Brain targeting with surface-modified poly(d,l-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 1, 2011, Pages 84-88

  Tahara, Kohei ^a,b   Miyazaki, Yuta ^c   Kawashima, Yoshiaki ^a   Kreuter, Jörg ^d   Yamamoto, Hiromitsu ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

Chitosan; Nanoparticle; PLGA; Poloxamer 188; Polysorbate 80; Surface modification

Indexed keywords

6 COUMARIN; CHITOSAN; COUMARIN DERIVATIVE; NANOPARTICLE; POLOXAMER; POLYGLACTIN; POLYSORBATE 80; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN SLICE; CAROTID ARTERY; CENTRAL NERVOUS SYSTEM DISEASE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; CAROTID ARTERIES; CENTRAL NERVOUS SYSTEM DISEASES; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FLUORESCENT DYES; INJECTIONS, INTRAVENOUS; LACTIC ACID; MALE; NANOPARTICLES; PHYSICOCHEMICAL PHENOMENA; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TISSUE DISTRIBUTION;

EID: 78650680356     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.11.002     Document Type: Article

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