Practical issues in stem cell therapy for Alzheimer's disease

Current Alzheimer Research

Volumn 4, Issue 4, 2007, Pages 370-377

  Sugaya, K ^a,c   Kwak, Y D ^a   Ohmitsu, O ^a   Marutle, A ^a   Greig, N H ^b   Choumrina, E ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

amyloid; (+) phenserine; Amyloid precursor protein; Gliosis; Neural differentiation; Neurogenesis; Stem cell

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHENSERINE; PYRIMIDINE DERIVATIVE;

ALZHEIMER DISEASE; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; COGNITION; CONFERENCE PAPER; CYTOLOGY; DOWN SYNDROME; GENE SILENCING; GENETIC TRANSFECTION; GLIA CELL; GLIOSIS; HUMAN; KNOCKOUT MOUSE; MESENCHYMAL STEM CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; STEM CELL TRANSPLANTATION;

ALZHEIMER DISEASE; ANIMALS; GENE THERAPY; HUMANS; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 34548663535     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720507781788936     Document Type: Conference Paper

References (72)

1. Brustle O, Choudhary K, Karram K, Huttner A, Murray K, Dubois-Dalcq M, McKay RD. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nat Biotechnol 16(11): 1040-4 (1998).
2. Brustle O, McKay RD. The neuroepithelial stem cell concept: implications for neuro-oncology. J Neurooncol 24(1): 57-9 (1995).
3. Flax JD, Aurora S, Yang C, Simonin C, Wills AM, Billinghurst LL, et al. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol 16(11): 1033-9 (1998).
4. Alvarez-Buylla A, Garcia-Verdugo JM. Neurogenesis in adult subventricular zone. J Neurosci 22(3): 629-34 (2002).
5. Gould E, Reeves AJ, Fallah M, Tanapat P, Gross CG, Fuchs E. Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci USA 96(9): 5263-7 (1999).
6. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97(6): 703-16 (1999).
7. Johansson CB, Svensson M, Wallstedt L, Janson AM, Frisn J. Neural Stem Cells in the Adult Human Brain. Exp Cell Res 253(2): 733-736 (1999).
8. Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96(1): 25-34 (1999).
9. Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, et al. A new method for the rapid and long term growth of human neural precursor cells. J Neurosci Methods 85(2): 141-52 (1998).
10. Qu T, Brannen CL, Kim HM, Sugaya K. Human neural stem cells improve cognitive function of aged brain. Neuroreport 12(6): 1127-32 (2001).
11. Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18(6): 675-9 (2000).
12. Chazal G, Durbec P, Jankovski A, Rougon G, Cremer H. Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse. J Neurosci 20(4): 1446-57 (2000).
13. Conover JC, Doetsch F, Garcia-Verdugo JM, Gale NW, Yancopoulos GD, Alvarez-Buylla A. Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat Neurosci 3(11): 1091-7 (2000).
14. Jacques TS, Relvas JB, Nishimura S, Pytela R, Edwards GM, Streuli CH, et al. Neural precursor cell chain migration and division are regulated through different beta1 integrins. Development 125(16): 3167-77 (1998).
15. Kim HM, Qu T, Kriho V, Lacor P, Smalheiser N, Pappas GD, et al. Reelin function in neural stem cell biology. Proc Natl Acad Sci USA 99(6): 4020-5 (2002).
16. Richards M, Fong CY, Chan WK, Wong PC, Bongso A. Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells. Nat Biotechnol 20(9): 933-6 (2002).
17. Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, et al. G protein-mediated neuronal DNA fragmenta tion induced by familial Alzheimer's disease-associated mutants of APP. Science 272(5266): 1349-52 (1996).
18. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414(6864): 643-8 (2001).
19. Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, et al. Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. J Alzheimers Dis 1(4-5): 275-85 (1999).
20. Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U, et al. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131(9): 2173-81 (2004).
21. Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, et al. Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79(5): 755-65 (1994).
22. Zheng H, Jiang M, Trumbauer ME, Hopkins R, Sirinathsinghji DJ, Stevens KA, et al. Mice deficient for the amyloid precursor protein gene. Ann N Y Acad Sci 777(421-6 (1996).
23. Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, et al. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci 20(21): 7951-63 (2000).
24. Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, et al. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6(4): 327-31 (1999).
25. Pietrzik CU, Hoffmann J, Stober K, Chen CY, Bauer C, Otero DA, et al. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci USA 95(4): 1770-5 (1998).
26. Sabo SL, Ikin AF, Buxbaum JD, Greengard P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J Cell Biol 153(7): 1403-14 (2001).
27. Nishimura I, Takazaki R, Kuwako K, Enokido Y, Yoshikawa K. Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons. Exp Cell Res 286(2): 241-51 (2003).
28. Burton TR, Dibrov A, Kashour T, Amara FM. Anti-apoptotic wildtype Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway. Brain Res Mol Brain Res 108(1-2): 102-20 (2002).
29. Brannen CL, Sugaya K. In vitro differentiation of multipotent human neural progenitors in serum-free medium. Neuroreport 11(5): 1123-8 (2000).
30. LeBlanc A. Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis. J Neurosci 15(12): 7837-46 (1995).
31. LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J Biol Chem 274(33): 23426-36 (1999).
32. Sandhu JK, Sikorska M, Walker PR. Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells. J Neurosci Res 68(5): 604-14 (2002).
33. Deb-Rinker P, Ly D, Jezierski A, Sikorska M, Walker PR. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem 280(8): 6257-60 (2005).
