메뉴 건너뛰기




Volumn 12, Issue 3, 2012, Pages 186-196

Nanotech revolution for the Anti-Cancer drug delivery through Blood-Brain-Barrier

Author keywords

Brain delivery; Drug delivery; Drug targeting; Liposomes; Nanoparticles; Tumour

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; ALBUMIN; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CHITOSAN; CREMOPHOR; CYTOTOXIC AGENT; DOXORUBICIN; FOLIC ACID; IRINOTECAN; LIPOSOME; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL; MONOCLONAL ANTIBODY; NANOCARRIER; NANOPARTICLE; PHARMACOLOGICAL BIOMARKER; PHOSPHOLIPID; POLYGLACTIN; POLYLACTIDE; POLYMER; PROTEIN KINASE INHIBITOR; SOLID LIPID NANOPARTICLE; TAXANE DERIVATIVE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID; ZOLEDRONIC ACID;

EID: 84857130085     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800912799277421     Document Type: Review
Times cited : (56)

References (104)
  • 1
    • 35448989290 scopus 로고    scopus 로고
    • Targeting cancer with bugs and liposomes: Ready, aim, fire
    • Cheong, I.; Huang, X.; Thornton, K.; Diaz, L. A.; Zhou, S. Targeting cancer with bugs and liposomes: Ready, aim, fire. Cancer Res. 2007, 67, 9605-9608.
    • (2007) Cancer Res , vol.67 , pp. 9605-9608
    • Cheong, I.1    Huang, X.2    Thornton, K.3    Diaz, L.A.4    Zhou, S.5
  • 2
    • 33644555585 scopus 로고    scopus 로고
    • Cutaneous reactions to chemotherapy and their management
    • Wyatt, A. J.; Leonard, G. D.; Sachs, D. L. Cutaneous reactions to chemotherapy and their management. Am. J. Clin. Dermatol. 2006, 7, 45-63.
    • (2006) Am. J. Clin. Dermatol , vol.7 , pp. 45-63
    • Wyatt, A.J.1    Leonard, G.D.2    Sachs, D.L.3
  • 3
    • 0031665530 scopus 로고    scopus 로고
    • The development of combination therapy involving camptothecins: A review of preclinical and early clinical studies
    • DeJonge, M. J. A.; Sparreboom, A.; Verweij, J. The development of combination therapy involving camptothecins: a review of preclinical and early clinical studies. Cancer Treat. Rev. 1998, 24, 205-220.
    • (1998) Cancer Treat. Rev , vol.24 , pp. 205-220
    • Dejonge, M.J.A.1    Sparreboom, A.2    Verweij, J.3
  • 4
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridinediphosphateglucuronosyltransferase isoform1A1 in the glucuronidation of its active metabolite (SN-28) in human liver microsomes
    • Iyer, L.; King, C. D.; Whitington, P. F.; Green, M. D.; Tephly, T. R.; Coffman, B. L.; Ratain, M. J. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridinediphosphateglucuronosyltransferase isoform1A1 in the glucuronidation of its active metabolite (SN-28) in human liver microsomes. J. Clin. Invest. 1998, 101, 847-854.
    • (1998) J. Clin. Invest , vol.101 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Tephly, T.R.5    Coffman, B.L.6    Ratain, M.J.7
  • 5
    • 67651180631 scopus 로고    scopus 로고
    • Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice
    • Atyabi, F.; Farkhondehfai, A.; Esmaeili, F.; Dinarvand, R. Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice. Acta Pharm. 2009, 59, 133-144.
    • (2009) Acta Pharm , vol.59 , pp. 133-144
    • Atyabi, F.1    Farkhondehfai, A.2    Esmaeili, F.3    Dinarvand, R.4
  • 6
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    • O'Brien, M. E.; Wigler, N.; Inbar, M.; Rosso, R.; Grischke, E.; Santoro, A.; Catane, R.; Kieback, D. G.; Tomczak, P.; Ackland, S. P.; Orlandi, F.; Mellars, L.; Alland, L.; Tendler, C. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann. Oncol. 2004, 15, 440-449.
