-
1
-
-
0037169357
-
Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models
-
Balmain A, (2002) Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models. Cell 108: 145-152.
-
(2002)
Cell
, vol.108
, pp. 145-152
-
-
Balmain, A.1
-
2
-
-
0037370476
-
The genetics and genomics of cancer
-
Balmain A, Gray J, Ponder B, (2003) The genetics and genomics of cancer. Nat Genet 33 (Suppl): 238-244.
-
(2003)
Nat Genet
, vol.33
, Issue.SUPPL.
, pp. 238-244
-
-
Balmain, A.1
Gray, J.2
Ponder, B.3
-
3
-
-
0037307891
-
Genomic approaches to identification of tumor-susceptibility genes using mouse models
-
Mao JH, Balmain A, (2003) Genomic approaches to identification of tumor-susceptibility genes using mouse models. Curr Opin Genet Dev 13: 14-19.
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 14-19
-
-
Mao, J.H.1
Balmain, A.2
-
4
-
-
77049105158
-
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer
-
Galvan A, Ioannidis JP, Dragani TA, (2010) Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet 26: 132-41.
-
(2010)
Trends Genet
, vol.26
, pp. 132-141
-
-
Galvan, A.1
Ioannidis, J.P.2
Dragani, T.A.3
-
5
-
-
77956309446
-
Genome-Wide Association Studies of Cancer
-
Stadler ZK, Thom P, Robson ME, Weitzel JN, Kauff ND, et al. (2010) Genome-Wide Association Studies of Cancer. J Clin Oncol 28: 4255-67.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4255-4267
-
-
Stadler, Z.K.1
Thom, P.2
Robson, M.E.3
Weitzel, J.N.4
Kauff, N.D.5
-
7
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
-
8
-
-
0035866354
-
Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice
-
Nagase H, Mao JH, de Koning JP, Minami T, Balmain A, (2001) Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice. Cancer Res 61: 1305-8.
-
(2001)
Cancer Res
, vol.61
, pp. 1305-1308
-
-
Nagase, H.1
Mao, J.H.2
de Koning, J.P.3
Minami, T.4
Balmain, A.5
-
9
-
-
0035802288
-
Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome
-
Tripodis N, Hart AA, Fijneman RJ, Demant P, (2001) Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst 93: 1484-91.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1484-1491
-
-
Tripodis, N.1
Hart, A.A.2
Fijneman, R.J.3
Demant, P.4
-
10
-
-
0042093747
-
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
-
Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, et al. (2003) Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 34: 403-412.
-
(2003)
Nat Genet
, vol.34
, pp. 403-412
-
-
Ewart-Toland, A.1
Briassouli, P.2
de Koning, J.P.3
Mao, J.H.4
Yuan, J.5
-
11
-
-
0042941698
-
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice
-
Nagase H, Mao JH, Balmain A, (2003) Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res 63: 4849-4853.
-
(2003)
Cancer Res
, vol.63
, pp. 4849-4853
-
-
Nagase, H.1
Mao, J.H.2
Balmain, A.3
-
12
-
-
0014654544
-
Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome
-
Li FP, Fraumeni JF Jr, (1969) Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J Natl Cancer Inst 43: 1365-1373.
-
(1969)
J Natl Cancer Inst
, vol.43
, pp. 1365-1373
-
-
Li, F.P.1
Fraumeni Jr., J.F.2
-
13
-
-
0015043748
-
Mutation and cancer: statistical study of retinoblastoma
-
Knudson AG Jr, (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68: 820-823.
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 820-823
-
-
Knudson Jr., A.G.1
-
14
-
-
28844454891
-
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers
-
Hienonen T, Salovaara R, Mecklin JP, Järvinen H, Karhu A, Aaltonen LA, (2006) Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers. Int J Cancer 118: 505-508.
