-from regional challenges to global solutions. Nat Med 2009, 15:1006-1009.
3. Albani S., Colomb J., Prakken B. Translational medicine 2.0: from clinical diagnosis-based to molecular-targeted therapies in the era of globalization. Clin Pharmacol Ther 2010, 87:642-645.
4. Anitua E., Sánchez M., Orive G., Andia I. Delivering growth factors for therapeutics. Trends Pharmacol Sci 2008, 29:37-41.
5. Anitua E., Sánchez M., Orive G. Potential of endogenous regenerative technology for in situ regenerative medicine. Adv Drug Deliv Rev 2010, 62:741-752.
6. Arnoczky S.P., Cook J.L., Carter T., Turner A.S. Translational models for studying meniscal repair and replacement: what they can and cannot tell us. Tissue Eng Part B Rev 2010, 16:31-39.
7. Atala A., Bauer S.B., Soker S., Yoo J.J., Retik A.B. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet 2006, 367:1241-1246.
8. Bajada S., Mazakova I., Richardson J.B., Ashammakhi N. Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2008, 2:169-183.
9. Banerjee C. Stem cells therapies in basic science and translational medicine: current status and treatment monitoring strategies. Curr Pharm Biotechnol 2011, 12:469-487.
10. Baylis F., McLeod C. The stem cell debate continues: the buying and selling of eggs for research. J Med Ethics 2007, 33:726-731.
11. Beaman F.D., Bancroft L.W., Peterson J.J., Kransdorf M.J. Bone graft materials and synthetic substitutes. Radiol Clin North Am 2006, 44:451-461.
12. Belardelli F., Rizza P., Moretti F., Carella C., Galli M.C., Migliaccio G. Translational research on advanced therapies. Ann Ist Super Sanita 2011, 47:72-78.
13. Benetti F., Peñherrera E., Maldonado T., Vera Y.D., Subramanian V., Geffner L. Direct myocardial implantation of human fetal stem cells in heart failure patients: long-term results. Heart Surg Forum 2010, 13:E31-E35.
14. Bhansali A., Upreti V., Khandelwal N., Marwaha N., Gupta V., Sachdeva N., et al. Efficacy of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cells Dev 2009, 18:1407-1416.
15. Bianco P. Back to the future: moving beyond "mesenchymal stem cells". J Cell Biochem 2011, 112:1713-1721.
16. Bosch G., van Schie H.T., de Groot M.W., Cadby J.A., van de Lest C.H., Barneveld A., et al. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 2010, 28:211-217.
17. Buter D. Translational research: crossing the valley of death. Nature 2008, 453:840-842.
18. Cao C.F. Translational medicine: a new concept to guide the prevention and treatment of periodontal diseases. Zhonghua Kou Qiang Yi Xue Za Zhi 2009, 44:321-323.
19. Carpenter S. Science careers: carving a career in translational research. Science 2007, 317:966-967.
20. Casagrande L., Cordeiro M.M., Nör S.A., Nör J.E. Dental pulp stem cells in regenerative dentistry. Odontology 2011, 99:1-7.
21. Catón J., Bostanci N., Remboutsika E., De Bari C., Mitsiadis T.A. Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. J Cell Mol Med 2011, 15:1054-1065.
22. Cervelli V., Gentile P., Scioli M.G., Grimaldi M., Casciani C.U., Spagnoli L.G., et al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods 2009, 15:625-634.
23. Chapple I.L. Periodontal diagnosis and treatment-where does the future lie?. Periodontol 2000 2009, 51:9-24.
24. Chavakis E., Urbich C., Dimmeler S. Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol 2008, 45:514-522.
25. Chen F.M., Jin Y. Periodontal tissue engineering and regeneration: current approaches and expanding opportunities. Tissue Eng Part B Rev 2010, 16:219-255.
26. Chen F.M., Shelton R.M., Jin Y., Chapple I.L. Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives. Med Res Rev 2009, 29:472-513.
