[35S]GTPγS binding and opioid tolerance and efficacy in mouse spinal cord

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 1, 2012, Pages 155-165

  Madia, Priyanka A ^a   Navani, Dipesh M ^a   Yoburn, Byron C ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

35S GTP S binding assay; Analgesia; Desensitization; Efficacy; G protein uncoupling; Opioid tolerance

Indexed keywords

CLOCINNAMOX; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETORPHINE; FENTANYL CITRATE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O[3 (35 S)THIO]TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE DERIVATIVE; HYDROMORPHONE; MORPHINE; MU OPIATE RECEPTOR; NALTREXONE; OPIATE AGONIST; OXYCODONE; PLACEBO; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BINDING; DRUG DETERMINATION; DRUG EFFICACY; DRUG TOLERANCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SPINAL CORD; TAIL FLICK TEST;

ALGORITHMS; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INJECTIONS, SPINAL; MALE; MEMBRANES; MICE; MORPHINE; PAIN MEASUREMENT; RADIOLIGAND ASSAY; REACTION TIME; RECEPTORS, OPIOID, MU; SPINAL CORD; SULFUR RADIOISOTOPES;

MUS;

EID: 84856600322     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.11.001     Document Type: Article

References (51)

1. A. Bailey, A. Metaxas, R. Al-Hasani, H.L. Keyworth, D.M. Forster, and I. Kitchen Mouse strain differences in locomotor, sensitisation and rewarding effect of heroin; association with alterations in MOP-r activation and dopamine transporter binding Eur J Neurosci 31 2010 742 753
2. J.W. Black, and P. Leff Operational models of pharmacological agonism Proc R Soc Lond B Biol Sci 220 1983 141 162 (Pubitemid 14217337)
3. J.W. Black, P. Leff, N.P. Shankley, and J. Wood An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonism on agonist dissociation constant estimation Br J Pharmacol 84 1985 561 571 (Pubitemid 15169246)
4. L.M. Bohn, R.R. Gainetdinov, F.T. Lin, R.J. Lefkowitz, and M.G. Caron Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence Nature 408 2000 720 723 (Pubitemid 32015987)
5. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
6. C.S. Breivogel, D.E. Selley, and S.R. Childers Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes J Neurochem 68 1997 1462 1472 (Pubitemid 27133053)
7. T.F. Burke, J.H. Woods, J.W. Lewis, and F. Medzihradsky Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice J Pharmacol Exp Ther 271 1994 715 721 (Pubitemid 24377755)
8. J. Celver, M. Xu, W. Jin, J. Lowe, and C. Chavkin Distinct domains of the mu-opioid receptor control uncoupling and internalization Mol Pharmacol 65 2004 528 537 (Pubitemid 38264020)
9. K. Chan, M. Brodsky, T. Davis, S. Franklin, C.E. Inturrisi, and B.C. Yoburn The effect of the irreversible mu-opioid receptor antagonist clocinnamox on morphine potency, receptor binding and receptor mRNA Eur J Pharmacol 287 1995 135 143
10. C. Contet, D. Filliol, A. Matifas, and B.L. Kieffer Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity Neuropharmacology 54 2008 475 486
11. B.M. Cox, and A.T. Crowder Receptor domains regulating mu opioid receptor uncoupling and internalization: relevance to opioid tolerance Mol Pharmacol 65 2004 492 495 (Pubitemid 38264015)
12. S.V. Dighe, P.A. Madia, S. Sirohi, and B.C. Yoburn Continuous morphine produces more tolerance than intermittent or acute treatment Pharmacol Biochem Behav 92 2009 537 542
13. A. Duttaroy, and B.C. Yoburn The effect of intrinsic efficacy on opioid tolerance Anesthesiology 82 1995 1226 1236
14. J. Elliott, L. Guo, and J.R. Traynor Tolerance to mu-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5′-O-(3-[35S]-thio)triphosphate binding Br J Pharmacol 121 1997 1422 1428 (Pubitemid 27317556)
15. P.J. Emmerson, M.J. Clark, A. Mansour, H. Akil, J.H. Woods, and F. Medzihradsky Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor J Pharmacol Exp Ther 278 1996 1121 1127 (Pubitemid 27166961)
16. D.J. Finney Probit analysis 3rd ed. 1973 Cambridge University Press London, UK
17. C. Harrison, and J.R. Traynor The [35S]GTPgammaS binding assay: approaches and applications in pharmacology Life Sci 74 2003 489 508 (Pubitemid 37377904)
18. L. He, J.A. Kim, and J.L. Whistler Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor FASEB J 23 2009 4327 4334
19. J.L. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur J Pharmacol 67 1980 313 316 (Pubitemid 10007057)
20. T. Koch, and V. Höllt Role of receptor internalization in opioid tolerance and dependence Pharmacol Ther 117 2008 199 206
21. P. Kumar, S. Sunkaraneni, S. Sirohi, S.V. Dighe, E.A. Walker, and B.C. Yoburn Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation Eur J Pharmacol 597 2008 39 45
22. P.A. Madia, S.V. Dighe, S. Sirohi, E.A. Walker, and B.C. Yoburn Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse Psychopharmacology (Berl) 207 2009 413 422
23. C.E. Maher, J.C. Eisenach, H.L. Pan, R. Xiao, and S.R. Childers Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord Brain Res 895 2001 1 8 (Pubitemid 32231131)
