Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13205-13213

  Lingaraju, Gondichatnahalli M ^a   Davis, C Ainsley ^c   Setser, Jeremy W ^b   Samson, Leona D ^a,b   Drennan, Catherine L ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BETHUNE COOKMAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE POCKET; BINDING AFFINITIES; CANCER CHEMOTHERAPY; DNA DAMAGES; DNA DUPLEXES; DNA GLYCOSYLASE; DNA LESIONS; ENVIRONMENTAL AGENTS; GENOTOXIC; LEAVING GROUPS; PROTEIN-DNA COMPLEXES; REACTIVE OXYGEN AND NITROGEN SPECIES; STRUCTURAL BASIS; VINYL CHLORIDES;

BINDING ENERGY; CHEMOTHERAPY; CHLORINE COMPOUNDS; CRYSTAL STRUCTURE; DNA; HYDROGEN; HYDROGEN BONDS; OXYGEN; PATHOLOGY; REACTION KINETICS;

NUCLEIC ACIDS;

3,N4 ETHENOCYTOSINE CONTAINING DNA; ALKYLADENINE DNA GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; UNCLASSIFIED DRUG; VINYL CHLORIDE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DAMAGE; DNA PROTEIN COMPLEX; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DNA BINDING;

CATALYTIC DOMAIN; CYTOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA, NEOPLASM; HUMANS; HYDROGEN BONDING; NEOPLASM PROTEINS; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953861195     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.192435     Document Type: Article

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