The Orexin/Hypocretin System in Zebrafish Is Connected to the Aminergic and Cholinergic Systems

Journal of Neuroscience

Volumn 24, Issue 11, 2004, Pages 2678-2689

  Kaslin, Jan ^a   Nystedt, Johanna M ^a,b   Östergård, Maria ^a   Peitsaro, Nina ^b   Panula, Pertti ^a,b  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Acetylcholine; Danio rerio; Dopamine; Histamine; Narcolepsy; Noradrenaline; Serotonin; Teleost

Indexed keywords

ACETYLCHOLINE; CONTIG; DOPAMINE; HISTAMINE; NORADRENALIN; OREXIN; OREXIN A; OREXIN B; SEROTONIN;

ADRENERGIC ACTIVITY; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; ENERGY; ENERGY METABOLISM; EXON; FEEDING; GENETIC CODE; HOMEOSTASIS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LOCUS CERULEUS; MOLECULAR CLONING; NARCOLEPSY; NERVE PROJECTION; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAPHE NUCLEUS; SLEEP PATTERN; SLEEP WAKING CYCLE; WAKEFULNESS; ZEBRA FISH;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; CARRIER PROTEINS; CHOLINERGIC FIBERS; CLONING, MOLECULAR; DOPAMINE; HISTAMINE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; NEURAL PATHWAYS; NEURONS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; PROTEIN PRECURSORS; RNA, MESSENGER; SEROTONIN; TYROSINE 3-MONOOXYGENASE; ZEBRAFISH;

EID: 1642350904     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4908-03.2004     Document Type: Article

References (49)

