Continuous morphine produces more tolerance than intermittent or acute treatment

Pharmacology Biochemistry and Behavior

Volumn 92, Issue 3, 2009, Pages 537-542

  Dighe, Shveta V ^a   Madia, Priyanka A ^a   Sirohi, Sunil ^a   Yoburn, Byron C ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Acute treatment; Continuous treatment; Intermittent treatment; Morphine; Tolerance

Indexed keywords

MORPHINE; PLACEBO;

ACUTE DRUG ADMINISTRATION; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INTERMITTENT THERAPY; DRUG RELEASE; DRUG TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TREATMENT RESPONSE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; MALE; MICE; MORPHINE; SPECTROPHOTOMETRY, ULTRAVIOLET;

MUS;

EID: 62249214934     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.02.004     Document Type: Article

References (32)

1. Adams J.U., Paronis C.A., and Holtzman S.G. Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine. J Pharmacol Exp Ther 255 (1990) 1027-1032
2. Arden J.R., Segredo V., Wang Z., Lameh J., and Sadée W. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. J Neurochem 65 (1995) 1636-1645
3. Black J.W., and Leff P. Operational models of pharmacological agonism. Proc R Soc Lond B Biol Sci 220 (1983) 141-162
4. Duttaroy A., and Yoburn B.C. The effect of intrinsic efficacy on opioid tolerance. Anesthesiology 82 (1995) 1226-1236
5. Duttaroy A., Kirtman R., Farrell F., Phillips M., Philippe J., Monderson T., et al. The effect of cumulative dosing on the analgesic potency of morphine in mice. Pharmacol Biochem Behav 58 (1997) 67-71
6. Finney D.J. Probit analysis. 3rd ed. (1973), Cambridge University Press, London
7. Galandrin S., Oligny-Longpré G., and Bouvier M. The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol Sci 28 (2007) 423-430
8. Jarpe M.B., Knall C., Mitchell F.M., Buhl A.M., Duzic E., and Johnson G.L. Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol. Chem 273 (1998) 3097-3104
9. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., et al. Morphine activates opioid receptors without causing their rapid internalization. J Biol Chem 271 (1996) 19021-19024
10. Keith D.E., Anton B., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., et al. Mu-opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. Mol Pharmacol 53 (1998) 377-384
11. Kenakin T. Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol. Sci 16 (1995) 232-238
12. Kumar P., Sunkaraneni S., Sirohi S., Dighe S.V., Walker E.A., and Yoburn B.C. Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation. Eur J Pharmacol 597 (2008) 39-45
13. Mailman R.B. GPCR functional selectivity has therapeutic impact. Trends Pharmacol Sci 28 (2007) 390-396
14. Morgan D., and Picker M.J. The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor. Psychopharmacology 140 (1998) 20-28
15. Paronis C.A., and Holtzman S.G. Development of tolerance to the analgesic activity of mu agonists after continuous infusion of morphine, meperidine or fentanyl in rats. J Pharmacol Exp Ther 262 (1992) 1-9
16. Pawar M., Kumar P., Sunkaraneni S., Sirohi S., Walker E.A., and Yoburn B.C. Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2. Eur J Pharmacol 563 (2007) 92-101
17. Patel M.B., Patel C.N., Rajashekara V., and Yoburn B.C. Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo. Mol Pharmacol 62 (2002) 1464-1470
18. Pitts R.C., Allen R.M., Walker E.A., and Dykstra L.A. Clocinnamox antagonism of the antinociceptive effects of mu opioids in squirrel monkeys. J Pharmacol Exp Ther. 285 (1998) 1197-1206
19. Sirohi S., Dighe S.V., Walker E.A., and Yoburn B.C. The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulation. Pharmacol Biochem Behav 91 (2008) 115-120
20. Stafford K., Gomes A.B., Shen J., and Yoburn B.C. Mu-opioid receptor downregulation contributes to opioid tolerance in vivo. Pharmacol Biochem Behav 69 (2001) 233-237
21. Sosnowski M., and Yaksh T.L. Differential cross-tolerance between intrathecal morphine and sufentanil in the rat. Anesthesiology 73 (1990) 1141-1147
22. Stevens C.W., and Yaksh T.L. Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion. J. Pharmacol Exp. Ther 250 (1989) 1-8
23. Tiano M.J., Walker E.A., and Dykstra L.A. Cross-tolerance to etorphine differentiates μ-opioid agonists in a rat tail withdrawal assay. Analgesia 3 (1998) 251-257
24. Walker E.A., Richardson T.M., and Young A.M. Tolerance and cross-tolerance to morphine-like stimulus effects of mu opioids in rats. Psychopharmacology 133 (1997) 17-28
25. Walker E.A., Zernig G., and Young A.M. In vivo apparent affinity and efficacy estimates for mu opiates in a rat tail-withdrawal assay. Psychopharmacology 136 (1998) 15-23
26. Walker E.A., and Young A.M. Differential tolerance to antinociceptive effects of mu opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats. Psychopharmacology 154 (2001) 131-142
27. Whistler J.L., and von Zastrow M. Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci 95 (1998) 9914-9919
28. Yoburn B.C., Chen J., Huang T., and Inturrisi C.E. Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat. J Pharmacol Exp Ther 235 (1985) 282-286
29. Yoburn B.C., Purohit V., Patel K., and Zhang Q. Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo. Eur J Pharmacol 498 (2004) 87-96
30. Urban J.D., Clarke W.P., von Zastrow M., Nichols D.E., Kobilka B., Weinstein H., et al. Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320 (2007) 1-13
31. U.S. Pharmacopeia 23 National Formulary 18. The Official Compendia of Standards; authority of the United States Pharmacopeial Convention meeting at Washington D.C. (1995), The United States Pharmacopeial Convention, Inc 1038-1039
32. Zernig G., Issaevitch T., Broadbear J.H., Burke T.F., Lewis J.W., Brine G.A., et al. Receptor reserve and affinity of mu opioid agonists in mouse antinociception: correlation with receptor binding. Life Sci. 7 (1995) 2113-2125