27. Chen F.M., Zhang J., Zhang M., An Y., Chen F., Wu Z.F. A review on endogenous regenerative technology in periodontal regenerative medicine. Biomaterials 2010, 31:7892-7927.
28. Chen F.M., Zhang M., Wu Z.F. Toward delivery of multiple growth factors in tissue engineering. Biomaterials 2010, 31:6279-6308.
29. Chen F.M., Wu L.A., Zhang M., Zhang R., Sun H.H. Homing of endogenous stem/pregenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. Biomaterials 2011, 32:3189-3209.
30. Chen F.M., An Y., Zhang R., Zhang M. New insights into and novel applications of release technology in periodontal reconstructive therapies. J Control Release 2011, 149:92-110.
31. Chim H., Gosain A.K. Biomaterials in craniofacial surgery: experimental studies and clinical application. J Craniofac Surg 2009, 20:29-33.
32. Choi J.H., Gimble J.M., Lee K., Marra K.G., Rubin J.P., Yoo J.J., et al. Adipose tissue engineering for soft tissue regeneration. Tissue Eng Part B Rev 2010, 16:413-426.
33. Collins F. The bridge between lab and clinic. Nature 2010, 468:877.
34. Costello B.J., Shah G., Kumta P., Sfeir C.S. Regenerative medicine for craniomaxillofacial surgery. Oral Maxillofac Surg Clin North Am 2010, 22:33-42.
35. Csete M. Translational prospects for human induced pluripotent stem cells. Regen Med 2010, 5:509-519.
36. Cuende N., Izeta A. Clinical translation of stem cell therapies: a bridgeable gap. Cell Stem Cell 2010, 6:508-512.
37. Daley G.Q., Scadden D.T. Prospects for stem cell-based therapy. Cell 2008, 132:544-548.
38. Davatchi F., Abdollahi B.S., Mohyeddin M., Shahram F., Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 2011, 14:211-215.
39. Davidson E.H., Sultan S.M., Butala P., Tutela J.P., Canizares O., Wagner I.J., et al. Augmenting neovascularization accelerates distraction osteogenesis. Plast Reconstr Surg 2011, 128:406-414.
40. Demarco F.F., Casagrande L., Zhang Z., Dong Z., Tarquinio S.B., Zeitlin B.D., et al. Effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells. J Endod 2010, 36:1805-1811.
41. Derwin K.A., Baker A.R., Iannotti J.P., McCarron J.A. Preclinical models for translating regenerative medicine therapies for rotator cuff repair. Tissue Eng Part B Rev 2010, 16:21-30.
42. Dieckmann C., Renner R., Milkova L., Simon J.C. Regenerative medicine in dermatology: biomaterials, tissue engineering, stem cells, gene transfer and beyond. Exp Dermatol 2010, 19:697-706.
43. Discher D.E., Mooney D.J., Zandstra P.W. Growth factors, matrices, and forces combine and control stem cells. Science 2009, 324:1673-1677.
44. Dutta R.C., Dutta A.K. Cell-interactive 3D-scaffold; advances and applications. Biotechnol Adv 2009, 27:334-339.
45. Dutta R.C., Dutta A.K. Comprehension of ECM-cell dynamics: a prerequisite for tissue regeneration. Biotechnol Adv 2010, 28:764-769.
46. Editorial Phagocytes and the "bench-bedside interface". N Engl J Med 1968, 278:1014-1016.
47. Evans C.H., Palmer G.D., Pascher A., Porter R., Kwong F.N., Gouze E., et al. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng 2007, 13:1987-1993.
48. Fan Z., Yamaza T., Lee J.S., Yu J., Wang S., Fan G., et al. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol 2009, 11:1002-1009.
49. Feng F., Akiyama K., Liu Y., Yamaza T., Wang T.M., Chen J.H., et al. Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases. Oral Dis 2010, 16:20-28.
50. Feuerstein G.Z., Ruffolo R.R. Discontinued drugs in 2006: cardiovascular drugs translational medicine perspective. Expert Opin Investig Drugs 2007, 16:1315-1326.
