Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer

Journal of Clinical Oncology

Volumn 25, Issue 4, 2007, Pages 411-417

  Saeki, Toshiaki ^a   Nomizu, Tadashi ^a   Toi, Masakazu ^a   Ito, Yoshinori ^a   Noguchi, Shinzaburo ^a   Kobayashi, Tadashi ^a   Asaga, Taro ^a   Minami, Hironobu ^a   Yamamoto, Naohito ^a   Aogi, Kenjiro ^a   Ikeda, Tadashi ^a   Ohashi, Yasuo ^a   Sato, Wakao ^a   Tsuruo, Takashi ^a  

^a NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 [3 (4 DIPHENYLACETYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY]QUINOLINE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DOFEQUIDAR FUMARATE; DOXORUBICIN; FLUOROURACIL; UNCLASSIFIED DRUG; CAF PROTOCOL; DOFEQUIDAR; QUINOLINE DERIVATIVE;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; FEMALE; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MULTIDRUG RESISTANCE; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; BREAST TUMOR; DRUG RESISTANCE; MIDDLE AGED; PATHOLOGY; TREATMENT OUTCOME;

ADULT; AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CYCLOPHOSPHAMIDE; DOUBLE-BLIND METHOD; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; HUMANS; MIDDLE AGED; QUINOLINES; TREATMENT OUTCOME;

EID: 33846999327     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2006.08.1646     Document Type: Article

References (34)

1. Gottesman MM, Fojo T, Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2:48-58, 2002
2. Loe DW, Deeley RG, Cole SPC: Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A:945-957, 1996
3. Leonard GD, Fojo T, Bates SE: The role of ABC transporters in clinical practice. Oncologist 8:411-424, 2003
4. Michalak K, Hendrich AB, Wesolowska O, et al: Compounds that modulate multidrug resistance in cancer cells. Cell Biol Mol Lett 6:362-368, 2001
5. Thomas H, Coley HM: Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10:159-165, 2003
6. Ambudkar SV, Dey S, Hrycyna CA, et al: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398, 1999
7. Krishna R, Mayer LD: Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 11:265-283, 2000
8. Mechetner E, Kyshtoobayeva A, Zonis S, et al: Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin. Clin Cancer Res 4:389-398, 1998
9. Esteva FJ, Valero V, Pusztai L, et al: Chemotherapy of metastatic breast cancer: What to expect in 2001 and beyond. Oncologist 6:133-146, 2001
10. Hortobagyi GN: Treatment of breast cancer. N Engl J Med 339:974-984, 1998
11. National Comprehensive Cancer Network: Clinical Practice Guidelines in Oncology, version 1. Jenkintown, PA, National Comprehensive Cancer Network, 2005
12. Burger H, Foekens JA, Look MP, et al: RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: Correlation with chemotherapeutic response. Clin Cancer Res 9:827-836, 2003
13. Kroger N, Achterrath W, Hegewisch-Becker S, et al: Current options in treatment of anthracycline-resistant breast cancer. Cancer Treat Rev 25:279-291, 1999
14. Tsuruo T, Iida H, Tsukagoshi S, et al: Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41:1967-1972, 1981
15. Tsuruo T: Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies, in Ozols R (ed): Drug Resistance in Cancer Therapy. Norwell, MA, Kluwer Academic Publishers, 1989, pp 73-95
16. Tsuruo T, Naito M, Tomida A, et al: Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal. Cancer Sci 94:15-21, 2003
17. Sato W, Fukazawa N, Nakanishi O, et al: Reversal of multidrug resistance by a novel quinoline derivative, MS-209. Cancer Chemother Pharmacol 35:271-277, 1995
18. Nakanishi O, Baba M, Saito A, et al: Potentiation of the antitumor activity by a novel quinoline compound, MS-209, in multidrug-resistant solid tumor cell lines. Oncol Res 9:61-69, 1997
19. Narasaki F, Oka M, Fukuda M, et al: A novel quinoline derivative, MS-209, overcomes drug resistance of human lung cancer cells expressing the multidrug resistance-associated protein (MRP) gene. Cancer Chemother Pharmacol 40:425-432, 1997
20. Margolese RG, Hortobagyi GN, Bucholz TA: Neoplasms of the breast, in Kufe DW, Pollock RE, Weichselbaum RR, et al (eds): Cancer Medicine, (ed 6). Hamilton, Canada, BC Decker Inc, 2003
21. Wishart GC, Bissett D, Paul J, et al: Quinidine as a resistance modulator of epirubicin in advanced breast cancer: Mature results of a placebo-controlled randomized trial. J Clin Oncol 12:1771-1777, 1994
22. Belpomme D, Gauthier S, Pujade-Lauraine E, et al: Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma. Ann Oncol 11:1471-1476, 2000
23. Cocker HA, Tiffin N, Pritchard-Jones K, et al: In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line. Clin Cancer Res 7:3193-3198, 2001
24. List AF, Spier C, Greer J, et al: Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J Clin Oncol 11:1652-1660, 1993
25. Nooter K, Brutel de la Riviere G, Look MP, et al: The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer. Br J Cancer 76:486-493, 1997
26. Rudas M, Filipits M, Taucher S, et al: Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy. Breast Cancer Res Treat 81:149-157, 2003
27. Filipits M, Pohl G, Rudas M, et al: Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: The Austrian Breast and Colorectal Cancer Study Group. J Clin Oncol 23:1161-1168, 2005
28. Bradshaw DM, Arceci RJ: Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol 16:3674-3690, 1998
29. Ferry DR, Traunecker H, Kerr DJ: Clinical trials of P-glycoprotein reversal in solid tumours. Eur J Cancer 32A:1070-1081, 1996
30. Fisher GA, Sikic BI: Clinical studies with modulators of multidrug resistance. Hematol Oncol Clin North Am 9:363-382, 1995
31. Fisher GA, Lum BL, Hausdorff J, et al: Pharmacological considerations in the modulation of multidrug resistance. Eur J Cancer 32A:1082-1088, 1996
32. Kerr DJ, Graham J, Cummings J, et al: The effect of verapamil on the pharmacokinetics of adriamycin. Cancer Chemother Pharmacol 18:239-242, 1986
33. Baer MR, George SL, Dodge RK, et al: Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 100:1224-1232, 2002
34. Friedenberg WR, Rue M, Blood EA, et al: Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): A trial of the Eastern Cooperative Oncology Group. Cancer 106:830-838, 2006