Application of RNA interference for the control of female reproductive functions

Current Pharmaceutical Design

Volumn 18, Issue 3, 2012, Pages 325-336

  Sirotkin, Alexander V ^a,b  

^a Animal Production Research Centre Nitra   (El Salvador)

^b Department of Zoology and Anthropology   (El Salvador)

Author keywords

Apoptosis; Cancer; Fertility; Oocyte maturation; Ovarian; Proliferation; RNA delivery; RNA interference; Secretion

Indexed keywords

BMI1 PROTEIN; DICER; DOPAMINE; FIBROBLAST GROWTH FACTOR; INTERFERON; JANUS KINASE 1; JANUS KINASE 2; MICRORNA; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SOMATOMEDIN RECEPTOR; STAT3 PROTEIN; VASCULOTROPIN;

ANEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CELL PROLIFERATION; CORPUS LUTEUM; FEMALE FERTILITY; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HORMONE RELEASE; HUMAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; OOCYTE MATURATION; OVARY CANCER; OVARY CARCINOMA; OVARY CELL; OVARY FUNCTION; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; FEMALE; FERTILITY; GENE EXPRESSION REGULATION; HUMANS; INFERTILITY, FEMALE; OOCYTES; OVARIAN DISEASES; OVARIAN NEOPLASMS; OVARY; REPRODUCTION; RNA; RNA INTERFERENCE;

EID: 84856461738     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799040376     Document Type: Article

References (133)

