Understanding glaucomatous damage: Anatomical and functional data from ocular hypertensive rodent retinas

Progress in Retinal and Eye Research

Volumn 31, Issue 1, 2012, Pages 1-27

  Vidal Sanz, Manuel ^a   Salinas Navarro, Manuel ^a   Nadal Nicolás, Francisco M ^b   Alarcón Martínez, Luis ^a   Valiente Soriano, F Javier ^a   Miralles de Imperial, Jaime ^a   Avilés Trigueros, Marcelino ^a   Agudo Barriuso, Marta ^b   Villegas Pérez, Maria P ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

Glaucoma; Glaucomatous optic neuropathy; Intraocular pressure; Ocular hypertension; Optic nerve damage; Retinal degeneration; Retinal ganglion cells

Indexed keywords

1,1' DIOCTADECYL 3,3,3',3' TETRAMETHYLINDOCARBOCYANINE; 2 HYDROXYSTILBENE 4,4 DICARBOXAMIDINE BIS METHANESULFONATE; 4',6 DIAMIDINO 2 PHENYLINDOLE; DEXTRAN TETRAMETHYLRHODAMINE; HORSERADISH PEROXIDASE; HYDROXYSTILBAMIDINE; HYDROXYSTILBAMIDINE METHANESULFONATE; KETAMINE; MESYLIC ACID; RHODAMINE B ISOTHIOCYANATE; TOBRAMYCIN; TRACER; TRANSCRIPTION FACTOR POU4F1; UNCLASSIFIED DRUG; XYLAZINE;

ANESTHESIA INDUCTION; CAUTERIZATION; CELL COUNT; CELL DAMAGE; CELL DEATH; CELL DENSITY; CELL LOSS; CELL POPULATION; CORNEA DESICCATION; CORNEA DISEASE; DIAGNOSTIC TEST; EPISCLERAL VEIN PHOTOCAUTERIZATION; GLAUCOMA; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; INTRAOCULAR HYPERTENSION; NERVE CELL; NERVE FIBER DEGENERATION; NERVE FIBER TRANSPORT; NEUROFILAMENT; NONHUMAN; OPTIC NERVE FIBER; PERILIMBAR VEIN PHOTOCAUTERIZATION; PRIORITY JOURNAL; RETINA; RETINA AMACRINE CELL; RETINA GANGLION CELL; RETINA INJURY; REVIEW; STAINING; TONOMETRY; ANIMAL; DISEASE MODEL; INTRAOCULAR PRESSURE; MOUSE; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT;

ANIMALS; AXONS; DISEASE MODELS, ANIMAL; GLAUCOMA; INTRAOCULAR PRESSURE; MICE; OCULAR HYPERTENSION; RATS; RETINA; RETINAL GANGLION CELLS;

EID: 84857131171     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2011.08.001     Document Type: Review

References (230)

1. Agis, The Advanced Glaucoma Intervention Study The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am. J. Ophthalmol. 2000, 130:429-440.
2. Agoumi Y., Sharpe G.P., Hutchison D.M., Nicoleta M.T., Artes P.H., Chauhan B.C. Laminar and preliminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls. Ophthalmology 2011, 118:52-59.
3. Aguayo A.J., Vidal-Sanz M., Villegas-Pérez M.P., Bray G.M. Growth and connectivity of axotomized retinal neurons in adult rats with optic nerves substituted by PNS grafts linking the eye and the midbrain. Ann. N. Y. Acad. Sci. 1987, 495:1-9.
4. Agudo M., Pérez-Marín M.C., Lonngren U., Sobrado P., Conesa A., Cánovas I., Salinas-Navarro M., Miralles-Imperial J., Hallböök F., Vidal-Sanz M. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Mol. Vis. 2008, 14:1050-1063.
5. Agudo M., Pérez-Marín M.C., Sobrado-Calvo P., Lonngren U., Salinas-Navarro M., Cánovas I., Nadal-Nicolás F.M., Miralles-Imperial J., Hallbook F., Vidal-Sanz M. Proteins belonging to different branches of the apoptotic cascade are immediately up-regulated in the retina after optic nerve transection or optic nerve crush. Invest. Ophthalmol. Vis. Sci. 2009, 50:424-431.
6. Ahmed F.A., Hegazy K., Chaudhary P., Sharma S.C. Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure. Brain Res. 2001, 913:133-139.
7. Aihara M., Lindsey J.D., Weinreb R.N. Twenty-four-hour pattern of mouse intraocular pressure. Exp. Eye Res. 2003, 77:681-686.
8. Aihara M., Lindsey J.D., Weinreb R.N. Experimental mouse ocular hypertension: establishment of the model. Invest. Ophthalmol. Vis. Sci. 2003, 44:4314-4320.
9. Aihara M., Lindsey J.D., Weinreb R.N. Ocular hypertension in mice with a targeted type I collagen mutation. Invest. Ophthalmol. Vis. Sci. 2003, 44:1581-1585.
10. Alarcón-Martínez L., de la Villa P., Avilés-Trigueros M., Blanco R., Villegas-Pérez M.P., Vidal-Sanz M. Short and long term axotomy-induced ERG changes in albino and pigmented rats. Mol. Vis. 2009, 15:2373-2383.
11. Alarcón-Martínez L., Avilés-Trigueros M., Galindo-Romero C., Valiente-Soriano J., Agudo-Barriuso M., de la Villa P., Villegas-Pérez M.P., Vidal-Sanz M. ERG changes in albino and pigmented mice after optic nerve transection. Vis. Res. 2010, 50:2176-2187.
12. Anderton B.H., Breinburg D., Downes M.J., Green P.J., Tomlinson B.E., Ulrich J., Wood J.N., Kahn J. Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature 1982, 298:84-86.
13. Artes P.H., Chauhan B.C., Keltner J.L., Cello K.E., Johnson C.A., Anderson D.R., Gordon M.O., Kass M.A., Ocular Hypertension Treatment Study Group Longitudinal and cross-sectional analyses of visual field progression in participants of the Ocular Hypertension Treatment Study. Arch. Ophthalmol. 2010, 128:1528-1532.
14. Avilés-Trigueros M., Sauvé Y., Lund R.D., Vidal-Sanz M. Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cells axons regeneratin through peripheral nerve grafts in adult rats. J. Neurosci. 2000, 20:361-372.
15. Avilés-Trigueros M., Mayor-Torroglosa S., García-Avilés A., Lafuente M.P., Rodríguez M.E., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine. Exp. Neurol. 2003, 184:767-777.
16. Bakalash S., Kipnis J., Yoles E., Schwartz M. Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent. Invest. Ophthalmol. Vis. Sci. 2002, 43:2648-2653.
