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Volumn 24, Issue 3, 1998, Pages 205-220

The development of combination therapy involving camptothecins: A review of preclinical and early clinical studies

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETABOLITE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; CISPLATIN; DNA TOPOISOMERASE INHIBITOR; FLUOROURACIL; IRINOTECAN; TOPOTECAN;

EID: 0031665530     PISSN: 03057372     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-7372(98)90050-0     Document Type: Article
Times cited : (29)

References (153)
  • 1
    • 0023924786 scopus 로고
    • Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
    • Hsiang YH & Liu LE. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res. 1988; 48: 1722-1726.
    • (1988) Cancer Res. , vol.48 , pp. 1722-1726
    • Hsiang, Y.H.1    Liu, L.E.2
  • 2
    • 0024229066 scopus 로고
    • Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
    • Eng WK, Faucette L, Johnson RK, & Sternglanz R. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol 1988; 34: 755-760.
    • (1988) Mol. Pharmacol , vol.34 , pp. 755-760
    • Eng, W.K.1    Faucette, L.2    Johnson, R.K.3    Sternglanz, R.4
  • 3
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang YH, & Lihou MG, Liu LF. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 1989; 49: 5077-5082.
    • (1989) Cancer Res , vol.49 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 4
    • 0028694108 scopus 로고
    • Mechanisms of resistance to topoisomerase inhibitors
    • Chen AY, & Liu LF. Mechanisms of resistance to topoisomerase inhibitors. Cancer Treat. Res. 1994; 73: 263-281.
    • (1994) Cancer Treat. Res. , vol.73 , pp. 263-281
    • Chen, A.Y.1    Liu, L.F.2
  • 5
    • 0025129894 scopus 로고
    • An early phase II study of CPT-11: A new derivative of camptothecin, for the treatment of leukemia and lymphoma
    • Ohno R, Okada K, Masaoka T et al. An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma. J. Clin. Oncol. 1990; 8: 1907-1912.
    • (1990) J. Clin. Oncol. , vol.8 , pp. 1907-1912
    • Ohno, R.1    Okada, K.2    Masaoka, T.3
  • 6
    • 0026531753 scopus 로고
    • A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
    • Fukuoka M, Niitani H, Suzuki A. et al. A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J. Clin. Oncol. 1992; 10: 16-20.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 16-20
    • Fukuoka, M.1    Niitani, H.2    Suzuki, A.3
  • 7
    • 0026680292 scopus 로고
    • CPT-11: A new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer
    • Masuda N, Fukuoka M, Kusunoki Y. et al. CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer. J. Clin. Oncol. 1992; 10: 1225-1229.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1225-1229
    • Masuda, N.1    Fukuoka, M.2    Kusunoki, Y.3
  • 8
    • 0027194943 scopus 로고
    • Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer
    • Shimada Y, Yoshino M, Wakui A. et al. Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. J. Clin. Oncol. 1993; 11: 909-913.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 909-913
    • Shimada, Y.1    Yoshino, M.2    Wakui, A.3
  • 9
    • 0001657427 scopus 로고
    • A late phase II study of irinotecan (CPT-11) in patients with advanced gastric cancer
    • abstract 584
    • Kambe M, Wakui A, Nakao I. et al. A late phase II study of irinotecan (CPT-11) in patients with advanced gastric cancer. Proc. ASCO 1993; 12: 198 (abstract 584).
    • (1993) Proc. ASCO , vol.12 , pp. 198
    • Kambe, M.1    Wakui, A.2    Nakao, I.3
  • 10
    • 0028839053 scopus 로고
    • Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study
    • Wagener DJ Th, Verdonk HER, Dirix LY. et al. Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study. Ann. Oncol. 1995; 6: 129-132.
    • (1995) Ann. Oncol. , vol.6 , pp. 129-132
    • Wagener, D.J.Th.1    Verdonk, H.E.R.2    Dirix, L.Y.3
  • 11
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB. et al. Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J. Clin. Oncol. 1996; 14: 709-715.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 12
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothenberg ML, Eckardt JR, Kuhn JG. et al. Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J. Clin. Oncol. 1996; 14: 1128-1135.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 1128-1135
    • Rothenberg, M.L.1    Eckardt, J.R.2    Kuhn, J.G.3
  • 13
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY. et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy. J. Clin. Oncol. 1997; 15: 251-260.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 14
    • 0031037244 scopus 로고    scopus 로고
    • Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix
    • Verschraegen CF, Levy T, Kudelka AP. et al. Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix. J. Clin. Oncol. 1997; 15: 625-631.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 625-631
    • Verschraegen, C.F.1    Levy, T.2    Kudelka, A.P.3
  • 15
    • 0030818926 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with metastatic colorectal carcinoma
    • Pitot HC, Wender DB, O'Connell MJ. et al. Phase II trial of irinotecan in patients with metastatic colorectal carcinoma. J. Clin. Oncol. 1997; 15: 2910-2919.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2910-2919
    • Pitot, H.C.1    Wender, D.B.2    O'Connell, M.J.3
  • 16
    • 0028147296 scopus 로고
    • Phase II study of topotecan in metastatic non-small-cell lung cancer
    • Lynch ThJ Jr, Kalish L, Strauss G. et al. Phase II study of topotecan in metastatic non-small-cell lung cancer. J. Clin. Oncol. 1994; 12: 347-352.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 347-352
    • Lynch Jr., Th.1    Kalish, L.2    Strauss, G.3
  • 17
    • 0028829131 scopus 로고
    • Topotecan in colorectal cancer: A phase II study of the EORTC early clinical trials group
    • Creemers GJ, Wanders J, Gamucci T. et al. Topotecan in colorectal cancer: A phase II study of the EORTC early clinical trials group. Ann. Oncol. 1995; 6: 844-846.
    • (1995) Ann. Oncol. , vol.6 , pp. 844-846
    • Creemers, G.J.1    Wanders, J.2    Gamucci, T.3
  • 18
    • 0004484604 scopus 로고    scopus 로고
    • Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy
    • Perez-Soler R, Fossella FV, Glisson BS. et al. Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy. J. Clin. Oncol 1996; 14: 503-513.
    • (1996) J. Clin. Oncol , vol.14 , pp. 503-513
    • Perez-Soler, R.1    Fossella, F.V.2    Glisson, B.S.3
  • 19
    • 9244247616 scopus 로고    scopus 로고
    • Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma
    • Kudelka AP, Tresukosol D, Edwards CL. et al Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma. J. Clin. Oncol 1996; 14: 1552-1557.
    • (1996) J. Clin. Oncol , vol.14 , pp. 1552-1557
    • Kudelka, A.P.1    Tresukosol, D.2    Edwards, C.L.3
  • 20
    • 0029915134 scopus 로고    scopus 로고
    • Phase II study of topotecan in patients with recurrent malignant glioma
    • Macdonald D, Cairncross G, Stewart D. et al. Phase II study of topotecan in patients with recurrent malignant glioma. Ann. Oncol. 1996; 7: 205-207.
    • (1996) Ann. Oncol. , vol.7 , pp. 205-207
    • Macdonald, D.1    Cairncross, G.2    Stewart, D.3
  • 21
    • 0029790139 scopus 로고    scopus 로고
    • Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: An Eastern Cooperative Oncology Group trial
    • Schiller JH, Kim K-M, Hutson P. et al. Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: an Eastern Cooperative Oncology Group trial. J. Clin. Oncol. 1996; 14: 2345-2352.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2345-2352
    • Schiller, J.H.1    Kim, K.-M.2    Hutson, P.3
  • 22
    • 9544234452 scopus 로고    scopus 로고
    • Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer
    • Creemers GJ, Gerrits CJH, Schellens JHM. et al. Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer. J. Clin. Oncol. 1996; 14: 2540-2545.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2540-2545
    • Creemers, G.J.1    Gerrits, C.J.H.2    Schellens, J.H.M.3
  • 23
    • 0000943873 scopus 로고
    • Phase II study of topotecan in advanced head and neck cancer: Identification of an active new agent
    • abstract 905
    • Robert F, Wheeler RH, Moltrop DC, Greene P. & Chen, S. Phase II study of topotecan in advanced head and neck cancer: Identification of an active new agent. Proc. ASCO 1994; 13: 281 (abstract 905).
    • (1994) Proc. ASCO , vol.13 , pp. 281
    • Robert, F.1    Wheeler, R.H.2    Moltrop, D.C.3    Greene, P.4    Chen, S.5
  • 24
    • 0029758947 scopus 로고    scopus 로고
    • Treatment of patients with small-cell lung cancer refractory to etoposide and cis-platin with the topoisomerase I poison topotecan
    • Perez-Soler R, Glisson BS, Lee JS. et al Treatment of patients with small-cell lung cancer refractory to etoposide and cis-platin with the topoisomerase I poison topotecan. J. Clin. Oncol. 1996; 14: 2785-2790.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2785-2790
    • Perez-Soler, R.1    Glisson, B.S.2    Lee, J.S.3
  • 25
    • 10544229791 scopus 로고    scopus 로고
    • Topotecan an active drug in the second-line treatment of epithelial ovarian cancer: Results of a large European phase II study
    • Creemers GJ, Bolis G, Gore M. et al. Topotecan an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study. J. Clin. Oncol. 1996; 14: 3056-3061.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 3056-3061
    • Creemers, G.J.1    Bolis, G.2    Gore, M.3
  • 26
    • 0002887514 scopus 로고    scopus 로고
    • Phase II study of topotecan in patients with squamous carcinoma of the lung previously untreated with chemotherapy
    • abstract 1619
    • Perez-Soler R, Khuri F, Pisters KM. et al. Phase II study of topotecan in patients with squamous carcinoma of the lung previously untreated with chemotherapy. Proc. ASCO 1997; 16: 450a (abstract 1619).