1. Cogoni C, Macino G. Post-transcriptional gene silencing across kingdoms. Genes Dev 2000; 10: 638-43.
2. Guru T. A silence that speaks volumes. Nature 2000; 404: 804-08.
3. Hammond SM, Caudy AA, Hannon GJ. Post-transcriptional Gene Silencing by Double-stranded RNA. Nature Rev Gen 2001; 2: 110-9.
4. Hannon GJ. RNA interference. Nature 2002; 418: 244-51.
5. Guo S, Kempheus KJ. Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 1995; 81: 611-20.
6. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11.
7. Kennerdell JR, Carthew RW. Heritable gene silencing in Drosophila using double-stranded RNA. Nature Biotech 2000 18: 896-8.
8. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: Doublestranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 2000; 101: 25-33.
9. Hutvagner G, Zamore PD. RNAi: nature abhors a double-strand. Curr Opin Genetics & Development 2002; 12: 225-32.
10. Schmid A, Schindelholz B, Zinn K. Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila. Trends Neurosci 2002; 25: 71-4.
11. Sui G, Soohoo C, Affar E-B, et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002; 99: 5515-20.
12. Yu J-Y, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 2002; 99: 6047-52.
13. Stefani G, Slack F. MicroRNAs in search of a target. Cold Spring Harb Symp Quant Biol 2006; 71: 129-34.
14. Seto, A.G., R.E. Kingston, N.C. Lau. The coming of age for piwi proteins. Molecular Cell 2007; 26: 603-9.
15. Farazi TA, Juranek SA, Tuschl T. The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development 2008; 135: 1201-14.
16. Doran T., Helliwell C (eds.) RNA Interference: Methods for Plants and Animals (Principles and Protocol Series). Cabi 2008; 272 pp.
17. Thompson AJ, Patel K. Antisense inhibitors, ribozymes, and siRNAs. Clin Liver Dis 2009; 13: 375-90.
18. Amarzguioui M, Rossi JJ, Kim D. Approaches for chemically synthesized siRNA and vector-mediated RNAi. FEBS Lett 2005; 579: 5974-81.
19. Mangala LS, Han HD, Lopez-Berestein G, Sood AK. Liposomal siRNA for ovarian cancer. Methods Mol Biol 2009; 555: 29-42.
20. Webb R, Campbell BK. Development of the dominant follicle: mechanisms of selection and maintenance of oocyte quality. Soc Reprod Fertil Suppl 2007; 64: 141-63
21. Oktem O, Oktay K. The ovary: anatomy and function throughout human life. Ann N Y Acad Sci 2008; 1127: 1-9.
22. Tingen C, Kim A, Woodruff TK. The primordial pool of follicles and nest breakdown in mammalian ovaries. Mol Hum Reprod 2009; 15: 795-803.
23. Hunzicker-Dunn M, Maizels ET. FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A. Cell Signal 2006; 18: 1351-9.
24. Pangas SA. Growth factors and ovarian development. Semin Reprod Med 2007; 25: 225-34.
25. Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 2006; 34: 1416-26.
26. Li YF, Hu W, Fu SQ, Li JD, Liu JH, Kavanagh JJ. Aromatase inhibitors in ovarian cancer: is there a role? Int J Gynecol Cancer 2008; 18: 600-14.
27. Yoshida S, Furukawa N, Haruta S, et al. Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: a review. Int J Gynecol Cancer 2009; 19: 992-997.
28. Christenson LK. MicroRNA control of ovarian function. Anim Reprod 2010; 7: 129-33.
29. Malek A, Tchernitsa O. Evaluation of targets for ovarian cancer gene silencing therapy: in vitro and in vivo approaches. Methods Mol Biol 2010; 623: 423-36.
30. Sirotkin AV. RNA interference and ovarian functions. J Cell Physiol 2010; 225: 354-63.
31. Desset S, Buchon N, Meignin C, Coiffet M, Vaury C. In Drosophila melanogaster the COM locus directs the somatic silencing of two retrotransposons through both Piwi-dependent and-independent pathways. PLoS One 2008; 3: e1526
32. Malone CD, Brennecke J, Dus M, et al. Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell 2009; 137: 522-35.
33. Saito K, Inagaki S, Mituyama T, et al. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature 2009; 461: 1296-9.
34. Ro S, Song R, Park C, Zheng H, Sanders KM, Yan W. Cloning and expression profiling of small RNAs expressed in the mouse ovary. RNA 2007; 13: 2366-80.