17. Balkema G.W., Dräger U.C. Origins of uncrossed retinofugal projections in normal and hypopigmented mice. Vis. Neurosci. 1990, 4:595-605.
18. Barnstable C.J., Dräger U.C. Thy-1 antigen: a ganglion cell specific marker in rodent retina. Neuroscience 1984, 11:847-855.
19. Bayer A.U., Neuhardt T., May A.C., Martus P., Maag K.P., Brodie S., Lütjen-Drecoll E., Podos S.M., Mittag T. Retinal morphology and ERG response in the DBA/2NNia mouse model of angle-closure glaucoma. Invest. Ophthalmol. Vis. Sci. 2001, 42:1258-1265.
20. Bernstein S.L., Koo J.H., Slater B.J., Guo Y., Margolis F.L. Analysis of optic nerve stroke by retinal Bex expression. Mol. Vis. 2006, 12:147-155.
21. Bernstein S.L., Guo Y., Slater B.J., Puche A., Kelman S.E. Neuron stress and loss following rodent anterior ischemic optic neuropathy in double-reporter transgenic mice. Invest. Ophthalmol. Vis. Sci. 2007, 48:2304-2310.
22. Bodeutsch N., Siebert H., Dermon C., Thanos S. Unilateral injury to the adult rat optic nerve causes multiple cellular responses in the contralateral site. J. Neurobiol. 1999, 38:116-128.
23. Bray G.M., Vidal-Sanz M., Aguayo A.J. Regeneration of axons from the central nervous system of adult rats. Prog. Brain Res. 1987, 71:373-379.
24. Buckingham B.P., Inman D.M., Lambert W., Oglesby E., Clakins D.J., Steele M.R., Vetter M.L., Marsh-Armstrong N., Horner P.J. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008, 28:2735-2744.
25. Bui B.V., Fortune B. Ganglion cell contributions to the rat full-field electroretinogram. J. Physiol. 2004, 555:153-173.
26. Casson R.J., Wood J.P., Osborne N.N. Hypoglycaemia exacerbates ischaemic retinal injury in rats. Br. J. Ophthalmol. 2004, 88:816-820.
27. Chang B., Smith R.S., Hawes N.L., Anderson M.G., Zabaleta A., Savinova O., Roderick T.H., Heckenlively J.R., Davisson M.T., John S.W. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat. Genetc. 1999, 21:405-409.
28. Chauhan B.C., Pan J., Archibald M.L., LeVatte T.L., Kelly M.E., Tremblay F. Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage. Invest. Ophthalmol. Vis. Sci. 2002, 43:2969-2976.
29. Chen H., Wei X., Cho K.S., Chen G., Sappington R., Calkins D.J., Chen D.F. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest. Ophthalmol. Vis. Sci. 2011, 52:36-44.
30. Cheunsuang O., Morris R. Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 2005, 52:228-233.
31. Chidlow G., Casson R., Sobrado-Calvo P., Vidal-Sanz M., Osborne N.N. Measurement of retinal injury in the rat after optic nerve transection: an RT-PCR study. Mol. Vis. 2005, 11:387-396.
32. Choi S.S., Zawadki R.J., Lim M.C., Brandt J.D., Keltner J.L., Doble N., Werner J.S. Evidence for outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging. Br. J. Ophthalmol. 2011, 95:131-141.
33. Cone F.E., Gelman S.E., Son J.L., Pease M.E., Quigley H.A. Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection. Exp. Eye Res. 2010, 91:415-424.
34. Costa V.P., Harris A., Stefánsson E., Flammer J., Krieglstein G.K., Orzalesi N., Heijl A., Renard J.P., Serra L.M. The effects of antiglaucoma and systemic medications on ocular blood flow. Prog. Retin. Eye Res. 2003, 22:769-805.
35. Cowey A., Perry V.H. The projection of the temporal retina in rats, studied by retrograde transport of horseradish peroxidase. Exp. Brain Res. 1979, 35:457-464.
36. Crish A.D., Sappington R.M., Inman D.M., Horner P.J., Calkins D.J. Distal axonopathy with structural persistence in glaucomatous degeneration. Proc. Natl. Acad. Sci. U S A. 2010, 107:5196-5201.
37. Cuenca N., Pinilla I., Fernández-Sánchez L., Salinas-Navarro M., Alarcón-Martínez L., Avilés-Trigueros M., de la Villa P., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice. Exp. Eye Res. 2010, 91:273-285.
38. Danias J., Shen F., Goldblum D., Chen B., Ramos-Esteban J., Podos S.M., Mittag T. Cytoarchitecture of the retinal ganglion cells in the rat. Invest. Ophthalmol. Vis. Sci. 2002, 43:587-594.
39. Danias J., Kontiola A.I., Filippopoulos T., Mittag T. Method for the noninvasive measurement of intraocular pressure in mice. Investig. Ophthalmol. Vis. Sci. 2003, 44:1138-1141.
40. Danias J., Lee K.C., Zamora M.F., Chen B., Shen F., Filippopoulos T., Su Y., Goldblum D., Podos S.M., Mittag T. Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice. Invest. Ophthalmol. Vis. Sci. 2003, 44:5151-5162.
41. Danias J., Shen F., Kavalarakis M., Chen B., Goldblum D., Lee K., Zamora M.F., Su Y., Brodie S.E., Podos S.M., Mittag T. Characterization of retinal damage in the episcleral vein cauterization rat glaucoma model. Exp. Eye Res. 2006, 82:219-228.
42. Dieterich D.C., Trivedi N., Engelmann R., Gundelfinger E.D., Gordon-Weeks P.R., Kreutz M.R. Partial regeneration and long-term survival of rat retinal ganglion cells after optic nerve crush is accompanied by altered expression, phosphorylation and distribution of cytoskeletal proteins. Eur. J. Neurosci. 2002, 15:1433-1443.
43. Dkhissi O., Chanut E., Versaux-Botteri C., Minvielle F., Trouvin J.H., Nguyen-Legros J. Changes in retinal dopaminergic cells and dopamine rhythmic metabolism during the development of a glaucoma-like disorder in quails. Invest. Ophthalmol. Vis. Sci. 1996, 37:2335-2344.
44. Dräger U.C., Olsen J.F. Ganglion cell distribution in the retina of the mouse. Invest. Ophthalmol. Vis. Sci. 1981, 20:285-293.
45. Dräger U.C., Hofbauer A. Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in retina. Nature 1984, 309:624-626.
46. Drouyer E., Dkhissi-Benyahya O., Chiquet C., WoldeMussie E., Ruiz L., Wheeler L.A., Denis P., Cooper H.M. Glaucoma alters the circadian timing system. PloS ONE 2008, 3:e3931. 10.1372/journal.pone.0003931.