    • (1997) Proc. ASCO , vol.16
    • Perez-Soler, R.1    Khuri, F.2    Pisters, K.M.3
  • 27
    • 0000391321 scopus 로고    scopus 로고
    • Efficacy of topotecan in advanced epithelial ovarian cancer after failure of platinum and paclitaxel: International topotecan study group trial
    • abstract 763
    • Gordon A, Bookman M, Malmstrom H. et al. Efficacy of topotecan in advanced epithelial ovarian cancer after failure of platinum and paclitaxel: international topotecan study group trial. Proc. ASCO 1996; 15: 282 (abstract 763).
    • (1996) Proc. ASCO , vol.15 , pp. 282
    • Gordon, A.1    Bookman, M.2    Malmstrom, H.3
  • 28
    • 0003326033 scopus 로고    scopus 로고
    • Topotecan window in patients with rhabdomyosarcoma (RMS): An IRSG study
    • abstract 1837
    • Vietti T, Crist W, Ruby E. et al. Topotecan window in patients with rhabdomyosarcoma (RMS): an IRSG study. Proc. ASCO 1997; 16: 510a (abstract 1837).
    • (1997) Proc. ASCO , vol.16
    • Vietti, T.1    Crist, W.2    Ruby, E.3
  • 29
    • 0030913459 scopus 로고    scopus 로고
    • Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: A phase II study in patients with refractory and sensitive disease
    • Ardizzoni A, Hansen H, Dombernowsky P. et al. Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. J. Clin. Oncol. 1997; 15: 2090-2096.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2090-2096
    • Ardizzoni, A.1    Hansen, H.2    Dombernowsky, P.3
  • 31
    • 0028006314 scopus 로고
    • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human rumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
    • Husain I, Mohler JL, Seigler HF. & Besterman JF. Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human rumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Res. 1994; 54: 539-546.
    • (1994) Cancer Res. , vol.54 , pp. 539-546
    • Husain, I.1    Mohler, J.L.2    Seigler, H.F.3    Besterman, J.F.4
  • 32
    • 0024358188 scopus 로고
    • DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
    • Giovanella BC, Stehlin JS, Wall ME. et al. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 1989; 24: 1046-1048.
    • (1989) Science , vol.24 , pp. 1046-1048
    • Giovanella, B.C.1    Stehlin, J.S.2    Wall, M.E.3
  • 33
    • 0026326003 scopus 로고
    • P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy
    • Van der Zee AGJ, Hollema H, de Jong S. et al. P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy. Cancer Res. 1991; 51: 5915-5920.
    • (1991) Cancer Res. , vol.51 , pp. 5915-5920
    • Van Der Zee, A.G.J.1    Hollema, H.2    De Jong, S.3
  • 34
    • 0001074068 scopus 로고
    • Tissue expression of topoisomerase I and II in digestive tract cancers and adjacent normal tissues
    • abstract 2603
    • Hirabayashi N, Kim R, Nishiyama M. et al. Tissue expression of topoisomerase I and II in digestive tract cancers and adjacent normal tissues. Proc. AACR 1992; 33: 436 (abstract 2603).
    • (1992) Proc. AACR , vol.33 , pp. 436
    • Hirabayashi, N.1    Kim, R.2    Nishiyama, M.3
  • 35
    • 0029047211 scopus 로고
    • Inhibition of cis-diamminedichloroplatinum (U)-induced DNA interstrand cross-link removal by 7-ethyl-10-hydroxy-camptothecin in HST-1 human squamous-carcinoma cells
    • Masumoto N, Nakano S, Esaki T, Fujishima H, Tatsumoto T. & Niho Y. Inhibition of cis-diamminedichloroplatinum (U)-induced DNA interstrand cross-link removal by 7-ethyl-10-hydroxy-camptothecin in HST-1 human squamous-carcinoma cells. Int. J. Cancer 1995; 62: 70-75.
    • (1995) Int. J. Cancer , vol.62 , pp. 70-75
    • Masumoto, N.1    Nakano, S.2    Esaki, T.3    Fujishima, H.4    Tatsumoto, T.5    Niho, Y.6
  • 36
    • 0024532122 scopus 로고
    • Inhibition of potentially lethal DNA damage repair in human tumor cells by β-Lapachone, an activator of topoisomerase I
    • Boothman DA, Trask DK. & Pardee AB. Inhibition of potentially lethal DNA damage repair in human tumor cells by β-Lapachone, an activator of topoisomerase I. Cancer Res. 1989; 49: 605-612.
    • (1989) Cancer Res. , vol.49 , pp. 605-612
    • Boothman, D.A.1    Trask, D.K.2    Pardee, A.B.3
  • 37
    • 0343928169 scopus 로고    scopus 로고
    • Regulation of topoisomerase I activity following DNA damage: Evidence for a topoisomerase I complex
    • abstract 1214
    • Rumbos H. & Grosovsky A. Regulation of topoisomerase I activity following DNA damage: evidence for a topoisomerase I complex. Proc. AACR 1997; 38:181 (abstract 1214).
    • (1997) Proc. AACR , vol.38 , pp. 181
    • Rumbos, H.1    Grosovsky, A.2
  • 38
    • 0030068657 scopus 로고    scopus 로고
    • Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells
    • Fukuda M, Nishio K, Kanzawa F. et al. Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells. Cancer Res 1996; 56: 789-793.
    • (1996) Cancer Res , vol.56 , pp. 789-793
    • Fukuda, M.1    Nishio, K.2    Kanzawa, F.3
  • 39
    • 0003164399 scopus 로고    scopus 로고
    • Down-regulation of topoisomerase I induced by cisplatin
    • abstract 99
    • Aoe K, Kiura K, Ueoka H. et al. Down-regulation of topoisomerase I induced by cisplatin. Proc. AACR 1997; 38: 15 (abstract 99).
    • (1997) Proc. AACR , vol.38 , pp. 15
    • Aoe, K.1    Kiura, K.2    Ueoka, H.3
  • 40
    • 0003243748 scopus 로고    scopus 로고
    • Remarkable synergistic interaction between camptothecin analogs and cisplatin against human esophageal cancer cell lines
    • abstract 101
    • Takiyama I, Terashima M, Ikeda K. et al. Remarkable synergistic interaction between camptothecin analogs and cisplatin against human esophageal cancer cell lines. Proc. AACR 1997; 38: 15 (abstract 101).
    • (1997) Proc. AACR , vol.38 , pp. 15
    • Takiyama, I.1    Terashima, M.2    Ikeda, K.3
  • 41
    • 0031965435 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitro
    • Ma J, Maliepaard M, Nooter K. et al. Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitro. Cancer Chemother. Pharmacol. 1998; 41: 307-316.
    • (1998) Cancer Chemother. Pharmacol. , vol.41 , pp. 307-316
    • Ma, J.1    Maliepaard, M.2    Nooter, K.3
  • 43
    • 0343492426 scopus 로고
    • CPT-11 cisplatin: An effective preclinical combination in the therapy of advanced human bladder cancer (TCC)
    • abstract 1605
    • Keane T, McGuire W, Petros J, Sun C. & Graham S Jr CPT-11 cisplatin: an effective preclinical combination in the therapy of advanced human bladder cancer (TCC). Proc. ASCO 1995; 14: 491 (abstract 1605).
    • (1995) Proc. ASCO , vol.14 , pp. 491
    • Keane, T.1    McGuire, W.2    Petros, J.3    Sun, C.4    Graham Jr., S.5
  • 44
    • 0026587170 scopus 로고
    • Effects of CPT-11 in combination with other anti-cancer agents in culture
    • Kano, Y, Suzuki, K., Akutsu, M. et al. Effects of CPT-11 in combination with other anti-cancer agents in culture. Int. J. Cancer 1992; 50: 604-610.
    • (1992) Int. J. Cancer , vol.50 , pp. 604-610
    • Kano, Y.1    Suzuki, K.2    Akutsu, M.3
  • 45
    • 0025118047 scopus 로고
    • Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells
    • Katz EJ, Vick JS, Kling KM, Andrews PA. & Howell SB. Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells. Eur. J. Cancer 1990; 26: 724-727.
    • (1990) Eur. J. Cancer , vol.26 , pp. 724-727
    • Katz, E.J.1    Vick, J.S.2    Kling, K.M.3    Andrews, P.A.4    Howell, S.B.5
  • 46
    • 0026600884 scopus 로고
    • Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice
    • Kim R, Hirabayashi N, Nishiyama M, Jinushi K, Toge T. & Okada K. Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice. Int. J. Cancer 1992; 50: 760-766.