24. C.E. Maher, T.J. Martin, and S.R. Childers Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration Life Sci 77 2005 1140 1154 (Pubitemid 40835892)
25. T.J. Martin, W.R. Kahn, R. Xiao, and S.R. Childers Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain Synapse 61 2007 176 184 (Pubitemid 46106814)
26. J. McPherson, G. Rivero, M. Baptist, J. Llorente, S. Al-Sabah, and C. Krasel mu-Opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization Mol Pharmacol 78 2010 756 766
27. C.A. Paronis, and J.H. Woods Clocinnamox dose-dependently antagonizes morphine-analgesia and [3H]DAMGO binding in rats Eur J Pharmacol 337 1997 27 34 (Pubitemid 27468857)
28. M.B. Patel, C.N. Patel, V. Rajashekara, and B.C. Yoburn Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo Mol Pharmacol 62 2002 1464 1470 (Pubitemid 35403842)
29. M. Pawar, P. Kumar, S. Sunkaraneni, S. Sirohi, E.A. Walker, and B.C. Yoburn Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of μ-opioid receptors and dynamin-2 Eur J Pharmacol 563 2007 92 101 (Pubitemid 46602222)
30. D.E. Selley, E.J. Nestler, C.S. Breivogel, and S.R. Childers Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment Brain Res 746 1997 10 18 (Pubitemid 27060327)
31. D.E. Selley, L.J. Sim, R. Xiao, Q. Liu, and S.R. Childers mu-Opioid receptor-stimulated guanosine-5′-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy Mol Pharmacol 51 1997 87 96 (Pubitemid 27049549)
32. D.E. Selley, Q. Liu, and S.R. Childers Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus J Pharmacol Exp Ther 285 1998 496 505 (Pubitemid 28237424)
33. L.J. Sim, D.E. Selley, S.I. Dworkin, and S.R. Childers Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain J Neurosci 16 1996 2684 2692
34. L.J. Sim-Selley, D.E. Selley, L.J. Vogt, S.R. Childers, and T.J. Martin Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain J Neurosci 20 2000 4555 4562 (Pubitemid 30396621)
35. L.J. Sim-Selley, K.L. Scoggins, M.P. Cassidy, L.A. Smith, W.L. Dewey, and F.L. Smith Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance Br J Pharmacol 151 2007 1324 1333 (Pubitemid 47255897)
36. S. Sirohi, P. Kumar, and B.C. Yoburn Mu-opioid receptor up-regulation and functional supersensitivity are independent of antagonist efficacy J Pharmacol Exp Ther 323 2007 701 707 (Pubitemid 350005140)
37. S. Sirohi, S.V. Dighe, E.A. Walker, and B.C. Yoburn The analgesic efficacy of fentanyl: relationship to tolerance and μ-opioid receptor regulation Pharmacol Biochem Behav 91 2008 115 120
38. P.A. Smith, D.E. Selley, L.J. Sim-Selley, and S.P. Welch Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors Eur J Pharmacol 571 2007 129 137 (Pubitemid 47379686)
39. K. Stafford, A.B. Gomes, J. Shen, and B.C. Yoburn mu-Opioid receptor downregulation contributes to opioid tolerance in vivo Pharmacol Biochem Behav 69 2001 233 237 (Pubitemid 32566268)
40. P.G. Strange Use of the GTPgammaS ([(35)S]GTPgammaS and Eu-GTPgammaS) binding assay for analysis of ligand potency and efficacy at G protein-coupled receptors Br J Pharmacol 161 2010 1238 1249
41. J.R. Traynor, and S.R. Nahorski Modulation by mu-opioid agonists of guanosine-5′-O-(3 [35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells Mol Pharmacol 47 1995 848 854
42. E.M. Unterwald, J.M. Rubenfeld, Y. Imai, J.B. Wang, G.R. Uhl, and M.J. Kreek Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels Brain Res Mol Brain Res 33 1995 351 355
43. D. Wang, K.M. Raehal, E.T. Lin, J.J. Lowery, B.L. Kieffer, and E.J. Bilsky Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence J Pharmacol Exp Ther 308 2004 512 520 (Pubitemid 38134212)
44. D. Wang, X. Sun, and W. Sadee Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment J Pharmacol Exp Ther 321 2007 544 552 (Pubitemid 46624496)
45. J.L. Whistler, and M. von Zastrow Morphine-activated opioid receptors elude desensitization by beta-arrestin Proc Natl Acad Sci U S A 95 1998 9914 9919 (Pubitemid 28415269)
46. S. Wolfram Mathematica: a system for doing mathematics by computer 1991 Addison-Wesley Publishing Company Reading, MA
47. B.C. Yoburn, J. Chen, T. Huang, and C.E. Inturrisi Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat J Pharmacol Exp Ther 235 1985 282 286 (Pubitemid 16248715)
48. B.C. Yoburn, A. Cohen, J.G. Umans, G.S. Ling, and C.E. Inturrisi The graded and quantal nature of opioid analgesia in the rat tailflick assay Brain Res 331 1985 327 336 (Pubitemid 15115342)
49. B.C. Yoburn, V. Purohit, K. Patel, and Q. Zhang Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo Eur J Pharmacol 498 2004 87 96 (Pubitemid 39208065)
50. G. Zernig, T. Issaevitch, J.H. Broadbear, T.F. Burke, J.W. Lewis, and G.A. Brine Receptor reserve and affinity of mu opioid agonists in mouse antinociception: correlation with receptor binding Life Sci 57 1995 2113 2125
51. G. Zernig, T. Issaevitch, and J.H. Woods Calculation of agonist efficacy, apparent affinity, and receptor population changes after administration of insurmountable antagonists: comparison of different analytical approaches J Pharmacol Toxicol Methods 35 1996 223 237 (Pubitemid 26249102)