51. Feuerstein G.Z., Zaleska M.M., Krams M., Wang X., Day M., Rutkowski J.L., et al. Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J Cereb Blood Flow Metab 2008, 28:217-219.
52. Filho Cerruti H., Kerkis I., Kerkis A., Tatsui N.H., da Costa Neves A., Bueno D.F., et al. Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports. Artif Organs 2007, 31:268-273.
53. Fouillard L., Chapel A., Bories D., Bouchet S., Costa J.M., Rouard H., et al. Infusion of allogeneic-related HLA mismatched mesenchymal stem cells for the treatment of incomplete engraftment following autologous haematopoietic stem cell transplantation. Leukemia 2007, 21:568-570.
54. Gan Y., Dai K., Zhang P., Tang T., Zhu Z., Lu J. The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion. Biomaterials 2008, 29:3973-3982.
55. Gimble J.M., Guilak F., Bunnell B.A. Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther 2010, 1:19.
56. Ginty P.J., Rayment E.A., Hourd P., Williams D.J. Regenerative medicine, resource and regulation: lessons learned from the remedi project. Regen Med 2011, 6:241-253.
57. Gómez-Barrena E., Rosset P., Müller I., Giordano R., Bunu C., Layrolle P., et al. Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology. J Cell Mol Med 2011, 15:1266-1286.
58. Griffin M., Iqbal S.A., Bayat A. Exploring the application of mesenchymal stem cells in bone repair and regeneration. J Bone Joint Surg Br 2011, 93:427-434.
59. Griffith L.G., Naughton G. Tissue engineering-current challenges and expanding opportunities. Science 2002, 295:1009-1014.
60. Gronthos S., Mankani M., Brahim J., Robey P.G., Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000, 97:13625-13630.
61. Gronthos S., Arthur A., Bartold P.M., Shi S. A method to isolate and culture expand human dental pulp stem cells. Methods Mol Biol 2011, 698:107-121.
62. Guldberg R.E. Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration. J Bone Miner Res 2009, 24:1507-1511.
63. Gurtner G.C., Callaghan M.J., Longaker M.T. Progress and potential for regenerative medicine. Annu Rev Med 2007, 58:299-312.
64. Hilfiker A., Kasper C., Hass R., Haverich A. Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?. Langenbecks Arch Surg 2011, 396:489-497.
65. Hörig H., Marincola E., Marincola F.M. Obstacles and opportunities in translational research. Nat Med 2005, 11:705-708.
66. Horwitz E.M., Prockop D.J., Gordon P.L., Koo W.W., Fitzpatrick L.A., Neel M.D., et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 2001, 97:1227-1231.
67. Howe A.J., Shand J.A., Menown I.B. Advances in cardiology: clinical trial update. Future Cardiol 2011, 7:299-310.
68. Huang Y.S. Strengthen researches on translational medicine and regenerative medicine in burns. Zhonghua Shao Shang Za Zhi 2010, 26:167-169.
69. Huang G.T., Gronthos S., Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009, 88:792-806.
70. Huang G.T., Yamaza T., Shea L.D., Djouad F., Kuhn N.Z., Tuan R.S., et al. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 2010, 16:605-615.
71. Humes H.D. Translational medicine and the National Institutes of Health road map: steep grades and tortuous curves. J Lab Clin Med 2005, 146:51-54.
72. Hussain M.A., Theise N.D. Stem-cell therapy for diabetes mellitus. Lancet 2004, 364:203-205.
73. Hyun I., Lindvall O., Ahrlund-Richter L., Cattaneo E., Cavazzana-Calvo M., Cossu G., et al. New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell 2008, 3:607-609.
74. Inanç B., Elçin Y.M. Stem cells in tooth tissue regeneration-challenges and limitations. Stem Cell Rev 2011, 7:683-692.
75. Iwata T., Yamato M., Tsuchioka H., Takagi R., Mukobata S., Washio K., et al. Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials 2009, 30:2716-2723.