35. Fiedler SD, Carletti MZ, Hong X, Christenson LK. Hormonal regulation of MicroRNA expression in periovulatory mouse mural granulosa cells. Biol Reprod 2008; 79: 1030-7.
36. Otsuka M, Zheng M, Hayashi M, et al. Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest 2008; 118: 1944-54.
37. Watanabe T, Takeda A, Tsukiyama T, et al. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev 2006; 20: 1732-43.
38. Watanabe T, Totoki Y, Toyoda A, et al. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 2008; 453: 539-43.
39. Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. Microarray analyses of newborn mouse ovaries lacking Nobox. Biol Reprod 2007; 77: 312-9.
40. Tam OH, Aravin AA, Stein P, et al. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 2008; 453: 534-8.
41. Tang F, Barbacioru C, Wang Y, et al. mRNA-Seq wholetranscriptome analysis of a single cell. Nat Methods 2009; 6: 377-82.
42. Tesfaye D, Worku D, Rings F, et al. Identification and expression profiling of microRNAs during bovine oocyte maturation using heterologous approach. Mol Reprod Dev 2009; 76: 665-77.
43. Bonnet A, Dalbiès-Tran R, Sirard MA. Opportunities and challenges in applying genomics to the study of oogenesis and folliculogenesis in farm animals. Reproduction 2008; 135: 119-28.
44. Forde N, Mihm M, Canty MJ, et al. Differential expression of signal transduction factors in ovarian follicle development: a functional role for betaglycan and FIBP in granulosa cells in cattle. Physiol Genomics 2008; 33: 193-204.
45. Toloubeydokhti T, Bukulmez O, Chegini N. Potential regulatory functions of microRNAs in the ovary. Semin Reprod Med 2008; 26: 469-78.
46. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007; 67: 8433-8.
47. Iorio MV, Visone R, Di Leva G, et al. MicroRNA signatures in human ovarian cancer. Cancer Res 2007; 67: 8699-707.
48. Nam EJ, Yoon H, Kim SW, et al. MicroRNA expression profiles in servus ovarian carcinoma. Clin Cancer Res 2008; 14: 2690-5.
49. Merritt WM, Lin YG, Han LY, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 2008; 359: 2641-450.
50. Dahiya N, Morin P. MicroRNAs in Ovarian Carcinomas. Endocr Relat Cancer. 2009 Nov 10. [Epub ahead of print]
51. Lodes MJ, Caraballo M, Suciu D, Munro S, Kumar A, Anderson B. Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One 2009; 4: e6229.
52. Wang Y, Lee CG. MicroRNA and cancer--focus on apoptosis. J Cell Mol Med 2009; 13: 12-23.
53. Lei L, Jin S, Gonzalez G, Behringer RR, Woodruff TK. The regulatory role of Dicer in folliculogenesis in mice. Mol Cell Endocrinol 2010; 315: 63-73.
54. Nagaraja AK, Andreu-Vieyra C, Franco HL, et al. Deletion of Dicer in somatic cells of the female reproductive tract causes sterility. Mol Endocrinol 2008; 22: 2336-52.
55. Murchison EP, Stein P, Xuan Z, et al. Critical roles for Dicer in the female germline. Genes Dev 2007; 21: 682-93
56. Tang F, Kaneda M, O'Carroll D, et al. Maternal microRNAs are essential for mouse zygotic development. Genes Dev 2007; 21: 644-8.
57. Kaneda M, Tang F, O'Carroll D, Lao K, Surani MA. Essential role for Argonaute2 protein in mouse oogenesis. Epigenetics Chromatin 2009; 2: 9.
58. Wang N, Zhang P, Guo X, Zhou Z, Sha J. Hnrnpk, a protein differentially expressed in immature rat ovarian development, is required for normal primordial follicle assembly and development. Endocrinology 2011; 152: 1024-35.
59. An Y, Cai Y, Guan Y, et al. Inhibitory effect of small interfering RNA targeting insulin-like growth factor-I receptor in ovarian cancer OVCAR3 cells. Cancer Biother Radiopharm 2010; 25: 545-52.
60. Wen J, Zhang H, Li G, et al. PAR6, a potential marker for the germ cells selected to form primordia follicles in mouse ovary. PLoS One 2009; 4: e7372.
61. Gulia-Nuss M, Robertson AE, Brown MR, Strand MR. Insulin-Like Peptides and tle Target of Rapamycin Pathway Coordinately Regulate Blood Digestion and Egg Maturation in the Mosquito Aedes aegypti. PLoS One 2011; 6: e20401.