47. Ebneter A., Casson R.J., Wood J.P., Chidlow G. Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury. Invest. Ophthalmol. Vis. Sci. 2010, 51:6448-6460.
48. Filippopoulos T., Danias J., Chen B., Podos S.M., Mittag T.W. Topographic and morphologic analyses of retinal ganglion cell loss in old DBA/2NNia mice. Invest. Ophthalmol. Vis. Sci. 2006, 47:1968-1974.
49. Filippopoulos T., Matsubara A., Danias J., Huang W., Dobberfuhl A., Ren L., Mittag T., Miller J.W., Grosskreutz C.L. Predictability and limitations of non-invasive murine tonometry: comparison of two devices. Exp. Eye Res. 2006, 83:194-201.
50. Fitzgibbon T., Taylor S.F. Retinotopy of the human retinal nerve fibre layer and optic nerve head. J. Comp. Neurol. 1996, 375:238-251.
51. Flammer J., Orgül S., Costa V.P., Orzalesi N., Krieglstein G.K., Serra L.M., Renard J.P., Stefánson E. The impact of ocularblood flow in glaucoma. Prog. Retin. Eye Res. 2002, 21:359-393.
52. Fortune B., Bui B.V., Morrison J.C., Johnson E.C., Dong J., Cepurna W.O., Jia L., Barber S., Cioffi G.A. Selective ganglion cell functional loss in rats with experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2004, 45:1854-1862.
53. Fritzsch B. Fast axonal diffusion of 3000 molecular weight dextran amines. J. Neurosci. Methods 1993, 50:95-103.
54. Fu C.T., Sretavan D. Laser-induced ocular hypertension in albino CD-1 mice. Invest. Ophthalmol. Vis. Sci. 2010, 51:980-990.
55. Fu C.T., Tran T., Sretavan D. Axonal/Glial upregulation of EphB/ephrin-B signaling in mouse experimental ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2010, 51:991-1001.
56. Gaasterland D., Kupfer C. Experimental glaucoma in the rhesus monkey. Invest. Ophthalmol. 1974, 13:455-457.
57. Galindo-Romero C., Avilés-Trigueros M., Jiménez-López M., Valiente-Soriano F.J., Salinas-Navarro M., Nadal-Nicolás F.M., Villegas-Pérez M.P., Vidal-Sanz M., Agudo-Barriuso M. Axotomy-induced retinal ganglion cell death in adult mice: quantitative and topographic time course analices. Exp. Eye Res. 2011, 92:377-387.
58. García-Ayuso D., Salinas-Navarro M., Agudo M., Cuenca N., Pinilla I., Vidal-Sanz M., Villegas-Pérez M.P. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp. Eye Res. 2010, 91:800-810.
59. García-Ayuso D., Salinas-Navarro M., Agudo-Barriuso M., Alarcón-Martínez L., Vidal-Sanz M., Villegas-Pérez M.P. Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration. Mol. Vis. 2011, 17:1716-1733.
60. García-Valenzuela E., Shareef S., Walsh J., Sharma S.C. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp. Eye Res. 1995, 61:33-44.
61. Goldblum D., Mittag T. Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye. Vis. Res. 2002, 42:471-478.
62. Gómez-Ramírez A.M., Villegas-Pérez M.P., Miralles de Imperial J., Salvador-Silva M., Vidal-Sanz M. Effects of intramuscular injection of botulinum toxin and doxorubicin on the survival of abducens motoneurons. Invest. Ophthalmol. Vis. Sci. 1999, 40:414-424.
63. Grafstein B. The retina as a regenerating organ. The Retina: A Model for Cell Biology Studies, Part II 1986, 275-335. Academic Press, New York. R. Adler, D.B. Farber (Eds.).
64. Gross R.L., Ji J., Chang P., Pennesi M.E., Yang Z., Zhang J., Wu S.M. A mouse model of elevated intraocular pressure: retina and optic nerve findings. Trans. Am. Ophthalmol. Soc. 2003, 101:163-169.
65. Grozdanic S.D., Betts D.M., Sakaguchi D.S., Allbaugh R.A., Kwon Y.H., Kardon R.H. Laser-induced mouse model of chronic ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2003, 44:4337-4346.
66. Grozdanic S.D., Betts D.M., Sakaguchi D.S., Kwon Y.H., Kardon R.H., Sonea I.M. Temporary elevation of the intraocular pressure by cauterization of vortex and episcleral veins in rats causes functional deficits in the retina and optic nerve. Exp. Eye Res. 2003, 77:27-33.
67. Grozdanic S.C., Kwon Y.H., Sakaguchi D.S., Kardon R.H., Sonea I.M. Functional evaluation of retina and optic nerve in the rat model of chronic ocular hypertension. Exp. Eye Res. 2004, 79:75-83.
68. Guillery R.W., Mason C.A., Taylor J.S.H. Developmental determinants at the mammalian optic chiasm. J. Neurosci. 1995, 15:4727-4737.
69. Guo Y., Cepurna W.O., Dyck J.A., Doser T.A., Johnson E.C., Morrison J.C. Retinal responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer. Invest. Ophthalmol. Vis. Sci. 2010, 52:3003-3018.
70. Guo Y., Johnson E.C., Cepurna W.O., Dyck C.J., Doser T., Morrison J.C. Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2011, 52:1460-1473.
71. Hänninen V.A., Pantcheva M.B., Freeman E.E., Poulin N.R., Grosskreutz C.L. Activation of caspase 9 in a rat model of experimental glaucoma. Curr. Eye Res. 2002, 25:389-395.
72. Holcombe D.J., Lengefeld N., Gole G.A., Barnett N.L. Selective inner retinal dysfunction precedes ganglion cell loss in a mouse glaucoma model. Br. J. Ophthalmol. 2008, 92:683-688.
73. Howell G.R., Libby R.T., Jakobs T.C., Smith R.S., Phalan F.C., Barter J.W., Barbay J.M., Marchant J.K., Mahesh N., Porciatti V., Whitmore A.V., Masland R.H., John S.W.M. Axons of retinal ganglin cells are insulted in the optic nerve early in DBA/2J glaucoma. J. Cell Biol. 2007, 179:1523-1537.
74. Howell G.R., Libby R.T., Marchant J.K., Wilson L.A., Cosma I.M., Smith R.S., Anderson M.G., John S.W. Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. BMC Genet. 2007, 8:45.
75. Huang X., Kong W., Zhou Y., Gregori G. Distortion of axonal cytoskeleton: an early sign of glaucomatous damage. Invest. Ophthalmol. Vis. Sci. 2011, 52:2879-2888.
76. Ishii Y., Kwong J.M., Caprioli J. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2003, 44:1982-1992.
77. Jakobs T.C., Libby R.T., Ben Y., John S.W.M., Masland R.H. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 2005, 171:313-325.
