Biosensor-based approach to the identification of protein kinase ligands with dual-site modes of action

Journal of Biomolecular Screening

Volumn 17, Issue 2, 2012, Pages 183-193

  Navratilova, Iva ^a,b   MacDonald, Graeme ^a   Robinson, Colin ^a   Hughes, Samantha ^a   Mathias, John ^a   Phillips, Chris ^a   Cook, Andrew ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

allosteric; ITK; kinase; SPR biosensor; X ray crystallography

Indexed keywords

ADENOSINE TRIPHOSPHATE; INTERLEUKIN 2; LIGAND; PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOSENSOR; CONTROLLED STUDY; ENZYME ACTIVE SITE; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BIOSENSING TECHNIQUES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HIGH-THROUGHPUT SCREENING ASSAYS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SURFACE PLASMON RESONANCE;

EID: 84856298523     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111422746     Document Type: Article

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