76. Jacobsohn D.A., Duerst R., Tse W., Kletzel M. Reduced intensity haemopoietic stem-cell transplantation for treatment of non-malignant diseases in children. Lancet 2004, 364:156-162.
77. Jiang X.W. The practice of translational medicine at Harvard Medical School and its implication in China. Zhonghua Yi Xue Za Zhi 2010, 90:1519-1521.
78. Johnson E.O., Troupis T., Soucacos P.N. Tissue-engineered vascularized bone grafts: basic science and clinical relevance to trauma and reconstructive microsurgery. Microsurgery 2011, 31:176-182.
79. Kagami H., Agata H., Tojo A. Bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for bone tissue engineering: basic science to clinical translation. Int J Biochem Cell Biol 2011, 43:286-289.
80. Katz A.M. The "gap" between bench and bedside: widening or narrowing?. J Card Fail 2008, 14:91-94.
81. Khan S.N., Cammisa F.P., Sandhu H.S., Diwan A.D., Girardi F.P., Lane J.M. The biology of bone grafting. J Am Acad Orthop Surg 2005, 13:77-86.
82. Kim J.Y., Xin X., Moioli E.K., Chung J., Lee C.H., Chen M., et al. Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing. Tissue Eng Part A 2010, 16:3023-3031.
83. Kim K., Lee C.H., Kim B.K., Mao J.J. Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res 2010, 89:842-847.
84. Kimura Y., Miyazaki N., Hayashi N., Otsuru S., Tamai K., Kaneda Y., et al. Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue. Tissue Eng Part A 2010, 16:1263-1270.
85. Kiskinis E., Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest 2010, 120:51-59.
86. Kränkel N., Spinetti G., Amadesi S., Madeddu P. Targeting stem cell niches and trafficking for cardiovascular therapy. Pharmacol Ther 2011, 129:62-81.
87. Kraus K.H., Kirker-Head C. Mesenchymal stem cells and bone regeneration. Vet Surg 2006, 35:232-242.
88. Kreeger K. From bench to bedside. Nature 2003, 424:1090-1091.
89. Kuehn B.M. PhD programs adopt bench-to-bedside model to speed translational research. JAMA 2006, 295:1506-1507.
90. Kuhbier J.W., Weyand B., Radtke C., Vogt P.M., Kasper C., Reimers K. Isolation, characterization, differentiation, and application of adipose-derived stem cells. Adv Biochem Eng Biotechnol 2010, 123:55-105.
91. Kumagai K., Vasanji A., Drazba J.A., Butler R.S., Muschler G.F. Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model. J Orthop Res 2008, 26:165-175.
92. Kuroda R., Ishida K., Matsumoto T., Akisue T., Fujioka H., Mizuno K., et al. Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. Osteoarthritis Cartilage 2007, 15:226-231.
93. Laird D.J., von Andrian U.H., Wagers A.J. Stem cell trafficking in tissue development, growth, and disease. Cell 2008, 132:612-630.
94. Lazarus H.M., Koc O.N., Devine S.M., Curtin P., Maziarz R.T., Holland H.K., et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005, 11:389-398.
95. Ledford H. Translational research: the full cycle. Nature 2008, 453:843-845.
96. Lee K., Chan C.K., Patil N., Goodman S.B. Cell therapy for bone regeneration-bench to bedside. J Biomed Mater Res B Appl Biomater 2009, 89:252-263.
97. Lee C.H., Cook J.L., Mendelson A., Moioli E.K., Yao H., Mao J.J. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet 2010, 376:440-448.
98. Lee K., Silva E.A., Mooney D.J. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface 2011, 8:153-170.
99. Lenfant C. Shattuck lecture-clinical research to clinical practice-lost in translation?. N Engl J Med 2003, 349:868-874.
100. Levenberg S., Rouwkema J., Macdonald M., Garfein E.S., Kohane D.S., Darland D.C., et al. Engineering vascularized skeletal muscle tissue. Nat Biotechnol 2005, 23:879-884.
101. Liang J., Zhang H., Hua B., Wang H., Lu L., Shi S., et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 2010, 69:1423-1429.
