Mitochondrial injury and caspase activation by the local anesthetic lidocaine

Anesthesiology

Volumn 101, Issue 5, 2004, Pages 1184-1194

  Johnson, Michael E ^a,d   Uhl, Cindy B ^a   Spittler, Karl Heinz ^c   Wang, Hongxun ^a   Gores, Gregory J ^b  

^a Department of Anesthesiology ^*  (United States)

^b MAYO CLINIC   (United States)

^c EASTERN MAINE MEDICAL CENTER   (United States)

^d Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYTOCHROME C; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHOSPHATIDYLSERINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; MEMBRANE POTENTIAL; MITOCHONDIAL MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION DAMAGE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL ANESTHESIA; SPINAL GANGLION;

ANESTHETICS, LOCAL; ANIMALS; APOPTOSIS; BUFFERS; CASPASES; CELLS, CULTURED; CYTOCHROMES C; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENT DYES; LIDOCAINE; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NECROSIS; NEURONS, AFFERENT; NEUROTOXINS; OXYGEN CONSUMPTION; RATS; SPINAL CORD;

EID: 7244234419     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200411000-00019     Document Type: Article

References (61)

1. Johnson ME: Potential neurotoxicity of spinal anesthesia with lidocaine. Mayo Clin Proc 2000; 75:921-32
2. Kishimoto T, Bollen AW, Drasner K: Comparative spinal neurotoxicity of prilocaine and lidocaine. ANESTHESIOLOGY 2002; 97:1250-3
3. Pollock JE: Transient neurologic symptoms: Etiology, risk factors, and management. Reg Anesth Pain Med 2002; 27:581-6
4. Wang D, Wu X, Li J, Xiao F, Liu X, Meng M: The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg 2002; 95:1134-41
5. Lei B, Cottrell JE, Kass IS: Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia. ANASTHESIOLOGY 2001; 95:445-51
6. Van Zundert AA, Grouls RJ, Korsten HH, Lambert DH: Spinal anesthesia: Volume or concentration-what matters? Reg Anesth 1996; 21:112-8
7. Johnson ME, Saenz JA, DaSilva AD, Uhl CB, Gores GJ: Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. ANESTHESIOLOGY 2002; 97:1466-76
8. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD: Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 1998; 285:413-21
9. Dabadie P, Bendriss P, Erny P, Mazat JP: Uncoupling effects of local anesthetics on rat liver mitochondria. FEBS Lett 1987; 226:77-82
10. Chazotte B, Vanderkooi G, Chignell D: Further studies on F1-ATPase inhibition by local anesthetics. Biochim Biophys Acta 1982; 680:310-6
11. Chazotte B, Vanderkooi G: Multiple sites of inhibition of mitochondrial electron transport by local anesthetics. Biochim Biophys Acta 1981; 636:153-61
12. Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton SA: Neuronal necrosis and apoptosis: Two distinct events induced by exposure to glutamate or oxidative stress. Adv Neurol 1997; 72:95-101
13. Kroemer G, Reed JC: Mitochondrial control of cell death. Nat Med 2000; 6:513-9
14. Johnson ME, Uhl CB: Low dose lidocaine causes neuronal injury and apoptosis (abstract). ANESTHESIOLOGY 2001; 95(suppl):A985
15. Friederich P, Schmitz TP: Lidocaine-induced cell death in a human model of neuronal apoptosis. Eur J Anaesthesiol 2002; 19:564-70
16. Boselli E, Duflo F, Debon R, Allaouchiche B, Chassard D, Thomas L, Portoukalian J: The induction of apoptosis by local anesthetics: A comparison between lidocaine and ropivacaine. Anesth Analg 2003; 96:755-6
17. Adams JM: Ways of dying: Multiple pathways to apoptosis. Genes Dev 2003; 17:2481-95
18. Zamzami N, Kroemer G: The mitochondrion in apoptosis: How Pandora's box opens. Nat Rev Mol Cell Biol 2001; 2:67-71
19. Penninger JM, Kroemer G: Mitochondria, AIF and caspases: Rivaling for cell death execution. Nat Cell Biol 2003; 5:97-9
20. Martinou JC, Green DR: Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001; 2:63-7
21. Newmeyer DD, Ferguson-Miller S: Mitochondria: Releasing power for life and unleashing the machineries of death. Cell 2003; 112:481-90
22. Wood JN, Bevan SJ, Coote PR, Dunn PM, Harmar A, Hogan P, Latchman DS, Morrison C, Rougon G, Theveniau M, Wheatley S: Novel cell lines display properties of nociceptive sensory neurons. Proc R Soc Lond B Biol Sci 1990; 241:187-94
23. Kobrinsky EM, Pearson HA, Dolphin AC: Low- and high-voltage-activated calcium channel currents and their modulation in the dorsal root ganglion cell line ND7-23. Neurosci 1994; 58:539-52
24. 2+ channel currents in cultured rat cerebellar granule neurones. J Physiol (Lond) 1995; 482:493-509
25. Mailhos C, Howard MK, Latchman DS: A common pathway mediates retinoic acid and PMA-dependent programmed cell death (apoptosis) of neuronal cells. Brain Res 1994; 644:7-12
26. Smolewski P, Grabarek J, Halicka HD, Darzynkiewicz Z: Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis. J Immunol Methods 2002; 265:111-21
27. Bossy-Wetzel E, Green DR: Detection of apoptosis by annexin V labeling. Methods Enzymol 2000; 322:15-8