78. Jeffery G. Architecture of the optic chiasm and the mechanisms that sculpt its development. Physiol. Rev. 2001, 81:1393-1414.
79. Jeffery G., Levitt J.B., Cooper H.M. Segregated hemispheric pathways through the optic chiasm distinguish primates from rodents. Neuroscience 2008, 157:637-643.
80. Jeon C.J., Strettoi E., Masland R.H. The major cell populations of the mouse retina. J. Neurosci. 1998, 18:8936-8946.
81. Ji J., Chang P., Pennesi M.E., Yang Z., Zhang J., Li D., Wu S.M., Gross R.L. Effects of elevated intraocular pressure on mouse retinal ganglion cells. Vis. Res. 2005, 45:169-179.
82. Jia L., Cepurna W.O., Johnson E.C., Morrison J.C. Effect of general anaesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest. Ophthalmol. Vis. Sci. 2000, 41:3415-3419.
83. John S.W., Smith R.S., Savinova O.V., Hawes N.L., Chang B., Turnbull D., Davisson M., Roderick T.H., Heckenlively J.R. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest. Ophthalmol. Vis. Sci. 1998, 39:951-962.
84. John S.W., Anderson M.G., Smith R.S. Mouse genetics: a tool to help unlock the mechanisms of glaucoma. J. Glaucoma 1999, 8:400-412.
85. Johnson E.C., Deppmeier L.M., Wentzien S.K., Hsu I., Morrison J.C. Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2000, 41:431-442.
86. Johnson E.C., Jia L., Cepurna W.O., Doser T.A., Morrison J.C. Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2007, 48:3161-3177.
87. Kass M.A., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.L., Miller J.P., Parrish R.K., Wilson M.R., Gordon M.O. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch. Ophthalmol. 2002, 120:701-713.
88. Kielczewski J., Pease M.E., Quigley H.A. The effect of experimental glaucoma and optic nerve transaction on amacrine cells in the rat retina. Invest. Ophthalmol. Vis. Sci. 2005, 46:3188-3196.
89. Kipfer-Kauer A., McKinnon S.J., Frueh B.E., Goldblum D. Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. Curr. Eye Res. 2010, 35:828-834.
90. Kong W.C., Cho E.Y. Antibodies against neurofilament subunits label retinal ganglion cells but not displaced amacrine cells of hamsters. Life Sci. 1999, 64:1773-1778.
91. Kontiola A.I. A new induction-based impact method for measuring intraocular pressure. Acta Ophthalmol. Scand. 2000, 78:142-145.
92. Kontiola A.I., Goldblum D., Mittag T., Danias J. The induction/impact tonometer: a new instrument to measure intraocular pressure in the rat. Exp. Eye Res. 2001, 73:781-785.
93. Krishna R., Mermoud A., Baerveldt G., Minckler D.S. Circadian rhythm of intraocular pressure: a rat model. Ophthalmic Res. 1995, 27:163-167.
94. Lafuente M.P., Villegas-Pérez M.P., Sellés-Navarro I., Mayor-Torroglosa S., Miralles de Imperial J., Vidal-Sanz M. Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. Neuroscience 2002, 109:157-168.
95. Lafuente López-Herrera M.P., Mayor-Torroglosa S., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine. Exp. Neurol. 2002, 178:243-258.
96. Lambert W.E., Ruiz L., Crish S.D., Wheeler L.A., Calkins D.J. Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol. Neurodegeneration 2011, 6:4.
97. Lebrun-Julien F., Morquette B., Douillette A., Saragovi H.U., Di Polo A. Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Mol. Cell Neurosci. 2009, 40:410-420.
98. Lei Y., Garrahan N., Hermann B., Becker D.L., Hernandez M.R., Boulton M.E., Morgan J.E. Quantification of retinal transneuronal degeneration in human glaucoma: a novel multiphoton-DAPI approach. Invest. Ophthalmol. Vis. Sci. 2008, 49:1940-1945.
99. Lei Y., Garrahan N., Hermann B., Fautsch M.P., Johnson D.H., Hernandez M.R., Boulton M., Morgan J.E. Topography of neuron loss in the retinal ganglion cell layer in human glaucoma. Br. J. Ophthalmol. 2009, 93:1676-1679.
100. Lei Y., Garrahan N., Hermann B., Fautsch M.P., Johnson D.H., Hernandez M.R., Boulton M., Morgan J.E. Transretinal degeneration in ageing human retina: a multiphoton microscopy analysis. Br. J. Ophthalmol. 2010, 95:727-730.
101. Leske M.C. The epidemiology of open-angle glaucoma: a review. Am. J. Epidemiol. 1983, 118:166-191.
102. Levkovitch-Verbin H., Quigley H.A., Martin K.R., Valenta D., Baumrind L.A., Pease M.E. Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats. Invest. Ophthalmol. Vis. Sci. 2002, 43:402-410.
103. Levkovitch-Verbin H., Martin K.R., Quigley H.A., Baumrind L.A., Pease M.E., Valenta D. Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transection. J. Glaucoma 2002, 11:396-405.
104. Libby R.T., Anderson M.G., Pang I.H., Robinson Z.H., Savinova O.V., Cosma I.M., Snow A., Wilson L.A., Smith R.S., Clark A.F., John S.W. Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis. Neurosci. 2005, 22:637-648.
105. Lindqvist N., Peinado-Ramon P., Vidal-Sanz M., HallbBöök F. GDNF, Ret, GFR alpha 1 and 2 in the adult rat retino-tectal system after optic nerve transection. Exp. Neurol. 2004, 187:487-499.
106. Lönngren U., Näpänkangas U., Lafuente M., Mayor S., Lindqvist N., Vidal-Sanz M., Hallböök F. The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment. Brain Res. Bull. 2006, 71:208-218.
107. Mabuchi F., Aihara M., Mackey M.R., Lindsey J.D., Weinreb R.N. Optic nerve damage in experimental mouse ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2003, 44:4321-4330.
108. Mabuchi F., Aihara M., Mackey M.R., Lindsey J.D., Weinreb R.N. Regional optic nerve damage in experimental mouse glaucoma. Invest. Ophthalmol. Vis. Sci. 2004, 45:4352-4358.
109. Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:1632-1636.
110. Marco-Gomariz M.A., Hurtado-Montalbán N., Vidal-Sanz M., Lund R.D., Villegas-Pérez M.P. Phototoxic induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats. J. Comp. Neurol. 2006, 498:163-179.
111. Martin K.R.G., Quigley H.A., Zack D.J., Levkovitch-Verbin H., Kielczewski J., Valenta D., Baumrind L., Pease M.E., Kelin R.L., Hauswirth W.W. Gene therapy with Brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2003, 44:4357-4365.