    • (2004) Ann. Oncol , vol.15 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3    Rosso, R.4    Grischke, E.5    Santoro, A.6    Catane, R.7    Kieback, D.G.8    Tomczak, P.9    Ackland, S.P.10    Orlandi, F.11    Mellars, L.12    Alland, L.13    Tendler, C.14
  • 7
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy
    • Gabizon, A. A. Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 2001, 19, 424-436.
    • (2001) Cancer Invest , vol.19 , pp. 424-436
    • Gabizon, A.A.1
  • 8
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen, T. M.; Cullis, P.R. Drug delivery systems: Entering the mainstream. Science 2004, 303, 1818-1822.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 9
    • 0036148405 scopus 로고    scopus 로고
    • Development of bisphosphonates
    • Fleisch, H. Development of bisphosphonates. Breast Cancer Res. 2002, 4, 30-34.
    • (2002) Breast Cancer Res , vol.4 , pp. 30-34
    • Fleisch, H.1
  • 10
    • 0037304115 scopus 로고    scopus 로고
    • Antitumor effects of bisphosphonates
    • Green, J. R. Antitumor effects of bisphosphonates. Cancer 2003, 97, 840-847.
    • (2003) Cancer , vol.97 , pp. 840-847
    • Green, J.R.1
  • 11
    • 0026619940 scopus 로고
    • Cholesterol and mevalonic acid modulation in cell metabolism and multiplication
    • Soma, M. R.; Corsini, A.; Paoletti, R. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol. Lett. 1992, 64-65.
    • (1992) Toxicol. Lett , pp. 64-65
    • Soma, M.R.1    Corsini, A.2    Paoletti, R.3
  • 12
    • 0242503684 scopus 로고    scopus 로고
    • New insights into the molecular mechanisms of action of bisphosphonates
    • Rogers, M. J. New insights into the molecular mechanisms of action of bisphosphonates. Curr. Pharm. Des. 2003, 9, 2643-2658.
    • (2003) Curr. Pharm. Des , vol.9 , pp. 2643-2658
    • Rogers, M.J.1
  • 13
    • 12944334190 scopus 로고    scopus 로고
    • From molds and macrophages to mevalonate: A decade of progress in understanding the molecular mode of action of bisphosphonates
    • Rogers, M. J. From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates. Calcif. Tissue Int. 2004, 75, 451-461.
    • (2004) Calcif. Tissue Int , vol.75 , pp. 451-461
    • Rogers, M.J.1
  • 14
    • 4644370323 scopus 로고    scopus 로고
    • Crystallographic analysis of CaaXprenyltransferases complexed with substrates defines rules of protein substrate selectivity
    • Reid, T. S.; Terry, K. L.; Casey, P. J.; Beese, L. S. Crystallographic analysis of CaaXprenyltransferases complexed with substrates defines rules of protein substrate selectivity. J. Mol. Biol. 2004, 343, 417-433.
    • (2004) J. Mol. Biol , vol.343 , pp. 417-433
    • Reid, T.S.1    Terry, K.L.2    Casey, P.J.3    Beese, L.S.4
  • 17
    • 34147222698 scopus 로고    scopus 로고
    • R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation
    • Caraglia, M.; Marra, M.; Leonetti, C.; Meo, G.; D'Alessandro, A. M.; Baldi, A.; Santini, D.; Tonini, G.; Bertieri, R.; Zupi, G.; Budillon, A.; Abbruzzese, A. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. J. Cell. Physiol. 2007, 211, 533-543.
