Brain derived neurotrophic factor maintains Brn3a expression in axotomized rat retinal ganglion cells

Experimental Eye Research

Volumn 92, Issue 4, 2011, Pages 260-267

  Sanchez Migallon M C ^b   Nadal Nicolas F M ^a,b   Jimenez Lopez M ^b   Sobrado Calvo, P ^b   Vidal Sanz, M ^b   Agudo Barriuso, M ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Axotomy; BDNF; Brn3a; RGC; Spatial distribution; Survival

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; FLUOROGOLD; TRANSCRIPTION FACTOR POU4F1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL DENSITY; CELL LABELING; CELL PROTECTION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; IMMUNOFLUORESCENCE; NERVE FIBER TRANSECTION; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RETINA GANGLION CELL; SINGLE DRUG DOSE; WESTERN BLOTTING;

ANIMALS; AXOTOMY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; INTRAVITREAL INJECTIONS; OPTIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS; TRANSCRIPTION FACTOR BRN-3A;

EID: 79952623960     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2011.02.001     Document Type: Article

References (51)

1. Aguayo A.J., Vidal-Sanz M., Villegas-Perez M.P., Bray G.M. Growth and connectivity of axotomized retinal neurons in adult rats with optic nerves substituted by PNS grafts linking the eye and the midbrain. Ann. N. Y. Acad. Sci. 1987, 495:1-9.
2. Agudo M., Perez-Marin M.C., Lonngren U., Sobrado P., Conesa A., Canovas I., Salinas-Navarro M., Miralles-Imperial J., Hallbook F., Vidal-Sanz M. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Mol. Vis. 2008, 14:1050-1063.
3. Agudo M., Perez-Marin M.C., Sobrado-Calvo P., Lonngren U., Salinas-Navarro M., Canovas I., Nadal-Nicolas F.M., Miralles-Imperial J., Hallbook F., Vidal-Sanz M. Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush. Invest. Ophthalmol. Vis. Sci. 2009, 50(1):424-431.
4. Alarcon-Martinez L., de la V., Aviles-Trigueros M., Blanco R., Villegas-Perez M.P., Vidal-Sanz M. Short and long term axotomy-induced ERG changes in albino and pigmented rats. Mol. Vis. 2009, 15:2373-2383.
5. Avilés-Trigueros M., Mayor-Torroglosa S., García-Avilés A., Lafuente M.P., Rodríguez M.E., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine. Exp. Neurol. 2003, 184(2):767-777.
6. Barnstable C.J., Drager U.C. Thy-1 antigen: a ganglion cell specific marker in rodent retina. Neuroscience 1984, 11(4):847-855.
7. Berkelaar M., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 1994, 14(7):4368-4374.
8. Bernstein S.L., Koo J.H., Slater B.J., Guo Y., Margolis F.L. Analysis of optic nerve stroke by retinal Bex expression. Mol. Vis. 2006, 12:147-155.
9. Bray G.M., Villegas-Perez M.P., Vidal-Sanz M., Aguayo A.J. Death and survival of axotomized retinal ganglion cells. Regeneration and Plasticity in the Mammalian Visual System 1992, 29-45. MITT Press. D. Man-Kit Lam, G.M. Bray (Eds.).
10. Bray G.M., Villegas-Perez M.P., Vidal-Sanz M., Carter D.A., Aguayo A.J. Neuronal and nonneuronal influences on retinal ganglion cell survival, axonal regrowth, and connectivity after axotomy. Ann. N. Y Acad. Sci. 1991, 633:214-228.
11. Buckingham B.P., Inman D.M., Lambert W., Oglesby E., Calkins D.J., Steele M.R., Vetter M.L., Marsh-Armstrong N., Horner P.J. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008, 28(11):2735-2744.
12. Chidlow G., Casson R., Sobrado-Calvo P., Vidal-Sanz M., Osborne N.N. Measurement of retinal injury in the rat after optic nerve transection: an RT-PCR study. Mol. Vis. 2005, 11:387-396.
13. Dabin I., Barnstable C.J. Rat retinal Muller cells express Thy-1 following neuronal cell death. Glia 1995, 14(1):23-32.
