Only tetracaine and not other local anaesthetics induce apoptosis in rat cortical astrocytes

British Journal of Anaesthesia

Volumn 103, Issue 5, 2009, Pages 719-725

  Lee, W Y ^a   Park, C J ^b   Shin, T J ^a   Yum, K W ^a   Yoon, T G ^c   Seo, K S ^a   Kim, H J ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c Konkuk University School of Medicine   (South Korea)

Author keywords

Anaesthetics local, tetracaine; Complications, neurological; Toxicity, local anaesthetics

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACETYLCYSTEINE; BUPIVACAINE; LACTATE DEHYDROGENASE; LEVOBUPIVACAINE; LIDOCAINE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; ROPIVACAINE; TETRACAINE; TROLOX C;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; LOCAL ANESTHESIA; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; TOXICITY TESTING; WESTERN BLOTTING;

EID: 74949127390     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep237     Document Type: Article

References (25)

1. Adams HJ, Mastri AR, Eicholzer AW, Kilpatrick G. Morphologic effects of intrathecal etidocaine and tetracaine on the rabbit spinal cord. Anesth Analg 1974; 53: 904-908
2. Myers RR, Kalichman MW, Reisner LS, Powell HC. Neurotoxicity of local anesthetics: altered perineurial permeability, edema, and nerve fiber injury. Anesthesiology 1986; 64: 29-35
3. Ouyang YB, Giffard RG. Changes in astrocyte mitochondrial function with stress: effects of Bcl-2 family proteins. Neurochem Int 2004; 45: 371-379
4. Brown DR. Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity. Mol Cell Neurosci 1999; 13: 379-389
5. Chen Y, Swanson RA. Astrocytes and brain injury. J Cereb Blood Flow Metab 2003; 23: 137-149
6. Kurosinski P, Gotz J. Glial cells under physiologic and pathologic conditions. Arch Neurol 2002; 59: 1524-1528
7. Langeveld CH, Jongenelen CA, Schepens E, Stoof JC, Bast A, Drukarch B. Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development. Neurosci Lett 1995; 192: 13-16
8. O'Malley EK, Sieber BA, Black IB, Dreyfus CF. Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture. Brain Res 1992; 582: 65-70
9. Takeshima T, Johnston JM, Commissiong JW. Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J Neurosci 1994; 14: 4769-4779
10. McCarthy KD, De Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980; 85: 890-902
11. Dohi T, Okada K, Xia F, et al.. An IAP-IAP complex inhibits apoptosis. J Biol Chem 2004; 279: 34087-34090
12. Saito S, Radwan I, Obata H, Takahashi K, Goto F. Direct neurotoxicity of tetracaine on growth cones and neurites of growing neurons in vitro. Anesthesiology 2001; 95: 726-733
13. Ohtake K, Matsumoto M, Wakamatsu H, Kawai K, Nakakimura K, Sakabe T. Glutamate release and neuronal injury after intrathecal injection of local anesthetics. Neuroreport 2000; 11: 1105-1119
14. Yamashita A, Matsumoto M, Matsumoto S, Itoh M, Kawai K, Sakabe T. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analg 2003; 97: 512-519
15. Parpura V, Basarsky TA, Liu F, Jeftinija K, Jeftinija S, Haydon PG. Glutamate-mediated astrocyte-neuron signalling. Nature 1994; 369: 744-747
16. Pasti L, Volterra A, Pozzan T, Carmignoto G. Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J Neurosci 1997; 17: 7817-7830
17. McNaught KS, Jenner P. Dysfunction of rat forebrain astrocytes in culture alters cytokine and neurotrophic factor release. Neurosci Lett 2000; 285: 61-65
18. Niiyama S, Tanaka E, Yamamoto S, Yasumoto S, Kano T, Higashi H. Bupivacaine, but not tetracaine, protects against the in vitro ischemic insult of rat hippocampal CA1 neurons. Neurosci Res 2002; 42: 231-241
19. Fagiolini M, Caleo M, Strettoi E, Maffei L. Axonal transport blockade in the neonatal rat optic nerve induces limited retinal ganglion cell death. J Neurosci 1997; 17: 7045-7052
20. Kadle R, Suksang C, Roberson ED, Fellows RE. Identification of an insulin-like factor in astrocyte conditioned medium. Brain Res 1988; 460: 60-67
21. Ferrara N, Ousley F, Gospodarowicz D. Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen. Brain Res 1988; 462: 223-232
22. Tan Z, Dohi S, Chen J, Banno Y, Nozawa Y. Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death. Anesthesiology 2002; 96: 1191-1201
23. Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 1994; 62: 45-53
24. Lucius R, Sievers J. Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes. Brain Res 1996; 743: 56-62
25. Foldes FF, Molloy R, McNall P, Koukal LR. Comparison of toxicity of intravenously given local anesthetic agents in man. J Am Med Assoc 1960; 172: 1493-1498