Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee

American Journal of Sports Medicine

Volumn 39, Issue 1, 2011, Pages 164-172

  Teeple, Erin ^a   Elsaid, Khaled A ^b   Jay, Gregory D ^a,c   Ling Zhang, ^a   Badger, Gary J ^d   Akelman, Matthew ^a   Bliss, Thomas F ^a   Fleming, Braden C ^a,c  

^a RHODE ISLAND HOSPITAL   (United States)

^b MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^c Brown University   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

ACL injury; arthritis; cartilage; hyaluronic acid; lubricin

Indexed keywords

GLYCOPROTEIN; HYALURONIC ACID; LUBRICIN;

ANIMAL; ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS; ARTICLE; CHEMISTRY; DISEASE COURSE; DRUG EFFECT; HOSPITALIZATION; INJURY; INTRAARTICULAR DRUG ADMINISTRATION; KNEE INJURY; LEWIS RAT; MALE; OSTEOARTHRITIS; PATHOLOGY; RADIOGRAPHY; RAT; SYNOVIAL FLUID; TREATMENT OUTCOME;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS; DISEASE PROGRESSION; GLYCOPROTEINS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; KNEE INJURIES; MALE; OSTEOARTHRITIS; RATS; RATS, INBRED LEW; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; TREATMENT OUTCOME;

EID: 78751557802     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546510378088     Document Type: Article

References (59)