-
(2006)
Int J Cancer
, vol.118
, pp. 505-508
-
-
Hienonen, T.1
Salovaara, R.2
Mecklin, J.P.3
Järvinen, H.4
Karhu, A.5
Aaltonen, L.A.6
-
15
-
-
10644269326
-
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumor suppressor gene
-
Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, et al. (2004) Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumor suppressor gene. Nature 432: 775-779.
-
(2004)
Nature
, vol.432
, pp. 775-779
-
-
Mao, J.H.1
Perez-Losada, J.2
Wu, D.3
Delrosario, R.4
Tsunematsu, R.5
-
16
-
-
23044502672
-
Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway
-
Perez-Losada J, Mao JH, Balmain A, (2005) Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res 65: 6488-6492.
-
(2005)
Cancer Res
, vol.65
, pp. 6488-6492
-
-
Perez-Losada, J.1
Mao, J.H.2
Balmain, A.3
-
17
-
-
2942614705
-
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
-
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, et al. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-2125.
-
(2004)
EMBO J
, vol.23
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
Tsunematsu, R.5
-
18
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
Welcker M, Orian A, Jin J, Grim JA, Harper JW, et al. (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 101: 9085-9090.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.A.4
Harper, J.W.5
-
19
-
-
1342275412
-
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling
-
Nateri AS, Riera-Sans L, Da Costa C, Behrens A, (2004) The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303: 1374-1378.
-
(2004)
Science
, vol.303
, pp. 1374-1378
-
-
Nateri, A.S.1
Riera-Sans, L.2
Da Costa, C.3
Behrens, A.4
-
20
-
-
0035812709
-
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
-
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, et al. (2001) Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294: 173-177.
-
(2001)
Science
, vol.294
, pp. 173-177
-
-
Koepp, D.M.1
Schaefer, L.K.2
Ye, X.3
Keyomarsi, K.4
Chu, C.5
-
21
-
-
0035921928
-
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
-
Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK, (2001) Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413: 311-316.
-
(2001)
Nature
, vol.413
, pp. 311-316
-
-
Moberg, K.H.1
Bell, D.W.2
Wahrer, D.C.3
Haber, D.A.4
Hariharan, I.K.5
-
22
-
-
0035921849
-
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
-
Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, et al. (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413: 316-322.
-
(2001)
Nature
, vol.413
, pp. 316-322
-
-
Strohmaier, H.1
Spruck, C.H.2
Kaiser, P.3
Won, K.A.4
Sangfelt, O.5
-
23
-
-
0034791336
-
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
-
Wu G, Lyapina S, Das I, Li J, Gurney M, et al. (2001) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 21: 7403-7415.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7403-7415
-
-
Wu, G.1
Lyapina, S.2
Das, I.3
Li, J.4
Gurney, M.5
-
24
-
-
0035929669
-
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
-
Oberg C, Li J, Pauley A, Wolf E, Gurney M, et al. (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 276: 35847-35853.
-
(2001)
J Biol Chem
, vol.276
, pp. 35847-35853
-
-
Oberg, C.1
Li, J.2
Pauley, A.3
Wolf, E.4
Gurney, M.5
-
25
-
-
0035860804
-
Functional interaction between SEL-10, an F-box, and the nuclear form of activated Notch1 receptor
-
Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, et al. (2001) Functional interaction between SEL-10, an F-box, and the nuclear form of activated Notch1 receptor. J Biol Chem 276: 34371-34378.
-
(2001)
J Biol Chem
, vol.276
, pp. 34371-34378
-
-
Gupta-Rossi, N.1
Le Bail, O.2
Gonen, H.3
Brou, C.4
Logeat, F.5
-
26
-
-
33745613510
-
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation
-
Fujii Y, Yada M, Nishiyama M, Kamura T, Takahashi H, et al. (2006) Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci 97: 729-736.
-
(2006)
Cancer Sci
, vol.97
, pp. 729-736
-
-
Fujii, Y.1
Yada, M.2
Nishiyama, M.3
Kamura, T.4
Takahashi, H.5
-
27
-
-
51749095471
-
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
-
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, et al. (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321: 1499-1502.