    • (2007) J. Cell. Physiol , vol.211 , pp. 533-543
    • Caraglia, M.1    Marra, M.2    Leonetti, C.3    Meo, G.4    D'Alessandro, A.M.5    Baldi, A.6    Santini, D.7    Tonini, G.8    Bertieri, R.9    Zupi, G.10    Budillon, A.11    Abbruzzese, A.12
  • 23
    • 77955305765 scopus 로고    scopus 로고
    • Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells
    • Shmeeda, H.; Amitay, Y.; Gorin, J.; Tzemach, D.; Mak, L.; Ogorka, J.; Kumar, S.; Zhang, J. A.; Gabizon, A. Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells. J. Control. Release 2010, 146, 76-83.
    • (2010) J. Control. Release , vol.146 , pp. 76-83
    • Shmeeda, H.1    Amitay, Y.2    Gorin, J.3    Tzemach, D.4    Mak, L.5    Ogorka, J.6    Kumar, S.7    Zhang, J.A.8    Gabizon, A.9
  • 24
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman, M. W.; Reese, T. S. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 1969, 40, 648-677.
    • (1969) J. Cell Biol , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 25
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese, T. S.; Karnovsky, M. J. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 1967, 34, 207-217.
    • (1967) J. Cell Biol , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 26
    • 0033526158 scopus 로고    scopus 로고
    • Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
    • Bodor, N.; Buchwald, P. Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv. Drug Deliv. Rev. 1999, 36, 229-254.
    • (1999) Adv. Drug Deliv. Rev , vol.36 , pp. 229-254
    • Bodor, N.1    Buchwald, P.2
  • 27
    • 0025143227 scopus 로고
    • Astrocytes induce neural microvascular endothelial cells to form capillary-like structures in vitro
    • Laterra, J.; Guerin, C.; Goldstein, G. W. Astrocytes induce neural microvascular endothelial cells to form capillary-like structures in vitro. J. Cell Physiol. 1990, 144, 204-215.
    • (1990) J. Cell Physiol , vol.144 , pp. 204-215
    • Laterra, J.1    Guerin, C.2    Goldstein, G.W.3
  • 28
    • 0023425237 scopus 로고
    • Tight junctions of brain endothelium in vitro are enhanced by astroglia
    • Tao-Cheng, J. H.; Nagy, Z.; Brightman, M. W. Tight junctions of brain endothelium in vitro are enhanced by astroglia. J. Neurosci. 1987, 7, 3293-3299.
    • (1987) J. Neurosci , vol.7 , pp. 3293-3299
    • Tao-Cheng, J.H.1    Nagy, Z.2    Brightman, M.W.3
  • 29
    • 0029820236 scopus 로고    scopus 로고
    • Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes
    • Gu, J. G.; Nath, A.; Geiger, J. D. Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes. J. Neurochem. 1996, 67, 972-977.
    • (1996) J. Neurochem , vol.67 , pp. 972-977
    • Gu, J.G.1    Nath, A.2    Geiger, J.D.3
  • 30
    • 0034214069 scopus 로고    scopus 로고
    • Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes
    • Decleves, X.; Regina, A.; Laplanche, J. L.; Roux, F.; Boval, B.; Launay, J. M.; Scherrmann, J. M. Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes. J. Neurosci. Res. 2000, 60, 594-601.
    • (2000) J. Neurosci. Res , vol.60 , pp. 594-601
    • Decleves, X.1    Regina, A.2    Laplanche, J.L.3    Roux, F.4    Boval, B.5    Launay, J.M.6    Scherrmann, J.M.7
  • 32
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control. Release 2000, 65, 271-284.
    • (2000) J. Control. Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 35
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
    • Yuan, F.; Dellian, M.; Fukumura, D.; Leunig, M.; Berk, D. A.; Torchilin, V. P.; Jain, R. K. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size. Cancer Res. 1995, 55, 3752- 3756.
    • (1995) Cancer Res , vol.55 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3    Leunig, M.4    Berk, D.A.5    Torchilin, V.P.6    Jain, R.K.7
  • 36
    • 0024994008 scopus 로고
    • Vascular and interstitial barriers to delivery of therapeutic agents in tumors
    • Jain, R. K. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev. 1990, 9, 253-266.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 253-266
    • Jain, R.K.1
  • 38
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain R. K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 1987, 6, 559-593.