112. Masland R.H. Cell populations of the retina: the Proctor Lecture. Invest. Ophthalmol. Vis. Sci. 2011, 52:4581-4591.
113. Mayor-Torroglosa S., Villegas-Pérez M.P., Salazar J.J., Ramírez J.M., Triviño A., Ramírez A.I., Coll l., Vidal-Sanz M. Chronic ocular hypertension alters retrograde axoplasmic transport in adult rats. Ophthalmic Res. 2004, 36. Abstract 362.
114. Mayor-Torroglosa S., De la Villa P., Rodríguez M.E., Lafuente López-Herrera M.P., Avilés-Trigueros M., García-Avilés A., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Ischemia results three months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine. Invest. Ophtalmol. Vis. Sci. 2005, 46:3825-3835.
115. McKerracher L., Vallee R.B., Aguayo A.J. Microtubule-associated protein 1A (MAP 1A) is a ganglion cell marker in adult rat retina. Vis. Neurosci. 1989, 2:349-356.
116. McKinnon S.J., Reitsamer H.A., Ransom N.L., Caldwell M., Harrison J.M., Kiel J.W. Induction and tonopen measurement of ocular hypertension in C57BL/6 mice. Invest. Ophthalmol. Vis. Sci. 2003, 52. E-Abstract 3319.
117. McKinnon S.J., Schlamp C.L., Nickells R.W. Mouse models of retinal ganglion cell death and glaucoma. Exp. Eye Res. 2009, 88:816-824.
118. Mittag T.W., Danias J., Pohorenec G., Yuan H.M., Burakgazi E., Chalmers-Redman R., Podos S.M., Tatton W.G. Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2000, 41:3451-3459.
119. Montalbán-Soler, L., Alarcón-Martínez, L., Jiménez-López, M., Salinas-Navarro, M., Galindo-Romero, C., Bezerra de Sá, F., García-Ayuso, D., Avilés-Trigueros, M., Vidal-Sanz, M., Agudo-Barriuso, M., Villegas-Pérez, M.P., 2011. Retinal compensatory changes after light-damage in albino mice. (Submitted).
120. Moon J.I., Kim I.B., Gwon J.S., Park M.H., Kang T.H., Lim E.J., Choi K.R., Chun M.H. Changes in retinal neuronal populations in the DBA/2J mouse. Cell Tissue Res. 2005, 320:51-59.
121. Moore C.G., Milne S.T., Morrison J.C. Noninvasive measurement of rat intraocular pressure with the Tono-Pen. Invest. Ophthalmol. Vis. Sci. 1993, 34:363-369.
122. Moore C.G., Epley D., Milne S.T., Morrison J.C. Long-term non-invasive measurement of intraocular pressure in the rat eye. Curr. Eye Res. 1995, 14:711-717.
123. Moore C.G., Johnson E.C., Morrison J.C. Circadian rhythm of intraocular pressure in the rat. Curr. Eye Res. 1996, 15:185-191.
124. Morrison J.C., Farrell S., Johnson E., Deppmeier L., Moore C.G., Grossmann E. Structure and composition of the rodent lamina cribrosa. Exp. Eye Res. 1995, 60:127-135.
125. Morrison J.C., Fraunfelder F.W., Milne S.T., Moore C.G. Limbal microvasculature of the rat eye. Invest. Ophthalmol. Vis. Sci. 1995, 36:751-756.
126. Morrison J.C., Moore C.G., Deppmeier L.M., Gold B.G., Meshul C.K., Johnson E.C. A rat model of chronic pressure-induced optic nerve damage. Exp. Eye Res. 1997, 64:85-96.
127. Morrison J.C., Cepurna W.O., Johnson E.C. Modeling glaucomatous optic nerve damage. Int. Ophthalmol. Clin. 1999, 39:29-41.
128. Morrison J.C., Johnson E.C., Cepurna W., Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Progr. Ret. Eye Res. 2005, 24:217-240.
129. Morrison J.C., Johnson E., Cepurna W.O. Rat models for glaucoma research. Prog. Brain Res. 2008, 173:285-301.
130. Morrison J.C., Jia L., Cepurna W., Guo Y., Johnson E. Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats. Invest. Ophthalmol. Vis. Sci. 2009, 50:2802-2808.
131. Morrison J.C., Cepurna W.O., Guo Y., Johnson E.C. Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma. Exp. Eye Res. 2010, [Epub ahead of print].
132. Murphy J.A., Franklin T.B., Rafuse V.F., Clarke D.B. The neural cell adhesion molecule is necessary for normal adult retinal ganglion cell number and survival. Mol. Cell. Neurosci. 2007, 36:280-292.
133. Nadal-Nicolás F.M., Jiménez-López M., Sobrado-Calvo P., Nieto-López L., Cánovas-Martínez I., Salinas-Navarro M., Vidal-Sanz M., Agudo M. Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest. Ophthalmol. Vis. Sci. 2009, 50:3860-3868.
134. Nakazawa T., Nakazawa C., Matsubara A., Noda K., Hisatomi T., She H., Michaud N., Moghadam A.H., Miller J.W., Benowitz L.I. Tumor necrosis factor-α mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J. Neurosci. 2006, 26:12633-12641.
135. Neufeld A.H., Das S., Vora S., Gachie E., Kawai S., Manning P.T., Connor J.R. A prodrug of a selective inhibitor of inducible nitric oxide synthase is neuroprotective in the rat model of glaucoma. J. Glaucoma 2002, 11:221-225.
136. Nguyen J.V., Soto I., Kim K.Y., Bushong E.A., Oglesby E., Valiente-Soriano F.J., Yang Z., Davis C.H., Bedont J.L., Son J.L., Wei J.O., Buchman V.L., Zack D.J., Vidal-Sanz M., Ellisman M.H., Marsh-Armstrong N. Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc. Natl. Acad. Sci. U S A. 2011, 108:1176-1181.
137. Nork T.M., Ver Hoeve J.N., Poulsen G.L., Nickells R.W., Davis M.D., Weber A.J., Vaegan Sarks S.H., Lemley H.L., Millecchia L.L. Swelling and loss of photoreceptors in chronic human and experimental glaucomas. Arch. Ophthalmol. 2000, 118:235-245.
138. Nouri-Mahdavi K., Hoffman D., Gaasterland D., Caprioli J. Prediction of visual field progression in glaucoma. Invest. Ophthalmol. Vis. Sci. 2004, 45:4346-4351.
139. Ortín-Martínez A., Jiménez-López M., Nadal-Nicolás F.M., Salinas-Navarro M., Alarcón-Martínez L., Sauvé Y., Villegas-Pérez M.P., Vidal-Sanz M., Agudo-Barriuso M. Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats. Invest. Ophthalmol. Vis. Sci. 2010, 51:3171-3183.