102. Lin N.H., Gronthos S., Bartold P.M. Stem cells and future periodontal regeneration. Periodontol 2000 2009, 51:239-251.
103. Lindvall O., Kokaia Z. Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci 2009, 30:260-267.
104. Littman B.H., Di Mario L., Plebani M., Marincola F.M. What's next in translational medicine?. Clin Sci (Lond) 2007, 112:217-227.
105. Liu J., Lv Y.Y. Interpretation of translational medicine: patient-oriented research. Zhonghua Yi Xue Za Zhi 2008, 88:2665-2666.
106. Liu Y., Zheng Y., Ding G., Fang D., Zhang C., Bartold P.M., et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 2008, 26:1065-1073.
107. Locke M., Feisst V., Dunbar P.R. Concise review: human adipose-derived stem cells: separating promise from clinical need. Stem Cells 2011, 29:404-411.
108. Lutolf M.P., Gilbert P.M., Blau H.M. Designing materials to direct stem-cell fate. Nature 2009, 462:433-441.
109. Madonna R., De Caterina R. Stem cells and growth factor delivery systems for cardiovascular disease. J Biotechnol 2011, 154:291-297.
110. Malliaras K., Marbán E. Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull 2011, 98:161-185.
111. Mankoff S.P., Brander C., Ferrone S., Marincola F.M. Lost in translation: obstacles to translational medicine. J Transl Med 2004, 2:14.
112. Mao J. Translational pain research: achievements and challenges. J Pain 2009, 10:1001-1011.
113. Mao J.J., Stosich M.S., Moioli E.K., Lee C.H., Fu S.Y., Bastian B., et al. Facial reconstruction by biosurgery: cell transplantation versus cell homing. Tissue Eng Part B Rev 2010, 16:257-262.
114. Marincola F.M. Translational medicine: a two-way road. J Transl Med 2003, 1:1.
115. Mark A.L., Kelch R.P. Clinician scientist training program: a proposal for training medical students in clinical research. J Investig Med 2001, 49:486-490.
116. Martínez-Zapata M.J., Martí-Carvajal A., Solà I., Bolibar I., Angel Expósito J., Rodriguez L., et al. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 2009, 49:44-56.
117. Martino H.F., Oliveira P.S., Souza F.C., Costa P.C., Assunção E., Silva E., Villela R., et al. A safety and feasibility study of cell therapy in dilated cardiomyopathy. Braz J Med Biol Res 2010, 43:989-995.
118. McCarty R.C., Xian C.J., Gronthos S., Zannettino A.C., Foster B.K. Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury. Open Orthop J 2010, 4:204-210.
119. Meng J., Muntoni F., Morgan J.E. Stem cells to treat muscular dystrophies - where are we?. Neuromuscul Disord 2011, 21:4-12.
120. Meregalli M., Farini A., Parolini D., Maciotta S., Torrente Y. Stem cell therapies to treat muscular dystrophy: progress to date. BioDrugs 2010, 24:237-247.
121. Milne C.P., Kaitin K.I. Translational medicine: an engine of change for bringing new technology to community health. Sci Transl Med 2009, 1. [5cm5].
122. Miura M., Gronthos S., Zhao M., Lu B., Fisher L.W., Robey P.G., Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003, 100:5807-5812.
123. Moore D.R. Reverse translation: clearing a path from bedside to bench. Nature 2008, 454:274.
124. Moran C.J., Shannon F.J., Barry F.P., O'Byrne J.M., O'Brien T., Curtin W. Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention. J Bone Joint Surg Br 2010, 92:1195-1202.
125. Morrow G.R., Bellg A.J. Behavioral science in translational research and cancer control. Cancer 1994, 74(4 Suppl.):1409-1417.
126. Morsczeck C., Götz W., Schierholz J., Zeilhofer F., Kühn U., Möhl C., et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 2005, 24:155-165.
127. Mosna F., Sensebé L., Krampera M. Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide. Stem Cells Dev 2010, 19:1449-1470.