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 39
    • 0034873050 scopus 로고    scopus 로고
    • Host factors influencing the preferential localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue
    • Schiffelers, R. M.; Storm, G.; Bakker-Woudenberg, I. A. Host factors influencing the preferential localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue. Pharm. Res. 2001, 18, 780-787.
    • (2001) Pharm. Res , vol.18 , pp. 780-787
    • Schiffelers, R.M.1    Storm, G.2    Bakker-Woudenberg, I.A.3
  • 40
    • 0036644479 scopus 로고    scopus 로고
    • Neutrophil transepithelial migration: Evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration
    • Edens, H. A.; Levi, B. P.; Jaye, D. L.; Walsh, S.; Reaves, T. A.; Turner, J. R.; Nusrat, A.; Parkos, C. A. Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration. J. Immunol. 2002, 169, 476-486.
    • (2002) J. Immunol , vol.169 , pp. 476-486
    • Edens, H.A.1    Levi, B.P.2    Jaye, D.L.3    Walsh, S.4    Reaves, T.A.5    Turner, J.R.6    Nusrat, A.7    Parkos, C.A.8
  • 41
    • 0024551243 scopus 로고
    • Liposomes with prolonged circulation times: Factors affecting uptake by reticuloendothelial and other tissues
    • Allen, T. M.; Hansen, C.; Rutledge, J. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta 1989, 981, 27-35.
    • (1989) Biochim. Biophys. Acta , vol.981 , pp. 27-35
    • Allen, T.M.1    Hansen, C.2    Rutledge, J.3
  • 42
    • 0842279809 scopus 로고
    • Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
    • Gabizon, A.; Papahadjopoulos, D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 6949-6953.
    • (1988) Proc. Natl. Acad. Sci. U.S.A , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 43
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen, T. M.; Hansen, C.; Martin, F.; Redemann, C.; Yau-Young, A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1991, 1066, 29-36.
    • (1991) Biochim. Biophys. Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 45
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • Huwyler, J.; Wu, D.; Pardridge, W.M. Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 14164-14169.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , pp. 14164-14169
    • Huwyler, J.1    Wu, D.2    Pardridge, W.M.3
  • 46
    • 0029585915 scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: Biodistribution and therapeutic efficacy
    • Siegal, T.; Horowitz, A.; Gabizon, A. Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy. J. Neurosurg. 1995, 83, 1029-1037.
    • (1995) J. Neurosurg , vol.83 , pp. 1029-1037
    • Siegal, T.1    Horowitz, A.2    Gabizon, A.3
  • 47
    • 0043268760 scopus 로고    scopus 로고
    • Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis
    • Schmidt, J.; Metselaar, J. M.; Wauben, M. H.; Toyka, K. V.; Storm, G.; Gold, R. Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis. Brain 2003, 126, 1895-1904.
    • (2003) Brain , vol.126 , pp. 1895-1904
    • Schmidt, J.1    Metselaar, J.M.2    Wauben, M.H.3    Toyka, K.V.4    Storm, G.5    Gold, R.6
  • 49
    • 29344443996 scopus 로고    scopus 로고
    • Effect of repetitive administration of Doxorubicin-containing liposomes on plasma pharmacokinetics and drug biodistribution in a rat brain tumor model
    • Arnold, R. D.; Mager, D. E.; Slack, J. E.; Straubinger, R. M. Effect of repetitive administration of Doxorubicin-containing liposomes on plasma pharmacokinetics and drug biodistribution in a rat brain tumor model. Clin. Cancer Res. 2005, 11, 8856-8865.
    • (2005) Clin. Cancer Res , vol.11 , pp. 8856-8865
    • Arnold, R.D.1    Mager, D.E.2    Slack, J.E.3    Straubinger, R.M.4
  • 51
    • 0035984818 scopus 로고    scopus 로고
    • Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxorubicin in brain and other tissues
    • Zara, G. P.; Cavalli, R.; Bargoni, A.; Fundaro, A.; Vighetto, D.; Gasco, M. R. Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: pharmacokinetics and distribution of doxorubicin in brain and other tissues. J. Drug Target 2002, 10, 327-335.
