Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells

Anesthesia and Analgesia

Volumn 111, Issue 6, 2010, Pages 1389-1393

  Braun, Sebastian ^a   Werdehausen, Robert ^a   Gaza, Nina ^a   Hermanns, Henning ^a   Kremer, David ^b   Küry, Patrick ^b   Hollmann, Markus W ^a   Stevens, Markus F ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZETHONIUM CHLORIDE; KETAMINE; KETANEST S; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CELL ASSAY; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; GLIA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LYMPHOMA CELL; MITOCHONDRION; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS; ANIMALS; APOPTOSIS; ASTROCYTES; BENZETHONIUM; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; KETAMINE; LYMPHOMA; MITOCHONDRIA; NECROSIS; NEUROGLIA; NEURONS; PRESERVATIVES, PHARMACEUTICAL; RATS; TIME FACTORS;

EID: 78650307599     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181f690e4     Document Type: Article

References (13)

1. Walker SM, Goudas LC, Cousins MJ, Carr DB. Combination spinal analgesic chemotherapy: a systematic review. Anesth Analg 2002;95:674-715
2. Hocking G, Cousins MJ. Ketamine in chronic pain manage-ment: an evidence-based review. Anesth Analg 2003;97:1730-9
3. Vranken JH, Troost D, de Haan P, Pennings FA, van der Vegt MH, Dijkgraaf MG, Hollmann MW. Severe toxic dam-age to the rabbit spinal cord after intrathecal administration of preservative-free S(+)-ketamine. Anesthesiology 2006; 105:813-8
4. Vranken JH, Troost D, Wegener JT, Kruis MR, van der Vegt MH. Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neu-ropathic cancer pain. Pain 2005;117:231-5
5. Malinovsky JM, Lepage JY, Cozian A, Mussini JM, Pinaudt M, Souron R. Is ketamine or its preservative responsible for neurotoxicity in the rabbit? Anesthesiology 1993;78:109-15
6. Errando CL, Sifre C, Moliner S, Valia JC, Gimeno O, Minguez A, Boils P. Subarachnoid ketamine in swine-pathological find-ings after repeated doses: acute toxicity study. Reg Anesth Pain Med 1999;24:146-52
7. Yip KW, Mao X, Au PY, Hedley DW, Chow S, Dalili S, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Benzethonium chlo-ride: a novel anticancer agent identified by using a cell-based small-molecule screen. Clin Cancer Res 2006;12:5557-69
8. Braun S, Gaza N, Werdehausen R, Hermanns H, Bauer I, Durieux ME, Hollmann MW, Stevens MF. Ketamine induces apoptosis via the mitochondrial pathway in human lympo-cytes and neuronal cells. Br J Anaesth 2010;105:347-54
9. Tan PH, Kuo MC, Kao PF, Chia YY, Liu K. Patient-controlled epidural analgesia with morphine or morphine plus ketamine for post-operative pain relief. Eur J Anaesthesiol1999;16:820-5
10. Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K. Differential role of caspase-8 and BID activation during radiation-and CD95-induced apoptosis. On-cogene 2000;19:1181-90
11. Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF. Lidocaine induces apoptosis via the mitochondrial pathway independently of death recep-tor signaling. Anesthesiology 2007;107:136-43
12. Werdehausen R, Fazeli S, Braun S, Hermanns H, Essmann F, Hollmann MW, Bauer I, Stevens MF. Apoptosis induction by different local anaesthetics in a neuroblastoma cell line. Br J Anaesth 2009;103:711-8
13. Tallarida RJ. An overview of drug combination analysis with isobolograms. J Pharmacol Exp Ther 2006;319:1-7