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Volumn 27, Issue SUPPL.2, 2012, Pages 42-46

Iron and steatohepatitis

Author keywords

Alcoholic liver disease; Fatty liver disease; Hepcidin; Iron; Steatohepatitis

Indexed keywords

ALCOHOL; CCAAT ENHANCER BINDING PROTEIN ALPHA; FERROPORTIN; HEPCIDIN; IRON; JANUS KINASE 2; MESSENGER RNA; STAT3 PROTEIN;

EID: 84856954278     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.07014.x     Document Type: Review
Times cited : (56)

References (50)
  • 1
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis and new therapeutic targets
    • Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011; 141(5): 1572-85.
    • (2011) Gastroenterology , vol.141 , Issue.5 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 2
    • 80053449479 scopus 로고    scopus 로고
    • Genetic modifiers of non-alcoholic fatty liver disease progression
    • Anstee QM, Daly AK, Day CP. Genetic modifiers of non-alcoholic fatty liver disease progression. Biochim. Biophys. Acta 2011; 1812: 1557-66.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 1557-1566
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 3
    • 80052657110 scopus 로고    scopus 로고
    • Pathology of hepatic iron overload
    • Deugnier Y, Turlin B. Pathology of hepatic iron overload. Semin. Liver Dis. 2011; 31: 260-71.
    • (2011) Semin. Liver Dis. , vol.31 , pp. 260-271
    • Deugnier, Y.1    Turlin, B.2
  • 4
    • 58149302689 scopus 로고    scopus 로고
    • Iron in NASH, chronic liver diseases and HCC: how much iron is too much?
    • Pietrangelo A. Iron in NASH, chronic liver diseases and HCC: how much iron is too much? J. Hepatol. 2009; 50: 249-51.
    • (2009) J. Hepatol. , vol.50 , pp. 249-251
    • Pietrangelo, A.1
  • 5
    • 36849075284 scopus 로고    scopus 로고
    • Iron chelation beyond transfusion iron overload
    • Pietrangelo A. Iron chelation beyond transfusion iron overload. Am. J. Hematol. 2007; 82: 1142-6.
    • (2007) Am. J. Hematol. , vol.82 , pp. 1142-1146
    • Pietrangelo, A.1
  • 6
    • 0029922315 scopus 로고    scopus 로고
    • Metals, oxidative stress, and hepatic fibrogenesis
    • Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin. Liver Dis. 1996; 16: 13-30.
    • (1996) Semin. Liver Dis. , vol.16 , pp. 13-30
    • Pietrangelo, A.1
  • 7
    • 78649634981 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: therapeutic implications
    • Pietrangelo A. Hepcidin in human iron disorders: therapeutic implications. J. Hepatol. 2011; 54: 173-81.
    • (2011) J. Hepatol. , vol.54 , pp. 173-181
    • Pietrangelo, A.1
  • 8
    • 79959562083 scopus 로고    scopus 로고
    • Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
    • Corradini E, Meynard D, Wu Q etal. Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 2011; 54: 273-84.
    • (2011) Hepatology , vol.54 , pp. 273-284
    • Corradini, E.1    Meynard, D.2    Wu, Q.3
  • 9
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • Vecchi C, Montosi G, Zhang K etal. ER stress controls iron metabolism through induction of hepcidin. Science 2009; 325: 877-80.
    • (2009) Science , vol.325 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3
  • 10
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. Iron regulation and erythropoiesis. Curr. Opin. Hematol. 2008; 15: 169-75.
    • (2008) Curr. Opin. Hematol. , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 14
    • 84855281868 scopus 로고    scopus 로고
    • Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries
    • Ji C. Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem. Res. Int. 2012; 2012: 216450.
    • (2012) Biochem. Res. Int. , vol.2012 , pp. 216450
    • Ji, C.1
  • 15
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E etal. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J. Biol. Chem. 2006; 281: 22974-82.
    • (2006) J. Biol. Chem. , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.D.1    Schafer, D.2    Klein, E.3
  • 16
    • 33644773569 scopus 로고    scopus 로고
    • Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease
    • Bridle K, Cheung TK, Murphy T etal. Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol. Clin. Exp. Res. 2006; 30: 106-12.
    • (2006) Alcohol. Clin. Exp. Res. , vol.30 , pp. 106-112
    • Bridle, K.1    Cheung, T.K.2    Murphy, T.3
  • 17
    • 34848838993 scopus 로고    scopus 로고
    • Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    • Harrison-Findik DD, Klein E, Crist C, Evans J, Timchenko N, Gollan J. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology 2007; 46: 1979-85.
    • (2007) Hepatology , vol.46 , pp. 1979-1985
    • Harrison-Findik, D.D.1    Klein, E.2    Crist, C.3    Evans, J.4    Timchenko, N.5    Gollan, J.6
