5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5676-5684

  Da Settimo, Federico ^a   Primofiore, Giampaolo ^a   Taliani, Sabrina ^a   Marini, Anna Maria ^a   La Motta, Concettina ^a   Simorini, Francesca ^a   Salerno, Silvia ^a   Sergianni, Valentina ^a   Tuccinardi, Tiziano ^a   Martinelli, Adriano ^a   Cosimelli, Barbara ^b   Greco, Giovanni ^b   Novellino, Ettore ^b   Ciampi, Osele ^a   Trincavelli, Maria Letizia ^a   Martini, Claudia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL[1,2,3]TRIAZOLO[1,2 A][1,2,4]BENZOTRIAZIN 1,5(6H) DIONE; 5 AMINO 2 PHENYL[1,2,3]TRIAZOLO[1,2 A][1,2,4]BENZOTRIAZIN 1 ONE; 9 CHLORO 5 (4 METHOXYBENZOYL)AMINO 2 PHENYL[1,2,3]TRIAZOLO[1,2 A][1,2,4]BENZOTRIAZIN 1 ONE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; AMIDE; AMIDINE; AMINOPHENYLTRIAZOLOBENZOTRIAZINONE; LIGAND; PHENYLTRIAZOLOBENZOTRIAZINDIONE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MELTING POINT; MOLECULAR DOCKING; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; SIMULATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TRIAZOLES;

EID: 36148939460     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0708376     Document Type: Article

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