Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitization

Cancer Research

Volumn 69, Issue 12, 2009, Pages 5108-5114

  Ahsan, Aarif ^a   Hiniker, Susan M ^a   Davis, Mary A ^a   Lawrence, Theodore S ^a   Nyati, Mukesh K ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IRRADIATION; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIVITY; RADIOSENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; HUMANS; NEOPLASMS; RADIATION-SENSITIZING AGENTS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 67449127097     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0466     Document Type: Article

References (32)

1. Nyati MK, Morgan MA, Feng FY, Lawrence TS. Integration of EGFR inhibitors with radiochemotherapy. Nat Rev Cancer 2006;6:876-885 (Pubitemid 44629899)
2. Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000;6:2166-2174 (Pubitemid 30399181)
3. Bianco C, Tortora G, Bianco R, et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor- tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res 2002;8:3250-3258 (Pubitemid 35155038)
4. Nyati MK, Maheshwari D, Hanasoge S, et al. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res 2004;10:691-700. (Pubitemid 38180439)
5. Chinnaiyan P, Huang S, Vallabhaneni G, et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res 2005;65:3328-3335 (Pubitemid 40524617)
6. Raben D, Helfrich B, Chan DC, et al. The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer. Clin Cancer Res 2005;11:795-805. (Pubitemid 40116908)
7. Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359:1116-1127
8. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567-578 (Pubitemid 43209104)
9. Schmidt-Ullrich RK, Mikkelsen RB, Dent P, et al. Radiation- induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997;15:1191-1197 (Pubitemid 27429622)
10. Nyati MK, Feng FY, Maheshwari D, et al. Ataxia telangiectasia mutated down-regulates phosphoextracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Cancer Res 2006;66:11554-11559 (Pubitemid 46094161)
11. Harari PM, Huang SM. Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int J Radiat Oncol Biol Phys 2001;49:427-433 (Pubitemid 32120240)
12. Krug AW, Schuster C, Gassner B, et al. Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling. J Biol Chem 2002;277:45892-45897 (Pubitemid 35417570)
13. Hoy CA, Seamer LC, Schimke RT. Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram. Cytometry 1989;10:718-725 (Pubitemid 20004731)
14. Fertil B, Malaise EP. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 1985;11:1699-1707 (Pubitemid 15233633)
15. Hoffmann T, Hafner D, Ballo H, Haas I, Bier H. Antitumor activity of anti-epidermal growth factor receptor monoclonal antibodies and cisplatin in ten human head and neck squamous cell carcinoma lines. Anticancer Res 1997;17:4419-4425 (Pubitemid 28081723)
16. Chun PY, Feng FY, Scheurer AM, Davis MA, Lawrence TS, Nyati MK. Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma. Cancer Res 2006;66:981-988 (Pubitemid 43165966)
17. Ravid T, Heidinger JM, Gee P, Khan EM, Goldkorn T. c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes. J Biol Chem 2004;279:37153-37162 (Pubitemid 39129066)
18. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I. Cbl-CIN85-endophilin complex mediates ligand- induced downregulation of EGF receptors. Nature 2002;416:183-187 (Pubitemid 34246476)
19. Boerner JL, Demory ML, Silva C, Parsons SJ. Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II. Mol Cell Biol 2004;24:7059-7071 (Pubitemid 39014433)
20. Clark S, Dunlop M. Modulation of phospholipase A2 activity by epidermal growth factor (EGF) in CHO cells transfected with human EGF receptor. Role of receptor cytoplasmic subdomain. Biochem J 1991;274:715-721
21. Olsson P, Gedda L, Goike H, et al. Uptake of a boronated epidermal growth factor-dextran conjugate in CHO xenografts with and without human EGF-receptor expression. Anticancer Drug Des 1998;13:279-289 (Pubitemid 28230945)
22. Yacoub A, McKinstry R, Hinman D, Chung T, Dent P, Hagan MP. Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. Radiat Res 2003;159:439-452 (Pubitemid 36397765)
23. Hall EJ, Giaccia AJ. Radiobiology for the radiologist. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
24. Weichselbaum RR, Little JB. Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal X-ray damage. Radiology 1982;145:511-513
25. Weichselbaum RR, Malcolm AW, Little JB. Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy. Radiology 1982;142:225-227
26. Lawrence TS, Blackstock AW, McGinn C. The mechanism of action of radiosensitization of conventional chemotherapeutic agents. Semin Radiat Oncol 2003;13:13-21. (Pubitemid 36173256)
27. McGinn CJ, Miller EM, Lindstrom MJ, Kunugi KA, Johnston PG, Kinsella TJ. The role of cell-cycle redistribution in radiosensitization-implications regarding the mechanism of fluorodeoxyuridine radiosensitization. Int J Radiat Oncol Biol Phys 1994;30:851-859 (Pubitemid 24355936)
28. Wilson GD, Bentzen SM, Harari PM. Biologic basis for combining drugs with radiation. Semin Radiat Oncol 2006;16:2-9. (Pubitemid 41832311)
29. Feng FY, Varambally S, Tomlins SA, et al. Role of epidermal growth factor receptor degradation in gemcitabine- mediated cytotoxicity. Oncogene 2007;26:3431-3439 (Pubitemid 46788888)
30. Tanaka T, Munshi A, Brooks C, Liu J, Hobbs ML, Meyn RE. Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity. Clin Cancer Res 2008;14:1266-1273 (Pubitemid 351302576)
31. Dent P, Yacoub A, Contessa J, et al. Stress and radiation- induced activation of multiple intracellular signaling pathways. Radiat Res 2003;159:283-300. (Pubitemid 36314943)
32. Lammering G, Hewit TH, Hawkins WT, et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. J Natl Cancer Inst 2001;93:921-929 (Pubitemid 32624649)