14. Drager U.C., Olsen J.F. Ganglion cell distribution in the retina of the mouse. Invest. Ophthalmol. Vis. Sci. 1981, 20(3):285-293.
15. Galindo-Romero C., Aviles-Trigueros M., Jimenez-Lopez M., Valiente-Soriano F.J., Nadal-Nicolas F., Nieto-Lopez L., Vidal-Sanz M., Agudo-Barriuso M. Time course of retinal ganglion cell degeneration in adult mice after optic nerve axotomy. IOVS 2010, 51:637.
16. García-Ayuso D., Salinas-Navarro M., Agudo M., Cuenca N., Pinilla I., Vidal-Sanz M., Villegas-Pérez M.P. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp. Eye Res. 2010 Dec, 91(6):800-810.
17. Guo Y., Cepurna W.O., Dyck J.A., Doser T.A., Johnson E.C., Morrison J.C. Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer. Invest. Ophthalmol. Vis. Sci. 2010, 51(6):3003-3018.
18. Jeon C.J., Strettoi E., Masland R.H. The major cell populations of the mouse retina. J. Neurosci. 1998, 18(21):8936-8946.
19. Kobbert C., Apps R., Bechmann I., Lanciego J.L., Mey J., Thanos S. Current concepts in neuroanatomical tracing. Prog. Neurobiol. 2000, 62(4):327-351.
20. Lafuente López-Herrera M.P., Mayor-Torroglosa S., Miralles de Imperial J., Villegas-Pérez M.P., Vidal-Sanz M. Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine. Exp. Neurol. 2002, 178(2):243-258.
21. Linden R., Perry V.H. Massive retinotectal projection in rats. Brain Res. 1983, 272(1):145-149.
22. Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 1994, 91(5):1632-1636.
23. Nadal-Nicolas F.M., Jimenez-Lopez M., Sobrado-Calvo P., Nieto-Lopez L., Canovas-Martinez I., Salinas-Navarro M., Vidal-Sanz M., Agudo M. Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest. Ophthalmol. Vis. Sci. 2009, 50(8):3860-3868.
24. Ortin-Martinez A., Jimenez-Lopez M., Nadal-Nicolas F.M., Salinas-Navarro M., Alarcon-Martinez L., Sauve Y., Villegas-Perez M.P., Vidal-Sanz M., Agudo-Barriuso M. Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats. Invest. Ophthalmol. Vis. Sci. 2010, 51(6):3171-3183.
25. Parrilla-Reverter G., Agudo M., Nadal-Nicolas F., Alarcon-Martinez L., Jimenez-Lopez M., Salinas-Navarro M., Sobrado-Calvo P., Bernal-Garro J.M., Villegas-Perez M.P., Vidal-Sanz M. Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study. Vis. Res. 2009, 49(23):2808-2825.
26. Parrilla-Reverter G., Agudo M., Sobrado-Calvo P., Salinas-Navarro M., Villegas-Perez M.P., Vidal-Sanz M. Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury: a quantitative in vivo study. Exp. Eye Res. 2009, 89(1):32-41.
27. Peinado-Ramon P., Salvador M., Villegas-Perez M.P., Vidal-Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest. Ophthalmol. Vis. Sci. 1996, 37(4):489-500.
28. Perry V.H. Evidence for an amacrine cell system in the ganglion cell layer of the rat retina. Neuroscience 1981, 6(5):931-944.
29. Perry V.H., Henderson Z., Linden R. Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat. J. Comp. Neurol. 1983, 219(3):356-368.
30. Perry V.H., Morris R.J., Raisman G. Is Thy-1 expressed only by ganglion cells and their axons in the retina and optic nerve?. J. Neurocytol. 1984, 13(5):809-824.
31. Quina L.A., Pak W., Lanier J., Banwait P., Gratwick K., Liu Y., Velasquez T., O'Leary D.D., Goulding M., Turner E.E. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J. Neurosci. 2005, 25(50):11595-11604.
32. Salinas-Navarro M., Alarcon-Martinez L., Valiente-Soriano F.J., Jimenez-Lopez M., Mayor-Torroglosa S., Aviles-Trigueros M., Villegas-Perez M.P., Vidal-Sanz M. Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration. Exp. Eye Res. 2010, 90(1):168-183.