  • 18
    • 33846293650 scopus 로고    scopus 로고
    • Hepcidin is down-regulated in alcohol loading
    • Ohtake T, Saito H, Hosoki Y etal. Hepcidin is down-regulated in alcohol loading. Alcohol. Clin. Exp. Res. 2007; 31 (Suppl.): S2-8.
    • (2007) Alcohol. Clin. Exp. Res. , vol.31 , Issue.SUPPL.
    • Ohtake, T.1    Saito, H.2    Hosoki, Y.3
  • 19
    • 0033373209 scopus 로고    scopus 로고
    • Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury
    • Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am. J. Physiol. 1999; 277 (Pt 1): G1240-50.
    • (1999) Am. J. Physiol. , vol.277 , Issue.PART 1
    • Tsukamoto, H.1    Lin, M.2    Ohata, M.3    Giulivi, C.4    French, S.W.5    Brittenham, G.6
  • 21
    • 0034065378 scopus 로고    scopus 로고
    • Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study
    • Ganne-Carrié N, Christidis C, Chastang C etal. Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study. Gut 2000; 46: 277-82.
    • (2000) Gut , vol.46 , pp. 277-282
    • Ganne-Carrié, N.1    Christidis, C.2    Chastang, C.3
  • 22
    • 37349033182 scopus 로고    scopus 로고
    • Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis
    • Nahon P, Sutton A, Rufat P etal. Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis. Gastroenterology 2008; 134: 102-10.
    • (2008) Gastroenterology , vol.134 , pp. 102-110
    • Nahon, P.1    Sutton, A.2    Rufat, P.3
  • 23
    • 0036163634 scopus 로고    scopus 로고
    • Excess alcohol greatly increases the prevalence of cirrhosis in hereditary HC: quantifying the risk
    • Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary HC: quantifying the risk. Gastroenterology 2002; 122: 281-9.
    • (2002) Gastroenterology , vol.122 , pp. 281-289
    • Fletcher, L.M.1    Dixon, J.L.2    Purdie, D.M.3    Powell, L.W.4    Crawford, D.H.G.5
  • 24
    • 0019985082 scopus 로고
    • Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis
    • Chapman RW, Morgan MY, Laulicht M, Hoffbrand AV, Sherlock S. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig. Dis. Sci. 1982; 27: 909-16.
    • (1982) Dig. Dis. Sci. , vol.27 , pp. 909-916
    • Chapman, R.W.1    Morgan, M.Y.2    Laulicht, M.3    Hoffbrand, A.V.4    Sherlock, S.5
  • 26
    • 0042384686 scopus 로고    scopus 로고
    • Iron-induced oxidant stress in alcoholic liver fibrogenesis
    • Pietrangelo A. Iron-induced oxidant stress in alcoholic liver fibrogenesis. Alcohol 2003; 30: 121-9.
    • (2003) Alcohol , vol.30 , pp. 121-129
    • Pietrangelo, A.1
  • 27
    • 0030858597 scopus 로고    scopus 로고
    • Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages
    • Lin M, Rippe RA, Niemelä O, Brittenham G, Tsukamoto H. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages. Am. J. Physiol. 1997; 272 (Pt 1): G1355.
    • (1997) Am. J. Physiol. , vol.272 , Issue.PART 1
    • Lin, M.1    Rippe, R.A.2    Niemelä, O.3    Brittenham, G.4    Tsukamoto, H.5
  • 28
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    • Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010; 51: 679-89.
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 29
    • 38149030206 scopus 로고    scopus 로고
    • Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
    • Kotronen A, Juurinen L, Hakkarainen A etal. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 2008; 31: 165-9.
    • (2008) Diabetes Care , vol.31 , pp. 165-169
    • Kotronen, A.1    Juurinen, L.2    Hakkarainen, A.3
  • 30
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science 2011; 332: 1519-23.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 31
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
    • Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J. Hepatol. 2009; 51: 371-9.
    • (2009) J. Hepatol. , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3    Caldwell, S.H.4
  • 32
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP. From fat to inflammation. Gastroenterology 2006; 130: 207-10.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 34
    • 0032692722 scopus 로고    scopus 로고
    • Insulin resistance-associated hepatic iron overload
    • Mendler MH, Turlin B, Moirand R etal. Insulin resistance-associated hepatic iron overload. Gastroenterology 1999; 117: 1155-63.
    • (1999) Gastroenterology , vol.117 , pp. 1155-1163
    • Mendler, M.H.1    Turlin, B.2    Moirand, R.3
  • 35
    • 77249139227 scopus 로고    scopus 로고
    • HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Fracanzani AL, Bugianesi E etal. HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease. Gastroenterology 2010; 138: 905-12.
    • (2010) Gastroenterology , vol.138 , pp. 905-912
    • Valenti, L.1    Fracanzani, A.L.2    Bugianesi, E.3
  • 36