    • (1992) Int. J. Cancer , vol.50 , pp. 760-766
    • Kim, R.1    Hirabayashi, N.2    Nishiyama, M.3    Jinushi, K.4    Toge, T.5    Okada, K.6
  • 47
    • 0029945885 scopus 로고    scopus 로고
    • Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines
    • Kaufmann SH, Peereboom D, Buckwalter CA. et al. Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines. J. Natl. Cancer Inst. 1996; 88: 734-741.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 734-741
    • Kaufmann, S.H.1    Peereboom, D.2    Buckwalter, C.A.3
  • 48
    • 0028153260 scopus 로고
    • Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
    • Chou T-C, Motzer RJ, Tong Y. & Bosl GJ. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J. Natl. Cancer Inst. 1994; 86: 1517-1524.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1517-1524
    • Chou, T.-C.1    Motzer, R.J.2    Tong, Y.3    Bosl, G.J.4
  • 50
    • 10544249871 scopus 로고    scopus 로고
    • Sequences of topotecan and cisplatin: Phase I, pharmacologic, and in vitro studies to examine sequence dependence
    • Rowinsky EK, Kaufmann SH, Baker SD. et al. Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence. J. Clin. Oncol. 1996; 14: 3074-3084.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 3074-3084
    • Rowinsky, E.K.1    Kaufmann, S.H.2    Baker, S.D.3
  • 51
    • 0001201052 scopus 로고    scopus 로고
    • In vivo combination chemotherapy evaluations of topotecan with cisplatin and temozolomide
    • abstract 1988
    • Waud WR, Rubinstein LV, Kalyandrug S, Plowman J. & Alley MC. In vivo combination chemotherapy evaluations of topotecan with cisplatin and temozolomide. Proc. AACR 1996; 37: 292 (abstract 1988).
    • (1996) Proc. AACR , vol.37 , pp. 292
    • Waud, W.R.1    Rubinstein, L.V.2    Kalyandrug, S.3    Plowman, J.4    Alley, M.C.5
  • 52
    • 4243905396 scopus 로고    scopus 로고
    • In vivo evaluation of the irinotecan-oxaliplatin combination
    • abstract 793
    • Bissery MC, Vrignaud P. & Lavelle F. In vivo evaluation of the irinotecan-oxaliplatin combination. Proc. ECCO 1997; 33: S177 (abstract 793).
    • (1997) Proc. ECCO , vol.33
    • Bissery, M.C.1    Vrignaud, P.2    Lavelle, F.3
  • 53
    • 0001385726 scopus 로고    scopus 로고
    • Oxaliplatin (LOHP) and cisplatin (CDDP) in combination with 5FU, specific thymidylate synthase (TS) inhibitors (AG337, ZD694) and topoisomerase I (Topo-I) inhibitors (SN38, CPT-11), in human colonic, ovarian and breast cancers
    • abstract 1981
    • Raymond E, Djelloul S, Buquet-Fagot C. et al. Oxaliplatin (LOHP) and cisplatin (CDDP) in combination with 5FU, specific thymidylate synthase (TS) inhibitors (AG337, ZD694) and topoisomerase I (Topo-I) inhibitors (SN38, CPT-11), in human colonic, ovarian and breast cancers. Proc. AACR 1996; 37: 291 (abstract 1981).
    • (1996) Proc. AACR , vol.37 , pp. 291
    • Raymond, E.1    Djelloul, S.2    Buquet-Fagot, C.3
  • 56
    • 0030698003 scopus 로고    scopus 로고
    • Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps
    • Pourquier P, Pilon AA, Kohlhagen G, Mazumder A, Sharma A. & Pommier Y. Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. J. Biol. Chem. 1997; 272: 26441-26447.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26441-26447
    • Pourquier, P.1    Pilon, A.A.2    Kohlhagen, G.3    Mazumder, A.4    Sharma, A.5    Pommier, Y.6
  • 57
    • 0027082880 scopus 로고
    • CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer
    • Masuda N, Fukuoka M, Takada M. et al. CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer. J. Clin. Oncol. 1992; 10: 1775-1780.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1775-1780
    • Masuda, N.1    Fukuoka, M.2    Takada, M.3
  • 58
    • 0027372606 scopus 로고
    • Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer
    • Masuda N, Fukuoka M, Kudoh S. et al. Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer. Br. J. Cancer 1993; 68: 777-782.
    • (1993) Br. J. Cancer , vol.68 , pp. 777-782
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 59
    • 0011811413 scopus 로고
    • CPT-11 Study Group on Gynecologic Malignancy. Phase I study of irinotecan (CPT-11) in combination with cisplatin (CDDP) on cervical carcinoma
    • abstract 856
    • Sugiyama T, Takeuchi S, Noda K, & Yakushiji M. CPT-11 Study Group on Gynecologic Malignancy. Phase I study of irinotecan (CPT-11) in combination with cisplatin (CDDP) on cervical carcinoma. Proc. ASCO 1994; 13: 268 (abstract 856).
    • (1994) Proc. ASCO , vol.13 , pp. 268
    • Sugiyama, T.1    Takeuchi, S.2    Noda, K.3    Yakushiji, M.4
  • 60
    • 0010257868 scopus 로고    scopus 로고
    • Phase I study of irinotecan (CPT-11) and cisplatin (CDDP) by divided administration in patients with non-small cell lung cancer (NSCLC)
    • abstract 1169
    • Kobayashi K, Soma T, Shinbara A. et al. Phase I study of irinotecan (CPT-11) and cisplatin (CDDP) by divided administration in patients with non-small cell lung cancer (NSCLC). Proc. ASCO 1996; 15: 388 (abstract 1169).
    • (1996) Proc. ASCO , vol.15 , pp. 388
    • Kobayashi, K.1    Soma, T.2    Shinbara, A.3
  • 61
    • 0031055829 scopus 로고    scopus 로고
    • Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer
    • Shirao K, Shimada Y, Kondo H. et al. Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer. J. Clin. Oncol. 1997; 15:921-927.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 921-927
    • Shirao, K.1    Shimada, Y.2    Kondo, H.3
  • 62
    • 0010295188 scopus 로고    scopus 로고
    • A phase I study of irinotecan (CPT-11) and cisplatin (CDDP) in advanced lung cancer (ED-SCLC and IIIB/IV-NSCLC)
    • abstract 1154
    • Ueoka H, Tabata M, Shibayama T. et al. A phase I study of irinotecan (CPT-11) and cisplatin (CDDP) in advanced lung cancer (ED-SCLC and IIIB/IV-NSCLC). Proc. ASCO 1996; 15: 385 (abstract 1154).
    • (1996) Proc. ASCO , vol.15 , pp. 385
    • Ueoka, H.1    Tabata, M.2    Shibayama, T.3
  • 63
    • 0031015720 scopus 로고    scopus 로고
    • A phase I study of irinotecan and infusional cisplatin for advanced non-small-cell lung cancer
    • Mori K, Ohnishi T, Yokoyama K. & Tominaga K. A phase I study of irinotecan and infusional cisplatin for advanced non-small-cell lung cancer. Cancer Chemother. Pharmacol. 1997; 39: 327-332.
    • (1997) Cancer Chemother. Pharmacol. , vol.39 , pp. 327-332
    • Mori, K.1    Ohnishi, T.2    Yokoyama, K.3    Tominaga, K.4
  • 64
    • 7144245608 scopus 로고    scopus 로고
    • Phase I study of weekly cisplatin (CDDP) plus irinotecan (CPT-11) in patients (PTS) with advanced solid tumors
    • abstract 1540
    • Saltz L, Kanowitz J, Kelsen D. et al. Phase I study of weekly cisplatin (CDDP) plus irinotecan (CPT-11) in patients (PTS) with advanced solid tumors. Proc. ASCO 1996; 15: 484 (abstract 1540).
    • (1996) Proc. ASCO , vol.15 , pp. 484
    • Saltz, L.1    Kanowitz, J.2    Kelsen, D.3
  • 65
    • 0028175150 scopus 로고
    • Phase I study of irinotecan and cisplatin with granulocyte colony-stimulating factor support for advanced non-small-cell lung cancer
    • Masuda N, Fukuoka M, Kudoh S. et al. Phase I study of irinotecan and cisplatin with granulocyte colony-stimulating factor support for advanced non-small-cell lung cancer. J. Clin. Oncol 1994; 12: 90-96.
    • (1994) J. Clin. Oncol , vol.12 , pp. 90-96
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 66
    • 0031106353 scopus 로고    scopus 로고
    • A phase I study of irinotecan and infusional cisplatin with recombinant human granulocyte colony-stimulating factor support in the treatment of advanced non-small cell lung cancer
    • Mori K, Hirose T, Machida S, Yokoyama K. & Tominaga K. A phase I study of irinotecan and infusional cisplatin with recombinant human granulocyte colony-stimulating factor support in the treatment of advanced non-small cell lung cancer. Eur. J. Cancer 1997; 33: 503-505.