140. Panda S., Jonas J.B. Decreased photoreceptor count in human eyes with secondary angle-closure glaucoma. Invest. Ophthalmol. Vis. Sci. 1992, 33:2532-2536.
141. Pang I.H., Clark A.F. Rodent models for glaucoma retinopathy and optic neuropathy. J. Glaucoma 2007, 16:483-505.
142. Park K.H., Cozier F., Ong O.C., Caprioli J. Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2001, 42:1522-1530.
143. Parrilla-Reverter G., Agudo M., Sobrado-Calvo P., Salinas-Navarro M., Villegas-Pérez M.P., Vidal-Sanz M. Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crushinjury: a quantitative in vivo study. Exp. Eye Res. 2009, 89:32-41.
144. Parrilla-Reverter G., Agudo M., Nadal-Nicolás F., Alarcón-Martínez L., Jiménez-López M., Salinas-Navarro M., Sobrado-Calvo P., Bernal-Garro J.M., Villegas-Pérez M.P., Vidal-Sanz M. Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study. Vis. Res. 2009, 49:2808-2825.
145. Pease M.E., Hammond J.C., Quigley H.A. Manometric calibration and comparison of TonoLab and TonoPen tonometers in rats with experimental glaucoma and in normal mice. J. Glaucoma 2006, 15:512-519.
146. Pease M.E., Cone F.E., Gelman S., Son J.L., Quigley H.A. Calibration of the TonoLab tonometer in mice with spontaneous or experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2011, 52:858-864.
147. Peinado-Ramón P., Salvador M., Villegas-Pérez M., Vidal-Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest. Ophtalmol. Vis. Sci. 1996, 37:489-500.
148. Perry V.H. Evidence for an amacrine cell system in the ganglion cell layer of the rat retina. Neurosci 1981, 6:931-934.
149. Perry V.H., Henderson Z., Linden R. Postnatal changes in retinal ganglion cells and optic axon populations in the pigmented rat. J. Comp. Neurol. 1983, 219:356-368.
150. Peters L.L., Robledo R.F., Bult C.J., Churchill G.A., Paigen B.J., Svenson K.L. The mouse as a model for human biology: a resource guide for complex trait analysis. Nat. Rev. Genet. 2007, 8:58-69.
151. Quigley H.A., Anderson D.R. The dynamics and location of axonal transport blockade by acute intraocular elevation in primate optic nerve. Invest. Ophthalmol. Vis. Sci. 1976, 15:606-616.
152. Quigley H.A., Anderson D.R. Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Invest. Ophthalmol. Vis. Sci. 1977, 16:640-644.
153. Quigley H.A., Addicks E.M. Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest. Ophthalmol. Vis. Sci. 1980, 19:137-152.
154. Quigley H.A., Hohman R.M. Laser energy levels for trabecular meshwork damage in the primate eye. Invest. Ophthalmol. Vis. Sci. 1983, 24:1305-1307.
155. Quigley H.A., Hohman R.M., Addicks E.M., Massof R.W., Green W.R. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am. J. Ophthalmol. 1983, 95:673-691.
156. Quigley H.A. Glaucoma. The Lancet 2011, 377:1367-1377.
157. Quina L.A., Pak W., Lanier J., Banwait P., Gratwick K., Liu Y., Velasquez T., O'Leary D.D., Goulding M., Turner E.E. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J. Neurosci. 2005, 25:11595-11604.
158. Ramírez A.I., Salazar J.J., de Hoz R., Rojas B., Gallego B.I., Salinas-Navarro M., Alarcón-Martínez L., Ortín-Martínez A., Avilés-Trigueros M., Vidal-Sanz M., Triviño A., Ramírez J.M. Quantification of the effect of different levels of IOP in the astroglia of the rat retina ipsilateral and contralateral to experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2010, 51:5690-5696.
159. Ramón y Cajal S. Estudios sobre la degeneración y regeneración del sistema nervioso 1914, Imprenta de hijos de Nicolás Moya, Madrid, 203-217.
160. Reichstein D., Ren L., Filippopoulos T., Mittag T., Danias J. Apoptotic retinal ganglion cell death in the DBA/2 mouse model of glaucoma. Exp. Eye Res. 2007, 84:13-21.
161. Resnikoff S., Pascolini D., Etya'ale D., Kocur I., Pararajasegaram R., Pokharel G.P., Mariotti S.P. Global data on visual impairment in the year 2002. Bull. World Health Organ 2004, 82:844-851.
162. Richardson P.M., Issa V.M., Shemie S. Regeneration and retrograde degeneration of axons in the rat optic nerve. J. Neurocytol. 1982, 11:949-966.
163. Ruiz-Ederra J., Verkman A.S. Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Exp. Eye Res. 2006, 82:879-884.
164. Salinas-Navarro M., Triviño A., Ramírez A.I., Salazar J.J., Ramírez J.M., Villegas-Pérez M.P., Vidal-Sanz M. Long term effects of laser-induced ocular hypertension: retrograde degeneration of retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 2006, 47. E-Abstract 1560.
165. Salinas-Navarro M., Napankanagas U., Turunen N., Veijola J., Valiente-Soriano F., Villegas-Pérez M.P., Vidal-Sanz M. Effects of acute increase of intraocular pressure in adult pigmented rats: Assessment of the retinal nerve fiber layer (in vivo) and the Retinal Ganglion Cell Population. Invest. Ophthalmol. Vis. Sci. 2008, 49. E-Abstract 5480.
166. Salinas-Navarro M., Mayor-Torroglosa S., Jiménez-López M., Avilés-Trigueros M., Holmes T., Lund R.D., Villegas-Pérez M.P., Vidal-Sanz M. A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats. Vis. Res. 2009, 49:115-126.
167. Salinas-Navarro M., Jiménez-López M., Valiente-Soriano F.J., Alarcón-Martínez L., Avilés-Trigueros M., Mayor S., Holmes T., Lund R.D., Villegas-Pérez M.P., Vidal-Sanz M. Retinal ganglion cell population in adult albino and pigmented mice: a computerised analysis of the entire population and its spatial distribution. Vis. Res. 2009, 49:637-647.
168. Salinas-Navarro M., Alarcón-Martínez L., Valiente-Soriano F.J., Ortín-Martínez A., Jiménez-López M., Avilés-Trigueros M., Villegas-Pérez M.P., de la Villa P., Vidal-Sanz M. Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino swiss mice. Mol. Vis. 2009, 15:2578-2598.
169. Salinas-Navarro M., Alarcón-Martínez L., Valiente-Soriano F.J., Jiménez-López M., Mayor-Torroglosa S., Avilés-Trigueros M., Villegas-Pérez M.P., Vidal-Sanz M. Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration. Exp. Eye Res. 2010, 90:168-183.