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • Nelson JE, Wilson L, Brunt EM etal. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 2011; 53: 448-57.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3
  • 38
    • 80052940689 scopus 로고    scopus 로고
    • Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target
    • Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J. Hepatol. 2011; 55: 920-32.
    • (2011) J. Hepatol. , vol.55 , pp. 920-932
    • Dongiovanni, P.1    Fracanzani, A.L.2    Fargion, S.3    Valenti, L.4
  • 39
    • 33748265283 scopus 로고    scopus 로고
    • Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    • Bekri S, Gual P, Anty R etal. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006; 131: 788-96.
    • (2006) Gastroenterology , vol.131 , pp. 788-796
    • Bekri, S.1    Gual, P.2    Anty, R.3
  • 40
    • 35848934560 scopus 로고    scopus 로고
    • Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    • Chung B, Matak P, McKie AT, Sharp PJ. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J. Nutr. 2007; 137: 2366-70.
    • (2007) J. Nutr. , vol.137 , pp. 2366-2370
    • Chung, B.1    Matak, P.2    McKie, A.T.3    Sharp, P.J.4
  • 41
    • 78650155191 scopus 로고    scopus 로고
    • Effect of body mass index reduction on serum hepcidin levels and iron status in obese children
    • Amato A, Santoro N, Calabrò P etal. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int. J. Obes. (Lond) 2010; 34: 1772-4.
    • (2010) Int. J. Obes. (Lond) , vol.34 , pp. 1772-1774
    • Amato, A.1    Santoro, N.2    Calabrò, P.3
  • 42
    • 58149280387 scopus 로고    scopus 로고
    • Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis
    • Sorrentino P, D'Angelo S, Ferbo U, Micheli P, Bracigliano A, Vecchione R. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J. Hepatol. 2009; 50: 351-7.
    • (2009) J. Hepatol. , vol.50 , pp. 351-357
    • Sorrentino, P.1    D'Angelo, S.2    Ferbo, U.3    Micheli, P.4    Bracigliano, A.5    Vecchione, R.6
  • 43
    • 79956028847 scopus 로고    scopus 로고
    • Alterations in lipid, carbohydrate and iron metabolism in patients with non-alcoholic steatohepatitis (NASH) and metabolic syndrome
    • Zimmermann A, Zimmermann T, Schattenberg J etal. Alterations in lipid, carbohydrate and iron metabolism in patients with non-alcoholic steatohepatitis (NASH) and metabolic syndrome. Eur. J. Intern. Med. 2011; 22: 305-10.
    • (2011) Eur. J. Intern. Med. , vol.22 , pp. 305-310
    • Zimmermann, A.1    Zimmermann, T.2    Schattenberg, J.3
  • 44
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M etal. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-38.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 45
    • 0141656292 scopus 로고    scopus 로고
    • Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary HC
    • Valenti L, Dongiovanni P, Fracanzani AL etal. Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary HC. Dig. Liver Dis. 2003; 35: 172-8.
    • (2003) Dig. Liver Dis. , vol.35 , pp. 172-178
    • Valenti, L.1    Dongiovanni, P.2    Fracanzani, A.L.3
  • 46
    • 41949114990 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction in insulin resistance
    • Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ. Res. 2008; 102: 401-14.
    • (2008) Circ. Res. , vol.102 , pp. 401-414
    • Kim, J.A.1    Wei, Y.2    Sowers, J.R.3
  • 47
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology 2002; 122: 931-9.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 48
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti L, Fracanzani AL, Dongiovanni P etal. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am. J. Gastroenterol. 2007; 102: 1251-8.
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3
  • 49
    • 1442281989 scopus 로고    scopus 로고
    • Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    • Bugianesi E, Manzini P, D'Antico S etal. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004; 39: 179-87.
    • (2004) Hepatology , vol.39 , pp. 179-187
    • Bugianesi, E.1    Manzini, P.2    D'Antico, S.3
  • 50
    • 84155188801 scopus 로고    scopus 로고
    • Serum ferritin is an independent predictor of histologic severity and advanced fibrosis among patients with nonalcoholic fatty liver disease
    • for the NASH Clinical Research Network.
    • Kowdley KV, Belt P, Wilson LA etal. for the NASH Clinical Research Network. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis among patients with nonalcoholic fatty liver disease. Hepatology 2012; 55(1): 77-85.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 77-85
    • Kowdley, K.V.1    Belt, P.2    Wilson, L.A.3


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