    • (1997) Eur. J. Cancer , vol.33 , pp. 503-505
    • Mori, K.1    Hirose, T.2    Machida, S.3    Yokoyama, K.4    Tominaga, K.5
  • 67
    • 0029902106 scopus 로고    scopus 로고
    • Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliairy index and intestinal toxicity
    • Mick R, Gupta E, Vokes EE, & Retain MJ. Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliairy index and intestinal toxicity. J. Clin. Oncol. 1996; 14: 2012-2019.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2012-2019
    • Mick, R.1    Gupta, E.2    Vokes, E.E.3    Retain, M.J.4
  • 68
    • 0001494498 scopus 로고
    • Clinical pharmacological evaluation of CPT-11 and cisplatin (CDDP) in patients with small cell lung cancer (SCLC)
    • abstract 1470
    • Sumiyoshi H, Fujiwara Y, Ohoshi N, Egusa Y, Yamaoka N, & Yamakido M. Clinical pharmacological evaluation of CPT-11 and cisplatin (CDDP) in patients with small cell lung cancer (SCLC). Proc. ASCO 1995; 14: 457 (abstract 1470).
    • (1995) Proc. ASCO , vol.14 , pp. 457
    • Sumiyoshi, H.1    Fujiwara, Y.2    Ohoshi, N.3    Egusa, Y.4    Yamaoka, N.5    Yamakido, M.6
  • 69
  • 70
    • 0025851286 scopus 로고
    • Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer
    • Negoro S, Fukuoka M, Masuda N. et al. Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer. J. Natl. Cancer Inst. 1991; 83: 1164-1168.
    • (1991) J. Natl. Cancer Inst. , vol.83 , pp. 1164-1168
    • Negoro, S.1    Fukuoka, M.2    Masuda, N.3
  • 71
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients
    • De Forni M, Bugat R, Chabot GG. et al. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res. 1994; 54: 4347-4354.
    • (1994) Cancer Res. , vol.54 , pp. 4347-4354
    • De Forni, M.1    Bugat, R.2    Chabot, G.G.3
  • 72
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
    • Chabot GG, Abigerges D, Catimel G. et al. Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann. Oncol. 1995; 6: 141-151.
    • (1995) Ann. Oncol. , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 73
    • 0028357591 scopus 로고
    • Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-campothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer
    • Shinkai T, Arioka H, Eguchi K. et al. Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-campothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer. 1994; Cancer Res. 54: 2636-2642.
    • (1994) Cancer Res. , vol.54 , pp. 2636-2642
    • Shinkai, T.1    Arioka, H.2    Eguchi, K.3
  • 74
    • 4243274953 scopus 로고    scopus 로고
    • Phase I dose escalation study of carboplatin (CBDCA) and irinotecan (CPT-11)
    • abstract 890
    • Sugiura S, Saka H, Ando M. et al. Phase I dose escalation study of carboplatin (CBDCA) and irinotecan (CPT-11). Proc. ASCO 1997; 16: 252a (abstract 890).
    • (1997) Proc. ASCO , vol.16
    • Sugiura, S.1    Saka, H.2    Ando, M.3
  • 75
    • 0345505283 scopus 로고
    • A combination phase-I-II study of carboplatin/irinotecan plus G-CSF with the Calvert equation in patients with advanced non-small cell lung cancer (NSCLC)
    • abstract 1150
    • Okamoto H, Nagatomo A, Kunitoh H, & Watanabe K. A combination phase-I-II study of carboplatin/irinotecan plus G-CSF with the Calvert equation in patients with advanced non-small cell lung cancer (NSCLC). Proc. ASCO 1995; 14: 373 (abstract 1150).
    • (1995) Proc. ASCO , vol.14 , pp. 373
    • Okamoto, H.1    Nagatomo, A.2    Kunitoh, H.3    Watanabe, K.4
  • 76
    • 85030349921 scopus 로고    scopus 로고
    • Oxaliplatin (L-OHP)/CPT-11 combination: Phase I study, preliminary results of an active combination in colorectal cancer (CRC)
    • abstract 96
    • Cvitkovic E, Wasserman E, Goldwasser F. et al. Oxaliplatin (L-OHP)/CPT-11 combination: phase I study, preliminary results of an active combination in colorectal cancer (CRC). In: Proc. 8th Conference on DNA Topoisomerase, 1997, abstract 96.
    • (1997) Proc. 8th Conference on DNA Topoisomerase
    • Cvitkovic, E.1    Wasserman, E.2    Goldwasser, F.3
  • 77
    • 0343789766 scopus 로고    scopus 로고
    • Final results of the pharmacokinetic study of both CPT-11 (C) and LOHP (L) in combination during a phase I trial in gastrointestinal cancer patients
    • abstract 778
    • Lokiec F, Wasserman E, Cvitkovic E. et al. Final results of the pharmacokinetic study of both CPT-11 (C) and LOHP (L) in combination during a phase I trial in gastrointestinal cancer patients. Proc. ASCO 1998; 17: 202a (abstract 778).
    • (1998) Proc. ASCO , vol.17
    • Lokiec, F.1    Wasserman, E.2    Cvitkovic, E.3
  • 78
    • 0030720766 scopus 로고    scopus 로고
    • Phase I study of daily times five topotecan and single injection of cisplatin in patients with previously untreated non-small-cell lung carinoma
    • Raymond E, Burris HA, Rowinsky EK. et al. Phase I study of daily times five topotecan and single injection of cisplatin in patients with previously untreated non-small-cell lung carinoma. Ann. Oncol. 1997; 8: 1003-1008.
    • (1997) Ann. Oncol. , vol.8 , pp. 1003-1008
    • Raymond, E.1    Burris, H.A.2    Rowinsky, E.K.3
  • 80
    • 0343976837 scopus 로고
    • Phase I trial of cisplatin (DDP) plus topotecan (T) on a daily ×5 schedule in patients with advanced solid tumors
    • abstract 1541
    • Saltz L, Kanowitz J, Schwartz G. et al. Phase I trial of cisplatin (DDP) plus topotecan (T) on a daily ×5 schedule in patients with advanced solid tumors. Proc. ASCO 1995; 14: 475 (abstract 1541).
    • (1995) Proc. ASCO , vol.14 , pp. 475
    • Saltz, L.1    Kanowitz, J.2    Schwartz, G.3
  • 81
    • 0343976836 scopus 로고    scopus 로고
    • Phase I study of continuous IV infusion topotecan (TT) in combination with cisplatin (C) in patients with advanced cancer (CALGB 9462)
    • abstract 1543
    • Lilenbaum RC, Miller AA, Batist G. et al. Phase I study of continuous IV infusion topotecan (TT) in combination with cisplatin (C) in patients with advanced cancer (CALGB 9462). Proc. ASCO 1996; 15: 485 (abstract 1543).
    • (1996) Proc. ASCO , vol.15 , pp. 485
    • Lilenbaum, R.C.1    Miller, A.A.2    Batist, G.3
  • 82
    • 0029993118 scopus 로고    scopus 로고
    • Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel
    • Miller A, Lilenbaum RC, Lynch Th J. et al. Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel. J. Clin. Oncol. 1996; 14: 1964-1965.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 1964-1965
    • Miller, A.1    Lilenbaum, R.C.2    Lynch, Th.J.3
  • 83
    • 0003317247 scopus 로고
    • A phase I trial of a fixed systemic exposure (AUC) of carboplatin (CARBO) with continuous infusion (CI) topotecan (TOPO) in paediatric solid tumors
    • abstract 1430
    • Heideman R, Kuttesch J, Stewart C. et al. A phase I trial of a fixed systemic exposure (AUC) of carboplatin (CARBO) with continuous infusion (CI) topotecan (TOPO) in paediatric solid tumors. Proc. ASCO 1995; 14: 447 (abstract 1430).
    • (1995) Proc. ASCO , vol.14 , pp. 447
    • Heideman, R.1    Kuttesch, J.2    Stewart, C.3
  • 84
    • 0345214065 scopus 로고    scopus 로고
    • A phase I and pharmacologic study of a combination of cyclophosphamide (CY) and topotecan (TOPO) in patients (pts) with refractory leukemia
    • abstract 712
    • Miller CB, O'Reilly S, Sartorius S. et al. A phase I and pharmacologic study of a combination of cyclophosphamide (CY) and topotecan (TOPO) in patients (pts) with refractory leukemia. Proc. ASCO 1997; 16: 203a (abstract 712).
    • (1997) Proc. ASCO , vol.16
    • Miller, C.B.1    O'Reilly, S.2    Sartorius, S.3
  • 85
    • 0031934032 scopus 로고    scopus 로고
    • Phase I study of topotecan in combination with cyclophosphamide in pediatric patients with malignant solid tumors: A Pediatric Oncology Group Study
    • Saylors RL III, Stewart CF, Zamboni WC. et al Phase I study of topotecan in combination with cyclophosphamide in pediatric patients with malignant solid tumors: a Pediatric Oncology Group Study. J. Clin. Oncol. 1998; 16: 945-952.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 945-952
    • Saylors III, R.L.1    Stewart, C.F.2    Zamboni, W.C.3
  • 86
    • 17144447367 scopus 로고    scopus 로고
    • Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer
    • Murren JR, Andersen S, Fedele J. et al. Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer. J. Clin. Oncol. 1997. 15: 148-157.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 148-157
    • Murren, J.R.1    Andersen, S.2    Fedele, J.3
  • 87
    • 13144276171 scopus 로고    scopus 로고
    • Efficacy of a combination of irinotecan (CPT-11) with mitomycin-C (MMC) for clear cell carcinoma of the ovary (OCCA) which is intrinsically platinum resistant
    • abstract 530
    • Shimizu Y, Umezawa S, Hasumi K, Yamauchi K, & Silverberg SG. Efficacy of a combination of irinotecan (CPT-11) with mitomycin-C (MMC) for clear cell carcinoma of the ovary (OCCA) which is intrinsically platinum resistant. Proc. ECCO 1997; 33: S119 (abstract 530).