170. Salinas-Navarro M., Nadal-Nicolás F., López-Nieto L., Jiménez-López M., Ortín-Martínez A., García-Ayuso D., Galindo-Romero C., Agudo-Barriuso M., Villegas-Pérez M.P., Vidal-Sanz M. Shortly after ocular hypertension there is loss of retinal ganglion cells, but not of other cells of the ganglion cell layer of the retina. Invest. Ophthalmol. Vis. Sci. 2011, 52. E-Abstract 2459.
171. Salvador-Silva M., Vidal-Sanz M., Villegas-Pérez M.P. Microglial cells in the retina of Carassius auratus: effects of optic nerve crush. J. Comp. Neurol. 2000, 417:431-447.
172. Samsel P.A., Kisiswa L., Erichsen J.T., Cross S.D., Morgan J.E. A novel method for the induction of experimental glaucoma using magnetic microspheres. Invest. Ophthalmo.l Vis. Sci. 2011, 52:1671-1675.
173. Sánchez-Migallón M.C., Nadal-Nicolás F.M., Jiménez-López M., Sobrado-Calvo P., Vidal-Sanz M., Agudo-Barriuso M. Brain derived neurotrophic factor maintains Brn3a expression in axotomized rat retinal ganglion cells. Exp. Eye Res. 2011, 92:260-267.
174. Sappington R.M., Carlson B.J., Crish S.D., Calkins D.J. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest. Ophthalmol. Vis. Sci. 2010, 51:207-216.
175. Sawada A., Neufeld A.H. Confirmation of the rat model of chronic, moderately elevated intraocular pressure. Exp. Eye Res. 1999, 69:525-531.
176. Sawai H., Clarke D.B., Kittlerova P., Bray G.M., Aguayo A.J. Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells. J. Neurosci. 1996, 16:3887-3894.
177. Schlamp C.L., Johnson E.C., Li Y., Morrison J.C., Nickells R.W. Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Mol. Vis. 2001, 7:192-201.
178. Schlamp C.L., Li Y., Dietz J.A., Janssen K.T., Nickells R.W. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BioMed Cent. Neurosci. 2006, 7:66.
179. Schmidt S.L., Vitral R.W., Linden R. Effects of prenatal ionizing irradiation on the development of the ganglion cell layer of the mouse retina. Int. J. Dev. Neurosci. 2001, 19:469-473.
180. Schmued L.C., Fallon J.H. Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 1986, 377:147-154.
181. Schmued L.C., Kyriakidis K., Fallon J.H., Ribak C.E. Neurons containing retrogradely transported Fluoro-Gold exhibit a variety of lysosomal profiles: a combined brightfield, fluorescence, and electron microscopic study. J. Neurocytol. 1989, 3:333-343.
182. Schneleben C., Pasquis B., Salinas-Navarro M., Joffre C., Creuzot-Garcher C.P., Vidal-Sanz M., Bron A.M., Bretillon L., Acar N. Graeffes Arch. Clin. Exp. Ophthalmol. 2009, 247:1191-1203.
183. Schori H., Kipnis J., Yoles E., WoldeMussie E., Ruiz G., Wheeler L.A., Schwartz M. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc. Natl. Acad. Sci. U S A 2001, 98:3398-3403.
184. Schumer R.A., Podos S.M. The nerve of glaucoma!. Arch. Ophthalmol. 1994, 112:37-44.
185. Sellés-Navarro I., Villegas-Pérez M.P., Salvador-Silva M., Ruiz-Gómez J.M., Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure- induced ischemia and survival intervals. Invest. Ophtalmol. Vis. Sci. 1996, 37:2002-2014.
186. Sellés-Navarro I., Ellezam B., Fajardo R., Latour M., McKerracher L. Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve. Exp. Neurol. 2001, 167:282-289.
187. Shareef S.R., García-Valenzuela E., Salierno A., Walsh J., Sharma S.C. Chronic ocular hypertension following episcleral venous occlusion in rats. Exp. Eye Res. 1995, 61:379-382.
188. Sieving P.A., Frishman L.J., Steinberg R.H. Scotopic threshold response of proximal retina in cat. J. Neurophysiol. 1986, 56:1049-1061.
189. Silveira L.C., Picanço-Diniz C.W., Oswaldo-Cruz E. The distribution and size of ganglion cells in the retinae of large Amazon rodents. Vis. Neurosci. 1989, 2:221-235.
190. Silveira L.C., Russelakis-Carneiro M., Perry V.H. The ganglion cell response to optic nerve injury in the cat: differential responses revealed by neurofibrillar staining. J. Neurocytol. 1994, 23:75-86.
191. Sobrado-Calvo P., Vidal-Sanz M., Villegas-Pérez M.P. Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor. J. Comp. Neurol. 2007, 501:866-878.
192. Son J.L., Soto I., Oglesby E., Lopez-Roca T., Pease M.E., Quigley H.A., Marsh-Armstrong N. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 2010, 58:780-789.
193. Soto I., Oglesby E., Buckingham B.P., Son J.L., Roberson E.D.O., Steel M.R., Inman D.M., Vetter M.L., Horner P.J., Marsh-Armstrong N. Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J. Neurosci. 2008, 28:548-561.
194. Soto I., Pease M.E., Son J.L., Shi X., Quigley H.A., Marsh-Armstrong N. Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss. Invest. Ophthalmol. Vis. Sci. 2011, 52:434-441.
195. Sternberger N.H., Sternberger L.A., Ulrich J. Aberrant neurofilament phosphorylation in Alzheimer disease. Proc. Natl. Acad. Sci. U S A. 1985, 82:4274-4276.
196. Sugiyama K., Gu Z.B., Kawase C., Yamamoto T., Kitazawa Y. Optic nerve and peripapillary choroidal microvasculature of the Rat Eye. Invest. Ophthalmol. Vis. Sci. 1999, 40:3084-3090.
197. Surgucheva I., Weisman A.D., Goldberg J.L., Shnyra A., Surguchov A. Gamma-synuclein as a marker of retinal ganglion cells. Mol. Vis. 2008, 14:1540-1548.
198. Thanos S., Vidal-Sanz M., Aguayo A.J. The use of rhodamine-B-isothiocyanate (RITC) as an anterograde and retrograde tracer in the adult rat visual system. Brain Res. 1987, 17:317-321.
199. Ueda J., Sawaguchi S., Hanyu T., Yaoeda K., Fukuchi T., Abe H., Ozawa H. Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink.Jpn. J. Ophthalmol. 1998, 42:337-344.
200. Urcola J.H., Hernández M., Vecino E. Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death. Exp. Eye Res. 2006, 83:429-437.