    • (2002) J. Drug Target , vol.10 , pp. 327-335
    • Zara, G.P.1    Cavalli, R.2    Bargoni, A.3    Fundaro, A.4    Vighetto, D.5    Gasco, M.R.6
  • 52
    • 4544240398 scopus 로고    scopus 로고
    • Paclitaxel nanoparticles for the potential treatment of brain tumors
    • Koziara, J. M.; Lockman, P. R.; Allen, D. D.; Mumper, R. J. Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Release 2004, 99, 259-269.
    • (2004) J. Control. Release , vol.99 , pp. 259-269
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 58
    • 33947630376 scopus 로고    scopus 로고
    • Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: Role of apolipoproteins in receptor-mediated endocytosis
    • Kim, H. R.; Andrieux, K.; Gil, S.; Taverna, M.; Chacun, H.; Desmaele, D.; Taran, F.; Georgin, D.; Couvreur, P. Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis. Biomacromolecules 2007, 8, 793-799.
    • (2007) Biomacromolecules , vol.8 , pp. 793-799
    • Kim, H.R.1    Andrieux, K.2    Gil, S.3    Taverna, M.4    Chacun, H.5    Desmaele, D.6    Taran, F.7    Georgin, D.8    Couvreur, P.9
  • 60
    • 0028911362 scopus 로고
    • Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
    • Kreuter, J.; Alyautdin, R. N.; Kharkevich, D. A.; Ivanov, A. A. Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 1995, 674, 171-174.
    • (1995) Brain Res , vol.674 , pp. 171-174
    • Kreuter, J.1    Alyautdin, R.N.2    Kharkevich, D.A.3    Ivanov, A.A.4
  • 61
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Alyautdin, R. N.; Petrov, V. E.; Langer, K.; Berthold, A.; Kharkevich, D. A.; Kreuter, J. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm. Res. 1997, 14, 325-328.
    • (1997) Pharm. Res , vol.14 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    Berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 62
    • 0031962120 scopus 로고    scopus 로고
    • Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: An in situ brain perfusion study
    • Alyautdin, R. N.; Tezikov, E. B.; Ramge, P.; Kharkevich, D. A.; Begley, D. J.; Kreuter, J. Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study. J. Microencapsul. 1998, 15, 67-74.
    • (1998) J. Microencapsul , vol.15 , pp. 67-74
    • Alyautdin, R.N.1    Tezikov, E.B.2    Ramge, P.3    Kharkevich, D.A.4    Begley, D.J.5    Kreuter, J.6
  • 63
    • 33846499122 scopus 로고    scopus 로고
    • Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants
    • Petri, B.; Bootz, A.; Khalansky, A.; Hekmatara, T.; Muller, R.; Uhl, R.; Kreuter, J.; Gelperina, S. Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants. J. Control. Release 2007, 117, 51-58.
    • (2007) J. Control. Release , vol.117 , pp. 51-58
    • Petri, B.1    Bootz, A.2    Khalansky, A.3    Hekmatara, T.4    Muller, R.5    Uhl, R.6    Kreuter, J.7    Gelperina, S.8
  • 64
    • 79960297652 scopus 로고    scopus 로고
    • Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
    • Tian, X. H.; Lin, X. N.; Wei, F.; Feng, W.; Huang, Z. C.; Wang, P.; Ren, L.; Diao, Y. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int. J. Nanomedicine 2011, 6, 445-452,
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 445-452
    • Tian, X.H.1    Lin, X.N.2    Wei, F.3    Feng, W.4    Huang, Z.C.5    Wang, P.6    Ren, L.7    Diao, Y.8
  • 65
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
    • Kreuter, J. Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. J. Nanosci. Nanotechnol. 2004, 4, 484-488.
