Epidural pain relief in labour: Potencies of levobupivacaine and racemic bupivacaine

British Journal of Anaesthesia

Volumn 81, Issue 6, 1998, Pages 899-901

  Lyons, G ^a   Columb, M ^b   Wilson, R C ^a   Johnson, R V ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b WITHINGTON HOSPITAL   (United Kingdom)

Author keywords

Anaesthetics local, bupivacaine; Analgesia, obstetric; Analgesic techniques, epidural; Pharmacokinetics, stereoisomers

Indexed keywords

BUPIVACAINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DILUTION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; EPIDURAL ANESTHESIA; EPIDURAL DRUG ADMINISTRATION; FEMALE; HUMAN; LABOR; MAJOR CLINICAL STUDY; PAIN; PRIORITY JOURNAL; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL;

EID: 0031742311     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.6.899     Document Type: Article

References (14)

1. Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 1979; 51: 285-291.
2. Heath ML. Deaths after intravenous regional anaesthesia. British Medical Journal 1982; 285: 913-914.
3. Santos AC, Pedersen H, Finster M. Local anesthetics. In: Chestnut DH, ed. Obstetric Anesthesia. St Louis: Mosby, 1994; 207.
4. Aberg G. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacologica et Toxicologica 1972; 31: 273-286.
5. Columb MO, Lyons G. Determination of the minimum local analgesic concentrations of epidural bupivacaine and lidocaine in labor. Anesthesia and Analgesia 1995; 81: 833-837.
6. Breen TW, Shapiro T, Glass B, Foster-Payne D, Oriol N. Epidural anesthesia for labor in an ambulatory patient Anesthesia and Analgesia 1993; 77: 919-926.
7. Dixon WJ, Massey FJ. Introduction to Statistical Analysis, 4th Edn. New York: McGraw-Hill, 1983; 428-439.
8. Armitage P, Berry G. Statistical Methods in Medical Research, 3rd Edn. Oxford: Blackwell Scientific Publications, 1994; 136-141.
9. Altman DG. Practical Statistics for Medical Research. London: Chapman and Hall, 1991; 212-213.
10. Aps C, Reynolds F. An intradermal study of the local anaesthetic and vascular effects of the isomers of bupivacaine. British Journal of Clinical Pharmacology 1978; 6: 63-68.
11. De Jong RH. Local Anesthetics. St Louis: Mosby, 1994; 158-161.
12. Aberg G. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmocologica et Toxicologica 1972; 31: 273-286.
13. Luduena FP, Bogado EF, Tullar BF. Optical isomers of mepivacaine and bupivacaine. Archives Internationales de Pharmacodynamie et de Therapie 1972; 200: 359-369.
14. Gristwood R, Bardsley H, Baker H, Dickens J. Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcain): New clinical evidence. Expert Opinion in Investigational Drugs 1994; 3: 1209-1212.