Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells

European Journal of Anaesthesiology

Volumn 29, Issue 1, 2012, Pages 35-41

  Werdehausen, Robert ^a   Braun, Sebastian ^a   Fazeli, Sepideh ^b   Hermanns, Henning ^a   Hollmann, Markus W ^c   Bauer, Inge ^a   Stevens, Markus F ^c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Apoptosis; Local anaesthetics; Stereoisomerism; Stereospecificity; Toxicity

Indexed keywords

ARTICAINE; BUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PIPECOLOXYLIDINE; PRILOCAINE; PROCAINE; ROPIVACAINE; TETRACAINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LIPOPHILICITY; PARTITION COEFFICIENT; STEREOISOMERISM; STEREOSPECIFICITY;

AMIDES; ANESTHETICS, LOCAL; APOPTOSIS; BUPIVACAINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; LYMPHOMA, T-CELL; MICROSCOPY, FLUORESCENCE; NECROSIS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856483456     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32834cd6c4     Document Type: Article

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