    • (2004) J. Nanosci. Nanotechnol , vol.4 , pp. 484-488
    • Kreuter, J.1
  • 67
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao, K.; Jiang, X. Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int. J. Pharm. 2006, 310, 213-219.
    • (2006) Int. J. Pharm , vol.310 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 68
    • 78650680356 scopus 로고    scopus 로고
    • Brain targeting with surface-modified poly(d,l-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration
    • Tahara, K.; Miyazaki, Y.; Kawashima, Y.; Kreuter, J.; Yamamoto, H. Brain targeting with surface-modified poly(d,l-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration. Eur. J. Pharm. Biopharm. 2011, 77, 1, 84-88.
    • (2011) Eur. J. Pharm. Biopharm , vol.77 , Issue.1 , pp. 84-88
    • Tahara, K.1    Miyazaki, Y.2    Kawashima, Y.3    Kreuter, J.4    Yamamoto, H.5
  • 70
    • 79952606654 scopus 로고    scopus 로고
    • Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier
    • Kulkarni, S. A.; Feng, S. S. Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier. Nanomedicine(Lond.) 2011, 6, 377-394.
    • (2011) Nanomedicine(Lond.) , vol.6 , pp. 377-394
    • Kulkarni, S.A.1    Feng, S.S.2
  • 71
    • 79955801224 scopus 로고    scopus 로고
    • Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers
    • Wohlfart, S.; Khalansky, A. S.; Gelperina, S.; Maksimenko, O.; Bernreuther, C.; Glatzel, M.; Kreuter, J. Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. PLoS ONE 2011, 6, 19121.
    • (2011) PLoS ONE , vol.6 , pp. 19121
    • Wohlfart, S.1    Khalansky, A.S.2    Gelperina, S.3    Maksimenko, O.4    Bernreuther, C.5    Glatzel, M.6    Kreuter, J.7
  • 72
    • 12344273724 scopus 로고    scopus 로고
    • Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
    • Tsuji, A. Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx. 2005, 2, 54-62.
    • (2005) NeuroRx , vol.2 , pp. 54-62
    • Tsuji, A.1
  • 73
    • 27544434764 scopus 로고    scopus 로고
    • Glucose transport to the brain: A systems model
    • Qutub, A. A.; Hunt, C. A. Glucose transport to the brain: a systems model. Brain Res. Brain Res. Rev. 2005, 49, 595-617.
    • (2005) Brain Res. Brain Res. Rev , vol.49 , pp. 595-617
    • Qutub, A.A.1    Hunt, C.A.2
  • 74
    • 23444461417 scopus 로고    scopus 로고
    • Glucose metabolism and Alzheimer's disease
    • Schubert, D. Glucose metabolism and Alzheimer's disease. Ageing Res. Rev. 2005, 4, 240-257.
    • (2005) Ageing Res. Rev , vol.4 , pp. 240-257
    • Schubert, D.1
  • 75
    • 0021720313 scopus 로고
    • Identification and characterization of the glucose transporter of the blood-brain barrier by cytochalasin B binding and immunological reactivity
    • Dick, A. P.; Harik, S. I.; Klip, A.; Walker, D. M. Identification and characterization of the glucose transporter of the blood-brain barrier by cytochalasin B binding and immunological reactivity. Proc. Natl. Acad. Sci. U.S.A. 1984, 81, 7233-7237.
    • (1984) Proc. Natl. Acad. Sci. U.S.A , vol.81 , pp. 7233-7237
    • Dick, A.P.1    Harik, S.I.2    Klip, A.3    Walker, D.M.4
  • 76
    • 0024300189 scopus 로고
    • Liposome targeting to mouse brain: Mannose as a recognition marker
    • Umezawa, F.; Eto, Y. Liposome targeting to mouse brain: mannose as a recognition marker. Biochem. Biophys. Res. Commun.1988, 153, 1038-1044.