201. Valiente-Soriano F., Salinas-Navarro M., Jiménez-López M., Ortín-Martínez A., Alarcón-Martínez L., Cánovas I., Bernal J.M., Avilés-Trigueros M., Vidal-Sanz M. Effects of elevated intraocular pressure on the retinal ganglion cell population in adult pigmented mice. Invest. Ophthalmol. Vis. Sci. 2008, 49. E-Abstract 5480.
202. Van Buskirk E.M., Cioffi G.A. Glaucomatous optic neuropathy. Am. J. Ophthalmol. 1992, 113:447-452.
203. Veeranna, Lee J.H., Pareek T.K., Jaffee H., Boland B., Vinod K.Y., Amin N., Kulkarni A.B., Pant H.C., Nixon R.A. Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J. Neurochem 2008, 107:35-49.
204. Vidal-Sanz M., Bray G.M., Villegas-Pérez M.P., Thanos S., Aguayo A.J. Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J. Neurosci. 1987, 7:2894-2907.
205. Vidal-Sanz M., Villegas-Pérez M.B., Bray G.M., Aguayo A.J. Persistent retrograde labeling of adult rat retinal ganglion cells with the carbocyanine dye-diI. Exp. Neurol. 1988, 102:92-101.
206. Vidal-Sanz M., Bray G.M., Aguayo A.J. Regenerated synapses persist in the superior colliculus after the regrowth of retinal ganglion cell axons. J. Neurocytol. 1991, 20:940-952.
207. Vidal-Sanz M., Villegas-Pérez M.P., Bray G.M., Aguayo A.J. Use of peripheral nerve grafts to study regeneration after CNS injury. Neuroprotocols 1993, 3:29-33.
208. Vidal-Sanz M., Lafuente M., Sobrado-Calvo P., Sellés-Navarro I., Rodríguez E., Mayor-Torroglosa S., Villegas-Pérez M.P. Death and neuroprotection of retinal ganglion cells after different types of injury. Neurotox. Res. 2000, 2:215-227.
209. Vidal-Sanz M., Lafuente M.P., Mayor S., Miralles de Imperial J., Villegas-Pérez M.P. Retinal ganglion cell death induced by retinal ischemia: neuroprotective effects of two alpha-2 agonists. Surv. Ophtalmol. 2001, 42:262-267.
210. Vidal-Sanz M., Avilés-Trigueros M., Whiteley S.J., Sauvé Y., Lund R.D. Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies. Prog. Brain Res. 2002, 137:443-452.
211. Vidal-Sanz M., Mayor S., Ramírez A.I., Triviño A., Salazar J.J., Ramírez J.M., Salinas M., Villegas-Pérez M.P. Lasering the trabecular meshwork and limbal veins in adult rats results in ocular hypertension and retrograde degeneration of retinal ganglion cells. Ophthalmic Res. 2005, 37. (Abstract).
212. Vidal-Sanz M., De la Villa P., Avilés-Trigueros M., Mayor-Torroglosa S., Salinas-Navarro M., Alarcón-Martínez L., Villegas-Pérez M.P. Neuroprotection of retinal ganglion cell function and their central nervous system targets. Eye 2007, 21:42-45.
213. Villegas-Pérez M.P., Vidal-Sanz M., Bray G.M., Aguayo A.J. Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats. J. Neurosci. 1988, 8:265-280.
214. Villegas-Pérez M.P., Vidal-Sanz M., Rasminsky G.M., Bray G.M., Aguayo A.J. Rapid and protractred phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J. Neurobiol. 1993, 24:23-26.
215. Villegas-Pérez M.P., Vidal-Sanz M., Lund R.D. Mechanism of retinal ganglion cell loss in inherited retinal dystrophy. Neuroreport 1996, 7:1995-1999.
216. Villegas-Pérez M.P., Lawrence J.M., Vidal-Sanz M., Lavail M.M., Lund R.D. Ganglion cell loss in RCS rat retina: a result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J. Comp. Neurol. 1998, 392:58-77.
217. Villegas-Pérez M.P., Mayor-Torroglosa S., Salazar J.J., Ramírez J.M., Triviño A., Ramírez A.I., Salinas M., Miralles J., Vidal-Sanz M. In adult rats lasering of the trabecular meshwork and limbal veins results in ocular hypertension: alteration of retrograde axoplasmic transport. Invest. Ophthalmol. Vis. Sci. 2005, 46. (E-Abstract-1234).
218. Wang S., Villegas-Pérez M.P., Vidal-Sanz M., Lund R.D. Progressive optic axon dystrophy and vacuslar changes in rd mice. Invest. Ophthalmol. Vis. Sci. 2000, 41:537-545.
219. Wang S.W., Mu X., Bowers W.J., Kim D.S., Plas D.J., Crair M.C., Federoff H.J., Gan L., Klein W.H. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 2002, 129:467-477.
220. Wang S., Villegas-Pérez M.P., Holmes T., Lawrence J.M., Vidal-Sanz M., Hurtado-Montalban N., Lund R.D. Evolving neurovascular relationships in the RCS rat with age. Curr. Eye Res. 2003, 27:183-196.
221. Wang W.H., Millar J.C., Pang I.H., Wax M.B., Clark A.F. Noninvasive measurement of rodent intraocular pressure with a rebound tonometer. Invest. Ophthalmol. Vis. Sci. 2005, 46:4617-4621.
222. Wang X., Ng Y.K., Tay S.S. Factors contributing to neuronal degeneration in retinas of experimental glaucomatous rats. J. Neurosci. Res. 2005, 82:674-689.
223. Weishaupt J.H., Klöcker N., Bähr M. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J. Mol. Neurosci. 2005, 26:17-25.
224. Wessendorf M.W. Fluoro-Gold: composition, and mechanism of uptake. Brain Res. 1991, 553:135-148.
225. Whiteley S.J., Sauvé Y., Avilés-Trigueros M., Vidal-Sanz M., Lund R.D. Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed to the pretectum in adult rats. Exp. Neurol. 1998, 154:560-572.
226. WoldeMussie E., Ruiz G., Wijono M., Wheeler L.A. Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2001, 42:2849-2855.
227. WoldeMussie E., Wijono M., Ruiz G. Müller cell response to laser-induced increase in intraocular pressure in rats. Glia 2004, 47:109-119.
228. Wood J.N., Anderton B.H. Monoclonal antibodies to mammalian neurofilaments. Biosci. Rep. 1981, 1:263-268.
229. Yang Z., Quigley H.A., Pease M.E., Yang Y., Qian J., Valenta D., Zack D.J. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Invest. Ophthalmol. Vis. Sci. 2007, 48:5539-5548.
230. Zhou Y., Grinchuk O., Tomarev S.I. Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma. Invest. Ophthalmol. Vis. Sci. 2008, 49:1932-1939.