128. Moss S. Translational research: don't neglect basic science. Nature 2008, 454:274.
129. Mrozik K., Gronthos S., Shi S., Bartold P.M. A method to isolate, purify, and characterize human periodontal ligament stem cells. Methods Mol Biol 2010, 666:269-284.
130. Muschler G.F., Raut V.P., Patterson T.E., Wenke J.C., Hollinger J.O. The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. Tissue Eng Part B Rev 2010, 16:123-145.
131. Nandi S.K., Roy S., Mukherjee P., Kundu B., De D.K., Basu D. Orthopaedic applications of bone graft & graft substitutes: a review. Indian J Med Res 2010, 132:15-30.
132. Newnham E.A., Page A.C. Bridging the gap between best evidence and best practice in mental health. Clin Psychol Rev 2010, 30:127-142.
133. Nunes S.S., Song H., Chiang C.K., Radisic M. Stem cell-based cardiac tissue engineering. J Cardiovasc Transl Res 2011, 4:592-602.
134. Orlando G., Baptista P., Birchall M., De Coppi P., Farney A., Guimaraes-Souza N.K., et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int 2011, 24:223-232.
135. Otsuru S., Tamai K., Yamazaki T., Yoshikawa H., Kaneda Y. Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Biochem Biophys Res Commun 2007, 354:453-458.
136. Otsuru S., Tamai K., Yamazaki T., Yoshikawa H., Kaneda Y.A. Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. Stem Cells 2008, 26:223-234.
137. Parekkadan B., Milwid J.M. Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng 2010, 12:87-117.
138. Pearson H. A case history. Nature 2008, 453:846-849.
139. Pellegrini G., Seol Y.J., Gruber R., Giannobile W.V. Pre-clinical models for oral and periodontal reconstructive therapies. J Dent Res 2009, 88:1065-1076.
140. Perin E.C., Dohmann H.F., Borojevic R., Silva S.A., Sousa A.L., Silva G.V., et al. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 2004, 110(11 Suppl. 1):11213-11218.
141. Petrini C. Ethical issues in translational research. Perspect Biol Med 2010, 53:517-533.
142. Petrini C. From bench to bedside and to health policies: ethics in translational research. Clin Ter 2011, 162:51-59.
143. Petrou M., Foerster B.R., Reich D.S. Translational research in radiology: challenges and role in a patient-based practice. Acad Radiol 2009, 16:593-596.
144. Place E.S., Evans N.D., Stevens M.M. Complexity in biomaterials for tissue engineering. Nat Mater 2009, 8:457-470.
145. Plachokova A.S., Nikolidakis D., Mulder J., Jansen J.A., Creugers N.H. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res 2008, 19:539-545.
146. Placzek M.R., Chung I.M., Macedo H.M., Ismail S., Mortera Blanco T., Lim M., et al. Stem cell bioprocessing: fundamentals and principles. J R Soc Interface 2009, 6:209-232.
147. Plebani M. The changing scenario in laboratory medicine and the role of laboratory professionals in translational medicine. Clin Chim Acta 2008, 393:23-26.
148. Pober J.S., Neuhauser C.S., Pober J.M. Obstacles facing translational research in academic medical centers. FASEB J 2001, 15:2303-2313.
149. Pou A.M. Update on new biomaterials and their use in reconstructive surgery. Curr Opin Otolaryngol Head Neck Surg 2003, 11:240-244.
150. Procházka V., Gumulec J., Jalůvka F., Salounová D., Jonszta T., Czerný D., et al. Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Cell Transplant 2010, 19:1413-1424.
151. Ratcliffe E., Thomas R.J., Williams D.J. Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine. Br Med Bull 2011, 10.1093/bmb/ldr037.
152. Rayment E.A., Williams D.J. Concise review: mind the gap: challenges in characterizing and quantifying cell- and tissue-based therapies for clinical translation. Stem Cells 2010, 28:996-1004.
153. Reddi A.S., Kuppasani K., Ende N. Human umbilical cord blood as an emerging stem cell therapy for diabetes mellitus. Curr Stem Cell Res Ther 2010, 5:356-361.