    • (1988) Biochem. Biophys. Res. Commun , vol.153 , pp. 1038-1044
    • Umezawa, F.1    Eto, Y.2
  • 78
    • 0028342454 scopus 로고
    • Upregulation of the low density lipoprotein receptor at the blood-brain barrier: Intercommunications between brain capillary endothelial cells and astrocytes
    • Dehouck, B.; Dehouck, M. P.; Fruchart, J. C.; Cecchelli, R. Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. J. Cell Biol. 1994, 126, 465-473.
    • (1994) J. Cell Biol , vol.126 , pp. 465-473
    • Dehouck, B.1    Dehouck, M.P.2    Fruchart, J.C.3    Cecchelli, R.4
  • 79
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge, W. M.; Eisenberg, J.; Yang, J. Human blood-brain barrier transferrin receptor. Metabolism 1987, 36, 892-895.
    • (1987) Metabolism , vol.36 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 80
    • 0036463371 scopus 로고    scopus 로고
    • Drug and gene targeting to the brain with molecular Trojan horses
    • Pardridge, W. M. Drug and gene targeting to the brain with molecular Trojan horses. Nat. Rev. Drug Discov. 2002, 1, 131-139.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 131-139
    • Pardridge, W.M.1
  • 82
    • 0034734960 scopus 로고    scopus 로고
    • Endogenous carriers and ligands in non-immunogenic site-specific drug delivery
    • Vyas, S. P.; Sihorkar, V. Endogenous carriers and ligands in non-immunogenic site-specific drug delivery. Adv. Drug Deliv. Rev. 2000, 43, 101-164.
    • (2000) Adv. Drug Deliv. Rev , vol.43 , pp. 101-164
    • Vyas, S.P.1    Sihorkar, V.2
  • 83
    • 0036570288 scopus 로고    scopus 로고
    • The role of the transferrin-transferrin-receptor system in drug delivery and targeting
    • Li, H.; Sun, H.; Qian, Z. M. The role of the transferrin-transferrin-receptor system in drug delivery and targeting. Trends Pharmacol. Sci. 2002, 23, 206-209.
    • (2002) Trends Pharmacol. Sci , vol.23 , pp. 206-209
    • Li, H.1    Sun, H.2    Qian, Z.M.3
  • 84
    • 0035095564 scopus 로고    scopus 로고
    • Brain iron transport and neurodegeneration
    • Qian, Z. M.; Shen, X. Brain iron transport and neurodegeneration. Trends Mol. Med. 2001, 7, 103-108.
    • (2001) Trends Mol. Med , vol.7 , pp. 103-108
    • Qian, Z.M.1    Shen, X.2
  • 85
    • 23144445489 scopus 로고    scopus 로고
    • Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil
    • Soni, V.; Kohli, D. V.; Jain, S. K. Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil. J. Drug Target 2005, 13, 245-250.
    • (2005) J. Drug Target , vol.13 , pp. 245-250
    • Soni, V.1    Kohli, D.V.2    Jain, S.K.3
  • 86
    • 3543116768 scopus 로고    scopus 로고
    • Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo
    • Hatakeyama, H.; Akita, H.; Maruyama, K.; Suhara, T.; Harashima, H. Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. Int. J. Pharm. 2004, 281, 25-33.
    • (2004) Int. J. Pharm , vol.281 , pp. 25-33
    • Hatakeyama, H.1    Akita, H.2    Maruyama, K.3    Suhara, T.4    Harashima, H.5
  • 87
    • 79960167888 scopus 로고    scopus 로고
    • Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease
    • Kaili, H.; Yanbin, S.; Wenming, J.; Jiaying, H.; Shixian, H.; Xinguo, J. Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease. Int. J. Pharmaceutics. 2011, 415, 273-283.
    • (2011) Int. J. Pharmaceutics , vol.415 , pp. 273-283
    • Kaili, H.1    Yanbin, S.2    Wenming, J.3    Jiaying, H.4    Shixian, H.5    Xinguo, J.6
  • 88
    • 33847116764 scopus 로고    scopus 로고
    • Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
    • Kreuter, J.; Hekmatara, T.; Dreis, S.; Vogel, T.; Gelperina, S.; Langer, K. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J. Control. Release 2007, 118, 54-58.