    • (1997) Proc. ECCO , vol.33
    • Shimizu, Y.1    Umezawa, S.2    Hasumi, K.3    Yamauchi, K.4    Silverberg, S.G.5
  • 88
    • 0023792382 scopus 로고
    • Combined modalities of resistance in etoposide-resistant human KB cell lines
    • Ferguson PJ, Fisher MH, Stephenson J, Li D, Zhou B. & Cheng Y. Combined modalities of resistance in etoposide-resistant human KB cell lines. Cancer Res. 1988; 48: 5956-5964.
    • (1988) Cancer Res. , vol.48 , pp. 5956-5964
    • Ferguson, P.J.1    Fisher, M.H.2    Stephenson, J.3    Li, D.4    Zhou, B.5    Cheng, Y.6
  • 89
    • 0025114356 scopus 로고
    • Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines
    • Matsuo K, Kohno K, Takano H, Sato S, Kiue A. & Kuwano M. Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines. Cancer Res. 1990; 50: 5819-5824.
    • (1990) Cancer Res. , vol.50 , pp. 5819-5824
    • Matsuo, K.1    Kohno, K.2    Takano, H.3    Sato, S.4    Kiue, A.5    Kuwano, M.6
  • 90
    • 0025793634 scopus 로고
    • Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and the acidic glutathione S transferase
    • Lefevre D, Riou J-F, Ahomadegbe JC, Zhou D, Benard J. & Riou G. Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and the acidic glutathione S transferase. Biochem. Pharmacol. 1991; 41: 1967-1979.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 1967-1979
    • Lefevre, D.1    Riou, J.-F.2    Ahomadegbe, J.C.3    Zhou, D.4    Benard, J.5    Riou, G.6
  • 91
    • 0023739308 scopus 로고
    • Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I
    • Gupta RS, Gupta R, Eng B. et al. Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I. Cancer Res. 1988; 48: 6404-6410.
    • (1988) Cancer Res. , vol.48 , pp. 6404-6410
    • Gupta, R.S.1    Gupta, R.2    Eng, B.3
  • 92
    • 0025686125 scopus 로고
    • Elevated expression of DNA topoisomerase II in camptothecin-resistant tumor cell lines
    • Sugimoto Y, Tsukahara S, Oh-hara T, Liu LF. & Tsuruo T. Elevated expression of DNA topoisomerase II in camptothecin-resistant tumor cell lines. Cancer Res. 1990; 50: 7962-7965.
    • (1990) Cancer Res. , vol.50 , pp. 7962-7965
    • Sugimoto, Y.1    Tsukahara, S.2    Oh-hara, T.3    Liu, L.F.4    Tsuruo, T.5
  • 93
    • 0025893984 scopus 로고
    • Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in human leukemia cell line
    • Kaufmann S. Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in human leukemia cell line. Cancer Res 1991; 51: 1129-1136.
    • (1991) Cancer Res , vol.51 , pp. 1129-1136
    • Kaufmann, S.1
  • 94
    • 0345101412 scopus 로고    scopus 로고
    • Synergistic cytotoxic effects of camptothecin and topotecan with alkylating agents are drug-specific and dose-dependent in human brain tumor cell lines
    • abstract 1996
    • Janss AJ, Cnaan A, Spilsky A, Levow C, Yao Y. & Phillips PC. Synergistic cytotoxic effects of camptothecin and topotecan with alkylating agents are drug-specific and dose-dependent in human brain tumor cell lines. Proc. AACR 1996; 37: 294 (abstract 1996).
    • (1996) Proc. AACR , vol.37 , pp. 294
    • Janss, A.J.1    Cnaan, A.2    Spilsky, A.3    Levow, C.4    Yao, Y.5    Phillips, P.C.6
  • 95
    • 0026594602 scopus 로고
    • Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells
    • Bertrand R, O'Connor PM, Kerrigan D. & Pommier Y. Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells. Eur. J. Cancer 1992; 28A: 743-748.
    • (1992) Eur. J. Cancer , vol.28 A , pp. 743-748
    • Bertrand, R.1    O'Connor, P.M.2    Kerrigan, D.3    Pommier, Y.4
  • 96
    • 0030937484 scopus 로고    scopus 로고
    • Topotecan increases topoisomerase IIα levels and sensitivity to treatment with etoposide in schedule-dependent process
    • Whitacre CM, Zborowska E, Gordon NH, Mackay W. & Berger NA. Topotecan increases topoisomerase IIα levels and sensitivity to treatment with etoposide in schedule-dependent process. Cancer Res. 1997; 57: 1425-1428.
    • (1997) Cancer Res. , vol.57 , pp. 1425-1428
    • Whitacre, C.M.1    Zborowska, E.2    Gordon, N.H.3    Mackay, W.4    Berger, N.A.5
  • 97
    • 85030347143 scopus 로고    scopus 로고
    • Combination therapy with 9-aminocamptothecin (9-AC) and etoposide (VP-6) in human glioblastoma
    • abstract 2918
    • Ciesielski MJ, & Fenstermaker RA. Combination therapy with 9-aminocamptothecin (9-AC) and etoposide (VP-6) in human glioblastoma. Proc. AACR 1996; 37: 427 (abstract 2918).
    • (1996) Proc. AACR , vol.37 , pp. 427
    • Ciesielski, M.J.1    Fenstermaker, R.A.2
  • 98
    • 0000623584 scopus 로고
    • Synergistic cytotoxicity with combined inhibition of topoisomerase (Topo) I and II
    • abstract 2573
    • Anzai H, Frost P, Abbruzese JL. Synergistic cytotoxicity with combined inhibition of topoisomerase (Topo) I and II. Proc. AACR 1992; 33: 431 (abstract 2573).
    • (1992) Proc. AACR , vol.33 , pp. 431
    • Anzai, H.1    Frost, P.2    Abbruzese, J.L.3
  • 99
    • 0030034610 scopus 로고    scopus 로고
    • Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdo-myosarcoma
    • Houghton JA, Cheshire PJ, Hallman JD II. et al. Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdo-myosarcoma. Clin. Cancer Res. 1996; 2: 107-118.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 107-118
    • Houghton, J.A.1    Cheshire, P.J.2    Hallman II, J.D.3
  • 100
    • 0006498899 scopus 로고    scopus 로고
    • CPT-11/topoisomerase II (topo II) inhibitor combination therapy: Molecular pharmacology and therapeutic response
    • abstract 2937
    • Eder JP, Ikebe M, Wong E, Rizvi N, Chan VT-W. & Teicher BA. CPT-11/topoisomerase II (topo II) inhibitor combination therapy: molecular pharmacology and therapeutic response. Proc. AACR 1996; 37: 430 (abstract 2937).
    • (1996) Proc. AACR , vol.37 , pp. 430
    • Eder, J.P.1    Ikebe, M.2    Wong, E.3    Rizvi, N.4    Chan, V.T.-W.5    Teicher, B.A.6
  • 101
    • 0006958323 scopus 로고
    • Sequence dependent interaction of etoposide and topotecan
    • abstract 1744
    • Kozelsky TK. & Bonner JA. Sequence dependent interaction of etoposide and topotecan. Proc. AACR 1995; 36: 293 (abstract 1744).
    • (1995) Proc. AACR , vol.36 , pp. 293
    • Kozelsky, T.K.1    Bonner, J.A.2
  • 102
    • 0029801803 scopus 로고    scopus 로고
    • The significance of the sequence of administration of topotecan and etoposide
    • Bonner JA. & Kozelsky TF. The significance of the sequence of administration of topotecan and etoposide. Cancer Chemother. Pharmacol. 1996; 39: 109-112.
    • (1996) Cancer Chemother. Pharmacol. , vol.39 , pp. 109-112
    • Bonner, J.A.1    Kozelsky, T.F.2
  • 103
    • 0031039517 scopus 로고    scopus 로고
    • In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: Preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin
    • Jensen PB, Sorensen M, Christensen LJ. & Sehested M. In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin. Br. J. Cancer 1997; 75: 869-877.
    • (1997) Br. J. Cancer , vol.75 , pp. 869-877
    • Jensen, P.B.1    Sorensen, M.2    Christensen, L.J.3    Sehested, M.4
  • 105
    • 0003029383 scopus 로고
    • Measurement of tumor topoisomerase I and II levels during the sequential administration of topotecan and etoposide
    • abstract 358
    • Eckardt JR, Burris HA, Von Hoff DD. et al. Measurement of tumor topoisomerase I and II levels during the sequential administration of topotecan and etoposide. Proc. ASCO 1994; 13: 141 (abstract 358).