-
(2008)
Science
, vol.321
, pp. 1499-1502
-
-
Mao, J.H.1
Kim, I.J.2
Wu, D.3
Climent, J.4
Kang, H.C.5
DelRosario, R.6
-
28
-
-
71549161146
-
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
-
Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, et al. (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69: 8967-8976.
-
(2009)
Cancer Res
, vol.69
, pp. 8967-8976
-
-
Fu, L.1
Kim, Y.A.2
Wang, X.3
Wu, X.4
Yue, P.5
Lonial, S.6
-
29
-
-
38549086019
-
FBW7 ubiquitin ligase: a tumor suppressor at the crossroads of cell division, growth and differentiation
-
Welcker M, Clurman BE, (2008) FBW7 ubiquitin ligase: a tumor suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83-93.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
30
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, et al. (2011) Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154-7.
-
(2011)
Science
, vol.333
, pp. 1154-1157
-
-
Agrawal, N.1
Frederick, M.J.2
Pickering, C.R.3
Bettegowda, C.4
Chang, K.5
-
31
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, et al. (2007) FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67: 9006-9012.
-
(2007)
Cancer Res
, vol.67
, pp. 9006-9012
-
-
Akhoondi, S.1
Sun, D.2
von der Lehr, N.3
Apostolidou, S.4
Klotz, K.5
-
32
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, et al. (2004) Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279: 9417-9423.
-
(2004)
J Biol Chem
, vol.279
, pp. 9417-9423
-
-
Tsunematsu, R.1
Nakayama, K.2
Oike, Y.3
Nishiyama, M.4
Ishida, N.5
-
33
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, et al. (2004) Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A 101: 3338-3345.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
Yu, W.2
Li, M.3
Zhang, P.4
Finegold, M.5
-
34
-
-
0029086835
-
Distinct genetic loci control development of benign and malignant skin tumors in mice
-
Nagase H, Bryson S, Cordell H, Kemp CJ, Fee F, et al. (1995) Distinct genetic loci control development of benign and malignant skin tumors in mice. Nat Genet 10: 424-429.
-
(1995)
Nat Genet
, vol.10
, pp. 424-429
-
-
Nagase, H.1
Bryson, S.2
Cordell, H.3
Kemp, C.J.4
Fee, F.5
-
35
-
-
0033592852
-
A subset of skin tumor modifier loci determines survival time of tumor-bearing mice
-
Nagase H, Mao JH, Balmain A, (1999) A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A 96: 15032-7.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 15032-15037
-
-
Nagase, H.1
Mao, J.H.2
Balmain, A.3
-
36
-
-
0347383877
-
Genetic interactions between Pten and p53 in radiation-induced lymphoma development
-
Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, et al. (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene 22: 8379-8385.
-
(2003)
Oncogene
, vol.22
, pp. 8379-8385
-
-
Mao, J.H.1
Wu, D.2
Perez-Losada, J.3
Nagase, H.4
DelRosario, R.5
-
37
-
-
0034306983
-
Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis
-
Ginzinger DG, Godfrey TE, Nigro J, Moore DH 2nd, Suzuki S, et al. (2000) Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res 60: 5405-5409.
-
(2000)
Cancer Res
, vol.60
, pp. 5405-5409
-
-
Ginzinger, D.G.1
Godfrey, T.E.2
Nigro, J.3
Moore II, D.H.4
Suzuki, S.5
-
38
-
-
0035067396
-
Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay
-
Nigro JM, Takahashi MA, Ginzinger DG, Law M, Passe S, (2001) Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay. Am J Pathol 158: 1253-1262.
-
(2001)
Am J Pathol
, vol.158
, pp. 1253-1262
-
-
Nigro, J.M.1
Takahashi, M.A.2
Ginzinger, D.G.3
Law, M.4
Passe, S.5
|