Human umbilical cord blood as an emerging stem cell therapy for diabetes mellitus

Current Stem Cell Research and Therapy

Volumn 5, Issue 4, 2010, Pages 356-361

  Reddi, Alluru S ^a   Kuppasani, Kishore ^a   Ende, Norman ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Cells; Bone marrow; Clinical trials; Diabetes mellitus; Differentiation; Human umbilical cord blood; Regulatory t cells; Stem cells

Indexed keywords

GLUCOSE; INSULIN;

ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CELL DIFFERENTIATION; CORD BLOOD STEM CELL TRANSPLANTATION; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CHILD; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FETAL BLOOD; HUMANS; INSULIN; INSULIN-SECRETING CELLS; STEM CELL NICHE; STEM CELL TRANSPLANTATION;

EID: 78649999066     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488810793351668     Document Type: Article

References (46)

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-53.
2. Harold KC, Hagopian W, Auger JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002; 346: 1692-8.
3. Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 321: 1174-78.
4. Ende M, Ende N. Hematopoietic transplantation by means of fetal (cord) blood. Virginia Med Mon 1972; 99: 276-80.
5. de Wynter EA, Testa NG. Interest of cord blood stem cells. Biomed Pharmacother 2001; 35: 195-200.
6. Moise Jr KJ. Umbilical cord stem cells. Obstetr Gynecol 2005; 106: 1393-407.
7. Tse W, Laughlin MJ. Umbilical cord blood transplantation: A new alternative option. Hematology 2005; 377-83.
8. Rocha V, Gluckman E, Eurocord and European Blood and Marrow Transplant group. Biol Blood Marrow Transplant 2006; 12: 34-41.
9. Brunstein CG, Setubal DC, Wagner JE. Expanding the role of umbilical cord blood transplantation. Br J Hematol 2007; 137: 20-35.
10. Harris DT, Rogers I. Umbilical cord blood: a unique source of pluripotent stem cells for regenerative medicine. Curr Stem Cell Res Ther 2007; 4: 301-9.
11. Bieback K, Kluter H. Mesenchymal stromal cells from umbilical cord blood. Curr Stem Cell Res Ther 2007; 2(4): 310-23.
12. Haylock DN, Nilsson SK. Expansion of umbilical cord blood for clinical transplantation. Curr Stem Cell Res Ther 2007; 2(4): 324-35.
13. Riordan NH, Chan K, Marleau AM, Ichim TE. Cord blood in regenerative medicine: do we need immune suppression? J Translat Med 2007; 1-9.
14. Palma CA, Lindeman R, Tuch BE. Blood into beta-cells: can adult stem cells be used as a therapy for type 1 diabetes. Regen Med 2008; 3: 33-47.
15. Sullivan MJ. Banking on cord blood stem cells. Nature Rev Cancer 2008; 8: 554-63.
16. Kögler G, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004; 200: 123-35.
17. Zhao Y, Wang H, Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics, Exp Cell Res 2006; 312: 2454-64.
18. Murohara T. Therapeutic vasculogenesis using human cord bloodderived endothelial progenitors. Trends Cardiovasc Med 2001; 11: 303-7.
19. Brusko T, Atkinson M. Treg in type 1 diabetes. Cell Biochem Biophys 2007; 48: 165-75.
20. Zhang L, Yang R, Han ZC. Transplantation of umbilical cord blood-derived endothelial progenitor cells: a promising method of therapeutic revascularization. Eur J Hematol 2006; 76: 1-8.
21. Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate MSC-like cells from umbilical cord. Stem Cells 2003; 21: 105-10.
22. Kamolz L-P, Kolbus A, Wick N, et al. Cultured human epithelium: Human umbilical cord blood stem cells differentiate into keratinocytes under in vitro conditions. Burns 2006; 32: 16-19.
23. Kong KY, Ren J, Kraus M, et al. Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice. Stem Cells 2004; 22: 981-93.
24. Banerjee M, Kanitkar M, Bhonde RR. Approaches towards endogenous pancreatic regeneration. Rev Diabet Stud 2005; 2:165-76.
25. Denner L, Bodenburg Y, Zhao JG, et al. Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin. Cell Prolif 2007; 40: 367-80.
26. Sun B, Roh K-H, Lee S-R, et al. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem Biophys Res Commun 2007; 354: 919-23.
27. Gao F, Wu D-Q, Hu Y-H, et al. In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells. Translat Res 2008; 151: 293-302.
28. Parekh VS, Joglekar MV, Hardikar AA. Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage. Differentiation 2009; 78(48): 232-40. (Abstr).
29. Lee DD, Grossman E, Chong AS. Cellular therapies for type 1 diabetes. Horm Metab Res 2008; 40: 147-54.
30. Koblas T, Harman SM, Saudek F. The application of umbilical cord blood cells in the treatment of diabetes mellitus. Rev Diabet Stu 2005; 2: 228-34.
31. Ende N, Chen R, Mack R. NOD/LtJ type 1 diabetes in mice and the effect of stem cells (Berashis) derived from human umbilical cord blood. J Med 2002; 33: 181-87.
32. Ende N, Chen R, Reddi AS. Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice. Biochem Biophys Res Commun 2004; 325: 665-69.
33. Ende N, Chen R, Reddi AS. Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in type 2 diabetic mice. Biochem Biophys Res Commun 2004; 321: 168-71.
34. Zhang F-T, Wan H-J, Ye J, et al. Therapeutic effect of human umbilical cord blood cells on diabetic mice. Cell Res 2008 (Abstract).
35. Naruse K, Hamada Y, Nakashima E, et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes 2005; 54: 1823-2.
36. Tepper OM, Galiano RD, Capla JM, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002; 106: 2781-86.
37. Loomans CJM, de Koning EJP, Staal FJT, et al. Endothelial progenitor cell dysfunction. A novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004; 53: 195-99.
38. Zhao Y, Lin B, Darflinger R, et al. Human cord blood stem cellmodulated regulatory T lymphocytes reverse the autoimmune caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One 2009; 4: e4226.
39. Haller MJ, Viener H-L, Brusko T, et al. Insulin requirements, HbA1c, and stimulated C-peptide following autologous umbilical cord blood transfusion in children with TID. Diabetes 2007; 56 (suppl 1): A82 (Abstr).
40. Haller MJ, Viener H-L, Wasserfall C, et al. Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol 2008; 36: 710-15.
41. Viener H-L, Brusco T, Wasserfall C, et al. Changes in regulatory T cells following autologous umbilical cord blood transfusion in children with type 1 diabetes. Diabetes 2007; 56 (suppl 1): A82 (Abstract).
42. Haller MJ, Wassefall CH, McGrail KM, et al. Autologous umbilical cord blood transfusion in very young children with type 1 diabetes. Diabetes Care 2009; 32: 2041-46.
43. D. Umbilical cord blood and type 1 diabetes. A road ahead or dead end? Diabetes Care 2009; 32: 2138-39.
44. Bhattacharya N. Placental umbilical cord blood transfusion: a new method of treatment of patients with diabetes and microalbuminuria in the background of anemia. Clin Exp Obstet Gynecol 2006; 33: 164-8.
45. Voltarelli JC, Couri CEB, Stracieri ABPL, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2007; 297: 1568-76.
46. Bhansali A, Upreti V, Khandelwal N, et al. Efficacy of autologous bone marrow derived stem cell transplantation in patients with type 2 diabetes mellitus. Stem cells Dev 2009; 18(10): 1407-16. (Abstr).