    • (1994) Proc. ASCO , vol.13 , pp. 141
    • Eckardt, J.R.1    Burris, H.A.2    Von Hoff, D.D.3
  • 106
    • 0030727979 scopus 로고    scopus 로고
    • Combined inhibition of topoisomerases I and II - Is this a worthwhile/feasible strategy? Br
    • Vasey PA, Kaye SB. Combined inhibition of topoisomerases I and II - is this a worthwhile/feasible strategy? Br. J. Cancer 1997. 76: 1395-1397.
    • (1997) J. Cancer , vol.76 , pp. 1395-1397
    • Vasey, P.A.1    Kaye, S.B.2
  • 107
    • 9844220291 scopus 로고    scopus 로고
    • Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-lung cancer
    • Ando M, Eguchi K, Shinkai T. et al. Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-lung cancer. Br. J. Cancer 1997; 76: 1494-1499.
    • (1997) Br. J. Cancer , vol.76 , pp. 1494-1499
    • Ando, M.1    Eguchi, K.2    Shinkai, T.3
  • 108
    • 0027489835 scopus 로고
    • Phase I study of CPT-11 and etoposide in patients with refractory solid tumors
    • Karato A, Sasaki Y, Shinkai T. et al. Phase I study of CPT-11 and etoposide in patients with refractory solid tumors. J. Clin. Oncol. 1993; 11: 2030-2035.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 2030-2035
    • Karato, A.1    Sasaki, Y.2    Shinkai, T.3
  • 109
    • 0028035248 scopus 로고
    • Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony-stimulating factor support for advanced lung cancer
    • Masuda N, Fukuoka M, Kudoh S. et al. Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony-stimulating factor support for advanced lung cancer. J. Clin. Oncol. 1994; 12: 1833-1841.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 1833-1841
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 110
    • 1842266121 scopus 로고
    • Phase I study of irinotecan (CPT-11) and etoposide (E) with G-CSF in advanced lung cancer
    • abstract 331
    • Negoro S, Fukuoka M, Masuda N. et al. Phase I study of irinotecan (CPT-11) and etoposide (E) with G-CSF in advanced lung cancer. Proc. ASCO 1993; 12: 133 (abstract 331).
    • (1993) Proc. ASCO , vol.12 , pp. 133
    • Negoro, S.1    Fukuoka, M.2    Masuda, N.3
  • 111
    • 0344783314 scopus 로고    scopus 로고
    • A phase I trial of sequential topotecan and etoposide in adult acute myeloid leukemia (AML)
    • abstract 1050
    • Crump M, Lipton J, Hedley D. et al. A phase I trial of sequential topotecan and etoposide in adult acute myeloid leukemia (AML). Proc. ASCO 1996; 15: (abstract 1050).
    • (1996) Proc. ASCO , vol.15
    • Crump, M.1    Lipton, J.2    Hedley, D.3
  • 112
    • 0010236627 scopus 로고    scopus 로고
    • A phase I and pharmacodynamic study of sequential topotecan and etoposide (TE) in adult patients with refractory/relapsed acute leukemia (RAL)
    • abstract 1549
    • Cooper BW, Lazarus HM, Creger R. et al. A phase I and pharmacodynamic study of sequential topotecan and etoposide (TE) in adult patients with refractory/relapsed acute leukemia (RAL). Proc. ASCO 1996; 15: 486 (abstract 1549).
    • (1996) Proc. ASCO , vol.15 , pp. 486
    • Cooper, B.W.1    Lazarus, H.M.2    Creger, R.3
  • 113
    • 0011933177 scopus 로고
    • A phase I study of the topoisomerase I and II inhibitors topotecan (T) and etoposide (E)
    • abstract 349
    • Eckardt JR, Burris HA, Rodriguez GA. et al. A phase I study of the topoisomerase I and II inhibitors topotecan (T) and etoposide (E). Proc. ASCO 1993; 12: 137 (abstract 349).
    • (1993) Proc. ASCO , vol.12 , pp. 137
    • Eckardt, J.R.1    Burris, H.A.2    Rodriguez, G.A.3
  • 114
    • 0030813205 scopus 로고    scopus 로고
    • Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide
    • Herben VMM, ten Bokkel Huinink WW, Dubbelman AC. et al. Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide. Br. J. Cancer 1997; 76: 1500-1508.
    • (1997) Br. J. Cancer , vol.76 , pp. 1500-1508
    • Herben, V.M.M.1    Ten Bokkel Huinink, W.W.2    Dubbelman, A.C.3
  • 115
    • 0030957029 scopus 로고    scopus 로고
    • A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies
    • Tolcher AW, O'Shaugnessy JA, Weiss RB. et al. A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies. Clin. Cancer Res. 1997; 3: 755-760.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 755-760
    • Tolcher, A.W.1    O'Shaugnessy, J.A.2    Weiss, R.B.3
  • 116
    • 9844258262 scopus 로고
    • Pharmacokinetic study in the dose escalation study of CPT-11 and VP-16
    • abstract 2325
    • Karato A, Sasaki Y, Shiraishi J. et al. Pharmacokinetic study in the dose escalation study of CPT-11 and VP-16. Proc. AACR 1993; 34: 390 (abstract 2325).
    • (1993) Proc. AACR , vol.34 , pp. 390
    • Karato, A.1    Sasaki, Y.2    Shiraishi, J.3
  • 117
    • 0343839777 scopus 로고    scopus 로고
    • Combination chemotherapy with irinotecan and adriamycin for refractory or relapsed malignant lymphoma (ML): A pilot study
    • abstract 540P
    • Saotome T, Takagi T, Kumagai K, Takeshita A, Goto S, Sakai C. Combination chemotherapy with irinotecan and adriamycin for refractory or relapsed malignant lymphoma (ML): a pilot study. Ann. Oncol 1996; 7(Suppl. 5): 113 (abstract 540P).
    • (1996) Ann. Oncol , vol.7 , Issue.5 SUPPL. , pp. 113
    • Saotome, T.1    Takagi, T.2    Kumagai, K.3    Takeshita, A.4    Goto, S.5    Sakai, C.6
  • 118
    • 0031588364 scopus 로고    scopus 로고
    • Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo
    • Guichard S, Cussac D, Mennebelle I, Bugat R, Canai P. Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo. Int. J. Cancer 1997; 73: 729-734.
    • (1997) Int. J. Cancer , vol.73 , pp. 729-734
    • Guichard, S.1    Cussac, D.2    Mennebelle, I.3    Bugat, R.4    Canai, P.5
  • 119
    • 0344734003 scopus 로고    scopus 로고
    • The cytotoxicity of the irinotecan (CPT-11)-5-flourouracil (5-FU) combination in human colon carcinoma cell lines is related to the sequence-dependent introduction of DNA lesions
    • abstract 2133
    • Grivicich I, Mans DRA, da Rocha AB, Dalla Costa HS. & Schwartsmann G. The cytotoxicity of the irinotecan (CPT-11)-5-flourouracil (5-FU) combination in human colon carcinoma cell lines is related to the sequence-dependent introduction of DNA lesions. Proc. AACR 1997; 38: 318 (abstract 2133).
    • (1997) Proc. AACR , vol.38 , pp. 318
    • Grivicich, I.1    Mans, D.R.A.2    Da Rocha, A.B.3    Dalla Costa, H.S.4    Schwartsmann, G.5
  • 120
    • 9844246177 scopus 로고    scopus 로고
    • The cytotoxicity of the irinotecan (CPT-11)-5-fluorouracil (5-FU) combination in human colon carcinoma cell lines is sequence-dependent
    • abstract 36P
    • Mans DRA, Brondani da Rocha A, Gricivich I. & Sanvitto Della Costa H, Schwartsmann G. The cytotoxicity of the irinotecan (CPT-11)-5-fluorouracil (5-FU) combination in human colon carcinoma cell lines is sequence-dependent. Ann Oncol 1996; 7 (Suppl. 5): 9 (abstract 36P).
    • (1996) Ann Oncol , vol.7 , Issue.5 SUPPL. , pp. 9
    • Mans, D.R.A.1    Brondani Da Rocha, A.2    Gricivich, I.3    Sanvitto Della Costa, H.4    Schwartsmann, G.5
  • 121
    • 0345505328 scopus 로고    scopus 로고
    • Cytotoxic interactions of SN38, the active metabolite of irinotecan, and 5-FU or tomudex in 5-FU sensitive and 5-FU resistant colorectal carcinoma cell lines
    • abstract 13P
    • Harstrick A, Schleucher N, Vanhoefer U. et al. Cytotoxic interactions of SN38, the active metabolite of irinotecan, and 5-FU or tomudex in 5-FU sensitive and 5-FU resistant colorectal carcinoma cell lines. Ann Oncol 1996; 7 (Suppl. 5): 5 (abstract 13P).
    • (1996) Ann Oncol , vol.7 , Issue.5 SUPPL. , pp. 5
    • Harstrick, A.1    Schleucher, N.2    Vanhoefer, U.3
  • 122
    • 0011855371 scopus 로고
    • Enhanced antitumor activity of SN-38, an active metabolite of CPT-11, and 5-fluorouracil combination for human colorectal cancer cell lines
    • abstract 563
    • Funakoshi S, Aiba K, Shibata H. et al. Enhanced antitumor activity of SN-38, an active metabolite of CPT-11, and 5-fluorouracil combination for human colorectal cancer cell lines. Proc. ASCO 1993; 12: 193 (abstract 563).
