Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord

Brain Research

Volumn 895, Issue 1-2, 2001, Pages 1-8

  Maher, Catherine E ^a   Eisenach, James C ^a   Pan, Hui Lin ^a   Xiao, Ruoyu ^a   Childers, Steven R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ADENOSINE A1 RECEPTOR; BACLOFEN; CARBACHOL; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHINE SULFATE; MU OPIATE RECEPTOR; NORADRENALIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; RAT; SPINAL CORD DORSAL HORN; WITHDRAWAL REFLEX;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; INJECTIONS, SPINAL; MALE; MORPHINE; PAIN; PAIN THRESHOLD; POSTERIOR HORN CELLS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SULFUR RADIOISOTOPES;

EID: 0035937434     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03093-6     Document Type: Article

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