Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Uras, Iris Z ^a   List, Thomas ^a   Nijman, Sebastian M B ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; LYSINE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOLIPID; PROTEINASE; UBIQUITIN SPECIFIC PROTEASE 4; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; SIGNAL PEPTIDE; UBIQUITIN THIOLESTERASE; USP4 PROTEIN, HUMAN;

ARTICLE; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; DEUBIQUITINATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MONOUBIQUITINATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; UBIQUITINATION; METABOLISM; PHYSIOLOGY;

CELL LINE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84856736596     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031003     Document Type: Article

References (46)

1. Cantley LC, (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
2. Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD, (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22: 267-272.
3. Toker A, Cantley LC, (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387: 673-676.
4. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, et al. (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457-467.
5. Pearce LR, Komander D, Alessi DR, (2010) The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol 11: 9-22.
6. Lawlor MA, Alessi DR, (2001) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114: 2903-2910.
7. Downward J, (2004) PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15: 177-182.
8. Hanada M, Feng J, Hemmings BA, (2004) Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta 1697: 3-16.
9. Engelman JA, Luo J, Cantley LC, (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
10. Casamayor A, Morrice NA, Alessi DR, (1999) Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochem J 342 (Pt 2): 287-292.
11. McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, et al. (2004) The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J 23: 2071-2082.
12. Bayascas JR, Wullschleger S, Sakamoto K, Garcia-Martinez JM, Clacher C, et al. (2008) Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol 28: 3258-3272.
13. Scheid MP, Parsons M, Woodgett JR, (2005) Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol 25: 2347-2363.
14. Lim MA, Kikani CK, Wick MJ, Dong LQ, (2003) Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. Proc Natl Acad Sci U S A 100: 14006-14011.
15. Giasson BI, Lee VM, (2003) Are ubiquitination pathways central to Parkinson's disease? Cell 114: 1-8.
16. Hoeller D, Dikic I, (2009) Targeting the ubiquitin system in cancer therapy. Nature 458: 438-444.
17. Lopez-Otin C, Hunter T, (2010) The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer 10: 278-292.
18. Pickart CM, (2001) Mechanisms underlying ubiquitination. Annu Rev Biochem 70: 503-533.
19. Mukhopadhyay D, Riezman H, (2007) Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315: 201-205.
20. Bhoj VG, Chen ZJ, (2009) Ubiquitylation in innate and adaptive immunity. Nature 458: 430-437.
21. Chen ZJ, Sun LJ, (2009) Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 33: 275-286.
22. Raiborg C, Stenmark H, (2009) The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458: 445-452.
23. Aguilar RC, Wendland B, (2003) Ubiquitin: not just for proteasomes anymore. Curr Opin Cell Biol 15: 184-190.
24. Hershko A, Ciechanover A, (1998) The ubiquitin system. Annu Rev Biochem 67: 425-479.
25. Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, et al. (2005) A genomic and functional inventory of deubiquitinating enzymes. Cell 123: 773-786.
26. Cohen P, Tcherpakov M, (2010) Will the ubiquitin system furnish as many drug targets as protein kinases? Cell 143: 686-693.
27. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, et al. (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467: 179-184.
28. Yang WL, Wang J, Chan CH, Lee SW, Campos AD, et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-1138.
29. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-139.
30. Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128: 141-156.
31. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, et al. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279: 710-714.
32. King RW, Glotzer M, Kirschner MW, (1996) Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Molecular biology of the cell 7: 1343-1357.
33. Chan WM, Mak MC, Fung TK, Lau A, Siu WY, et al. (2006) Ubiquitination of p53 at multiple sites in the DNA-binding domain. Molecular cancer research: MCR 4: 15-25.
34. Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, et al. (2004) Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J 23: 3918-3928.
35. Filippa N, Sable CL, Hemmings BA, Van Obberghen E, (2000) Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation. Mol Cell Biol 20: 5712-5721.
36. Baker RT, Wang XW, Woollatt E, White JA, Sutherland GR, (1999) Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics 59: 264-274.
37. Currie RA, Walker KS, Gray A, Deak M, Casamayor A, et al. (1999) Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J 337 (Pt 3): 575-583.
38. Huang TT, D'Andrea AD, (2006) Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol 7: 323-334.
39. Kannouche PL, Wing J, Lehmann AR, (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell 14: 491-500.
40. Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, et al. (2003) Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302: 1972-1975.
41. Marmor MD, Yarden Y, (2004) Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23: 2057-2070.
42. Mora A, Komander D, van Aalten DM, Alessi DR, (2004) PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15: 161-170.
43. Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, et al. (2006) The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Mol Pharmacol 69: 1083-1094.
44. Zhao B, Schlesiger C, Masucci MG, Lindsten K, (2009) The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway. J Cell Mol Med 13: 1886-1895.
45. Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, et al. (2011) USP4 targets TAK1 to downregulate TNFalpha-induced NF-kappaB activation. Cell Death Differ.
46. Zhang X, Berger FG, Yang J, Lu X, (2011) USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J 30: 2177-2189.