    • (1993) Proc. ASCO , vol.12 , pp. 193
    • Funakoshi, S.1    Aiba, K.2    Shibata, H.3
  • 123
    • 0141493785 scopus 로고    scopus 로고
    • Schedule dependency of the synergism between combination of topotecan, 5-fluoruracil and tomudex in HT29 and LOVO human adeno-carcinoma cell lines
    • abstract 1601
    • Taron M, Abad A, Mate JL. et al. Schedule dependency of the synergism between combination of topotecan, 5-fluoruracil and tomudex in HT29 and LOVO human adeno-carcinoma cell lines. Proc. ASCO 1996; 15: 500 (abstract 1601).
    • (1996) Proc. ASCO , vol.15 , pp. 500
    • Taron, M.1    Abad, A.2    Mate, J.L.3
  • 124
    • 85030346806 scopus 로고    scopus 로고
    • Antitumoral activity and evaluation of cellular targets during repetitive courses of CPT-11 and 5FU combination in HT-29 nude mice xenografts
    • abstract 103
    • Guichard S, Hennebelle I, Canal P. Antitumoral activity and evaluation of cellular targets during repetitive courses of CPT-11 and 5FU combination in HT-29 nude mice xenografts. In: Proc. 8th Conference on DNA Topoisomerase, 1997. abstract 103.
    • (1997) Proc. 8th Conference on DNA Topoisomerase
    • Guichard, S.1    Hennebelle, I.2    Canal, P.3
  • 125
    • 0344211496 scopus 로고    scopus 로고
    • In vitro synergism between SN-38 and tomudex (TX): Importance of scheduling and dose ratio
    • (1996) abstraact 621P
    • Aschele, C., Sobrero, A., Baldo, C., Ardizzoni, A., Bornmann, W. G, Bertino J. R. (1996) In vitro synergism between SN-38 and tomudex (TX): importance of scheduling and dose ratio. Ann Oncol. 1996; (Suppl. 5): 129 (abstraact 621P).
    • (1996) Ann Oncol. , Issue.5 SUPPL. , pp. 129
    • Aschele, C.1    Sobrero, A.2    Baldo, C.3    Ardizzoni, A.4    Bornmann, W.G.5    Bertino, J.R.6
  • 126
    • 0008461578 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of irinotecan, flourouracil, and leucovorin in patients with advanced solid tumors
    • Saltz LB, Kanowitz J, Kemeny NE. et al. Phase I clinical and pharmacokinetic study of irinotecan, flourouracil, and leucovorin in patients with advanced solid tumors. J. Clin. Oncol. 1996; 14: 2959-2967.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2959-2967
    • Saltz, L.B.1    Kanowitz, J.2    Kemeny, N.E.3
  • 127
    • 0028340348 scopus 로고
    • Simultaneous administration of CPT-11 and fluorouracil: Alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer
    • Sasaki Y, Ohtsu A, Shimada Y, Ono K. & Saijo N. Simultaneous administration of CPT-11 and fluorouracil: alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer. J. Natl. Cancer Inst. 1994; 86: 1096-1098.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1096-1098
    • Sasaki, Y.1    Ohtsu, A.2    Shimada, Y.3    Ono, K.4    Saijo, N.5
  • 128
    • 85058247799 scopus 로고    scopus 로고
    • Pharmacokinetics of irinotecan (CPT-11) and 5-flourouracil (5-FU) in a dose finding study in adult patients with solid tumours
    • abstract 1121
    • Carcas AJ, Frias J, Hernanz A. et al. Pharmacokinetics of irinotecan (CPT-11) and 5-flourouracil (5-FU) in a dose finding study in adult patients with solid tumours. Proc. ECCO 1997; 33: S248 (abstract 1121).
    • (1997) Proc. ECCO , vol.33
    • Carcas, A.J.1    Frias, J.2    Hernanz, A.3
  • 129
    • 0013605848 scopus 로고    scopus 로고
    • Phase I study of CPT-11 combined with sequential 5FU in metastatic colorectal cancer (CRC)
    • abstract 1527
    • Yamao T, Shimada Y, Shirao K. et al. Phase I study of CPT-11 combined with sequential 5FU in metastatic colorectal cancer (CRC). Proc. ASCO 1996; 15: 481 (abstract 1527).
    • (1996) Proc. ASCO , vol.15 , pp. 481
    • Yamao, T.1    Shimada, Y.2    Shirao, K.3
  • 130
    • 0003213959 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) study of CPT-11 (C) and 5-FU (F) combination
    • abstract 710
    • Benhammouda A, Bastian G, Rixe O. et al. A phase I and pharmacokinetic (PK) study of CPT-11 (C) and 5-FU (F) combination. Proc. ASCO 1997; 16: 202a (abstract 710).
    • (1997) Proc. ASCO , vol.16
    • Benhammouda, A.1    Bastian, G.2    Rixe, O.3
  • 132
    • 0001069899 scopus 로고
    • Combination phase I study of CPT-11 (irinotecan) combined with continuous infusion of 5-fluorouracil (5FU) in metastatic colorectal cancer
    • abstract 575
    • Shimida Y, Sasaki Y, Sugano K. et al. Combination phase I study of CPT-11 (irinotecan) combined with continuous infusion of 5-fluorouracil (5FU) in metastatic colorectal cancer. Proc ASCO 1993; 12: 196 (abstract 575).
    • (1993) Proc ASCO , vol.12 , pp. 196
    • Shimida, Y.1    Sasaki, Y.2    Sugano, K.3
  • 133
    • 0013692353 scopus 로고    scopus 로고
    • Phase I dose finding study of irinotecan (CPT-11) over a short i.v. infusion combined with a fixed dose of 5-fluorouracil (5-FU) over a protracted infusion in patients (pts) with advanced solid tumors
    • abstract 775
    • Sastre J, Paz-Ares L, Diaz-Rubio E. et al. Phase I dose finding study of irinotecan (CPT-11) over a short i.v. infusion combined with a fixed dose of 5-fluorouracil (5-FU) over a protracted infusion in patients (pts) with advanced solid tumors. Proc. ASCO 1998; 17: 201a (abstract 775).
    • (1998) Proc. ASCO , vol.17
    • Sastre, J.1    Paz-Ares, L.2    Diaz-Rubio, E.3
  • 134
    • 0007683443 scopus 로고    scopus 로고
    • Phase I study of a weekly schedule of irinotecan (CPT-11), high dose folinic acid (FA) and 5-fluorouracil (5-FU) as first line chemotherapy (CT) in metastatic colorectal cancer: Final results
    • abstract 779
    • Vanhoefer U, Harstrick A, Achterrath W. et al. Phase I study of a weekly schedule of irinotecan (CPT-11), high dose folinic acid (FA) and 5-fluorouracil (5-FU) as first line chemotherapy (CT) in metastatic colorectal cancer: final results. Proc. ASCO 1998; 17: 202a (abstract 779).
    • (1998) Proc. ASCO , vol.17
    • Vanhoefer, U.1    Harstrick, A.2    Achterrath, W.3
  • 135
    • 0000315348 scopus 로고    scopus 로고
    • Phase I/II study of escalating dose of CPT-11 in combination with LV5FU2 ("De Gramont" regimen) every two weeks in the treatment of colorectal cancer (CRC) after 5-FU failure
    • abstract 823
    • Ducreaux, M, Rougier Ph, Ychou M. et al. Phase I/II study of escalating dose of CPT-11 in combination with LV5FU2 ("De Gramont" regimen) every two weeks in the treatment of colorectal cancer (CRC) after 5-FU failure. Proc. ASCO 1997; 16: 234a (abstract 823).
    • (1997) Proc. ASCO , vol.16
    • Ducreaux, M.1    Rougier, Ph.2    Ychou, M.3
  • 136
    • 0345505297 scopus 로고    scopus 로고
    • st line chemotherapy (CT) of metastatic colorectal cancer (CRC): preliminary results
    • abstract 758
    • st line chemotherapy (CT) of metastatic colorectal cancer (CRC): preliminary results. Proc. ECCO 1997; 33: S169 (abstract 758).
    • (1997) Proc. ECCO , vol.33
    • Barone, C.1    Pozzo, C.2    Starkhammar, H.3
  • 137
    • 0000919664 scopus 로고    scopus 로고
    • A phase II multicenter trial of alternating cycles of irinotecan (CPT-11) and 5-FU/LV in patients with previously untreated metastatic colorectal cancer (CRC)
    • abstract 944
    • Rothenberg ML, Pazdur R, Rowinsky EK. et al. A phase II multicenter trial of alternating cycles of irinotecan (CPT-11) and 5-FU/LV in patients with previously untreated metastatic colorectal cancer (CRC). Proc. ASCO 1997; 16: 266a (abstract 944).