62. Hatta T, Tsuji N, Miyoshi T, et al. Leucine aminopeptidase, HlLAP, from the ixodid tick Haemaphysalis longicornis, plays vital roles in the development of oocytes. Parasitol Int 2010; 59: 286-9.
63. Poulton JS, Huang YC, Smith L, et al. The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. Development 2011; 138: 1737-45.
64. Parthasarathy R, Sheng Z, Sun Z, Palli SR. Ecdysteroid regulation of ovaria growth and oocyte maturation in the red flour beetle, Tribolium castaneum. Insect Biochem Mol Biol 2010; 40: 429-39.
65. Sirotkin AV, Lauková M, Ovcharenko D, Brenaut P, Mlyncek M. Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J Cell Physiol 2010; 223: 49-56.
66. Sirotkin AV, Ovcharenko D, Benco A, Mlyncek M. Protein kinases controlling PCNA and p53 expression in human ovarian cells. Funct Integr Genomics 2009b; 9: 185-95.
67. Tsuda N, Kawano K, Efferson CL, Ioannides CG. Synthetic microRNA and double-stranded RNA targeting the 3'-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells. Int J Oncol 2005; 27: 1299-306.
68. Lu YM, Zhang SL, Meng LR, Zhao YY. Influence of human epidermal growth factor receptor-2 siRNA on chemosensitivity to cisplatin of human ovarian carcinoma cells: an in vitro experiment. Zhonghua Yi Xue Za Zhi 2008; 88: 909-13.
69. Bruegmann E, Gruemmer R, Neulen J, Motejlek K. Regulation of soluble vascular endothelial growth factor receptor 1 secretion from human endothelial cells by tissue inhibitor of metalloproteinase 1. Mol Hum Reprod 2009 Jul 7. [Epub ahead of print] PMID: 19584194
70. Wang FQ, Barfield E, Dutta S, Pua T, Fishman DA. VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPAinduced epithelial ovarian cancer (EOC) invasion. Gynecol Oncol 2009 Sep 16. [Epub ahead of print]
71. Zhou J, Gan N, Zhang W, Lu W, Xie X. Proliferation suppression and apoptosis of ovarian carcinoma cells induced by small interfering RNA against vascular endothelial growth factor. J Obstet Gynaecol Res 2010; 36: 232-8.
72. Adham SA, Sher I, Coomber BL. Molecular blockade of VEGFR2 in human epithelial ovarian carcinoma cells. Lab Invest 2010; 90: 709-23.
73. Donahue RN, McLaughlin PJ, Zagon IS. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. Am J Physiol Regul Integr Comp Physiol 2009; 296: R1716-25.
74. Rayhman O, Klipper E, Muller L, Davidson B, Reich R, Meidan R. Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells. Cancer Res 2008; 68: 9265-73.
75. Paragh G, Kumar SM, Rakosy Z, Choi SC, Xu X, Acs G. RNA Interference-Mediated Inhibition Of Erythropoietin Receptor Expression Suppresses Tumor Growth And Invasiveness In A2780 Human Ovarian Carcinoma Cells. Am J Pathol 2009; 174: 1504-14.
76. Guo J, Schally AV, Zarandi M, Varga J, Leung PC. Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. Reprod Biol Endocrinol 2010; 8: 54.
77. Pierre P, Froment P, Nègre D, et al. Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of tle human granulosa tumor cell line, KGN. Hum Reprod 2009 Aug 11. [Epub ahead of print] PMID: 19671624
78. Tian L, Wu Z, Zhao Y, et al. Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells. J Endocrinol 2009; 202: 167-77.
79. Huang Y, Hua K, Zhou X, et al. Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. Cell Res 2008; 18: 780-91.
80. Moreno-Smith M, Lu C, Shahzad MM, et al. Dopamine Blocks Stress-Mediated Ovarian Carcinoma Growth. Clin Cancer Res 2011; 17: 3649-59.
81. Cole C, Lau S, Backen A, et al. Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer. Cancer Biol Ther 2010; 10: 495-504.
82. Tsuno T, Mejido J, Zhao T, Schmeisser H, Morrow A, Zoon KC. IRF9 is a Key Factor for Eliciting the Antiproliferative Activity of IFN-alpha. J Immunother 2009 Sep 11. [Epub ahead of print]
83. Bhattacharya R, Nicoloso M, Arvizo R, et al. MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer. Cancer Res 2009 Nov 10. [Epub ahead of print]
84. Oktay K, Buyuk E, Oktem O, Oktay M, Giancotti FG. The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis. Cell Cycle 2008; 7: 533-41.
