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Volumn 401, Issue 3, 2010, Pages 376-381

TGFβ and EGF synergistically induce a more invasive phenotype of epithelial ovarian cancer cells

Author keywords

EGF; Epithelial ovarian cancer; Epithelial mesenchymal transition; Slug; Snail; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

EID: 77958153789     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.09.059     Document Type: Article
Times cited : (47)

References (38)
  • 2
    • 55949089955 scopus 로고    scopus 로고
    • New insights into the pathogenesis of serous ovarian cancer and its clinical impact
    • Levanon K., Crum C., Drapkin R. New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J. Clin. Oncol. 2008, 26:5284-5293.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5284-5293
    • Levanon, K.1    Crum, C.2    Drapkin, R.3
  • 3
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: biology, endocrinology, and pathology
    • Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 2001, 22:255-288.
    • (2001) Endocr. Rev. , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3    Kang, S.K.4    Leung, P.C.5
  • 4
    • 60749137451 scopus 로고    scopus 로고
    • Beyond chemotherapy: targeted therapies in ovarian cancer
    • Yap T.A., Carden C.P., Kaye S.B. Beyond chemotherapy: targeted therapies in ovarian cancer. Nat. Rev. Cancer 2009, 9:167-181.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 167-181
    • Yap, T.A.1    Carden, C.P.2    Kaye, S.B.3
  • 5
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • Cannistra S.A. Cancer of the ovary. N. Engl. J. Med. 2004, 351:2519-2529.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2519-2529
    • Cannistra, S.A.1
  • 6
    • 35848946387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    • Ahmed N., Thompson E.W., Quinn M.A. Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm. J. Cell. Physiol. 2007, 213:581-588.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 581-588
    • Ahmed, N.1    Thompson, E.W.2    Quinn, M.A.3
  • 8
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 7:131-142.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 9
    • 16844368863 scopus 로고    scopus 로고
    • Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
    • Elloul S., Elstrand M.B., Nesland J.M., Trope C.G., Kvalheim G., Goldberg I., Reich R., Davidson B. Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 2005, 103:1631-1643.
    • (2005) Cancer , vol.103 , pp. 1631-1643
    • Elloul, S.1    Elstrand, M.B.2    Nesland, J.M.3    Trope, C.G.4    Kvalheim, G.5    Goldberg, I.6    Reich, R.7    Davidson, B.8
  • 10
    • 15544362735 scopus 로고    scopus 로고
    • Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level
    • Kurrey N.K., Amit K., Bapat S.A. Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol. Oncol. 2005, 97:155-165.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 155-165
    • Kurrey, N.K.1    Amit, K.2    Bapat, S.A.3
  • 11
    • 38549154187 scopus 로고    scopus 로고
    • The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients
    • Blechschmidt K., Sassen S., Schmalfeldt B., Schuster T., Hofler H., Becker K.F. The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. Br. J. Cancer 2008, 98:489-495.
    • (2008) Br. J. Cancer , vol.98 , pp. 489-495
    • Blechschmidt, K.1    Sassen, S.2    Schmalfeldt, B.3    Schuster, T.4    Hofler, H.5    Becker, K.F.6
  • 13
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008, 134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 14
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-beta superfamily
    • Attisano L., Wrana J.L. Signal transduction by the TGF-beta superfamily. Science 2002, 296:1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 15
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 16
    • 0029117933 scopus 로고
    • Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms
    • Henriksen R., Gobl A., Wilander E., Oberg K., Miyazono K., Funa K. Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms. Lab. Invest. 1995, 73:213-220.
    • (1995) Lab. Invest. , vol.73 , pp. 213-220
    • Henriksen, R.1    Gobl, A.2    Wilander, E.3    Oberg, K.4    Miyazono, K.5    Funa, K.6
  • 17
    • 0034987333 scopus 로고    scopus 로고
    • Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma
    • Higashi T., Sasagawa T., Inoue M., Oka R., Shuangying L., Saijoh K. Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma. Jpn. J. Cancer Res. 2001, 92:506-515.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 506-515
    • Higashi, T.1    Sasagawa, T.2    Inoue, M.3    Oka, R.4    Shuangying, L.5    Saijoh, K.6
  • 18
    • 0034934719 scopus 로고    scopus 로고
    • Increased levels of interleukin-10 and transforming growth factor-beta in the plasma and ascitic fluid of patients with advanced ovarian cancer
    • Santin A.D., Bellone S., Ravaggi A., Roman J., Smith C.V., Pecorelli S., Cannon M.J., Parham G.P. Increased levels of interleukin-10 and transforming growth factor-beta in the plasma and ascitic fluid of patients with advanced ovarian cancer. BJOG 2001, 108:804-808.
    • (2001) BJOG , vol.108 , pp. 804-808
    • Santin, A.D.1    Bellone, S.2    Ravaggi, A.3    Roman, J.4    Smith, C.V.5    Pecorelli, S.6    Cannon, M.J.7    Parham, G.P.8
  • 20
    • 0030905266 scopus 로고    scopus 로고
    • Expression of epidermal growth factor-related proteins and epidermal growth factor receptor in common epithelial ovarian tumors
    • Niikura H., Sasano H., Sato S., Yajima A. Expression of epidermal growth factor-related proteins and epidermal growth factor receptor in common epithelial ovarian tumors. Int. J. Gynecol. Pathol. 1997, 16:60-68.
    • (1997) Int. J. Gynecol. Pathol. , vol.16 , pp. 60-68
    • Niikura, H.1    Sasano, H.2    Sato, S.3    Yajima, A.4
  • 21