    • (1997) Proc. ASCO , vol.16
    • Rothenberg, M.L.1    Pazdur, R.2    Rowinsky, E.K.3
  • 138
    • 85058247507 scopus 로고    scopus 로고
    • Phase I dose finding study of irinotecan hydrochloride trihydrate (CPT11) with tomudex (TX) in patients with 5-FU refractory colorectal cancer
    • abstract 770
    • Cunningham D, Ross P, Webb A. et al. Phase I dose finding study of irinotecan hydrochloride trihydrate (CPT11) with tomudex (TX) in patients with 5-FU refractory colorectal cancer. Proc. ECCO 1997; 33: S172 (abstract 770).
    • (1997) Proc. ECCO , vol.33
    • Cunningham, D.1    Ross, P.2    Webb, A.3
  • 139
    • 0031027077 scopus 로고    scopus 로고
    • Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia
    • Seiter K, Feldman EJ, Halicka HD. et al. Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia. J. Clin. Oncol. 1997; 15: 44-51.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 44-51
    • Seiter, K.1    Feldman, E.J.2    Halicka, H.D.3
  • 140
    • 0001514084 scopus 로고    scopus 로고
    • In vivo evaluation of the docetaxel-irinotecan combination
    • abstract 2578
    • Bissery MC, Vrignaud P. & Lavelle F. In vivo evaluation of the docetaxel-irinotecan combination. Proc. AACR 1996; 37: 378 (abstract 2578).
    • (1996) Proc. AACR , vol.37 , pp. 378
    • Bissery, M.C.1    Vrignaud, P.2    Lavelle, F.3
  • 141
    • 0029163002 scopus 로고
    • Phase I study of paclitaxel and topotecan in patients with advanced tumors: A Cancer and Leukemia Group B study
    • Lilenbaum RC, Ratain MJ, Miller AA. et al Phase I study of paclitaxel and topotecan in patients with advanced tumors: a Cancer and Leukemia Group B study. J. Clin. Oncol. 1995; 13: 2230-2237.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2230-2237
    • Lilenbaum, R.C.1    Ratain, M.J.2    Miller, A.A.3
  • 142
    • 0031014626 scopus 로고    scopus 로고
    • Phase I trial and pharmacologic trial of sequences of paclitaxel and topotecan in previously treated ovarian epithelial malignancies: A Gynecologic Oncology Group study
    • O'Reilly S, Fleming GF, Baker SD. et al. Phase I trial and pharmacologic trial of sequences of paclitaxel and topotecan in previously treated ovarian epithelial malignancies: a Gynecologic Oncology Group study. J. Clin. Oncol. 1997; 15: 177-186.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 177-186
    • O'Reilly, S.1    Fleming, G.F.2    Baker, S.D.3
  • 143
    • 0010522942 scopus 로고    scopus 로고
    • Phase I study of paclitaxel (P) combined with 14-day topotecan (T) continuous IV (CTV) infusion in previously treated and untreated patients (pts)
    • abstract 839
    • Hochster H, Chachoua A, Sorich J. et al. Phase I study of paclitaxel (P) combined with 14-day topotecan (T) continuous IV (CTV) infusion in previously treated and untreated patients (pts). Proc. ASCO 1997; 16: 238a (abstract 839).
    • (1997) Proc. ASCO , vol.16
    • Hochster, H.1    Chachoua, A.2    Sorich, J.3
  • 144
    • 0000907355 scopus 로고    scopus 로고
    • Phase I dose-finding and pharmacokinetic (PK) study of docetaxel (D) in combination with irinotecan (I) in advanced solid tumors
    • abstract 709
    • Couteau C, Lokiec F, Vernillet L. et al. Phase I dose-finding and pharmacokinetic (PK) study of docetaxel (D) in combination with irinotecan (I) in advanced solid tumors. Proc. ASCO 1997; 16: 202a (abstract 709).
    • (1997) Proc. ASCO , vol.16
    • Couteau, C.1    Lokiec, F.2    Vernillet, L.3
  • 145
    • 0013608036 scopus 로고    scopus 로고
    • Phase I/II study of docetaxel (DOC) and irinotecan (CPT-11) for previously untreated advanced non-small cell lung cancer (NSCLC)
    • abstract 1891
    • Kudoh S, Negoro S, Masuda N. et al. Phase I/II study of docetaxel (DOC) and irinotecan (CPT-11) for previously untreated advanced non-small cell lung cancer (NSCLC). Proc. ASCO 1998; 17: 491a (abstract 1891).
    • (1998) Proc. ASCO , vol.17
    • Kudoh, S.1    Negoro, S.2    Masuda, N.3
  • 146
    • 4244113317 scopus 로고    scopus 로고
    • Phase II study irinotecan and infusional cisplatin with recombinant human granulocyte colony-stimulating factor support in the treatment of advanced non-small cell lung cancer
    • abstract 1714
    • Mori K, Hirose T, Tominaga K. Phase II study irinotecan and infusional cisplatin with recombinant human granulocyte colony-stimulating factor support in the treatment of advanced non-small cell lung cancer. Proc. ASCO 1997; 16: 476a (abstract 1714).
    • (1997) Proc. ASCO , vol.16
    • Mori, K.1    Hirose, T.2    Tominaga, K.3
  • 147
    • 0345505291 scopus 로고    scopus 로고
    • Phase II trial of irinotecan (CPT-11) plus cisplatin (CDDP) in advanced NSCLC
    • abstract 1674
    • DeVore R, Crawford J, Dimery I. et al. Phase II trial of irinotecan (CPT-11) plus cisplatin (CDDP) in advanced NSCLC. Proc. ASCO 1997; 16: 466a (abstract 1674).
    • (1997) Proc. ASCO , vol.16
    • Devore, R.1    Crawford, J.2    Dimery, I.3
  • 148
    • 0031015192 scopus 로고    scopus 로고
    • Phase II study of irinotecan and etoposide in patients with metastatic non-small lung cancer
    • Oshita F, Noda K, Nishiwaki Y. et al. Phase II study of irinotecan and etoposide in patients with metastatic non-small lung cancer. J. Clin. Oncol. 1997; 15: 304-309.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 304-309
    • Oshita, F.1    Noda, K.2    Nishiwaki, Y.3
  • 149
    • 0000541136 scopus 로고    scopus 로고
    • A randomized phase II study of topotecan (TOPA) and cisplatin (CDDP) with filgrastim (G-CSF) versus topotecan and paclitaxel (Taxol®) with filgrastim in patients with advanced non-small cell lung cancer
    • abstract 1755
    • Wiesenfeld M, Marks R, Grill J. et al. A randomized phase II study of topotecan (TOPA) and cisplatin (CDDP) with filgrastim (G-CSF) versus topotecan and paclitaxel (Taxol®) with filgrastim in patients with advanced non-small cell lung cancer. Proc. ASCO 1997; 16: 466a (abstract 1755).
    • (1997) Proc. ASCO , vol.16
    • Wiesenfeld, M.1    Marks, R.2    Grill, J.3
  • 150
    • 0031887545 scopus 로고    scopus 로고
    • Phase II study of irinotecan combined with cisplatin in patients with pre-viously untreated small-cell lung cancer
    • Kudoh S, Fujiwara Y, Takada Y. et al. Phase II study of irinotecan combined with cisplatin in patients with pre-viously untreated small-cell lung cancer. J. Clin. Oncol. 1998; 16: 1068-1074.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 1068-1074
    • Kudoh, S.1    Fujiwara, Y.2    Takada, Y.3
  • 151
    • 0010258101 scopus 로고    scopus 로고
    • Phase II study of a combination of CDDP and CPT-11 in metastatic gastric cancer: CPT-11 study group for gastric cancer
    • abstract 936
    • Boku N, Ohtsu A, Shimada Y. et al. Phase II study of a combination of CDDP and CPT-11 in metastatic gastric cancer: CPT-11 study group for gastric cancer. Proc. ASCO 1997; 16: 264a (abstract 936).
    • (1997) Proc. ASCO , vol.16
    • Boku, N.1    Ohtsu, A.2    Shimada, Y.3
  • 152
    • 0010287703 scopus 로고    scopus 로고
    • Irinotecan hydrochloride (CPT-11) combined with cisplatin (CDDP) in patients with relapsed or metastatic ovarian cancer
    • abstract 796
    • Sugiyama T, Nishida T, Ushijima K, Kumagai S, Yskushiji M. Irinotecan hydrochloride (CPT-11) combined with cisplatin (CDDP) in patients with relapsed or metastatic ovarian cancer. Proc. ASCO 1996; 15: 291 (abstract 796).
    • (1996) Proc. ASCO , vol.15 , pp. 291
    • Sugiyama, T.1    Nishida, T.2    Ushijima, K.3    Kumagai, S.4    Yskushiji, M.5
  • 153
    • 0007426114 scopus 로고    scopus 로고
    • Multicentric phase II trial of irinotecan (CPT-11) and cisplatin as first-line chemotherapy in recurrent or advanced cervical cancer: Japan CPT-11 study group trial
    • abstract 1360
    • Sugiyama T, Noda K, Yakushiji M. Multicentric phase II trial of irinotecan (CPT-11) and cisplatin as first-line chemotherapy in recurrent or advanced cervical cancer: Japan CPT-11 study group trial. Proc. ASCO 1998; 17: 352 (abstract 1360).
    • (1998) Proc. ASCO , vol.17 , pp. 352
    • Sugiyama, T.1    Noda, K.2    Yakushiji, M.3


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