Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transection

Journal of Glaucoma

Volumn 11, Issue 5, 2002, Pages 396-405

  Levkovitch Verbin, Hana ^a   Martin, Keith R G ^a   Quigley, Harry A ^a   Baumrind, Lisa A ^a   Pease, Mary Ellen ^a   Valenta, Danielle ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Amino acids; Glaucoma; Glutamate; Optic nerve transection; Rat; Retinal ganglion cells

Indexed keywords

AMINO ACID; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; GLAUCOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAOCULAR HYPERTENSION; LASER COAGULATION; NERVE TRANSECTION; NONHUMAN; OPTIC NERVE; OPTIC NERVE LESION; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; TISSUE LEVEL; VITREOUS BODY;

EID: 0036788668     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00061198-200210000-00005     Document Type: Article

References (41)

1. Fonnum F. Glutarnate: a neurotransmitter in mammalian brain. J Neurochem 1984;42:1-11.
2. Massey SC, Miller RF. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol 1990;63:16-30.
3. Eliasof S, Arriza JL, Leighton BH, et al. Localization and function of five glutamate transporters cloned from the salamander retina. Vision Res 1998;38:1443-54.
4. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-34.
5. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994;330:613-22.
6. Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist- a review of preclinical data. Neuropharmacology 1999;38:735-67.
7. Leske MC, Connell AM, Wu SY, et al. Risk factors for open-angle glaucoma. The Barbados Eye Study. Arch Ophthalmol 1995;113:918-24.
8. Tielsch JM. The epidemiology and control of open angle glaucoma: a population-based perspective. Annu Rev Public Health 1996;17:121-36.
9. Quigley HA. Neuronal death in glaucoma. Prog Retin Eye Res 1998;18:39-57.
10. Schwartz M, Yoles E. Self-destructive and self-protective processes in the damaged optic nerve: implications for glaucoma. Invest Ophthalmol Vis Sci 2000;41:349-51.
11. Farkas RH, Grosskreutz CL. Apoptosis, neuroprotection, and retinal ganglion cell death: an overview. Int Ophthabnol Clin 2001;41:111-30.
12. Quigley HA. Nickells RW, Kerrigan LA, et al. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 1995;36:774-86.
13. Garcia-Valenzuela E, Shareef S, Walsh J, et al. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res 1995;61:33-44.
14. Kerrigan LA, Zack DJ, Quigley HA, et al. TUNEL-positive ganglion cells in human primary open angle glaucoma. Arch Ophthalmol 1997;115:1031-5.
15. Lucas DR, Newhouse JP. The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch Ophthalmol 1957;58:193-201.
16. Olney JW. Glutamate-induced retinal degeneration in neonatal mice: electron microscopy of the acutely evolved lesion. J Neuropathol Exp Neurol 1969;28:455-74.
17. Sisk DR, Kuwabara T. Histologic changes in the inner retina of albino rats after intravitreal injection of monosodium L-glutamate. Graefes Arch Clin Exp Ophthalmol 1985;223:250-8.
18. Dreyer EB, Pan ZH, Storm S, et al. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport 1994;5:629-31.
19. Vorwerk CK, Lipton SA, Zurakowski D, et al. Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. Invest Ophthalmol Vis Sci 1996;37:1618-24.
20. Dreyer EB, Zurakowski D, Schumer RA, et al. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996;114:299-305.
21. Brooks DE, Garcia GA, Dreyer EB, et al. Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res 1997;58:864-7.
22. Dkhissi O, Chanut E, Wasowicz M, et al. Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder. Invest Ophthalmol Vis Sci 1999;40:990-5.
23. Yoles E, Schwartz M. Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve. Arch Ophthalmol 1998;116:906-10.
24. Chaudhary P, Ahmed F, Sharma SC. MK801-a neuroprotectant in rat hypertensive eyes. Brain Res 1998;792:154-8.
25. Yoles E. Muller S, Schwartz M. NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush. J Neurotrauma 1997;14:665-75.
26. Honkanen RA, Weaver YK, Baruah S. Vitreous amino acid levels in patients with glaucoma undergoing vitrectomy. Invest Opthalmol Vis Sci (ARVO abstract) 2001;42:S314.
27. Kwon YH, Rickman DW, Baruah S. Vitreous amino acid levels in experimental central artery occlusion in primates. Invest Opthalmol Vis Sci (ARVO abstract) 2001;42:S744.
28. Levkovitch-Verbin H, Quigley H, Kerrigan-Baumrind L, et al. Partial optic nerve transection in monkeys may result in secondary degeneration of retinal ganglion cells. Invest Opthalmol Vis Sci 2001;42:975-82.
29. Levkovitch-Verbin H, Quigley HA, Martin KRG, et al. Translimbal laser photocoagulation to the trabecular meshwork as a model for glaucoma in rats. Invest Opthalmol Vis Sci 2001;43:402-10.
30. Hare W, WoldeMussie E, Lai R, et al. Efficacy and safety of memantine, an NMDA-type open-channel blocker, for the reduction of retinal injury associated with experimental glaucoma in rat and monkey. Surv Ophthalmol 2001;45:S284-9.
31. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
32. Lagreze WA, Knorle R, Bach M, et al. Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci 1998;39:1063-6.
33. 2-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumujlation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther 2001;296:216-23.
34. Rechsteiner M, Rogers SW. PEST sequences and regulation by proteolysis. TIBS 1996;21:267-71.
35. Bodeutsch N, Siebert H, Dermon C, et al. Unilateral injury to the adult rat optic nerve causes multiple cellular responses in the contralateral site. J Neurobiol 1999;38:116-28.
36. Wamsley S, Steffen EA, Gabelt BT, et al. Vitreous glutamate concentration in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci (ARVO abstracts) 2002;43:S2882.
37. Carter-Dawson L, Crawford MLJ, Harwerth RS, et al. Vitreal glutamate concentration in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci 2002;43:2633-7.
38. Harada T, Harada C, Watanabe M, et al. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A 1998;95:4663-6.
39. Naskar R, Vorwerk CK, Dreyer EB. Concurrent downregulation of a glutamate transporter and receptor in glaucoma. Invest Ophthalmol Vis Sci 2000;41:1940-4.
40. Martin KR, Levkovitch-Verbin H, Kerrigan DF, et al. An immunohistochemical study of retinal glutamate transporters in a rat glaucoma model. Invest Ophthalmol Vis Sci (ARVO Abstracts). 2001;42:S511.
41. Vorwerk CK, Naskar R, Schuettauf F, et al. Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. Invest Ophthalmol Vis Sci 2000;41:3615-21.