154. Riegman P.H., van Veen E.B. Biobanking residual tissues. Hum Genet 2011, 130:357-368.
155. Ruff C.A., Fehlings M.G. Neural stem cells in regenerative medicine: bridging the gap. Panminerva Med 2010, 52:125-147.
156. Runyan C.M., Taylor J.A. Clinical applications of stem cells in craniofacial surgery. Facial Plast Surg 2010, 26:385-395.
157. Sah R.L., Ratcliffe A. Translational models for musculoskeletal tissue engineering and regenerative medicine. Tissue Eng Part B Rev 2010, 16:1-3.
158. Salem H.K., Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 2010, 28:585-596.
159. Sanberg P.R., Willing A.E., Garbuzova-Davis S., Saporta S., Liu G., Sanberg C.D., et al. Umbilical cord blood-derived stem cells and brain repair. Ann N Y Acad Sci 2005, 1049:67-83.
160. Sanchez-Serrano I. Success in translational research: lessons from the development of bortezomib. Nat Rev Drug Discov 2006, 5:107-114.
161. Schmidt B. Clinical development of antiepileptic drugs in adults. Neurotherapeutics 2007, 4:62-69.
162. Schwartz-Bloom R. Science education: a neuroscientist's view of translational medicine. J Neurosci 2005, 25:5667-5669.
163. Segers V.F., Lee R.T. Stem-cell therapy for cardiac disease. Nature 2008, 451:937-942.
164. Seo B.M., Miura M., Gronthos S., Bartold P.M., Batouli S., Brahim J., et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004, 364:149-155.
165. Shah I.M., Mackay S.P., McKay G.A. Therapeutic strategies in the treatment of diabetic nephropathy - a translational medicine approach. Curr Med Chem 2009, 16:997-1016.
166. Shekkeris A.S., Jaiswal P.K., Khan W.S. Clinical applications of mesenchymal stem cells in the treatment of fracture non-union and bone defects. Curr Stem Cell Res Ther 2011, [doi: BSP/CSCRT/E-Pub/00116].
167. Shevchenko R.V., James S.L., James S.E. A review of tissue-engineered skin bioconstructs available for skin reconstruction. J R Soc Interface 2010, 7:229-258.
168. Simon T.M., Aberman H.M. Cartilage regeneration and repair testing in a surrogate large animal model. Tissue Eng Part B Rev 2010, 16:65-79.
169. Snape K., Trembath R.C., Lord G.M. Translational medicine and the NIHR Biomedical Research Centre concept. QJM 2008, 101:901-906.
170. Solway J., Rehman B., Ross L.F. The University of Chicago Institute for Translational Medicine. Clin Transl Sci 2009, 2:394-397.
171. Sonoyama W., Liu Y., Fang D., Yamaza T., Seo B.M., Zhang C., et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 2006, 1:e79.
172. Sonoyama W., Liu Y., Yamaza T., Tuan R.S., Wang S., Shi S., et al. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 2008, 34:166-171.
173. Stamm C., Kleine H.D., Westphal B., Petzsch M., Kittner C., Nienaber C.A., et al. CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiovasc Surg 2004, 52:152-158.
174. Sugaya K., Kwak Y.D., Ohmitsu O., Marutle A., Greig N.H., Choumrina E. Practical issues in stem cell therapy for Alzheimer's disease. Curr Alzheimer Res 2007, 4:370-377.
175. Sun L., Akiyama K., Zhang H., Yamaza T., Hou Y., Zhao S., et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009, 27:1421-1432.
176. Sun L., Zhang T., Lan X., Du G. Effects of stem cell therapy on left ventricular remodeling after acute myocardial infarction: a meta-analysis. Clin Cardiol 2010, 33:296-302.
177. Sun H.H., Jin T., Yu Q., Chen F.M. Biological approaches toward dental pulp regeneration by tissue engineering. J Tissue Eng Regen Med 2011, 5:e1-e16.