1. Abatangelo G., Botti P., Del Bue M., et al. Intraarticular sodium hyaluronate injections in the Pond-Nuki experimental model of osteoarthritis in dogs: I, biochemical results. Clin Orthop Relat Res. 1989 ; 241: 278-285.
2. Abramson SB, Attur M., Amin AR, Clancy R. Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep. 2001 ; 3: 535-541.
3. Balazs EA, Watson D., Duff IF, Roseman S. Hyaluronic acid in synovial fluid: I, molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis Rheum. 1967 ; 10: 357-376.
4. Bjornsson S. Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue. Anal Biochem. 1993 ; 210: 282-291.
5. Blaine T., Moskowitz R., Udell J., et al. Treatment of persistent shoulder pain with sodium hyaluronate: a randomized, controlled trial, a multicenter study. J Bone Joint Surg Am. 2008 ; 90: 970-979.
6. Brandt KD, Smith GN Jr, Simon LS Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: what is the evidence ? Arthritis Rheum. 2000 ; 43: 1192-1203.
7. Chang D., Abu-Lail N., Coles J., Guilak F., Jay GD, Zauscher S. Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces. Soft Matter. 2009 ; 5: 3438-3445.
8. Charnley J. The lubrication of animal joints. Symposium on Biomechanics. London: Institution of Mechanical Engineers ; 1959: 12-19.
9. Dahl LB, Dahl IM, Engstrom-Laurent A., Granath K. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis. 1985 ; 44: 817-822.
10. Dowson D., Jin Z. -M. Micro-elastohydrodynamic lubrication of synovial joints. Eng Med. 1986 ; 15: 63-65.
11. Elsaid KA, Fleming BC, Oksendahl HL, et al. Decreased lubricin concentrations and markers of joint inflammation in synovial fluids from patients with anterior cruciate ligament injury. Arthritis Rheum. 2008 ; 58: 1707-1715.
12. Elsaid KA, Machan JT, Waller K., Fleming BC, Jay GD The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum. 2009 ; 60: 2997-3006.
13. Felson DT The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin Arthritis Rheum. 1990 ; 20: 42-50.
14. Flannery CR, Zollner R., Corcoran C., et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum. 2009 ; 60: 840-847.
15. Ghosh P., Read R., Armstrong S., Wilson D., Marshall R., McNair P. The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep: I, gait analysis and radiological and morphological studies. Semin Arthritis Rheum. 1993 ; 22 (6 Suppl 1). 18-30.
16. Ghosh P., Read R., Numata Y., Smith S., Armstrong S., Wilson D. The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep: II, cartilage composition and proteoglycan metabolism. Semin Arthritis Rheum. 1993 ; 22 (6 Suppl 1). 31-42.
17. Goldberg VM, Buckwalter JA Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis Cartilage. 2005 ; 13: 216-224.
18. Hayami T., Pickarski M., Zhuo Y., Wesolowski GA, Rodan GA, Duong le T. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006 ; 38: 234-243.
19. Huang MH, Yang RC, Chou PH Preliminary effects of hyaluronic acid on early rehabilitation of patients with isolated anterior cruciate ligament reconstruction. Clin J Sport Med. 2007 ; 17: 242-250.
20. Huskin JP, Vandekerckhove B., Delince P., et al. Multicentre, prospective, open study to evaluate the safety and efficacy of hylan G-F 20 in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy. Knee Surg Sports Traumatol Arthrosc. 2008 ; 16: 747-752.
21. Jay GD, Britt DE, Cha CJ Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J Rheumatol. 2000 ; 27: 594-600.
22. Jay GD, Cha CJ The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid. J Rheumatol. 1999 ; 26: 2454-2457.
23. Jay GD, Elsaid KA, Zack J., et al. Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis. J Rheumatol. 2004 ; 31: 557-564.
24. Jay GD, Haberstroh K., Cha CJ Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon. J Biomed Mater Res. 1998 ; 40: 414-418.
25. Jay GD, Harris DA, Cha CJ Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides. Glycoconjugate J. 2001 ; 18: 807-815.
26. Jay GD, Torres JR, Rhee DK, et al. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum. 2007 ; 56: 3662-3669.
27. Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS The role of lubricin in the mechanical behavior of synovial fluid. Proc Nat Acad Sci. 2007 ; 104: 6194-6199.
28. Jones AR, Chen S., Chai DH, et al. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum. 2009 ; 60: 133-142.
29. Jones ES Joint Lubrication. Lancet. 1934 ; 1: 1426-1427.
30. Jones ES Joint Lubrication. Lancet. 1936 ; 1: 1043-1044.
31. Kawano T., Miura H., Mawatari T., et al. Mechanical effects of the intraarticular administration of high molecular weight hyaluronic acid plus phospholipid on synovial joint lubrication and prevention of articular cartilage degeneration in experimental osteoarthritis. Arthritis Rheum. 2003 ; 48: 1923-1929.
32. Kellgren JK, Lawrence JS Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957 ; 15: 494-501.
33. Kraus VB, Huebner JL, Fink C., et al. Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum. 2002 ; 46: 420-427.
34. Krishnan R., Kopacz M., Ateshian GA Experimental verification of the role of interstitial fluid pressurization in cartilage lubrication. J Orthop Res. 2004 ; 22: 565-570.
35. Krishnan R., Park S., Eckstein F., Ateshian GA Inhomogeneous cartilage properties enhance superficial interstitial fluid support and frictional properties, but do not provide a homogeneous state of stress. J Biomech Eng. 2003 ; 125: 569-577.
36. Kumar P., Oka M., Toguchida J., et al. Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints. J Anat. 2001 ; 199: 241-250.
37. Linn FC Lubrication of animal joints II: the mechanism. J Biomech. 1968 ; 1: 193-205.
38. Louboutin H., Debarge R., Richou J., et al. Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors. Knee. 2009 ; 16: 239-244.
39. Mabuchi K., Tsukamoto Y., Obara T., Yamaguchi T. The effect of additive hyaluronic acid on animal joints with experimentally reduced lubricating ability. J Biomed Mater Res. 1994 ; 28: 865-870.
40. Moreland LW Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther. 2003 ; 5: 54-67.
41. Noble PW, Lake FR, Henson PM, Riches DW Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J Clin Invest. 1993 ; 91: 2368-2377.
42. Oiestad BE, Engebretsen L., Storheim K., Risberg MA Knee osteoarthritis after anterior cruciate ligament injury: a systematic review. Am J Sports Med. 2009 ; 37: 1434-1443.
43. Pelletier JP, Martel-Pelletier J., Abramson SB Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum. 2001 ; 44: 1237-1247.
44. Pritzker KP, Gay S., Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006 ; 14: 13-39.
45. Rhee DK, Marcelino J., Baker M., et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005 ; 115: 622-631.
46. Richette P., Ravaud P., Conrozier T., et al. Effect of hyaluronic acid in symptomatic hip osteoarthritis: a multicenter, randomized, placebo-controlled trial. Arthritis Rheum. 2009 ; 60: 824-830.
47. Rosenberg L. Chemical basis for the histological use of safranin O in the study of articular cartilage. J Bone Joint Surg Am. 1971 ; 53: 69-82.
48. Sandell LJ, Aigner T. Articular cartilage and changes in arthritis: an introduction, cell biology of osteoarthritis. Arthritis Res. 2001 ; 3: 107-113.
49. Schiavinato A., Lini E., Guidolin D., et al. Intraarticular sodium hyaluronate injections in the Pond-Nuki experimental model of osteoarthritis in dogs: II, morphological findings. Clin Orthop Relat Res. 1989 ; 241: 286-299.
50. Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL, Sah RL Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum. 2007 ; 56: 882-891.
51. Sharma L., Kapoor D., Issa S. Epidemiology of osteoarthritis: an update. Curr Opin Rheumatol. 2006 ; 18: 147-156.
52. Smith GN Jr, Myers SL, Brandt KD, Mickler EA Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis. Arthritis Rheum. 1998 ; 41: 976-985.
53. Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med. 2009 ; 37: 1636-1644.
54. Swann DA, Radin EL The molecular basis of articular lubrication: I, purification and properties of a lubricating fraction from bovine synovial fluid. J Biol Chem. 1972 ; 247: 8069-8073.
55. Swann DA, Silver FH, Slayter HS, Stafford W., Shore E. The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem J. 1985 ; 225: 195-201.
56. Teeple E., Elsaid KA, Fleming BC, et al. Coefficients of friction and cartilage damage in the guinea pig knee. J Orthop Res. 2008 ; 26: 231-237.
57. Teeple E., Fleming BC, Mechrefe AP, Crisco JJ, Brady MF, Jay GD Frictional properties of hartley guinea pig knees with and without proteolytic disruption of the articular surfaces. Osteoarthritis Cartilage. 2007 ; 15: 309-315.
58. Unsworth A., Dowson D., Wright V. The frictional behavior of synovial joints-part 1: natural joints. J Lubrication Technol. 1975: 369-376.
59. Witteveen AG, Giannini S., Guido G., et al. A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic ankle (talo-crural) osteoarthritis. Foot Ankle Surg. 2008 ; 14: 145-152.