Folate is absorbed across the colon of adults: Evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid

American Journal of Clinical Nutrition

Volumn 90, Issue 1, 2009, Pages 116-123

  Aufreiter, Susanne ^a,d   Gregory III, Jesse F ^f   Pfeiffer, Christine M ^g   Fazili, Zia ^g   Kim, Young In ^a,b,e   Marcon, Norman ^b,e   Kamalaporn, Patarapong ^e   Pencharz, Paul B ^a,c,d   O'Connor, Deborah L ^a,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f UNIVERSITY OF FLORIDA   (United States)

^g CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CARBON 13; FOLIC ACID; FOLINIC ACID; 5 METHYLTETRAHYDROHOMOFOLIC ACID; 5-METHYLTETRAHYDROHOMOFOLIC ACID; CARBON; DRUG DERIVATIVE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; CECUM; COLON ABSORPTION; COLONOSCOPY; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INFUSION; ISOTOPE LABELING; MALE; NORMAL HUMAN; SCREENING; TANDEM MASS SPECTROMETRY; COLON; GENETICS; GENOTYPE; INTESTINE ABSORPTION; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; CARBON ISOTOPES; CECUM; COLON; COLONOSCOPY; FEMALE; FOLIC ACID; FORMYLTETRAHYDROFOLATES; GENOTYPE; HUMANS; INTESTINAL ABSORPTION; LEUCOVORIN; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED;

EID: 67649848236     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.27345     Document Type: Article

References (60)

1. Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. 10th ed. . Washington, DC: National Academy Press, 1998.
2. De Wals P, Tairou F, Van Allen M, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 2007;357:135-142
3. Honein MA, Paulozzi L, Mathews T, Erickson D, Wong L-YC. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001;285:2981-2986 (Pubitemid 32550116)
4. American Medical Association (AMA). AMA report 6 of the Council on Science and Public Health (A-06): folic acid fortification of grain products. June 22, 2006.
5. Wilson RD, Johnson JA, Wyatt P, et al. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can 2007;29:1003-1011
6. Smith AD, Kim Y-I, Refsum H. Is folic acid good for everyone? Am J Clin Nutr 2008;87:517-533
7. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folate fortification. Am J Clin Nutr 2007;85:193-200. (Pubitemid 46067634)
8. Troen AM, Mitchell B, Sorensen B, et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136:189-194 (Pubitemid 43156507)
9. Yajnik CS, Deshpande SS, Jackson AA, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune maternal nutrition study. Diabetologia 2008;51:29-38.
10. Carter JY, Loolpapit MP, Lema OE, Tome JL, Nagelkerke NJ, Watkins WM. Reduction of the efficacy of antifolate antimalarial therapy by folic acid supplementation. Am J Trop Med Hyg 2005;73:166-170 (Pubitemid 41278766)
11. English M, Snow RW. Iron and folate supplementation and malaria risk. Lancet 2006;367:90-91 (Pubitemid 43077110)
12. Dervieux T, Furst D, Lein D, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis 2005;64:1180-1185 (Pubitemid 41113353)
13. Salim A, Tan E, Ilchyshin A, Berthe-Jones J. Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol 2006;154:1169-1174 (Pubitemid 43727401)
14. Kim YI. Folic acid supplementation and cancer risk: point. Cancer Epidemiol Biomarkers Prev 2008;17:2220-2225
15. Cole BF, Baron J, Sandler R, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007;297:2351-2359 (Pubitemid 46883748)
16. Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007;16:1325-1329 (Pubitemid 47076861)
17. Girdwood RH. The intestinal content in pernicious anemia of factors for the growth of Streptococcus faecalis and Lactobacillus leichmannii. Blood 1950;5:1009-1016
18. Denko CW, Grundy WE, Porter JW, Berryman GH, Friedemann TE, Youmannis JB. The excretion of B-complex vitamins in the urine and feces of seven normal adults. Arch Biochem 1946;10:33-40.
19. Kim TH, Yang J, Darling PB, O'Connor DL. A large pool of available folate exists in the large intestine of human infants and piglets. J Nutr 2004;134:1389-1394 (Pubitemid 38720711)
20. Krause LJ, Forsberg CW, O'Connor DL. Feeding human milk to rats increases Bifidobacterium in the cecum and colon which correlates with enhanced folate status. J Nutr 1996;126:1505-1511
21. Rong N, Selhub J, Goldin BR, Rosenberg IH. Bacterially synthesized folate in rat large intestine is incorporated into host tissue using folyl polyglutamates. J Nutr 1991;121:1955-1959
22. Asrar FM, O'Connor DL. Bacterially synthesized folate and supplemental folic acid are absorbed across the large intestine of piglets. J Nutr Biochem 2005;16:587-593
23. Keagy PM, Oace SM. Folic acid utilization from high fiber diets in rats. J Nutr 1984;114:1252-1259
24. Thoma C, Green TJ, Ferguson L. Citrus pectin and oligofructose improve folate status and lower serum total homocysteine in rats. Int J Vitam Nutr Res 2003;73:403-409 (Pubitemid 38009806)
25. Dudeja PK, Torania SA, Said HM. Evidence for the existence of a carrier-mediated folate uptake mechanism in human colonic luminal membranes. Am J Physiol 1997;272:G1408-15.
26. Dudeja PK, Kode A, Alnounou M, et al. Mechanism of folate transport across the human colonic basolateral membrane. Am J Physiol Gastrointest Liver Physiol 2001;281:G54-60. (Pubitemid 32916495)
27. Zimmerman J. Folic acid transport in organ-cultured mucosa of human intestine:evidence for distinct carriers. Gastroenterology 1990;99:964-972 (Pubitemid 20338452)
28. Molloy AM, Scott JM. Microbiological assay for serum, plasma and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 1997;281:434-452
29. Livak KJ. Allelic discrimination using fluorogenic probes and 5′ nuclease assay. Genet Anal 1999;14:143-149
30. Hyun TH, Tamura T. Tri-enzyme extraction in combination with microbiologic assay in food folate analysis: an updated review. Exp Biol Med (Maywood) 2005;230:444-454 (Pubitemid 40923421)
31. Pfeiffer CM, Fazili Z, McCoy L, Zhang M, Gunter EW. Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Clin Chem 2004;50:423-432 (Pubitemid 38156385)
32. Pietrzik K, Hages M, Remer T. Methodological aspects in vitamin bioavailability testing. J Micronutrient Anal 1990;7:207-222
33. Snyder WS, ed. Report of the Task Group on Reference Man. New York, NY: Pergamon Press, 1975. (ICRP publication no 23.)
34. Feldschuh J, Enson Y. Prediction of the normal blood volume. Relation of blood volume to body habitus. Circulation 1977;56:605-612
35. Gibson RS. Principles of nutritional assessment. 2nd ed. New York, NY: Oxford University Press, 2005:606-640
36. Clarke R, Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33:34-41. (Pubitemid 38111446)
37. Wright AJ, Finglas P, Dainty J, et al. Single oral doses of 13C forms of pteroylglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies. Br J Nutr 2003;90:363-371 (Pubitemid 36992538)
38. Wright AJ, Finglas P, Dainty J, et al. Differential kinetic behaviour and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of the primary site of PteGlu metabolism in humans. J Nutr 2005;135:619-623 (Pubitemid 40365228)
39. Davis SS, Hardy JG, Fara JW. Transit of pharmaceutical dosage forms the the small intestine. Gut 1986;27:886-892
40. Christensen FN, Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson CG. The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulations. J Pharm Pharmacol 1985;37:91-95
41. Parker G, Wilson CG, Hardy JG. The effect of capsule size and denisty on transit through the proximal colon. J Pharm Pharmacol 1988;40:376-377 (Pubitemid 18141430)
42. Hardy JG, Wilson CG, Wood E. Drug delivery to the proximal colon. J Pharm Pharmacol 1985;37:874-877
43. Houghton LA, Green TJ, Donovan UM, Gibson RS, Stephen AM, O'Connor DL. Association between dietary fiber intake and the folate status of a group of female adolescents. Am J Clin Nutr 1997;66:1414-1421
44. Wolever TMS, Assiff L, Basu T, et al. Miglitol, an α-glucosidase inhibitor, prevents the metformin-induced fall in serum folate and vitamin B12 in subjects with type 2 diabetes. Nutr Res 2000;20:1447-1456 (Pubitemid 30761225)
45. Shoveller AK, Brunton JA, Pencharz PB, Ball RO. The methionine requirement is lower in neonatal piglets fed parenterally than in those fed enterally. J Nutr 2003;133:1390-1397 (Pubitemid 36548711)
46. Bertolo RFP, Chen CZL, Law G, Pencharz PB, Ball RO. Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically. J Nutr 1998;128:1752-1759 (Pubitemid 28452862)
47. Elango R, Pencharz PB, Ball RO. The branched-chain amino acid requirement of parenterally fed neonatal piglets is less than the enteral requirement. J Nutr 2002;132:3123-3129
48. Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 2007;51:267-292 (Pubitemid 47083662)
49. Sanjoaquin MA, Allen M, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer 2005;113:825-828 (Pubitemid 40101266)
50. Zhao R, Matherly LH, Goldman ID. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 2009;11: 10.1017/S1462399409000969.
51. Matherly LH, Hou Z, Deng Y. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. Cancer Metastasis Rev 2007;26:111-128 (Pubitemid 46452186)
52. Qiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate maladsorption. Cell 2006;127:917-928 (Pubitemid 44792250)
53. Lewis SJ, Heaton KW. Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut 1997;41:245-251
54. Mai V, Greenwald B, Morris JJ, Raufman J-P, Stine O. Effect of bowel preparation and colonoscopy on post-procedure intestinal microbiota composition. Gut 2006;55:1822-1823 (Pubitemid 44893588)
55. Russell RM. Factors in aging that affect the bioavailability of nutrients. J Nutr 2001;131:1359S-61S.
56. Mahabir S, Ettinger S, Johnson LJ, et al. Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study. Eur J Clin Nutr 2008;62:644-650 (Pubitemid 351663404)
57. Casanueva E, Drijanski A, Fernández-Gaxiola AC, Meza C, Pfeffer F. Folate deficiency is associated with obesity and anemia in Mexican urban women. Nutr Res 2000;20:1389-1394 (Pubitemid 30761220)
58. Ashokkumar B, Mohammed ZM, Vaziri ND, Said HM. Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am J Clin Nutr 2007;86:159-166 (Pubitemid 47041606)
59. Olthof MR, Bots ML, Katan MB, Verhoef P. Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. PLoS Clin Trials 2006;1:e10.
60. Pintó X, Vilaseca MA, Balcells S, et al. A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations. Int J Med Sci 2005;2:58-63. (Pubitemid 40944953)