178. Sun H.H., Qu T.J., Zhang X.H., Yu Q., Chen F.M. Designing biomaterials for in situ periodontal regeneration. Biotechnol Prog 2011, 10.1002/btpr.698.
179. Tang L., Li N., Xie H., Jin Y. Characterization of mesenchymal stem cells from human normal and hyperplastic gingiva. J Cell Physiol 2011, 226:832-842.
180. Tare R.S., Kanczler J., Aarvold A., Jones A.M., Dunlop D.G., Oreffo R.O. Skeletal stem cells and bone regeneration: translational strategies from bench to clinic. Proc Inst Mech Eng H 2010, 224:1455-1470.
181. Tesio L. Measurement in clinical vs. biological medicine: the Rasch model as a bridge on a widening gap. J Appl Meas 2004, 5:362-366.
182. Thieme S., Ryser M., Gentsch M., Navratiel K., Brenner S., Stiehler M., et al. Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds. Tissue Eng Part C Methods 2009, 15:687-696.
183. Trombelli L., Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol 2008, 35(8 Suppl.):117-135.
184. Utsunomiya T., Shimada M., Imura S., Morine Y., Ikemoto T., Mori H., et al. Human adipose-derived stem cells: potential clinical applications in surgery. Surg Today 2011, 41:18-23.
185. Valdespino Gómez V.M. The translational research unit as support for the current practice of medicine. Cir Cir 2010, 78:191-195.
186. Vidaltamayo R., Bargas J., Covarrubias L., Hernández A., Galarraga E., Gutiérrez-Ospina G., Drucker-Colin R. Stem cell therapy for Parkinson's disease: a road map for a successful future. Stem Cells Dev 2010, 19:311-320.
187. Vilquin J.T., Rosset P. Mesenchymal stem cells in bone and cartilage repair: current status. Regen Med 2006, 1:589-604.
188. Volponi A.A., Pang Y., Sharpe P.T. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol 2010, 20:715-722.
189. Wang S., Cui J., Peng W., Lu M. Intracoronary autologous CD34+ stem cell therapy for intractable angina. Cardiology 2010, 117:140-147.
190. Wöhrle J., Merkle N., Mailänder V., Nusser T., Schauwecker P., von Scheidt F., et al. Results of intracoronary stem cell therapy after acute myocardial infarction. Am J Cardiol 2010, 105:804-812.
191. Wolf S. Editorial: the real gap between bench and bedside. N Engl J Med 1974, 290:802-803.
192. Wong V.W., Rustad K.C., Longaker M.T., Gurtner G.C. Tissue engineering in plastic surgery: a review. Plast Reconstr Surg 2010, 126:858-868.
193. Woolf S.H. The meaning of translational research and why it matters. JAMA 2008, 299:211-213.
194. Wright K.T., El Masri W., Osman A., Chowdhury J., Johnson W.E. Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 2011, 29:169-178.
195. Yang Z., Jin F., Zhang X., Ma D., Han C., Huo N., et al. Tissue engineering of cementum/periodontal-ligament complex using a novel three-dimensional pellet cultivation system for human periodontal ligament stem cells. Tissue Eng Part C Methods 2009, 15:571-581.
196. Yarak S., Okamoto O.K. Human adipose-derived stem cells: current challenges and clinical perspectives. An Bras Dermatol 2010, 85:647-656.
197. Zarzeczny A., Scott C., Hyun I., Bennett J., Chandler J., Chargé S., et al. iPS cells: mapping the policy issues. Cell 2009, 139:1032-1037.
198. Zerhouni E. The NIH roadmap. Science 2003, 302:63-72.
199. Zerhouni E.A. US biomedical research: basic, translational, and clinical sciences. JAMA 2005, 294:1352-1358.
200. Zimmermann W.H., Melnychenko I., Wasmeier G., Didié M., Naito H., Nixdorff U., et al. Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med 2006, 12:452-458.
201. Zinner D.E., Campbell E.G. Life-science research within US academic medical centers. JAMA 2009, 302:969-976.