    • (2007) J. Control. Release , vol.118 , pp. 54-58
    • Kreuter, J.1    Hekmatara, T.2    Dreis, S.3    Vogel, T.4    Gelperina, S.5    Langer, K.6
  • 90
    • 78650538843 scopus 로고    scopus 로고
    • Targeting the insulin receptor: Nanoparticles for drug delivery across the blood-brain barrier (BBB)
    • Ulbrich, K.; Knobloch, T.; Kreuter, J. Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB). J. Drug Target 2011, 19(2), 125-32.
    • (2011) J. Drug Target , vol.19 , Issue.2 , pp. 125-132
    • Ulbrich, K.1    Knobloch, T.2    Kreuter, J.3
  • 91
    • 0028079865 scopus 로고
    • In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate in brain capillary endothelium
    • Bickel, U.; Kang, Y. S.; Yoshikawa, T.; Pardridge, W. M. In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate in brain capillary endothelium. J. Histochem. Cytochem.1994, 42, 1493-1497.
    • (1994) J. Histochem. Cytochem , vol.42 , pp. 1493-1497
    • Bickel, U.1    Kang, Y.S.2    Yoshikawa, T.3    Pardridge, W.M.4
  • 92
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge, W. M.; Buciak, J. L.; Friden, P. M. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 1991, 259, 66-70.
    • (1991) J. Pharmacol. Exp. Ther , vol.259 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 96
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    • Ulbrich, K.; Hekmatara, T.; Herbert, E.; Kreuter, J. Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur. J. Pharm. Biopharm. 2009, 71, 251-256.
    • (2009) Eur. J. Pharm. Biopharm , vol.71 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 97
    • 0034454980 scopus 로고    scopus 로고
    • Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system
    • Cerletti, A.; Drewe, J.; Fricker, G.; Eberle, A. N.; Huwyler, J. Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system. J. Drug Target 2000, 8, 435-446.
    • (2000) J. Drug Target , vol.8 , pp. 435-446
    • Cerletti, A.1    Drewe, J.2    Fricker, G.3    Eberle, A.N.4    Huwyler, J.5
  • 98
  • 99
    • 0037222013 scopus 로고    scopus 로고
    • Global non-viral gene transfer to the primate brain following intravenous administration
    • Zhang, Y.; Schlachetzki, F.; Pardridge, W. M. Global non-viral gene transfer to the primate brain following intravenous administration. Mol. Ther. 2003, 7, 11-18.
    • (2003) Mol. Ther , vol.7 , pp. 11-18
    • Zhang, Y.1    Schlachetzki, F.2    Pardridge, W.M.3
  • 100
    • 1842636306 scopus 로고    scopus 로고
    • Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter
    • Zhang, Y.; Schlachetzki, F.; Zhang, Y. F.; Boado, R. J.; Pardridge, W. M. Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter. Hum. Gene Ther. 2004, 15, 339-350.
    • (2004) Hum. Gene Ther , vol.15 , pp. 339-350
    • Zhang, Y.1    Schlachetzki, F.2    Zhang, Y.F.3    Boado, R.J.4    Pardridge, W.M.5
  • 104
    • 77953478343 scopus 로고    scopus 로고
    • Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution
    • Tosi, G.; Vergoni, A. V.; Ruozi, B.; Bondioli, L.; Badiali, L.; Rivasi, F.; Costantino, L.; Forni, F.; Vandelli, M. A. Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: in vivo pharmacological evidence and biodistribution. J. Control. Release 2010, 145, 49-57.
    • (2010) J. Control. Release , vol.145 , pp. 49-57
    • Tosi, G.1    Vergoni, A.V.2    Ruozi, B.3    Bondioli, L.4    Badiali, L.5    Rivasi, F.6    Costantino, L.7    Forni, F.8    Vandelli, M.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.