85. Todd MC, Spruill SC, Meerbrey KL. Small interference RNAmediated suppression of overexpressed cyclin E protein restores G1/S regulation in NIH-OVCAR-3 ovarian cancer cells. Int J Oncol 2009; 35: 375-80.
86. Shin JS, Hong SW, Lee SL, et al. Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells. Int J Oncol 2008; 32: 435-9.
87. Kulkarni AA, Kingsbury SR, Tudzarova S, et al. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res 2009; 15: 2417-25.
88. Tanaka T, Mangala LS, Vivas-Mejia PE, et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res 2010; 70: 3687-3696.
89. Zhang X, Deng HX, Zhao X, et al. RNA interference-mediated silencing of the phosphatidylinositol 3-kinase catalytic subunit attenuates growth of human ovarian cancer cells in vitro and in vivo. Oncology 2009; 77: 22-32.
90. Hernandez L, Hsu SC, Davidson B, Birrer MJ, Kohn EC, Annunziata CM. Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer. Cancer Res 2010; 70: 4005-14.
91. Smith ER, Cai KQ, Smedberg JL, et al. Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells. PLoS One 2010; 5: e9295.
92. Leung EL, Wong JC, Johlfs MG, Tsang BK, Fiscus RR. Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Mol Cancer Res 2010; 8: 578-91.
93. Rao ZY, Cai MY, Yang GF, et al. EZH2 supports ovaria carcinoma cell invasion and/or metastasi via regulation of TGF-beta1 and is a predictor of outcome in ovaria carcinoma patiens. Carcinogenesis 2010; 31: 1576-83.
94. Linnerth NM, Greenaway JB, Petrik JJ, Moorehead RA. cAMP response element-binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation. Int J Gynecol Cancer 2008; 18: 1248-57.
95. Chan DW, Liu VW, To RM, Chiu et al. Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21(WAF1/CIP1) expression in ovarian cancer. Br J Cancer 2009; 146: 222-6
96. Yoshioka N, Suzuki N, Uekawa A, Kiguchi K, Ishizuka B. POU6F1 is tle transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. Hum Cell 2009; 22: 94-100.
97. Suzuki N, Yoshioka N, Uekawa A, et al. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Int J Gynecol Cancer 2010; 20: 212-9.
98. Huang F, Tong X, Fu L, Zhang R. Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell line in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai) 2008; 40: 519-25.
99. Cai L, Zhang G, Tong X, You et al. Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA. Eur J Obstet Gynecol Reprod Biol 2010; 148: 73-80.
100. Ma JJ, Chen BL, Xin XY. XIAP gene downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and reverses the cisplatin resistance of ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol 2009; 146: 222-6.
101. Shahzad MM, Arevalo JM, Armaiz-Pena GN, et al. Stress effects on FosB-and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J Biol Chem 2010; 285: 35462-70.
102. Tarapore P, Shu Y, Guo P, Ho S-M. Application of Phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Molecular Therapy 2011; 19: 386-94.
103. Lin Y, Peng S, Yu H, Teng H, Cui M. RNAi-mediated downregulation of NOB1 suppresses the growth and colony formation ability of human ovarian cancer cells. Med Oncol 2011 [Epub ahead of print] PubMed PMID: 21287298.
104. Luo Y, Yi Y, Yao Z. Growth arrest in ovarian cancer cells by hTERT inhibition short-hairpin RNA targeting human telomerase reverse transcriptase induces immediate growth inhibition but not necessarily induces apoptosis in ovaria cancer cells. Cancer Invest 2009; 27: 960-70.
105. Zhou Y, Yi X, Stoffer JB, et al. The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer. Mol Cancer Res 2008; 6: 1375-84.
106. Uddin S, Ahmed M, Hussain A, et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. Int J Cancer 2010; 126: 382-94.
107. Yotsumoto F, Yagi H, Suzuki SO, et al. Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem Biophys Res Commun 2008; 365: 555-61.
