Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 45, Issue 23, 2002, Pages 5030-5036

  Novellino, Ettore ^a   Abignente, Enrico ^a   Cosimelli, Barbara ^a   Greco, Giovanni ^a   Iadanza, Manuela ^a   Laneri, Sonia ^a   Lavecchia, Antonio ^a   Rimoli, Maria Grazia ^a   Da Settimo, Federico ^b   Primofiore, Giampaolo ^b   Tuscano, Daniela ^b   Trincavelli, Letizia ^b   Martini, Claudia ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(7 METHYL 2 PHENYLIMIDAZO[1,2 ALPHA][1,3,5]TRIAZIN 4 YL)AMINE; ADENOSINE RECEPTOR BLOCKING AGENT; N ACYL (7 ETHYL 2 PHENYLIMIDAZO[1,2 ALPHA][1,3,5]TRIAZIN 4 YL)AMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN MEMBRANE; CATTLE; DERIVATIZATION; DRUG DESIGN; DRUG SCREENING; ENHANCER REGION; LIPOPHILICITY; NONHUMAN; RECEPTOR AFFINITY; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; CATTLE; CEREBRAL CORTEX; CORPUS STRIATUM; IMIDAZOLES; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 0037038327     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020911e     Document Type: Article

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