Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo

International Journal of Pharmaceutics

Volumn 281, Issue 1-2, 2004, Pages 25-33

  Hatakeyama, Hiroto ^a   Akita, Hidetaka ^a   Maruyama, Kazuo ^b   Suhara, Tetsuya ^c   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Liposomes; Receptor mediated endocytosis; Tissue uptake; Transferrin

Indexed keywords

LIPOSOME; MACROGOL DERIVATIVE; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG MEGADOSE; DRUG TARGETING; DRUG UPTAKE; ENDOCYTOSIS; HEART; IN VIVO STUDY; LIVER; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ANIMALS; BRAIN; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HEART; INJECTIONS, INTRAVENOUS; JAPAN; KUPFFER CELLS; LIPOSOMES; LUNG; MICE; MICE, INBRED STRAINS; MUSCLE, SKELETAL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RECEPTORS, TRANSFERRIN; RETICULOENDOTHELIAL SYSTEM; SPLEEN; TRANSFERRIN; TRITIUM;

EID: 3543116768     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.05.025     Document Type: Article

References (35)

1. Allen T.M., Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim. Biophys. Acta. 1068:1991;133-141
2. Blume G., Cevc G. Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta. 1029:1990;91-97
3. Friden P.M., Olson T.S., Obar R., Walus L.R., Putney S.D. Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor. J. Pharmacol. Exp. Ther. 278:1996;1491-1498
4. Gloor S.M., Wachtel M., Bolliger M.F., Ishihara H., Landmann R., Frei K. Molecular and cellular permeability control at the blood-brain barrier. Brain Res. Rev. 36:2001;258-264
5. Godbey W.T., Wu K.K., Mikos A.G. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc. Natl. Acad. Sci. U.S.A. 96:1999;5177-5181
6. Harashima H., Komatsu S., Kojima S., Yanagi C., Morioka Y., Naito M., Kiwada H. Species difference in the disposition of liposomes among mice, rats, and rabbits: allometric relationship and species dependent hepatic uptake mechanism. Pharm. Res. 13:1996;1049-1054
7. Harashima H., Kume Y., Yamane C., Kiwada H. Non-Michaelis-Menten type hepatic uptake of liposomes in the rat. J. Pharm. Pharmacol. 44:1992;707-712
8. Harashima H., Ohshima S., Midori Y., Yachi K., Kikuchi H., Kiwada H. Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats: I. Biopharm. Drug Dispos. 13:1992;155-170
9. Herz J., Gerard R.D. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. U.S.A. 90:1993;2812-2816
10. Huber J.D., Egleton R.D., Davis T.P. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 24:2001;719-725
11. Huwyler J., Wu D., Pardridge W.M. Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. U.S.A. 93:1996;14164-14169
12. Huwyler J., Yang J., Pardridge W.M. Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat. J. Pharmacol. Exp. Ther. 282:1997;1541-1546
13. Ishida O., Maruyama K., Tanahashi H., Iwatsuru M., Sasaki K., Eriguchi M., Yanagie H. Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo. Pharm. Res. 18:2001;1042-1048
14. Klausner R.D., Van Renswoude J., Ashwell G., Kempf C., Schechter A.N., Dean A., Bridges K.R. Receptor-mediated endocytosis of transferrin in K562 cells. J. Biol. Chem. 258:1983;4715-4724
15. Klibanov A.L., Maruyama K., Beckerleg A.M., Torchilin V.P., Huang L. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062:1991;142-148
16. Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268:1990;235-237
17. Lee H.J., Boado R.J., Braasch D.A., Corey D.R., Pardridge W.M. Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology. J. Nucl. Med. 43:2002;948-956
18. Lee H.J., Engelhardt B., Lesley J., Bickel U., Pardridge W.M. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J. Pharmacol. Exp. Ther. 292:2000;1048-1052
19. Lee H.J., Zhang Y., Zhu C., Duff K., Pardridge W.M. Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical. J. Cereb. Blood Flow Metab. 22:2002;223-231
20. Litzinger D.C., Buiting A.M., van Rooijen N., Huang L. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta. 1190:1994;99-107
21. Liu D., Mori A., Huang L. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim. Biophys. Acta. 1104:1992;95-101
22. Maruyama K., Ishida O., Takizawa T., Moribe K. Possibility of active targeting to tumor tissues with liposomes. Adv. Drug Deliv. Rev. 40:1999;89-102
23. Matlin K.S., Reggio H., Helenius A., Simons K. Pathway of vesicular stomatitis virus entry leading to infection. J. Mol. Biol. 156:1982;609-631
24. Mori A., Klibanov A.L., Torchilin V.P., Huang L. Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett. 284:1991;263-266
25. Omori N., Maruyama K., Jin G., Li F., Wang S.J., Hamakawa Y., Sato K., Nagano I., Shoji M., Abe K. Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin. Neurol. Res. 25:2003;275-279
26. Pardridge W.M. Vector-mediated drug delivery to the brain. Adv. Drug Deliv. Rev. 36:1999;299-321
27. Ponka P., Lok C.N. The transferrin receptor: role in health and disease. Int. J. Biochem. Cell. Biol. 31:1999;1111-1137
28. Qian Z.M., Li H., Sun H., Ho K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev. 54:2002;561-587
29. Rejman, J., Oberle, V., Zuhorn, I.S., Hoekstra, D., 2003. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J.
30. Schnyder, A., Krahenbuhl, S., Torok, M., Drewe, J., Huwyler, J., 2003. Targeting of skeletal muscle in vitro using biotinylated immunoliposomes. Biochem. J.
31. Shi N., Boado R.J., Pardridge W.M. Antisense imaging of gene expression in the brain in vivo. Proc. Natl. Acad. Sci. U.S.A. 97:2000;14709-14714
32. Shi N., Boado R.J., Pardridge W.M. Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes. Pharm. Res. 18:2001;1091-1095
33. Shi N., Pardridge W.M. Noninvasive gene targeting to the brain. Proc. Natl. Acad. Sci. U.S.A. 97:2000;7567-7572
34. Steven A.C., Hainfeld J.F., Wall J.S., Steer C.J. Mass distributions of coated vesicles isolated from liver and brain: analysis by scanning transmission electron microscopy. J. Cell. Biol. 97:1983;1714-1723
35. Wolburg H., Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul. Pharmacol. 38:2002;323-337