Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

Biochimie

Volumn 94, Issue 3, 2012, Pages 854-863

  D'Ambrosio, Danilo ^a,b   Reichenbach, Patrick ^a   Micheli, Emanuela ^b   Alvino, Antonello ^b   Franceschin, Marco ^b   Savino, Maria ^b   Lingner, Joachim ^a  

^a EPFL   (Switzerland)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

G quadruplex; Inhibitor; Perylene diimide; Telomerase; Telomere; Telospot

Indexed keywords

DOUBLE STRANDED DNA; GENOMIC DNA; GUANINE QUADRUPLEX; HYDROSOLUBLE PERYLENE DIIMIDE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DIRECT ASSAY; DNA BINDING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; POLYACRYLAMIDE GEL ELECTROPHORESIS; TELESPOT ASSAY; TELOMERE;

CIRCULAR DICHROISM; G-QUADRUPLEXES; HUMANS; IMIDES; PERYLENE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TELOMERASE; TELOMERE;

EID: 84857038475     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.12.004     Document Type: Article

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