RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition

DNA Repair

Volumn 11, Issue 3, 2012, Pages 317-323

  Covo, Shay ^a   Westmoreland, James W ^a   Reddy, Amit K ^a   Gordenin, Dmitry A ^a   Resnick, Michael A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Double strand breaks; Hydroxyurea; RAD53; Rnr1

Indexed keywords

CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; HYDROXYUREA; RIBONUCLEOTIDE REDUCTASE; RNR1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CHEMOSENSITIZATION; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DOUBLE STRANDED DNA BREAK REPAIR; DRUG CYTOTOXICITY; DRUG RESISTANCE; ENZYME INHIBITION; GENE DOSAGE; GENETIC MODEL; GENOMIC INSTABILITY; GENOTOXICITY; IONIZING RADIATION; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOSENSITIVITY; TETRAPLOIDY; ULTRAVIOLET RADIATION; YEAST CELL;

CELL CYCLE PROTEINS; CYTOPROTECTION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DRUG RESISTANCE; GENOMIC INSTABILITY; HYDROXYUREA; MICROBIAL VIABILITY; MUTAGENS; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; RIBONUCLEOTIDE REDUCTASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 84856569963     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.12.008     Document Type: Article

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