33. Salinas-Navarro M., Alarcon-Martinez L., Valiente-Soriano F.J., Ortin-Martinez A., Jimenez-Lopez M., Aviles-Trigueros M., Villegas-Perez M.P., de la V., Vidal-Sanz M. Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice. Mol. Vis. 2009, 15:2578-2598.
34. Salinas-Navarro M., Jimenez-Lopez M., Valiente-Soriano F.J., Alarcon-Martinez L., Aviles-Trigueros M., Mayor S., Holmes T., Lund R.D., Villegas-Perez M.P., Vidal-Sanz M. Retinal ganglion cell population in adult albino and pigmented mice: a computerized analysis of the entire population and its spatial distribution. Vis. Res. 2009, 49(6):637-647.
35. Salinas-Navarro M., Mayor-Torroglosa S., Jimenez-Lopez M., Aviles-Trigueros M., Holmes T.M., Lund R.D., Villegas-Perez M.P., Vidal-Sanz M. A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats. Vis. Res. 2009, 49(1):115-126.
36. Salvador-Silva M., Vidal-Sanz M., Villegas-Perez M.P. Microglial cells in the retina of Carassius auratus: effects of optic nerve crush. J. Comp. Neurol. 2000, 417(4):431-447.
37. Schlamp C.L., Johnson E.C., Li Y., Morrison J.C., Nickells R.W. Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Mol. Vis. 2001, 7:192-201.
38. Sellés-Navarro I., Villegas-Pérez M.P., Salvador-Silva M., Ruiz-Gómez J.M., Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. A quantitative in vivo study. Invest. Ophthalmol. Vis. Sci. 1996, 37(10):2002-2014.
39. Sobrado-Calvo P., Vidal-Sanz M., Villegas-Perez M.P. Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor. J. Comp. Neurol. 2007, 501(6):866-878.
40. Soto I., Oglesby E., Buckingham B.P., Son J.L., Roberson E.D., Steele M.R., Inman D.M., Vetter M.L., Horner P.J., Marsh-Armstrong N. Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J. Neurosci. 2008, 28(2):548-561.
41. Surgucheva I., Weisman A.D., Goldberg J.L., Shnyra A., Surguchov A. Gamma-synuclein as a marker of retinal ganglion cells. Mol. Vis. 2008, 14:1540-1548.
42. Thanos S. Function-dependent labelling of microglial cells by means of carbocyanine dyes in vivo. Clin. Neuropathol. 1993, 12(5):298-301.
43. Thanos S., Vidal-Sanz M., Aguayo A.J. The use of rhodamine-B-isothiocyanate (RITC) as an anterograde and retrograde tracer in the adult rat visual system. Brain Res. 1987, 406(1-2):317-321.
44. Vidal-Sanz M., Aviles-Trigueros M., Whiteley S.J., Sauve Y., Lund R.D. Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies. Prog. Brain Res. 2002, 137:443-452.
45. Vidal-Sanz M., Bray G.M., Villegas-Perez M.P., Thanos S., Aguayo A.J. Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J. Neurosci. 1987, 7(9):2894-2909.
46. Vidal-Sanz M., Lafuente M.P., Mayor S., de Imperial J.M., Villegas-Perez M.P. Retinal ganglion cell death induced by retinal ischemia. neuroprotective effects of two alpha-2 agonists. Surv. Ophthalmol. 2001, 45(Suppl. 3):S261-S267.
47. Vidal-Sanz M., Villegas-Perez M.P., Bray G.M., Aguayo A.J. Persistent retrograde labeling of adult rat retinal ganglion cells with the carbocyanine dye diI. Exp. Neurol. 1988, 102(1):92-101.
48. Villegas-Perez M.P., Vidal-Sanz M., Bray G.M., Aguayo A.J. Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats. J. Neurosci. 1988, 8(1):265-280.
49. Villegas-Perez M.P., Vidal-Sanz M., Rasminsky M., Bray G.M., Aguayo A.J. Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J. Neurobiol. 1993, 24(1):23-36.
50. Weishaupt J.H., Klocker N., Bahr M. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J. Mol. Neurosci. 2005, 26(1):17-25.
51. Whiteley S.J., Sauve Y., Aviles-Trigueros M., Vidal-Sanz M., Lund R.D. Extent and duration of recovered pupillary light reflex following retinal ganglion cell axon regeneration through peripheral nerve grafts directed to the pretectum in adult rats. Exp. Neurol. 1998, 154(2):560-572.