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J., Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 2003, 21:2787-2799.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 22
    • 63049100044 scopus 로고    scopus 로고
    • Functional selectivity of EGF family peptide growth factors: implications for cancer
    • Wilson K.J., Gilmore J.L., Foley J., Lemmon M.A., Riese D.J. Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol. Ther. 2009, 122:1-8.
    • (2009) Pharmacol. Ther. , vol.122 , pp. 1-8
    • Wilson, K.J.1    Gilmore, J.L.2    Foley, J.3    Lemmon, M.A.4    Riese, D.J.5
  • 23
    • 4143076078 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor
    • El-Rayes B.F., LoRusso P.M. Targeting the epidermal growth factor receptor. Br. J. Cancer 2004, 91:418-424.
    • (2004) Br. J. Cancer , vol.91 , pp. 418-424
    • El-Rayes, B.F.1    LoRusso, P.M.2
  • 24
    • 35648971073 scopus 로고    scopus 로고
    • Ras proteins: paradigms for compartmentalised and isoform-specific signalling
    • Omerovic J., Laude A.J., Prior I.A. Ras proteins: paradigms for compartmentalised and isoform-specific signalling. Cell. Mol. Life Sci. 2007, 64:2575-2589.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 2575-2589
    • Omerovic, J.1    Laude, A.J.2    Prior, I.A.3
  • 25
    • 47949103896 scopus 로고    scopus 로고
    • Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition
    • Do T.V., Kubba L.A., Du H., Sturgis C.D., Woodruff T.K. Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. Mol. Cancer Res. 2008, 6:695-705.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 695-705
    • Do, T.V.1    Kubba, L.A.2    Du, H.3    Sturgis, C.D.4    Woodruff, T.K.5
  • 26
    • 34247359877 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
    • Lim R., Ahmed N., Borregaard N., Riley C., Wafai R., Thompson E.W., Quinn M.A., Rice G.E. Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition. Int. J. Cancer 2007, 120:2426-2434.
    • (2007) Int. J. Cancer , vol.120 , pp. 2426-2434
    • Lim, R.1    Ahmed, N.2    Borregaard, N.3    Riley, C.4    Wafai, R.5    Thompson, E.W.6    Quinn, M.A.7    Rice, G.E.8
  • 27
    • 58149218143 scopus 로고    scopus 로고
    • Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    • Colomiere M., Ward A.C., Riley C., Trenerry M.K., Cameron-Smith D., Findlay J., Ackland L., Ahmed N. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br. J. Cancer 2009, 100:134-144.
    • (2009) Br. J. Cancer , vol.100 , pp. 134-144
    • Colomiere, M.1    Ward, A.C.2    Riley, C.3    Trenerry, M.K.4    Cameron-Smith, D.5    Findlay, J.6    Ackland, L.7    Ahmed, N.8
  • 28
    • 59649086123 scopus 로고    scopus 로고
    • Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin
    • Colomiere M., Findlay J., Ackland L., Ahmed N. Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin. Int. J. Biochem. Cell Biol. 2009, 41:1034-1045.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 1034-1045
    • Colomiere, M.1    Findlay, J.2    Ackland, L.3    Ahmed, N.4
  • 29
    • 0035900696 scopus 로고    scopus 로고
    • Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling
    • Fu Y., Sies H., Lei X.G. Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J. Biol. Chem. 2001, 276:43004-43009.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43004-43009
    • Fu, Y.1    Sies, H.2    Lei, X.G.3
  • 30
    • 67749104045 scopus 로고    scopus 로고
    • Differential regulation of transforming growth factor beta signaling pathways by notch in human endothelial cells
    • Fu Y., Chang A., Chang L., Niessen K., Eapen S., Setiadi A., Karsan A. Differential regulation of transforming growth factor beta signaling pathways by notch in human endothelial cells. J. Biol. Chem. 2009, 284:19452-19462.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19452-19462
    • Fu, Y.1    Chang, A.2    Chang, L.3    Niessen, K.4    Eapen, S.5    Setiadi, A.6    Karsan, A.7
  • 31
  • 32
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • Peinado H., Olmeda D., Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat. Rev. Cancer 2007, 7:415-428.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 33
    • 51249090123 scopus 로고    scopus 로고
    • The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells
    • Ramos J.W. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int. J. Biochem. Cell Biol. 2008, 40:2707-2719.
    • (2008) Int. J. Biochem. Cell Biol. , vol.40 , pp. 2707-2719
    • Ramos, J.W.1
  • 34
    • 0034575168 scopus 로고    scopus 로고
    • TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103
    • Lin S.W., Lee M.T., Ke F.C., Lee P.P., Huang C.J., Ip M.M., Chen L., Hwang J.J. TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103. Clin. Exp. Metastasis 2000, 18:493-499.
    • (2000) Clin. Exp. Metastasis , vol.18 , pp. 493-499
    • Lin, S.W.1    Lee, M.T.2    Ke, F.C.3    Lee, P.P.4    Huang, C.J.5    Ip, M.M.6    Chen, L.7    Hwang, J.J.8
  • 35
    • 0037509851 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer
    • Itoh Y., Nagase H. Matrix metalloproteinases in cancer. Essays Biochem. 2002, 38:21-36.
    • (2002) Essays Biochem. , vol.38 , pp. 21-36
    • Itoh, Y.1    Nagase, H.2
  • 36
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2:161-174.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 37
    • 51749099175 scopus 로고    scopus 로고
    • The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer
    • Palayekar M.J., Herzog T.J. The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer. Int. J. Gynecol. Cancer 2008, 18:879-890.
    • (2008) Int. J. Gynecol. Cancer , vol.18 , pp. 879-890
    • Palayekar, M.J.1    Herzog, T.J.2
  • 38
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • Yingling J.M., Blanchard K.L., Sawyer J.S. Development of TGF-beta signalling inhibitors for cancer therapy. Nat. Rev. Drug Discov. 2004, 3:1011-1022.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.