Osteoarthritis year 2011 in review: Biology

Osteoarthritis and Cartilage

Volumn 20, Issue 3, 2012, Pages 192-196

  Lotz, M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Angiogenesis; Autophagy; Lubricin; Mitochondria

Indexed keywords

ANTIRHEUMATIC AGENT; HYALURONIC ACID; LUBRICATING AGENT; LUBRICIN; PROTEIN; RECOMBINANT HUMAN LUBRICIN; RECOMBINANT LUBRICIN; RECOMBINANT PROTEIN; SYNOVIAL FLUID LUBRICIN; SYNOVIOCYTE LUBRICIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; AUTOPHAGY; CELL ADHESION; CELL PROLIFERATION; CHONDROPROTECTION; DRUG POTENTIATION; HUMAN; LUBRICATION; MITOCHONDRION; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SYNOVIOCYTE;

AUTOPHAGY; GLYCOPROTEINS; HUMANS; HYALURONIC ACID; JOINTS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEOVASCULARIZATION, PATHOLOGIC; OSTEOARTHRITIS;

EID: 84857142257     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.11.015     Document Type: Review

References (52)

1. Szekanecz Z., Besenyei T., Paragh G., Koch A.E. New insights in synovial angiogenesis. Joint Bone Spine 2010, 77:13-19.
2. Marrelli A., Cipriani P., Liakouli V., Carubbi F., Perricone C., Perricone R., et al. Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation?. Autoimmun Rev 2011, 10:595-598.
3. Thairu N., Kiriakidis S., Dawson P., Paleolog E. Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience. Angiogenesis 2011, 14:223-234.
4. Shukunami C., Hiraki Y. Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue. Curr Pharm Des 2007, 13:2101-2112.
5. Feng Y., Wu Y.P., Zhu X.D., Zhang Y.H., Ma Q.J. Endostatin promotes the anabolic program of rabbit chondrocyte. Cell Res 2005, 15:201-206.
6. Walsh D.A., McWilliams D.F., Turley M.J., Dixon M.R., Franses R.E., Mapp P.I., et al. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology 2010, 49:1852-1861.
7. Ashraf S., Wibberley H., Mapp P.I., Hill R., Wilson D., Walsh D.A. Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis. Ann Rheum Dis 2011, 70:523-529.
8. Hasegawa A., Otsuki S., Pauli C., Miyaki S., Patil S., Steklov N., et al. Anterior cruciate ligament changes in human joint in aging and osteoarthritis. Arthritis Rheum 2011.
9. Suri S., Gill S.E., Massena de Camin S., Wilson D., McWilliams D.F., Walsh D.A. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheum Dis 2007, 66:1423-1428.
10. Wei T., Kulkarni N.H., Zeng Q.Q., Helvering L.M., Lin X., Lawrence F., et al. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis Cartilage 2010, 18:992-1000.
11. Pesesse L., Sanchez C., Henrotin Y. Osteochondral plate angiogenesis: a new treatment target in osteoarthritis. Joint Bone Spine 2011, 78:144-149.
12. Saito T., Kawaguchi H. HIF-2alpha as a possible therapeutic target of osteoarthritis. Osteoarthritis Cartilage 2010, 18:1552-1556.
13. Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
14. Ashraf S., Mapp P.I., Walsh D.A. Contributions of angiogenesis to inflammation, joint damage and pain in a rat model of osteoarthritis. Arthritis Rheum 2011.
15. Hsieh J.L., Shen P.C., Shiau A.L., Jou I.M., Lee C.H., Wang C.R., et al. Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J Orthop Res 2010, 28:1300-1306.
16. Matsumoto T., Cooper G.M., Gharaibeh B., Meszaros L.B., Li G., Usas A., et al. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Arthritis Rheum 2009, 60:1390-1405.
17. Klinger P., Surmann-Schmitt C., Brem M., Swoboda B., Distler J.H., Carl H.D., et al. Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue. Arthritis Rheum 2011, 63:2721-2731.
18. Carmeliet P., Jain R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473:298-307.
19. Lotz M.K., Carames B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol 2011, 7:579-587.
20. Loeser R.F. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage 2009, 17:971-979.
21. Campisi J., Andersen J.K., Kapahi P., Melov S. Cellular senescence: A link between cancer and age-related degenerative disease?. Semin Cancer Biol 2011.
22. Kirkwood T.B. Understanding the odd science of aging. Cell 2005, 120:437-447.
23. Sahin E., Colla S., Liesa M., Moslehi J., Muller F.L., Guo M., et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470:359-365.
24. Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
25. Tschopp J. Mitochondria: sovereign of inflammation?. Eur J Immunol 2011, 41:1196-1202.
26. Kim J., Xu M., Xo R., Mates A., Wilson G.L., Pearsall A.W., et al. Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes. Osteoarthritis Cartilage 2010, 18:424-432.
27. Rego-Perez I., Fernandez-Moreno M., Deberg M., Pertega S., Fernandez-Lopez C., Oreiro N., et al. Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis. Ann Rheum Dis 2011, 70:646-652.
28. Scott J.L., Gabrielides C., Davidson R.K., Swingler T.E., Clark I.M., Wallis G.A., et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis 2010, 69:1502-1510.
29. Green D.R., Galluzzi L., Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011, 333:1109-1112.
30. Mizushima N. Physiological functions of autophagy. Curr Top Microbiol Immunol 2009, 335:71-84.
31. Carames B., Taniguchi N., Otsuki S., Blanco F.J., Lotz M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 2010, 62:791-801.
32. Terkeltaub R., Yang B., Lotz M., Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Arthritis Rheum 2011, 63:1928-1937.
33. Nakagawa S., Arai Y., Mazda O., Kishida T., Takahashi K.A., Sakao K., et al. N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis. J Orthop Res 2010, 28:156-163.
34. Stanfel M.N., Shamieh L.S., Kaeberlein M., Kennedy B.K. The TOR pathway comes of age. Biochim Biophys Acta 2009, 1790:1067-1074.
35. Harrison D.E., Strong R., Sharp Z.D., Nelson J.F., Astle C.M., Flurkey K., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
36. Miller R.A., Harrison D.E., Astle C.M., Baur J.A., Boyd A.R., de Cabo R., et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011, 66:191-201.
37. Carames B., Taniguchi N., Seino D., Blanco F.J., D'Lima D., Lotz M. Mechanical injury suppresses autophagy regulators and its pharmacological activation results in chondroprotection. Arthritis Rheum 2011.
38. Carames B., Hasegawa A., Taniguchi N., Miyaki S., Blanco F.J., Lotz M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis 2011.
39. Hui A.Y., McCarty W.J., Masuda K., Firestein G.S., Sah R.L. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med 2011.
40. Greene G.W., Banquy X., Lee D.W., Lowrey D.D., Yu J., Israelachvili J.N. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A 2011, 108:5255-5259.
41. Marcelino J., Carpten J.D., Suwairi W.M., Gutierrez O.M., Schwartz S., Robbins C., et al. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat Genet 1999, 23:319-322.
42. Rhee D.K., Marcelino J., Baker M., Gong Y., Smits P., Lefebvre V., et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest 2005, 115:622-631.
43. Liu Y.J., Lu S.H., Xu B., Yang R.C., Ren Q., Liu B., et al. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood 2004, 103:4449-4456.
44. Knudson C.B., Knudson W. Hyaluronan and CD44: modulators of chondrocyte metabolism. Clin Orthop Relat Res 2004, S152-S162.
45. Bastow E.R., Byers S., Golub S.B., Clarkin C.E., Pitsillides A.A., Fosang A.J. Hyaluronan synthesis and degradation in cartilage and bone. Cell Mol Life Sci 2008, 65:395-413.
46. Flannery C.R., Zollner R., Corcoran C., Jones A.R., Root A., Rivera-Bermudez M.A., et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 2009, 60:840-847.
47. Jay G.D., Fleming B.C., Watkins B.A., McHugh K.A., Anderson S.C., Zhang L.X., et al. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 2010, 62:2382-2391.
48. Teeple E., Elsaid K.A., Jay G.D., Zhang L., Badger G.J., Akelman M., et al. Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee. Am J Sports Med 2011, 39:164-172.
49. Elsaid K.A., Machan J.T., Waller K., Fleming B.C., Jay G.D. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum 2009, 60:2997-3006.
50. van den Berg W.B. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage 2011, 19:338-341.
51. Matthews G.L., Hunter D.J. Emerging drugs for osteoarthritis. Expert Opin Emerg Drugs 2011, 16:479-491.
52. Le Graverand-Gastineau M.P. Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets. Curr Drug Targets 2010, 11:528-535.