Crucial role of interleukin-4 in the survival of colon cancer stem cells

Cancer Research

Volumn 68, Issue 11, 2008, Pages 4022-4025

  Francipane, Maria Giovanna ^a   Alea, Mileidys Perez ^a   Lombardo, Ylenia ^a   Todaro, Matilde ^a   Medema, J P ^a,b   Stassi, Giorgio ^a  

^a Cellular and Molecular Pathophysiology Laboratory   (Italy)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CELL SURFACE MARKER; INTERLEUKIN 4; TUMOR NECROSIS FACTOR;

ANTIGEN EXPRESSION; APOPTOSIS; AUTOCRINE EFFECT; CANCER STEM CELL; CELL FRACTIONATION; CELL RENEWAL; CELL SURVIVAL; COLON CARCINOMA; COLON TUMOR; CYTOTOXICITY; HUMAN; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REVIEW; STIMULUS; THERAPY EFFECT; PATHOLOGY; PHYSIOLOGY;

CELL SURVIVAL; COLONIC NEOPLASMS; HUMANS; INTERLEUKIN-4; NEOPLASTIC STEM CELLS;

EID: 49249106900     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6874     Document Type: Review

References (21)

1. Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-8.
2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
3. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003;100:3983-8.
4. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004;432:396-401.
5. Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on Cancer Stem Cells. Cancer Res 2006;66:9339-44.
6. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-7.
7. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10.
8. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445:111-5.
9. Todaro M, Perez Alea M, Di Stefano AB, et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007;1:389-402.
10. Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007;104:10158-63.
11. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50.
12. Todaro M, Perez Alea M, Scopelliti A, Medema JP, Stassi G. IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle 2008;7.
13. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-84.
14. Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313:1960-4.
15. Conticello C, Pedini F, Zeuner A, et al. IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins. J Immunol 2004;172:5467-77.
16. Todaro M, Zerilli M, Ricci-Vitiani L, et al. Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells. Cancer Res 2006;66:1491-9.
17. Prokopchuk O, Liu Y, Henne-Bruns D, Kornmann M. Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. Br J Cancer 2005;92:921-8.
18. Macdonald DC, Leir SH, Brooks C, Sanders E, Lackie P, Rosenberg W. CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines. Eur J Gastroenterol Hepatol 2003;15:1101-10.
19. Zorzos HS, Lazaris AC, Korkolopoulou PA, et al. Multidrug resistance proteins and topoisomerase IIα expression in colon cancer: association with metastatic potential. Pathology 2003;35:315-8.
20. Borish LC, Nelson HS, Lanz MJ, et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am J Respir Crit Care Med 1999;160:1816-23.
21. Aversa G, Punnonen J, Cocks BG, et al. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J Exp Med 1993;178:2213-8.