34. Iacovitti L, Stull ND, Jin H. Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line. Brain Res 912(1): 99-104, (2001).
35. Sheridan KM, Maltese WA. Expression of Rab3A GTPase and other synaptic proteins is induced in differentiated NT2N neurons. J Mol Neurosci 10(2): 121-8 (1998).
36. Kleppner SR, Robinson KA, Trojanowski JQ, Lee VM. Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain. J Comp Neurol 357(4): 618-32 (1995).
37. Bani-Yaghoub M, Underhill TM, Naus CC. Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells. Dev Genet 24(1-2): 69-81 (1999).
38. Ko JH, Park WS, Earm YE. The protein kinase inhibitor, staurosporine, inhibits L-type Ca2+ current in rabbit atrial myocytes. Biochem Biophys Res Commun 329(2): 531-7 (2005).
39. D'Sa-Eipper C, Roth KA. Caspase regulation of neuronal progenitor cell apoptosis. Dev Neurosci 22(1-2): 116-24 (2000).
40. Zhang XD, Gillespie SK, Hersey P. Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol Cancer Ther 3(2): 187-97 (2004).
41. Schumacher A, Arnhold S, Addicks K, Doerfler W. Staurosporine is a potent activator of neuronal, glial, and "CNS stem cell-like" neurosphere differentiation in murine embryonic stem cells. Mol Cell Neurosci 23(4): 669-80, (2003).
42. Reuter H, Bouron A, Neuhaus R, Becker C, Reber BF. Inhibition of protein kinases in rat pheochromocytoma (PC12) cells promotes morphological differentiation and down-regulates ion channel expression. Proc Biol Sci 249(1325): 211-6, (1992).
43. Kronfeld I, Zsukerman A, Kazimirsky G, Brodie C. Staurosporine induces astrocytic phenotypes and differential expression of specific PKC isoforms in C6 glial cells. J Neurochem 65(4): 1505-14, 1995.
44. Le Brocque D, Henry A, Cappai R, Li QX, Tanner JE, Galatis D, et al. Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gammasecretase products. Biochemistry 37(42): 14958-65, (1998).
45. Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 25(9-10): 1439-51, (2000).
46. Gomes FC, Paulin D, Moura Neto V. Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation. Braz J Med Biol Res 32(5): 619-31, (1999).
47. Bantounas I, Phylactou LA, Uney JB. RNA interference and the use of small interfering RNA to study gene function in mammalian systems. J Mol Endocrinol 33(3): 545-57 (2004).
48. Sasaki Y, Seto M, Komatsu K, Omura S. Staurosporine, a protein kinase inhibitor, attenuates intracellular Ca(2+)-dependent contractions of strips of rabbit aorta. Eur J Pharmacol 202(3): 367-72 (1991).
49. Cho JY, Katz DR, Chain BM. Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. Br J Pharmacol 140(2): 269-76, (2003).
50. Mills J, Laurent Charest D, Lam F, Beyreuther K, Ida N, Pelech SL, et al. Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. J Neurosci 17(24): 9415-22, 1997.
51. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270(46): 27489-94 (1995).
52. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364(2): 229-33 (1995).
53. Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, et al. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci USA 98(13): 7605-10, (2001).
54. Hugon J, Esclaire F, Lesort M, Kisby G, Spencer P. Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions. Drug Metab Rev 31(3): 635-47 (1999).
55. Piccini A, Ciotti MT, Vitolo OV, Calissano P, Tabaton M, Galli C. Endogenous APP derivatives oppositely modulate apoptosis through an autocrine loop [In Process Citation]. Neuroreport 11(7): 1375-9 (2000).
56. Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci USA 91(15): 7104-8 (1994).
57. Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, et al. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401(6750): 290-3 (1999).
58. Hotchin NA, Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol 131(6 Pt 2): 1857-65 (1995).
59. Sabo SL, Lanier LM, Ikin AF, Khorkova O, Sahasrabudhe S, Greengard P, et al. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J Biol Chem 274(12): 7952-7 (1999).
60. Ohsawa I, Takamura C, Morimoto T, Ishiguro M, Kohsaka S. Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur J Neurosci 11(6): 1907-13 (1999).
61. Masumura M, Hata R, Nishimura I, Uetsuki T, Sawada T, Yoshikawa K. Caspase-3 activation and inflammatory responses in rat hippocampus inoculated with a recombinant adenovirus expressing the Alzheimer amyloid precursor protein. Brain Res Mol Brain Res 80(2): 219-27 (2000).
62. Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, et al. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 359(9303): 310-5 (2002).
63. Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, Walker L, et al. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. J Neurosci 22(2): 515-22 (2002).
64. Coulson EJ, Paliga K, Beyreuther K, Masters CL. What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 36(3): 175-84 (2000).
65. Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci USA 89(22): 10758-62 (1992).
66. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, et al. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18(6): 661-9 19970.
67. McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res 804(1): 45-51 (1998).
68. Rootwelt T, Dunn M, Yudkoff M, Itoh T, Almaas R, Pleasure D. Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors. J Neurochem 71(4): 1544-53 (1998).
69. Oppenheim RW. Cell death during development of the nervous system. Annu Rev Neurosci 14(453-501 (1991).
70. Lesort M, Terro F, Esclaire F, Hugon J. Neuronal APP accumulates in toxic membrane blebbings. J Neural Transm 104(4-5): 497-513 (1997).
71. Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 17(3): 278-82 (1985).
72. Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, et al. Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. FEBS Lett 547(1-3): 193-6 (2003).