1. Abercrombie M (1946) Estimation of nuclear population from microtome sections. Anat Rec 94:239-247.
2. Alvarez CE, Sutcliffe JG (2002) Hypocretin is an early member of the incretin gene family. Neurosci Lett 324:169-172.
3. Balter M (1995) In Toulouse, the weather and the science are hot. Science 1269:480-481.
4. Beuckmann CT, Yanagisawa M (2002) Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med 80:329-342.
5. Brown RE, Sergeeva OA, Eriksson KS, Haas HL (2002) Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine, and noradrenaline). J Neurosci 22:8850-8859.
6. Cahill GM (2002) Clock mechanisms in zebrafish. Cell Tissue Res 309:27-34.
7. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.
8. Coggeshall RE, Lekan HA (1996) Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol 364:6-15.
9. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett II FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322-327.
10. Dooley K, Zon LI (2000) Zebrafish: a model system for the study of human disease. Curr Opin Genet Dev 10:252-256.
11. Eggermann E, Serafin M, Bayer L, Machard D, Saint-Mleux B, Jones BE, Muhlethaler M (2001) Orexins/hypocretins excite basal forebrain cholinergic neurones. Neuroscience 108:177-181.
12. Eriksson KS, Sergeeva O, Brown RE, Haas HL (2001) Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 21:9273-9279.
13. Fishman MC (2001) Genomics. Zebrafish: the canonical vertebrate. Science 294:1290-1291.
14. Galas L, Vaudry H, Braun B, van den Pol AN, de Lecea L, Sutcliffe JG, Chartrel N (2001) Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda. J Comp Neurol 429:242-252.
15. Greenspan RJ, Tononi G, Cirelli C, Shaw PJ (2001) Sleep and the fruit fly. Trends Neurosci 3:142-145.
16. Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, van Eeden FJ, Jiang YJ, Heisenberg CP, Kelsh RN, Furutani-Seiki M, Vogelsang E, Beuchle D, Schach U, Fabian C, Nusslein-Volhard C (1996) The identification of genes with unique and essential functions in the developement of the zebrafish, Danio rerio. Development 123:1-36.
17. Hendricks JC, Sehgal A, Pack AI (2000) The need for a simple animal model to understand sleep. Prog Neurobiol 4:339-351.
18. Holmqvist BI, Ekström P (1991) Galanin-like immunoreactivity in the brain of teleosts: distribution and relation to substance P, vasotocin, and isotocin in the Atlantic salmon (Salmo salar). J Comp Neurol 306:361-381.
19. Holmqvist BI, Ekström P (1995) Hypophysiotrophic systems in the brain of the Atlantic salmon. Neuronal innervation of the pituitary and the origin of pituitary dopamine and nonapeptides identified by means of combined carbocyanine tract tracing and immunocytochemistry. J Chem Neuroanat 8:125-145.
20. Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS, van den Pol AN (1999) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 415:145-159.
21. Kaslin J, Panula P (2001) Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio). J Comp Neurol 440:342-377.
22. Kilduff TS, Peyron C (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 23:359-365.
23. Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci 23:7-11.
24. Li Y, Gao XB, Sakurai T, van den Pol AN (2002) Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36:1169-1181.
25. Ma P (1994a) Catecholaminergic systems in the zebrafish. I. Number, morphology, and histochemical characteristics of neurons in the locus coeruleus. J Comp Neurol 344:242-255.
26. Ma P (1994b) Catecholaminergic systems in the zebrafish. II. Projection pathways and pattern of termination of the locus coeruleus. J Comp Neurol 344:256-269.
27. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6-25.
28. Mignot E, Taheri S, Nishino S (2002) Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci 2002:1071-1075.
29. Nieminen ML, Brandt A, Pietila P, Panula P (2002) Expression of mammalian RF-amide peptides neuropeptide FF (NPFF), prolactin-releasing peptide (PrRP) and the PrRP receptor in the peripheral tissues of the rat. Peptides 11:1695-1701.
30. Ohkubo T, Boswell T, Lumineau S (2002) Molecular cloning of chicken prepro-orexin cDNA and preferential expression in the chicken hypothalamus. Biochim Biophys Acta 1577:476-480.
31. Pace-Schott EF, Hobson JA (2002) The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 8:591-605.
32. Panda S, Hogenesch JB, Kay SA (2002) Circadian rhythms from flies to human. Nature 417:329-335.
33. Panula P, Airaksinen MS, Pirvola U, Kotilainen E (1990) A histamine-containing neuronal system in human brain. Neuroscience 34:127-132.
34. Peter RE, Fryer JN (1983) Endocrine functions of the hypothalamus of actinopterygians. In: Fish neurobiology: higher brain areas and functions, Vol II, (Davis RE, Northcutt GR, eds), pp 165-201. Ann Arbor, MI: University of Michigan.
35. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015.
36. Rink E, Wullimann MF (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res 889:316-330.
37. Risold PY, Griffond B, Kilduff TS, Sutcliffe JG, Fellmann D (1999) Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area. Neurosci Lett 259:153-156.
38. Russell SH, Small CJ, Kennedy AR, Stanley SA, Seth A, Murphy KG, Taheri S, Ghatei MA, Bloom SR (2001) Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 142:5294-5302.
39. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
40. Saper CB, Chou TC, Scammell TE (2001) The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24:726-731.
41. Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, Goto K (1999) Structure, tissue distribution, and pharmacological characterization of Xenopus orexins. Peptides 20:1169-1176.
42. Sutcliffe JG, de Lecea L (2002) The hypocretins: setting the arousal threshold. Nat Rev Neurosci 3:339-349.
43. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 3:469-474.
44. Trivedi P, Yu H, MacNeil DJ, Van der Ploeg LH, Guan XM (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438:71-75.
45. van den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 118:7962-7971.
46. Westerfield M (1995) The zebrafish book: guide for the laboratory use of zebrafish (Danio rerio), Chap 1-3, Ed 3. Eugene, OR: University of Oregon.
47. Whitmore D, Foulkes NS, Strahle U, Sassone-Corsi P (1998) Zebrafish clock rhythmic expression reveals independent peripheral circadian oscillators. Nat Neurosci 8:701-707.
48. Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T (2002) Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun 290:1237-1245.
49. Zhdanova IV, Wang SY, Leclair OU, Danilova NP (2001) Melatonin promotes sleep-like state in zebrafish. Brain Res 903:263-268.