28. Honda O, Kuroda M, Joja I, Asaumi J, Takeda Y, Akaki S, Togami I, Kanazawa S, Kawasaki S, Hiraki Y: Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide. Int J Oncol 2000; 16:283-8
29. Darzynkiewicz Z, Bedner E, Smolewski P, Lee BW, Johnson GL: Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases (FLICA). Methods Mol Biol 2002; 203:289-99
30. Fujii Y, Johnson ME, Gores GJ: Mitochondrial dysfunction during anoxia/ reoxygenation injury of liver sinusoidal endothelial cells. Hepatology 1994; 20: 177-85
31. 1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress. Hepatology 1999; 30:1490-7
32. Higuchi H, Adachi M, Miura S, Gores GJ, Ishii H: The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology 2001; 34:320-8
33. Goldstein JC, Waterhouse NJ, Juin P, Evan G1, Green DR: The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol 2000; 2:156-62
34. Grouselle M, Tueux O, Dabadie P, Georgescaud D, Mazat JP: Effect of local anaesthetics on mitochondrial membrane potential in living cells. Biochem J 1990; 271:269-72
35. Haschke RH, Fink BR: Lidocaine effects on brain mitochondrial metabolism in vitro. ANESTHESIOLOGY 1975; 42:737-40
36. Drasner K: Lidocaine spinal anesthesia: A vanishing therapeutic index? ANESTHESIOLOGY 1997; 87:469-72
37. Moore DC, Thompson GE: Neurotoxicity of local anesthetics: An issue or a scapegoat? Reg Anesth Pain Med 1998; 23:605-10
38. Eisenach JC, Yaksh TL: Safety in numbers: How do we study toxicity of spinal analgesics? ANESTHESIOLOGY 2002; 97:1047-9
39. Anderson PI, Bamburg JR: Effects of local anesthetics on nerve growth in culture. Dev Neurosci 1981; 4:273-90
40. Wilder RT, Berde CB, Griggs CT, Chickalingaiah R, Strichartz G: Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells. Reg Anesth 1993; 18:283-9
41. Hiruma H, Maruyama H, Simada ZB, Katakura T, Hoka S, Takenaka T, Kawakami T: Lidocaine inhibits neurite growth in mouse dorsal root ganglion cells in culture. Acta Neurobiol Exp (Warsz) 1999; 59:323-7
42. Kanai AMD, Hiruma HMD, Katakura TBS, Sase SMD, Kawakami TMD, Hoka SMD: Low-concentration lidocaine rapidly inhibits axonal transport in cultured mouse dorsal root ganglion neurons. ANESTHESIOLOGY 2001; 95:675-80
43. Saito SMD, Radwan IMD, Obata HMD, Takahashi KMD, Goto FMD: Direct neurotoxicity of tetracaine on growth cones and neurites of growing neurons in vitro. ANESTHESIOLOGY 2001; 95:726-33
44. Radwan IA, Saito S, Goto F: The neurotoxicity of local anesthetics on growing neurons: A comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine. Anesth Analg 2002; 94:319-24
45. Kalichman MW, Moorhouse DF, Powell HC, Myers RR: Relative neural toxicity of local anesthetics. J Neuropathol Exp Neurol 1993; 52:234-40
46. Lambert LA, Lambert DH, Strichartz GR: Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. ANESTHESIOLOGY 1994; 80:1082-93
47. Kanai Y, Katsuki H, Takasaki M: Lidocaine disrupts axonal membrane of rat sciatic nerve in vitro. Anesth Analg 2000; 91:944-8
48. Mörch ET, Rosenberg MK, Truant AT: Lidocaine for spinal anesthesia: A study of the concentration in the spinal fluid. Acta Anaesthesiol Scand 1957; 1:105-15
49. Sakura S, Bollen AW, Ciriales R, Drasner K: Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg 1995; 81:338-46
50. Takenami T, Yagishita S, Nara Y, Okamoto H, Hoka S: Neurotoxicity of spinal dibucaine is greater than lidocaine, tetracaine, and bupivacaine in rats (abstract). ANESTHESIOLOGY 2002; 96:A966
51. Auroy Y, Benhamou D, Bargues L, Ecoffey C, Falissard B, Mercier FJ, Bouaziz H, Samii K, Mercier F: Major complications of regional anesthesia in France: The SOS Regional Anesthesia Hotline Service. ANESTHESIOLOGY 2002; 97: 1274-80
52. Banker G, Goslin K: Types of nerve cell cultures, their advantages and limitations, Culturing Nerve Cells. Edited by Banker G, Goslin K. Cambridge, Massachusetts, MIT Press, 1991, pp 11-39
53. Heiskanen KM, Bhat MB, Wang HW, Ma J, Nieminen AL: Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J Biol Chem 1999; 274:5654-8
54. Sun X, Garlid KD: On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes. J Biol Chem 1992; 267:19147-54
55. Irwin W, Fontaine E, Agnolucci L, Penzo D, Betto R, Bortolotto S, Reggiani C, Salviati G, Bernardi P: Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem 2002; 277:12221-7
56. DeToledo JC: Lidocaine and seizures. Ther Drug Monit 2000; 22:320-2
57. Hollmann MW, Difazio CA, Durieux ME: Ca-signaling G-protein-coupled receptors: A new site of local anesthetic action? Reg Anesth Pain Med 2001; 26:565-71
58. Koppert W, Zeck S, Sittl R, Likar R, Knoll R, Schmelz M: Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans. ANESTHESIOLOGY 1998; 89:1345-53
59. Strichartz G: Protracted relief of experimental neuropathic pain by systemic local anesthetics: How, where, and when. ANESTHESIOLOGY 1995; 83:654-5
60. Polster BM, Basanez G, Young M, Suzuki M, Fiskum G: Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J Neurosci 2003; 23:2735-43
61. Ma W, Du W, Eisenach JC: Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. ANESTHESIOLOGY 2003; 98:203-8