108. Dickerson EB, Blackburn WH, Smith MH, Kapa LB, Lyon LA, McDonald JF. Chemosensitization of cancer cells by siRNA using targeted nanogel delivery. BMC Cancer 2010; 10: 10.
109. Lane D, Goncharenko-Khaider N, Rancourt C, Piché A. Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation. Oncogene 2010; 29: 3519-31.
110. Witham J, Valenti MR, De-Haven-Brandon AK, et al. The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin. Clin Cancer Res 2007; 13: 7191-8.
111. Brotin E, Meryet-Figuière M, Simonin K, et al. Bcl-x(L) and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis. Int J Cancer 2009 Jul 24. [Epub ahead of print]
112. Mancini F, Di Conza G, Pellegrino M, et al. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. EMBO J 2009; 28: 1926-39.
113. Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci USA 2011; 108: 745-50.
114. Vivas-Mejia PE, Rodriguez-Aguayo C, Han HD, et al. Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer. Clin Cancor Res 2011; 17: 3716-26.
115. Huang Y, Jin H, Liu Y, et al. FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5. Endocr Relat Cancer 2010; 18: 13-26.
116. Sirotkin AV, Ovcharenko D, Grossmann R, Lauková M, Mlyncek M. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. J Cell Physiol 2009; 219: 415-20.
117. Sirotkin AV, Ovcharenko D, Mlynček M. Identification of protein kinases that control ovarian hormone release by selective siRNAs. J Molec Endocrinol 2010b; 44: 45-53.
118. Wu YG, Bennett J, Talla D, Stocco C. Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells. Mol Endocrinol 2011; 25: 656-68.
119. Li Y, Liang XY, Wei LN, et al. Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alphahydroxylase/ 17, 20-lyase activity in vivo. Reprod Biol Endocrinol 2009 7: 73.
120. Hui YY, Lavoie HA. GATA4 reduction enhances 3',5'-cyclic adenosine 5'-monophosphate-stimulated steroidogenic acute regulatory protein messenger ribonucleic acid and progesterone production in luteinized porcine granulosa cells. Endocrinology 2008; 149: 5557-67.
121. Kobayashi S, Sakatani M, Kobayashi S, Okuda K, Takahashi M. Gene silencing of cyclooxygenase-2 mRNA by RNA interference in bovine cumulus-granulosa cells. J Reprod Dev 2007; 53: 1305-11.
122. Wang C, Xu B, Zhou B, et al. Reducing CYP51 inhibits FSHinduced resumption of mouse oocyte meiosis in vitro. J Lipid Res 2009 May 11. [Epub ahead of print] PMID: 19433477
123. Mattiske DM, Han L, Mann JR. Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm. Reproduction 2009; 137: 625-32.
124. Suh N, Baehner L, Moltzahn F, et al. MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol 2010; 20: 271-7.
125. Hasegawa A, Koyama K. Contribution of zona proteins to oocyte growth. Soc Reprod Fertil Suppl 2007; 63: 229-35.
126. Boldbaatar D, Battsetseg B, Matsuo T, et al. Tick vitellogenin receptor reveals critical role in oocyte development and transovarial transmission of Babesia parasite. Biochem Cell Biol 2008; 86: 331-44.
127. Lu HL, Vinson SB, Pietrantonio PV. Oocyte membrane localization of vitellogenin receptor coincides with queen flying age, and receptor silencing by RNAi disrupts egg formation in fire ant viržin queens. FEBS J 2009; 276: 3110-23.
128. Diaz-Albiter H, Mitford R, Genta FA, Sant'Anna MR, Dillon RJ. Reactive oxygen species scavenging by catalase is important for female Lutzomyia longipalpis fecundity and mortality. PLoS One 2011; 6: e17486.
129. Treerattrakool S, Panyim S, Udomkit A. Induction of ovarian maturation and spawning in Penaeus monodon broodstock by double-stranded RNA. Mar Biotechnik (NY) 2011; 13: 163-9.
130. Wu SC. RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells. Biotechnology Advances 2009; 27: 417-22.
131. Rahbek UL, Howard KA, Oupicky D, et al. Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. J Gene Med 2008; 10: 81-93.
132. Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 2008; 105: 11915-20.
133. Kim SH, Jeong JH, Lee SH, Kim SW, Park TG. LHRH receptormediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjug Chem 2008; 19: 2156-62.