Inhibition of 4E-BP1 Sensitizes U87 Glioblastoma Xenograft Tumors to Irradiation by Decreasing Hypoxia Tolerance

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 4, 2009, Pages 1219-1227

  Dubois, Ludwig ^a   Magagnin, Michaël G ^a   Cleven, Arjen H G ^a   Weppler, Sherry A ^a   Grenacher, Beat ^b   Landuyt, Willy ^c   Lieuwes, Natasja ^a   Lambin, Philippe ^a   Gorr, Thomas A ^b   Koritzinsky, Marianne ^a,d,e   Wouters, Bradly G ^a,d,e,f  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d PRINCESS MARGARET HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

4E BP1; Hypoxia; Radiotherapy; Translation; U87

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MATERIALS; CELL DEATH; ENERGY CONSERVATION; ENERGY MANAGEMENT; GROWTH (MATERIALS); ONCOLOGY; RADIOTHERAPY;

4E-BP1; CASPASE-3; DISEASE PROGRESSIONS; EUKARYOTIC CELLS; EUKARYOTIC INITIATION FACTORS; GLIOBLASTOMA; GROWTH ACTIVITIES; GROWTH PROPERTIES; GROWTH-PROMOTING EFFECTS; HUMAN TUMORS; HYPOXIA; HYPOXIC CELLS; IN-VITRO; IN-VIVO; RADIORESISTANCE; RATE-LIMITING FACTORS; SOLID TUMORS; STABLE EXPRESSIONS; TRANSLATION; TUMOR XENOGRAFTS; U87;

TUMORS;

ADENOSINE TRIPHOSPHATE; CASPASE 3; INITIATION FACTOR 4E BINDING PROTEIN 1; SHORT HAIRPIN RNA;

ANIMAL MODEL; ARTICLE; CELL DEATH; CELL HYPOXIA; CELL LINE; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; TUMOR GROWTH; XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL HYPOXIA; CELL SURVIVAL; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; GENE KNOCKOUT TECHNIQUES; GLIOBLASTOMA; HELA CELLS; HUMANS; MICE; MICE, NUDE; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS; RADIATION DOSAGE; RADIATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 61349148661     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.12.003     Document Type: Article

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