The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

Journal of Clinical Investigation

Volumn 115, Issue 3, 2005, Pages 622-631

  Rhee, David K ^a   Marcelino, Jose ^a   Baker, MacArthur ^b   Gong, Yaoqin ^a   Smits, Patrick ^c   Lefebvre, Véronique ^c   Jay, Gregory D ^d,e   Stewart, Matthew ^a   Wang, Hongwei ^a   Warman, Matthew L ^a,f   Carpten, John D ^b,g  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d BROWN UNIVERSITY   (United States)

^e Brown University   (United States)

^f CASE WESTERN RESERVE UNIVERSITY   (United States)

^g TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; LUBRICIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ADHESION; ARTHROPATHY; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CALCIFICATION; CAMPTODACTYLY; CARTILAGE; CARTILAGE CELL; CELL GROWTH; CELL PROLIFERATION; COXA VARA; FRICTION; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; MUTATION; NONHUMAN; PERICARDITIS; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SYNOVIOCYTE; TENDON SHEATH; X RAY;

ANIMALS; CARTILAGE; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; HINDLIMB; HUMANS; IN SITU HYBRIDIZATION; JOINT DISEASES; JOINTS; MICE; MICE, KNOCKOUT; PHENOTYPE; PROTEIN STRUCTURE, SECONDARY; PROTEOGLYCANS; RECOMBINANT PROTEINS; SURFACE PROPERTIES; SYNDROME; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 20044368802     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200522263     Document Type: Article

References (37)

1. Tudor-Locke, C., and Bassett, D.R., Jr. 2004. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med. 34:1-8.
2. Mankin, H. 1963. Localisation of tritiated thymidine in articular cartilage of rabbits. III. Mature articular cartilage. J. Bone Joint Surg. 45A:529-540.
3. Hunziker, E.B. 1999. Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis Cartilage. 7:15-28.
4. Felson, D.T., and Zhang, Y. 1998. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 41:1343-1355.
5. Levick, J. 1984. Blood flow and mass transport in synovial joints. In Handbook of Physiology, Microcirculation. Section 2, Volume IV, Part 2. E. Renkins and C. Michel, editors. American Physiological Society. Bethesda, Maryland, USA. 917-947.
6. Swann, D.A., and Radin, E.L. 1972. The molecular basis of articular Lubrication. I. Purification and properties of a Lubricating fraction from bovine synovial fluid. J. Biol. Chem. 247:8069-8073.
7. Jay, G.D., Haberstroh, K., and Cha, C.J. 1998. Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon. J. Biomed. Mater. Res. 40:414-418.
8. Jay, G.D. 1992. Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and Lubricating properties. Connect. Tissue Res. 28:71-88.
9. Jay, G.D., Britt, D.E., and Cha, C.J. 2000. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J. Rheumatol. 27:594-600.
10. Swann, D.A., Silver, F.H., Slayter, H.S., Stafford, W., and Shore, E. 1985. The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem. J. 225:195-201.
11. Marcelino, J., et al. 1999. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat. Genet. 23:319-322.
12. Schumacher, B.L.; Hughes, C.E., Kuettner, K.E., Caterson, B.; and Aydelotte, M.B. 1999. Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints. J. Orthop. Res. 17:110-120.
13. Schumacher, B.L., Block, J.A., Schmid, T.M., Aydelotte, M.B., and Kuettner, K.E. 1994. A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. Arch. Biochem. Biophys. 311:144-152.
14. Merberg, D., Fitz, L., and Temple, P. 1993. A comparison of vitronecrin and megakaryocyte stimulating factor. In Biology of Vitronectins and their Receptors. K. Preissner, S. Rosenblattt, C. Kost, J. Wegerhoff, and D. Mosher, editors. Elsevier Science Publishers BV. Amsterdam, The Netherlands. 45-54.
15. Líu, Y.J., et al. 2004. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood. 103:4449-4456.
16. Bahabri, S.A., et al. 1998. The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis Rheum. 41:730-735.
17. Deng, G., Curriden, S.A., Hu, G., Czekay, R.P., and Loskutoff, D.J. 2001. Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J. Cell. Physiol. 189:23-33.
18. Schvartz, I., Seger, D., and Shaltiel, S. 1999. Vitronectin. Int. J. Biochem. Cell Biol. 31:539-544.
19. Seiffert, D., and Smith, J.W. 1997. The cell adhesion domain in plasma vitronectin is cryptic. J. Biol. Chem. 272:13705-13710.
20. Zheng, X., Saunders, T.L., Camper, S.A., Samuelson, L.-C., and Ginsburg, D. 1995. Vitronectin is not essential for normal mammalian development and fertility. Proc. Natl. Acad. Sci. U. S. A. 92:12426-12430.
21. Jay, G.D., Harris, D.A., and Cha, C.J. 2001. Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides. Glycoconj. J. 18:807-815.
22. Van Klinken, B.J., Dekker, J., Buller, H.A., and Einerhand, A.W. 1995. Mucin gene structure and expression: protection vs. adhesion. Am. J. Physiol. 269:G613-G627.
23. Simmons, P.J., Levesque, J.P., and Haylock, D.N. 2001. Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells. Ann. N. Y. Acad. Sci. 938:196-206; discussion 206-197.
24. Velcich, A., et al. 2002. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 295:1726-1729.
25. Haines, R. 1947. The development of joints. J. Anat. 81:33-54.
26. Guerra, D., et al. 1996. Ultrastructural identification of a membrane-like structure on the surface of normal articular cartilage. J. Submicrosc. Cytol. Pathol. 28:385-393.
27. Skoog, V., Widenfalk, B., Ohlsen, L., and Wasteson, A. 1990. The effect of growth factors and synovial fluid on chondrogenesis in perichondrium. Scand. J. Plast. Reconstr. Surg. Hand Surg. 24:89-95.
28. Fassbender, H. 2002. Pathology and patbobiology of rheumatic diseases. Springer. Berlin, Germany. 503 pp.
29. Rees, S.G., et al. 2002. Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix Biol. 21:593-602.
30. Firestein, G.S. 1996. Invasive fibroblast-like synoviocytes in rheumatoid arrhritis. Passive responders or transformed aggressors? Arthritis Rheum. 39:1781-1790.
31. Firestein, G.S., Echeverri, F., Yeo, M., Zvaifler, N.J., and Green, D.R. 1997. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthricis synovium. Proc. Natl. Acad. Sci. U. S. A. 94:10895-10900.
32. Noyori, K., and Jasin, H.E. 1994. Inhibition of human fibroblast adhesion by cartilage surface proteoglycans. Arthritis Rheum. 37:1656-1663.
33. O'Boyle, K.P., Chen, T., and Kozlowski, S. 2000. Mucin inhibition of lymphocyte function does not require specific mucin-ligand interactions. Scand. J. Immunol. 52:46-52.
34. Swann, D.A., Hendren, R.B., Radin, E.L., Sotman, S.L., and Duda, E.A. 1981. The lubricating activity of synovial fluid glycoproteins. Arthritis Rheum. 24:22-30.
35. Jay, G.D., Tantravahi, U., Britt, D.E., Barrach, H.J., and Cha, C.J. 2001. Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J. Orthop. Res. 19:677-687.
36. Smits, P., et al. 2001. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev. Cell. 1:277-290.
37. Ikegawa, S., Sano, M., Koshizuka, Y., and Nakamura, Y. 2000. Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenet. Cell Genet. 90:291-297.