A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Lawless, Conor ^a,b   Jurk, Diana ^a,b   Gillespie, Colin S ^b   Shanley, Daryl ^a,b   Saretzki, Gabriele ^a,b   von Zglinicki, Thomas ^a,b   Passos, João F ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; REACTIVE OXYGEN METABOLITE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE; TERT PROTEIN, HUMAN;

ARTICLE; BIOACCUMULATION; CELL AGING; CELL ASSAY; CELL POPULATION; CELL PROLIFERATION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS; PREDICTION; PROCESS DEVELOPMENT; PROTEIN EXPRESSION; SENESCENCE; STOCHASTIC MODEL; STOCHASTIC STEP MODEL OF REPLICATIVE SENESCENCE; ANIMAL; FIBROBLAST; KINETICS; MAMMAL; METABOLISM; MOUSE; STATISTICS;

ANIMALS; CELL AGING; FIBROBLASTS; KINETICS; MAMMALS; MICE; REACTIVE OXYGEN SPECIES; STOCHASTIC PROCESSES; TELOMERASE;

EID: 84857134740     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032117     Document Type: Article

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