Searching for DNA lesions: Structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase

Biochemistry

Volumn 51, Issue 1, 2012, Pages 382-390

  Setser, Jeremy W ^a   Lingaraju, Gondichatnahalli M ^b,e   Davis, C Ainsley ^a,f   Samson, Leona D ^a,b,c   Drennan, Catherine L ^a,b,d  

^a Department Chemistry ^*  (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^f BETHUNE COOKMAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; DISORDERED STATE; DNA ADDUCTS; DNA BASIS; DNA BINDING; DNA GLYCOSYLASE; DNA LESIONS; ELECTROSTATIC SURFACES; STRUCTURAL EVIDENCE;

CONFORMATIONS;

DNA;

ALKYLADENINE DNA GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DNA ADDUCT; DNA BINDING; DNA DAMAGE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA ADDUCTS; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-BINDING PROTEINS; GENOME, HUMAN; HUMANS; MUTAGENESIS; NUCLEIC ACID HETERODUPLEXES; PLASMIDS; PROTEIN CONFORMATION;

EID: 84856812291     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201484k     Document Type: Article

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